Gene/Proteome Database (LMPD)

LMPD ID
LMP004928
Gene ID
64059
Species
Mus musculus (Mouse)
Gene Name
3-oxoacid CoA transferase 2A
Gene Symbol
Oxct2a
Synonyms
Oxct; Oxct2; Scot; Scot-t1
Alternate Names
succinyl-CoA:3-ketoacid coenzyme A transferase 2A, mitochondrial; 3-oxoacid CoA-transferase 2A; 3-oxoacid-CoA transferase 2A; succinyl-CoA:3-oxoacid CoA-transferase; haploid germ cell specific succinyl CoA transferase; testis-specific succinyl CoA:3-oxoacid CoA-transferase 1; testis-specific succinyl-CoA:3-oxoacid CoA-transferase 1; succinyl-CoA:3-ketoacid-coenzyme A transferase 2A, mitochondrial
Chromosome
4
Map Location
4 D2.2|4
EC Number
2.8.3.5

Proteins

succinyl-CoA:3-ketoacid coenzyme A transferase 2A, mitochondrial precursor
Refseq ID NP_071316
Protein GI 11968160
UniProt ID Q9JJN4
mRNA ID NM_022033
Length 520
RefSeq Status VALIDATED
MAALRLLAWALPRGVSALRPPPALPHRLIRRYVSDRSGSVHFYTDPVKAVEGVKDGSTVMLGGFGLCGIPENLIGALKTKGVKDLKIVSSNVGVDDFGLGILLASKQVRRVVCSYLGENALCEKLYLAGELELEMTPQGTLAERIRAGGTGVPAFYTPTGYGTLVQEGGSPIRYAPDGHLITLSEPREVREFQGRFYLLEHAIRADFALIKGWKADRSGNVIFRGSARNFNVPMCKAADISVVEVEEIVDVGTFAPEDIHVPNIYVDRVIKGPKFEKRIERLTTRDSKPAPGSKDNDPSRTRIIKRAALEFQDGMYANLGIGIPVLASNYISPKMTVYLHSENGILGLGPFPLKNEVDADVINAGKQTVTVVPGGCFFASDDSFAMIRGGHLQLTMLGAMQVSQYGDLANWMVPGKKVKGMGGAMDLVSSKKTRVVVTMEHCTKTKQPKILKKCTMPLTGKRCVDLIITEKAVFEVNHSKGLTLVELWEGSSVDDIKATTACSFAVSPNLKPMQQIKLDA
transit_peptide: 1..39 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (By similarity); propagated from UniProtKB/Swiss-Prot (Q9JJN4.2) calculated_mol_wt: 4322 peptide sequence: MAALRLLAWALPRGVSALRPPPALPHRLIRRYVSDRSGS mat_peptide: 40..520 product: Succinyl-CoA:3-ketoacid coenzyme A transferase 2A, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q9JJN4.2) calculated_mol_wt: 52169 peptide sequence: VHFYTDPVKAVEGVKDGSTVMLGGFGLCGIPENLIGALKTKGVKDLKIVSSNVGVDDFGLGILLASKQVRRVVCSYLGENALCEKLYLAGELELEMTPQGTLAERIRAGGTGVPAFYTPTGYGTLVQEGGSPIRYAPDGHLITLSEPREVREFQGRFYLLEHAIRADFALIKGWKADRSGNVIFRGSARNFNVPMCKAADISVVEVEEIVDVGTFAPEDIHVPNIYVDRVIKGPKFEKRIERLTTRDSKPAPGSKDNDPSRTRIIKRAALEFQDGMYANLGIGIPVLASNYISPKMTVYLHSENGILGLGPFPLKNEVDADVINAGKQTVTVVPGGCFFASDDSFAMIRGGHLQLTMLGAMQVSQYGDLANWMVPGKKVKGMGGAMDLVSSKKTRVVVTMEHCTKTKQPKILKKCTMPLTGKRCVDLIITEKAVFEVNHSKGLTLVELWEGSSVDDIKATTACSFAVSPNLKPMQQIKLDA

Gene Information

Entrez Gene ID
64059
Gene Name
3-oxoacid CoA transferase 2A
Gene Symbol
Oxct2a
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005739 IDA:MGI C mitochondrion
GO:0008260 IDA:MGI F 3-oxoacid CoA-transferase activity
GO:0046950 IDA:MGI P cellular ketone body metabolic process
GO:0046952 IEA:InterPro P ketone body catabolic process
GO:0006104 ISA:MGI P succinyl-CoA metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu00650 Butanoate metabolism
mmu00072 Synthesis and degradation of ketone bodies
mmu00280 Valine, leucine and isoleucine degradation

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY66-368 ketolysis

Domain Information

InterPro Annotations

Accession Description
IPR014388 3-oxoacid_CoA-transferase
IPR012792 3-oxoacid CoA-transferase, subunit A
IPR012791 3-oxoacid CoA-transferase, subunit B
IPR004164 Coenzyme A transferase active site
IPR004163 Coenzyme A transferase binding site
IPR004165 Coenzyme A transferase family I

UniProt Annotations

Entry Information

Gene Name
3-oxoacid CoA transferase 2A
Protein Entry
SCO2A_MOUSE
UniProt ID
Q9JJN4
Species
Mouse

Comments

Comment Type Description
Catalytic Activity Succinyl-CoA + a 3-oxo acid = succinate + a 3- oxoacyl-CoA. {ECO:0000255|PROSITE-ProRule:PRU10034}.
Function Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity). Probably play and important roles in the energy metabolism of spermatozoa. {ECO:0000250}.
Pathway Ketone metabolism; succinyl-CoA degradation; acetoacetyl- CoA from succinyl-CoA: step 1/1.
Similarity Belongs to the 3-oxoacid CoA-transferase family. {ECO:0000305}.
Subcellular Location Mitochondrion {ECO:0000250}.
Subunit Homodimer. {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP004928 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
11968160 RefSeq NP_071316 520 succinyl-CoA:3-ketoacid coenzyme A transferase 2A, mitochondrial precursor

Identical Sequences to LMP004928 proteins

Reference Database Accession Length Protein Name
GI:11968160 DBBJ BAC36595.1 520 unnamed protein product [Mus musculus]
GI:11968160 DBBJ BAC87737.1 520 succinyl-CoA:3-oxoacid CoA-transferase [Mus musculus]
GI:11968160 GenBank AAI37889.1 520 3-oxoacid CoA transferase 2A [Mus musculus]
GI:11968160 GenBank AAI37888.1 520 3-oxoacid CoA transferase 2A [Mus musculus]
GI:11968160 GenBank ADT54657.1 520 Sequence 135 from patent US 7842783
GI:11968160 SwissProt Q9JJN4.2 520 RecName: Full=Succinyl-CoA:3-ketoacid coenzyme A transferase 2A, mitochondrial; AltName: Full=3-oxoacid CoA-transferase 2A; AltName: Full=Testis-specific succinyl-CoA:3-oxoacid CoA-transferase 1; Short=SCOT-t1; Flags: Precursor [Mus musculus]

Related Sequences to LMP004928 proteins

Reference Database Accession Length Protein Name
GI:11968160 DBBJ BAB16879.1 520 Scot-t2 [Mus musculus]
GI:11968160 DBBJ BAC87739.1 520 succinyl CoA:3-oxoacid CoA-transferase [Mus musculus]
GI:11968160 GenBank AAI13759.1 520 3-oxoacid CoA transferase 2B [Mus musculus]
GI:11968160 GenBank ADT54658.1 520 Sequence 136 from patent US 7842783
GI:11968160 RefSeq NP_862907.2 520 succinyl-CoA:3-ketoacid coenzyme A transferase 2B, mitochondrial precursor [Mus musculus]
GI:11968160 SwissProt Q9ESL0.1 520 RecName: Full=Succinyl-CoA:3-ketoacid coenzyme A transferase 2B, mitochondrial; AltName: Full=3-oxoacid CoA-transferase 2B; AltName: Full=Testis-specific succinyl-CoA:3-oxoacid CoA-transferase 2; Short=SCOT-t2; Flags: Precursor [Mus musculus]