Gene/Proteome Database (LMPD)

LMPD ID
LMP004861
Gene ID
284161
Species
Homo sapiens (Human)
Gene Name
glycerophosphodiester phosphodiesterase domain containing 1
Gene Symbol
GDPD1
Synonyms
GDE4
Alternate Names
glycerophosphodiester phosphodiesterase domain-containing protein 1; glycerophosphodiester phosphodiesterase 4
Chromosome
17
Map Location
17q22
EC Number
3.1.-.-
Summary
This gene encodes a member of the glycerophosphodiester phosphodiesterase family of enzymes that catalyze the hydrolysis of deacylated glycerophospholipids to glycerol phosphate and alcohol. The encoded protein is localized to the cytoplasm and concentrates near the perinuclear region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Orthologs
View orthologs and multiple alignments for GDPD1

Proteins

glycerophosphodiester phosphodiesterase domain-containing protein 1 isoform 1
Refseq ID NP_872375
Protein GI 260763876
UniProt ID Q8N9F7
mRNA ID NM_182569
Length 314
RefSeq Status REVIEWED
MSSTAAFYLLSTLGGYLVTSFLLLKYPTLLHQRKKQRFLSKHISHRGGAGENLENTMAAFQHAVKIGTDMLELDCHITKDEQVVVSHDENLKRATGVNVNISDLKYCELPPYLGKLDVSFQRACQCEGKDNRIPLLKEVFEAFPNTPINIDIKVNNNVLIKKVSELVKRYNREHLTVWGNANYEIVEKCYKENSDIPILFSLQRVLLILGLFFTGLLPFVPIREQFFEIPMPSIILKLKEPHTMSRSQKFLIWLSDLLLMRKALFDHLTARGIQVYIWVLNEEQEYKRAFDLGATGVMTDYPTKLRDFLHNFSA
glycerophosphodiester phosphodiesterase domain-containing protein 1 isoform 2
Refseq ID NP_001159466
Protein GI 260763880
UniProt ID Q8N9F7
mRNA ID NM_001165994
Length 290
RefSeq Status REVIEWED
MSSTAAFYLLSTLGGYLVTSFLLLKYPTLLHQRKKQRFLSKHISHRGGAGENLENTMAAFQHAVKIGTDMLELDCHITKDEQVVVSHDENLKRATGVNVNISDLKYCELPPYLGKLDVSFQRACQCEGKDNRIPLLKEVFEAFPNTPINIDIKVNNNVLIKKVSELVKRYNREHLTVWGNANYEIVEKCYKENSDIPILFSLQRVLLILGLFFTGLLPFVPIREQFFEIPMPSIILKLKEPHTMSRSQKFLIWLSDLLLMRKALFDHLTARGIQVSFWNDAFWKQHSSPV
glycerophosphodiester phosphodiesterase domain-containing protein 1 isoform 3
Refseq ID NP_001159465
Protein GI 260763878
UniProt ID Q8N9F7
mRNA ID NM_001165993
Length 289
RefSeq Status REVIEWED
MSSTAAFYLLSTLGGYLVTSFLLLKYPTLLHQRKKQRFLSKHISHRGGAGENLENTMAAFQHAVKIGTDMLELDCHITKDEQVVVSHDENLKRATGVNVNISDLKYCELPPYLGKLDVSFQRACQCEGKDNRIPLLKEVFEAFPNTPINIDIKVNNNVLIKKVSELVKRYNREHLTVWGNANYEIVEKCYKENSDIPILFSLQRVLLILGLFFTGLLPFVPIREQFFEIPMPSIILKLKEPHTMSRSQKFLIWLSDLLLMRKALFEPLHPASKRNFEGHCSYLVVSCYF

Gene Information

Entrez Gene ID
284161
Gene Name
glycerophosphodiester phosphodiesterase domain containing 1
Gene Symbol
GDPD1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0016020 IDA:UniProtKB C membrane
GO:0008889 IEA:InterPro F glycerophosphodiester phosphodiesterase activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0006071 IEA:InterPro P glycerol metabolic process
GO:0006629 IEA:InterPro P lipid metabolic process

Domain Information

InterPro Annotations

Accession Description
IPR004129 Glycerophosphoryl diester phosphodiesterase
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain

UniProt Annotations

Entry Information

Gene Name
glycerophosphodiester phosphodiesterase domain containing 1
Protein Entry
GDPD1_HUMAN
UniProt ID
Q8N9F7
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8N9F7-1; Sequence=Displayed; Name=2; IsoId=Q8N9F7-2; Sequence=VSP_020807, VSP_020808; Name=3; Synonyms=UGPQ; IsoId=Q8N9F7-3; Sequence=VSP_020806;
Similarity Belongs to the glycerophosphoryl diester phosphodiesterase family.
Similarity Contains 1 GP-PDE domain.
Subcellular Location Cytoplasm . Membrane {ECO
Tissue Specificity Detected in placenta, liver, kidney, pancreas, spleen, thymus, ovary, small intestine and peripheral blood leukocytes.

Identical and Related Proteins

Unique RefSeq proteins for LMP004861 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
260763876 RefSeq NP_872375 314 glycerophosphodiester phosphodiesterase domain-containing protein 1 isoform 1
260763880 RefSeq NP_001159466 290 glycerophosphodiester phosphodiesterase domain-containing protein 1 isoform 2
260763878 RefSeq NP_001159465 289 glycerophosphodiester phosphodiesterase domain-containing protein 1 isoform 3

Identical Sequences to LMP004861 proteins

Reference Database Accession Length Protein Name
GI:260763880 GenBank AAH34432.1 290 GDPD1 protein [Homo sapiens]
GI:260763878 GenBank AAQ01751.1 289 UGPQ [Homo sapiens]
GI:260763880 GenBank EAW94411.1 290 glycerophosphodiester phosphodiesterase domain containing 1, isoform CRA_a [Homo sapiens]
GI:260763876 GenBank EAW94412.1 314 glycerophosphodiester phosphodiesterase domain containing 1, isoform CRA_b [Homo sapiens]
GI:260763876 GenBank ABW73991.1 314 glycerophosphodiester phosphodiesterase 4 [Homo sapiens]
GI:260763880 GenBank AIC53561.1 290 GDPD1, partial [synthetic construct]
GI:260763878 RefSeq XP_003817412.1 289 PREDICTED: glycerophosphodiester phosphodiesterase domain-containing protein 1 isoform X2 [Pan paniscus]
GI:260763880 RefSeq XP_003817413.1 290 PREDICTED: glycerophosphodiester phosphodiesterase domain-containing protein 1 isoform X1 [Pan paniscus]
GI:260763878 RefSeq XP_004041302.1 289 PREDICTED: glycerophosphodiester phosphodiesterase domain-containing protein 1 isoform 1 [Gorilla gorilla gorilla]
GI:260763876 RefSeq XP_004041303.1 314 PREDICTED: glycerophosphodiester phosphodiesterase domain-containing protein 1 isoform 2 [Gorilla gorilla gorilla]
GI:260763880 RefSeq XP_004041304.1 290 PREDICTED: glycerophosphodiester phosphodiesterase domain-containing protein 1 isoform 3 [Gorilla gorilla gorilla]
GI:260763876 SwissProt Q8N9F7.2 314 RecName: Full=Glycerophosphodiester phosphodiesterase domain-containing protein 1; AltName: Full=Glycerophosphodiester phosphodiesterase 4 [Homo sapiens]

Related Sequences to LMP004861 proteins

Reference Database Accession Length Protein Name
GI:260763876 DBBJ BAC04419.1 314 unnamed protein product [Homo sapiens]
GI:260763876 GenBank ABP27757.1 314 Sequence 2772 from patent US 7193069
GI:260763880 GenBank ABW73991.1 314 glycerophosphodiester phosphodiesterase 4 [Homo sapiens]
GI:260763876 GenBank AFE77844.1 314 glycerophosphodiester phosphodiesterase domain-containing protein 1 isoform 1 [Macaca mulatta]
GI:260763880 GenBank JAB27325.1 290 glycerophosphodiester phosphodiesterase domain-containing protein 1 isoform 2 [Callithrix jacchus]
GI:260763880 GenBank JAB50260.1 290 glycerophosphodiester phosphodiesterase domain-containing protein 1 isoform 2 [Callithrix jacchus]
GI:260763876 GenBank AHD71409.1 314 Sequence 6103 from patent US 8586006
GI:260763876 RefSeq XP_003272378.1 314 PREDICTED: glycerophosphodiester phosphodiesterase domain-containing protein 1 isoform 1 [Nomascus leucogenys]
GI:260763878 RefSeq XP_003272379.1 289 PREDICTED: glycerophosphodiester phosphodiesterase domain-containing protein 1 isoform 2 [Nomascus leucogenys]
GI:260763878 RefSeq XP_003912881.1 289 PREDICTED: glycerophosphodiester phosphodiesterase domain-containing protein 1 isoform X2 [Papio anubis]
GI:260763878 RefSeq XP_003929144.1 289 PREDICTED: glycerophosphodiester phosphodiesterase domain-containing protein 1 isoform X2 [Saimiri boliviensis boliviensis]
GI:260763880 RefSeq XP_004397712.1 292 PREDICTED: glycerophosphodiester phosphodiesterase domain-containing protein 1 isoform 2 [Odobenus rosmarus divergens]
GI:260763878 RefSeq XP_005583923.1 289 PREDICTED: glycerophosphodiester phosphodiesterase domain-containing protein 1 isoform X2 [Macaca fascicularis]
GI:260763880 RefSeq XP_006735120.1 290 PREDICTED: glycerophosphodiester phosphodiesterase domain-containing protein 1 isoform X2 [Leptonychotes weddellii]
GI:260763878 RefSeq XP_008009445.1 289 PREDICTED: glycerophosphodiester phosphodiesterase domain-containing protein 1 isoform X2 [Chlorocebus sabaeus]
GI:260763876 RefSeq XP_009188646.1 314 PREDICTED: glycerophosphodiester phosphodiesterase domain-containing protein 1 isoform X1 [Papio anubis]
GI:260763878 RefSeq XP_010375123.1 294 PREDICTED: glycerophosphodiester phosphodiesterase domain-containing protein 1 isoform X2 [Rhinopithecus roxellana]
GI:260763880 SwissProt Q8N9F7.2 314 RecName: Full=Glycerophosphodiester phosphodiesterase domain-containing protein 1; AltName: Full=Glycerophosphodiester phosphodiesterase 4 [Homo sapiens]