Gene/Proteome Database (LMPD)

LMPD ID
LMP004832
Gene ID
17977
Species
Mus musculus (Mouse)
Gene Name
nuclear receptor coactivator 1
Gene Symbol
Ncoa1
Synonyms
KAT13A; SRC-1; SRC1; bHLHe74
Alternate Names
nuclear receptor coactivator 1; NCoA-1; mNRC-1; SRC-a/NCoA-1; steroid receptor coactivator 1; steroid receptor coactivator-1; nuclear receptor coactivator protein 1
Chromosome
12
Map Location
12|12 A2-A3
EC Number
2.3.1.48

Proteins

nuclear receptor coactivator 1
Refseq ID NP_035011
Protein GI 6754800
UniProt ID P70365
mRNA ID NM_010881
Length 1405
RefSeq Status VALIDATED
MSGLGDSSSDPANPDSHKRKGSPCDTLASSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCEGRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNLLPKSLVNGVPWPQEATRRNSHTFNCRMLIHPPEDPGTENQEACQRYEVMQCFTVSQPKSIQEDGEDFQSCLICIARRLPRPPAITGVESFMTKQDTTGKIISIDTSSLRAAGRTGWEDLVRKCIYAFFQPQGREPSYARQLFQEVMTRGTASSPSYRFILNDGTMLSAHTKCKLCYPQSPDMQPFIMGIHIIDREHSGLSPQDDSNSGMSIPRINPSVNPGISPAHGVTRSSTLPPSNNNMVSARVNRQQSSDLNSSSSHTNSSNNQGNFGCSPGNQIVANVALNQGQAGSQSSNPSLNLNNSPMEGTGIALSQFMSPRRQANSGLATRARMSNNSFPPNIPTLSSPVGITSGACNNNNRSYSNIPVTSLQGMNEGPNNSVGFSAGSPVLRQMSSQNSPSRLSMQPAKAESKDSKEIASILNEMIQSDNSDNSANEGKPLDSGLLHNNDRLSEGDSKYSQTSHKLVQLLTTTAEQQLRHADIDTSCKDVLSCTGTSSSASSNPSGGTCPSSHSSLTERHKILHRLLQEGSPSDITTLSVEPEKKDSVPASTAVSVSGQSQGSASIKLELDAAKKKESKDHQLLRYLLDKDEKDLRSTPNLCLDDVKVKVEKKEQMDPCNTNPTPMTKPAPEEVKLESQSQFTADLDQFDQLLPTLEKAAQLPSLCETDRMDGAVTGVSIKAEVLPASLQPTTARAAPRLSRLPELELEAIDNQFGQPGAGDQIPWANNTLTTINQNKPEDQCISSQLDELLCPPTTVEGRNDEKALLEQLVSFLSGKDETELAELDRALGIDKLVQGGGLDVLSERFPPQQATPPLMMEDRPTLYSQPYSSPSPTAGLSGPFQGMVRQKPSLGAMPVQVTPPRGTFSPNMGMQPRQTLNRPPAAPNQLRLQLQQRLQGQQQLMHQNRQAILNQFAANAPVGMNMRSGMQQQITPQPPLNAQMLAQRQRELYSQQHRQRQIIQQQRAMLMRHQSFGNNIPPSSGLPVQMGTPRLPQGAPQQFPYPPNYGTNPGTPPASTSPFSQLAANPEASLATRSSMVNRGMAGNMGGQFGAGISPQMQQNVFQYPGPGLVPQGEATFAPSLSPGSSMVPMPVPPPQSSLLQQTPPTSGYQSPDMKAWQQGTMGNNNVFSQAVQSQPAPAQPGVYNNMSITVSMAGGNANIQNMNPMMGQMQMSSLQMPGMNTVCSEQMNDPALRHTGLYCNQLSSTDLLKTDADGNQDKKTEEFFSVVTTD

Gene Information

Entrez Gene ID
17977
Gene Name
nuclear receptor coactivator 1
Gene Symbol
Ncoa1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:Ensembl C cytoplasm
GO:0043005 IEA:Ensembl C neuron projection
GO:0000790 IEA:Ensembl C nuclear chromatin
GO:0005654 TAS:Reactome C nucleoplasm
GO:0003677 IDA:MGI F DNA binding
GO:0001012 IEA:Ensembl F RNA polymerase II regulatory region DNA binding
GO:0003682 IDA:MGI F chromatin binding
GO:0004402 IEA:UniProtKB-EC F histone acetyltransferase activity
GO:0030374 IEA:Ensembl F ligand-dependent nuclear receptor transcription coactivator activity
GO:0004871 IEA:InterPro F signal transducer activity
GO:0003713 IDA:UniProtKB F transcription coactivator activity
GO:0008134 IPI:UniProtKB F transcription factor binding
GO:0032870 IEA:Ensembl P cellular response to hormone stimulus
GO:0021549 IEA:Ensembl P cerebellum development
GO:0021987 IEA:Ensembl P cerebral cortex development
GO:0060206 IEA:Ensembl P estrous cycle phase
GO:0021766 IEA:Ensembl P hippocampus development
GO:0043967 IMP:UniProtKB P histone H4 acetylation
GO:0021854 IEA:Ensembl P hypothalamus development
GO:0060713 IGI:MGI P labyrinthine layer morphogenesis
GO:0007595 IEA:Ensembl P lactation
GO:0008584 IEA:Ensembl P male gonad development
GO:0060179 IEA:Ensembl P male mating behavior
GO:0042698 IEA:Ensembl P ovulation cycle
GO:0043065 IMP:UniProtKB P positive regulation of apoptotic process
GO:0045925 IEA:Ensembl P positive regulation of female receptivity
GO:0045666 IMP:UniProtKB P positive regulation of neuron differentiation
GO:0045944 IDA:MGI P positive regulation of transcription from RNA polymerase II promoter
GO:0000435 IMP:UniProtKB P positive regulation of transcription from RNA polymerase II promoter by galactose
GO:0045893 ISS:UniProtKB P positive regulation of transcription, DNA-templated
GO:2001141 IMP:UniProtKB P regulation of RNA biosynthetic process
GO:2001038 IMP:UniProtKB P regulation of cellular response to drug
GO:0032355 IEA:Ensembl P response to estradiol
GO:0032570 IEA:Ensembl P response to progesterone
GO:0032526 IEA:Ensembl P response to retinoic acid
GO:0006351 IEA:UniProtKB-KW P transcription, DNA-templated

KEGG Pathway Links

KEGG Pathway ID Description
mmu04919 Thyroid hormone signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR010011 Domain of unknown function DUF1518
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
IPR017426 Nuclear receptor coactivator
IPR028819 Nuclear receptor coactivator 1
IPR008955 Nuclear receptor coactivator Src-1
IPR014920 Nuclear receptor coactivator, Ncoa-type, interlocking
IPR009110 Nuclear receptor coactivator, interlocking
IPR000014 PAS domain
IPR013767 PAS_fold
IPR014935 Steroid receptor coactivator

UniProt Annotations

Entry Information

Gene Name
nuclear receptor coactivator 1
Protein Entry
NCOA1_MOUSE
UniProt ID
P70365
Species
Mouse

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=SRC-1A, SRC1a; IsoId=P70365-1; Sequence=Displayed; Name=2; Synonyms=SRC-1E, SRC1e; IsoId=P70365-2; Sequence=VSP_011740; Name=3; IsoId=P70365-3; Sequence=VSP_011741; Note=No experimental confirmation available.; Name=4; IsoId=P70365-4; Sequence=VSP_027855, VSP_027856; Note=No experimental confirmation available.;
Catalytic Activity Acetyl-CoA + [histone] = CoA + acetyl- [histone].
Disruption Phenotype Mice show partial hormone resistance: target organs such as uterus, prostate, testis and mammary gland exhibiting decreased growth and development in response to steroid hormones. Moreover, such mice are prone to obesity due to reduced energy expenditure. {ECO:0000269|PubMed:9506940}.
Domain Contains 7 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. LXXLL motifs 3, 4 and 5 are essential for the association with nuclear receptors. LXXLL motif 7, which is not present in isoform 2, increases the affinity for steroid receptors in vitro.
Domain The C-terminal (1113-1447) part mediates the histone acetyltransferase (HAT) activity. {ECO:0000250}.
Function Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3. {ECO:0000269|PubMed:12507421, ECO:0000269|PubMed:16148126, ECO:0000269|PubMed:8616895, ECO:0000269|PubMed:9506940}.
Ptm Sumoylated; sumoylation increases its interaction with PGR and prolongs its retention in the nucleus. It does not prevent its ubiquitination and does not exert a clear effect on the stability of the protein (By similarity). {ECO:0000250}.
Ptm Ubiquitinated; leading to proteasome-mediated degradation. Ubiquitination and sumoylation take place at different sites (By similarity). {ECO:0000250}.
Similarity Belongs to the SRC/p160 nuclear receptor coactivator family. {ECO:0000305}.
Similarity Contains 1 PAS (PER-ARNT-SIM) domain. {ECO:0000255|PROSITE-ProRule:PRU00140}.
Similarity Contains 1 bHLH (basic helix-loop-helix) domain. {ECO:0000255|PROSITE-ProRule:PRU00981}.
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00981, ECO:0000269|PubMed:8855229}.
Subunit Interacts with NCOA6 and NCOA2. Interacts with the FDL motif of STAT5A and STAT5B. Interacts with the LXXLL motif of STAT6. Interacts with STAT3 following IL-6 stimulation. Interacts with the basal transcription factor GTF2B. Interacts with COPS5, NR3C1, PCAF and TTLL5/STAMP. Interacts with the histone acetyltransferases EP300 and CREBBP, and the methyltransferase CARM1. Interacts with PSMB9. Interacts with UBE2L3; they functionally interact to regulate progesterone receptor transcriptional activity. Interacts with PRMT2 and DDX5. Interacts with ASXL1. Interacts with PRMT6. Interacts (via LXXLL 1, 2 and 3 motifs) with RORC (via AF-2 motif). Interacts in a ligand- dependent fashion with RXRA. {ECO:0000269|PubMed:10381882, ECO:0000269|PubMed:14757047, ECO:0000269|PubMed:16148126, ECO:0000269|PubMed:8616895, ECO:0000269|PubMed:8855229}.
Tissue Specificity Widely expressed. {ECO:0000269|PubMed:8855229, ECO:0000269|PubMed:9192892}.

Identical and Related Proteins

Unique RefSeq proteins for LMP004832 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6754800 RefSeq NP_035011 1405 nuclear receptor coactivator 1

Identical Sequences to LMP004832 proteins

Reference Database Accession Length Protein Name
GI:6754800 GenBank AAB38841.1 1405 steroid receptor coactivator-1 [Mus musculus]
GI:6754800 GenBank AAH68177.1 1405 Nuclear receptor coactivator 1 [Mus musculus]
GI:6754800 GenBank EDL01368.1 1405 nuclear receptor coactivator 1, isoform CRA_b [Mus musculus]
GI:6754800 RefSeq XP_006515072.1 1405 PREDICTED: nuclear receptor coactivator 1 isoform X5 [Mus musculus]

Related Sequences to LMP004832 proteins

Reference Database Accession Length Protein Name
GI:6754800 GenBank AAB01228.1 1405 steroid receptor coactivator 1a [Mus musculus]
GI:6754800 RefSeq XP_006515068.1 1447 PREDICTED: nuclear receptor coactivator 1 isoform X1 [Mus musculus]
GI:6754800 RefSeq XP_006515069.1 1447 PREDICTED: nuclear receptor coactivator 1 isoform X2 [Mus musculus]
GI:6754800 RefSeq XP_006515070.1 1447 PREDICTED: nuclear receptor coactivator 1 isoform X3 [Mus musculus]
GI:6754800 RefSeq XP_006515071.1 1446 PREDICTED: nuclear receptor coactivator 1 isoform X4 [Mus musculus]
GI:6754800 SwissProt P70365.2 1447 RecName: Full=Nuclear receptor coactivator 1; Short=NCoA-1; AltName: Full=Nuclear receptor coactivator protein 1; Short=mNRC-1; AltName: Full=Steroid receptor coactivator 1; Short=SRC-1 [Mus musculus]