Gene/Proteome Database (LMPD)

LMPD ID
LMP004810
Gene ID
8813
Species
Homo sapiens (Human)
Gene Name
dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit
Gene Symbol
DPM1
Synonyms
CDGIE; MPDS
Alternate Names
dolichol-phosphate mannosyltransferase subunit 1; DPM synthase subunit 1; MPD synthase subunit 1; mannose-P-dolichol synthase subunit 1; DPM synthase complex, catalytic subunit; dolichol monophosphate mannose synthase; dolichol-phosphate mannose synthase subunit 1; dolichyl-phosphate beta-D-mannosyltransferase subunit 1
Chromosome
20
Map Location
20q13.13
EC Number
2.4.1.83
Summary
Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. Human DPM1 lacks a carboxy-terminal transmembrane domain and signal sequence and is regulated by DPM2. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for DPM1

Proteins

dolichol-phosphate mannosyltransferase subunit 1
Refseq ID NP_003850
Protein GI 4503363
UniProt ID O60762
mRNA ID NM_003859
Length 260
RefSeq Status REVIEWED
MASLEVSRSPRRSRRELEVRSPRQNKYSVLLPTYNERENLPLIVWLLVKSFSESGINYEIIIIDDGSPDGTRDVAEQLEKIYGSDRILLRPREKKLGLGTAYIHGMKHATGNYIIIMDADLSHHPKFIPEFIRKQKEGNFDIVSGTRYKGNGGVYGWDLKRKIISRGANFLTQILLRPGASDLTGSFRLYRKEVLEKLIEKCVSKGYVFQMEMIVRARQLNYTIGEVPISFVDRVYGESKLGGNEIVSFLKGLLTLFATT

Gene Information

Entrez Gene ID
8813
Gene Name
dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit
Gene Symbol
DPM1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0033185 IDA:UniProtKB C dolichol-phosphate-mannose synthase complex
GO:0005783 IDA:MGI C endoplasmic reticulum
GO:0005789 IDA:HGNC C endoplasmic reticulum membrane
GO:0016020 IDA:UniProtKB C membrane
GO:0005634 IDA:UniProt C nucleus
GO:0043178 IEA:Ensembl F alcohol binding
GO:0004582 IDA:UniProtKB F dolichyl-phosphate beta-D-mannosyltransferase activity
GO:0004169 IDA:HGNC F dolichyl-phosphate-mannose-protein mannosyltransferase activity
GO:0005537 IEA:Ensembl F mannose binding
GO:0006501 TAS:Reactome P C-terminal protein lipidation
GO:0019673 IEA:Ensembl P GDP-mannose metabolic process
GO:0006506 IDA:UniProtKB P GPI anchor biosynthetic process
GO:0044267 TAS:Reactome P cellular protein metabolic process
GO:0019348 IDA:MGI P dolichol metabolic process
GO:0006488 TAS:Reactome P dolichol-linked oligosaccharide biosynthetic process
GO:0043687 TAS:Reactome P post-translational protein modification
GO:0018279 TAS:Reactome P protein N-linked glycosylation via asparagine
GO:0035269 IDA:HGNC P protein O-linked mannosylation
GO:0035268 IDA:HGNC P protein mannosylation

KEGG Pathway Links

KEGG Pathway ID Description
hsa01100 Metabolic pathways
hsa00510 N-Glycan biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_2032 Synthesis of dolichyl-phosphate mannose
REACT_22387 Synthesis of substrates in N-glycan biosythesis

Domain Information

InterPro Annotations

Accession Description
IPR001173 Glycosyltransferase 2-like
IPR029044 Nucleotide-diphospho-sugar transferases

UniProt Annotations

Entry Information

Gene Name
dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit
Protein Entry
DPM1_HUMAN
UniProt ID
O60762
Species
Human

Comments

Comment Type Description
Catalytic Activity GDP-mannose + dolichyl phosphate = GDP + dolichyl D-mannosyl phosphate.
Disease Congenital disorder of glycosylation 1E (CDG1E) [MIM
Function Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O- mannosylation of proteins; catalytic subunit of the dolichol- phosphate mannose (DPM) synthase complex.
Interaction Q9P2X0:DPM3; NbExp=4; IntAct=EBI-719526, EBI-9087337;
Pathway Protein modification; protein glycosylation.
Similarity Belongs to the glycosyltransferase 2 family.
Subcellular Location Endoplasmic reticulum.
Subunit Component of the dolichol-phosphate mannose (DPM) synthase complex composed of DPM1, DPM2 and DPM3; in the complex interacts directly with DPM3. {ECO
Web Resource Name=GGDB; Note=GlycoGene database; URL="http://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=DPM1";

Identical and Related Proteins

Unique RefSeq proteins for LMP004810 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
4503363 RefSeq NP_003850 260 dolichol-phosphate mannosyltransferase subunit 1

Identical Sequences to LMP004810 proteins

Reference Database Accession Length Protein Name
GI:4503363 DBBJ BAF82258.1 260 unnamed protein product [Homo sapiens]
GI:4503363 EMBL CAG33207.1 260 DPM1 [Homo sapiens]
GI:4503363 GenBank ACM84791.1 260 Sequence 10289 from patent US 6812339
GI:4503363 GenBank AFG79903.1 260 Sequence 162 from patent US 8137928
GI:4503363 RefSeq XP_002830465.2 260 PREDICTED: dolichol-phosphate mannosyltransferase subunit 1 [Pongo abelii]
GI:4503363 SwissProt O60762.1 260 RecName: Full=Dolichol-phosphate mannosyltransferase subunit 1; AltName: Full=Dolichol-phosphate mannose synthase subunit 1; Short=DPM synthase subunit 1; AltName: Full=Dolichyl-phosphate beta-D-mannosyltransferase subunit 1; AltName: Full=Mannose-P-dolichol synthase subunit 1; Short=MPD synthase subunit 1 [Homo sapiens]

Related Sequences to LMP004810 proteins

Reference Database Accession Length Protein Name
GI:4503363 GenBank AAH08466.1 260 Dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit [Homo sapiens]
GI:4503363 GenBank EAW75608.1 315 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit, isoform CRA_b [Homo sapiens]
GI:4503363 GenBank JAA33283.1 260 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit [Pan troglodytes]
GI:4503363 GenBank AIC55479.1 260 DPM1, partial [synthetic construct]
GI:4503363 RefSeq XP_001168296.1 260 PREDICTED: dolichol-phosphate mannosyltransferase subunit 1 [Pan troglodytes]
GI:4503363 RefSeq XP_003815313.1 260 PREDICTED: dolichol-phosphate mannosyltransferase subunit 1 [Pan paniscus]