Gene/Proteome Database (LMPD)

LMPD ID
LMP004839
Gene ID
56451
Species
Mus musculus (Mouse)
Gene Name
succinate-CoA ligase, GDP-forming, alpha subunit
Gene Symbol
Suclg1
Synonyms
1500000I01Rik; Sucla1
Alternate Names
succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; SCS-alpha; succinyl-CoA synthetase subunit alpha; succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial
Chromosome
6
Map Location
6|6 C3
EC Number
6.2.1.4

Proteins

succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial precursor
Refseq ID NP_063932
Protein GI 255958286
UniProt ID Q9WUM5
mRNA ID NM_019879
Length 346
RefSeq Status VALIDATED
MTATVVAAAATATMVSSSSGLAAARLLSRTFLLQQNGIRHGSYTASRKHIYIDKNTKIICQGFTGKQGTFHSQQALEYGTKLVGGTTPGKGGQKHLGLPVFNTVKEAKEKTGATASVIYVPPPFAAAAINEAIDAEIPLVVCITEGIPQQDMVRVKHRLTRQGTTRLIGPNCPGVINPGECKIGIMPGHIHKKGRIGIVSRSGTLTYEAVHQTTQVGLGQSLCIGIGGDPFNGTDFIDCLEVFLNDPATEGIILIGEIGGHAEENAAAFLKEHNSGPKAKPVVSFIAGITAPPGRRMGHAGAIIAGGKGGAKEKISALQSAGVVVSMSPAQLGTTIYKEFEKRKML
transit_peptide: 1..40 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (By similarity); propagated from UniProtKB/Swiss-Prot (Q9WUM5.4) calculated_mol_wt: 4075 peptide sequence: MTATVVAAAATATMVSSSSGLAAARLLSRTFLLQQNGIRH mat_peptide: 41..346 product: Succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q9WUM5.4) calculated_mol_wt: 32098 peptide sequence: GSYTASRKHIYIDKNTKIICQGFTGKQGTFHSQQALEYGTKLVGGTTPGKGGQKHLGLPVFNTVKEAKEKTGATASVIYVPPPFAAAAINEAIDAEIPLVVCITEGIPQQDMVRVKHRLTRQGTTRLIGPNCPGVINPGECKIGIMPGHIHKKGRIGIVSRSGTLTYEAVHQTTQVGLGQSLCIGIGGDPFNGTDFIDCLEVFLNDPATEGIILIGEIGGHAEENAAAFLKEHNSGPKAKPVVSFIAGITAPPGRRMGHAGAIIAGGKGGAKEKISALQSAGVVVSMSPAQLGTTIYKEFEKRKML

Gene Information

Entrez Gene ID
56451
Gene Name
succinate-CoA ligase, GDP-forming, alpha subunit
Gene Symbol
Suclg1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0005743 IDA:MGI C mitochondrial inner membrane
GO:0005739 IDA:MGI C mitochondrion
GO:0045244 IEA:Ensembl C succinate-CoA ligase complex (GDP-forming)
GO:0003878 IEA:InterPro F ATP citrate synthase activity
GO:0019003 IEA:Ensembl F GDP binding
GO:0005525 IEA:UniProtKB-KW F GTP binding
GO:0048037 IEA:InterPro F cofactor binding
GO:0044822 IEA:Ensembl F poly(A) RNA binding
GO:0004775 IEA:UniProtKB-EC F succinate-CoA ligase (ADP-forming) activity
GO:0004776 IEA:UniProtKB-EC F succinate-CoA ligase (GDP-forming) activity
GO:0006105 IEA:Ensembl P succinate metabolic process
GO:0006104 IEA:Ensembl P succinyl-CoA metabolic process
GO:0006099 IEA:UniProtKB-UniPathway P tricarboxylic acid cycle

KEGG Pathway Links

KEGG Pathway ID Description
mmu01200 Carbon metabolism
mmu00020 Citrate cycle (TCA cycle)

Domain Information

InterPro Annotations

Accession Description
IPR005811 ATP-citrate lyase/succinyl-CoA ligase
IPR017440 ATP-citrate lyase/succinyl-CoA ligase, active site
IPR003781 CoA-binding
IPR016040 NAD(P)-binding domain
IPR005810 Succinyl-CoA ligase, alpha subunit
IPR016102 Succinyl-CoA synthetase-like

UniProt Annotations

Entry Information

Gene Name
succinate-CoA ligase, GDP-forming, alpha subunit
Protein Entry
SUCA_MOUSE
UniProt ID
Q9WUM5
Species
Mouse

Comments

Comment Type Description
Catalytic Activity ATP + succinate + CoA = ADP + phosphate + succinyl-CoA.
Catalytic Activity GTP + succinate + CoA = GDP + phosphate + succinyl-CoA.
Function Catalyzes the ATP- or GTP-dependent ligation of succinate and CoA to form succinyl-CoA. The nature of the beta subunit determines the nucleotide specificity (By similarity). {ECO:0000250}.
Pathway Carbohydrate metabolism; tricarboxylic acid cycle.
Sequence Caution Sequence=AAD33927.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH11087.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB22331.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB23804.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC40634.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Similarity Belongs to the succinate/malate CoA ligase alpha subunit family. {ECO:0000305}.
Subcellular Location Mitochondrion {ECO:0000250}.
Subunit Heterodimer of an alpha and a beta subunit. {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP004839 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
255958286 RefSeq NP_063932 346 succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial precursor

Identical Sequences to LMP004839 proteins

Reference Database Accession Length Protein Name
GI:255958286 SwissProt Q9WUM5.4 346 RecName: Full=Succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; AltName: Full=Succinyl-CoA synthetase subunit alpha; Short=SCS-alpha; Flags: Precursor [Mus musculus]

Related Sequences to LMP004839 proteins

Reference Database Accession Length Protein Name
GI:255958286 RefSeq XP_004437258.1 346 PREDICTED: succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial [Ceratotherium simum simum]
GI:255958286 RefSeq XP_005364778.1 346 PREDICTED: succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial [Microtus ochrogaster]
GI:255958286 RefSeq XP_005655282.1 346 PREDICTED: succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial isoform X1 [Sus scrofa]
GI:255958286 RefSeq XP_007968242.1 415 PREDICTED: succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial [Chlorocebus sabaeus]
GI:255958286 RefSeq XP_008589148.1 346 PREDICTED: succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial isoform X1 [Galeopterus variegatus]
GI:255958286 RefSeq XP_008698280.1 346 PREDICTED: succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial isoform X1 [Ursus maritimus]