Gene/Proteome Database (LMPD)

LMPD ID
LMP004984
Gene ID
129807
Species
Homo sapiens (Human)
Gene Name
sialidase 4
Gene Symbol
NEU4
Synonyms
-
Chromosome
2
Map Location
2q37.3
Summary
The protein encoded by this gene belongs to a family of glycohydrolytic enzymes, which remove terminal sialic acid residues from various sialo derivatives, such as glycoproteins, glycolipids, oligosaccharides, and gangliosides. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Nov 2009]
Orthologs
View orthologs and multiple alignments for NEU4

Proteins

sialidase-4 isoform 1
Refseq ID NP_542779
Protein GI 21704287
UniProt ID Q8WWR8
mRNA ID NM_080741
Length 496
RefSeq Status REVIEWED
MMSSAAFPRWLSMGVPRTPSRTVLFERERTGLTYRVPSLLPVPPGPTLLAFVEQRLSPDDSHAHRLVLRRGTLAGGSVRWGALHVLGTAALAEHRSMNPCPVHDAGTGTVFLFFIAVLGHTPEAVQIATGRNAARLCCVASRDAGLSWGSARDLTEEAIGGAVQDWATFAVGPGHGVQLPSGRLLVPAYTYRVDRRECFGKICRTSPHSFAFYSDDHGRTWRCGGLVPNLRSGECQLAAVDGGQAGSFLYCNARSPLGSRVQALSTDEGTSFLPAERVASLPETAWGCQGSIVGFPAPAPNRPRDDSWSVGPGSPLQPPLLGPGVHEPPEEAAVDPRGGQVPGGPFSRLQPRGDGPRQPGPRPGVSGDVGSWTLALPMPFAAPPQSPTWLLYSHPVGRRARLHMGIRLSQSPLDPRSWTEPWVIYEGPSGYSDLASIGPAPEGGLVFACLYESGARTSYDEISFCTFSLREVLENVPASPKPPNLGDKPRGCCWPS
sialidase-4 isoform 2
Refseq ID NP_001161071
Protein GI 262527263
UniProt ID Q8WWR8
mRNA ID NM_001167599
Length 497
RefSeq Status REVIEWED
MMSSAAFPRWLQSMGVPRTPSRTVLFERERTGLTYRVPSLLPVPPGPTLLAFVEQRLSPDDSHAHRLVLRRGTLAGGSVRWGALHVLGTAALAEHRSMNPCPVHDAGTGTVFLFFIAVLGHTPEAVQIATGRNAARLCCVASRDAGLSWGSARDLTEEAIGGAVQDWATFAVGPGHGVQLPSGRLLVPAYTYRVDRRECFGKICRTSPHSFAFYSDDHGRTWRCGGLVPNLRSGECQLAAVDGGQAGSFLYCNARSPLGSRVQALSTDEGTSFLPAERVASLPETAWGCQGSIVGFPAPAPNRPRDDSWSVGPGSPLQPPLLGPGVHEPPEEAAVDPRGGQVPGGPFSRLQPRGDGPRQPGPRPGVSGDVGSWTLALPMPFAAPPQSPTWLLYSHPVGRRARLHMGIRLSQSPLDPRSWTEPWVIYEGPSGYSDLASIGPAPEGGLVFACLYESGARTSYDEISFCTFSLREVLENVPASPKPPNLGDKPRGCCWPS
sialidase-4 isoform 3
Refseq ID NP_001161072
Protein GI 262527265
UniProt ID Q8WWR8
mRNA ID NM_001167600
Length 484
RefSeq Status REVIEWED
MGVPRTPSRTVLFERERTGLTYRVPSLLPVPPGPTLLAFVEQRLSPDDSHAHRLVLRRGTLAGGSVRWGALHVLGTAALAEHRSMNPCPVHDAGTGTVFLFFIAVLGHTPEAVQIATGRNAARLCCVASRDAGLSWGSARDLTEEAIGGAVQDWATFAVGPGHGVQLPSGRLLVPAYTYRVDRRECFGKICRTSPHSFAFYSDDHGRTWRCGGLVPNLRSGECQLAAVDGGQAGSFLYCNARSPLGSRVQALSTDEGTSFLPAERVASLPETAWGCQGSIVGFPAPAPNRPRDDSWSVGPGSPLQPPLLGPGVHEPPEEAAVDPRGGQVPGGPFSRLQPRGDGPRQPGPRPGVSGDVGSWTLALPMPFAAPPQSPTWLLYSHPVGRRARLHMGIRLSQSPLDPRSWTEPWVIYEGPSGYSDLASIGPAPEGGLVFACLYESGARTSYDEISFCTFSLREVLENVPASPKPPNLGDKPRGCCWPS
sialidase-4 isoform 3
Refseq ID NP_001161073
Protein GI 262527267
UniProt ID Q8WWR8
mRNA ID NM_001167601
Length 484
RefSeq Status REVIEWED
Protein sequence is identical to GI:262527265 (mRNA isoform)
sialidase-4 isoform 3
Refseq ID NP_001161074
Protein GI 262527269
UniProt ID Q8WWR8
mRNA ID NM_001167602
Length 484
RefSeq Status REVIEWED
Protein sequence is identical to GI:262527265 (mRNA isoform)

Gene Information

Entrez Gene ID
129807
Gene Name
sialidase 4
Gene Symbol
NEU4
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0004308 IEA:InterPro F exo-alpha-sialidase activity

KEGG Pathway Links

KEGG Pathway ID Description
hsa00600 Sphingolipid metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_116105 Glycosphingolipid metabolism
REACT_200874 Sialic acid metabolism
REACT_22387 Synthesis of substrates in N-glycan biosythesis

Domain Information

InterPro Annotations

Accession Description
IPR026856 Sialidase family
IPR026946 Sialidase-4
IPR011040 Sialidases

UniProt Annotations

Entry Information

Gene Name
sialidase 4
Protein Entry
NEUR4_HUMAN
UniProt ID
Q8WWR8
Species
Human

Identical and Related Proteins

Unique RefSeq proteins for LMP004984 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
21704287 RefSeq NP_542779 496 sialidase-4 isoform 1
262527263 RefSeq NP_001161071 497 sialidase-4 isoform 2
262527265 RefSeq NP_001161072 484 sialidase-4 isoform 3

Identical Sequences to LMP004984 proteins

Reference Database Accession Length Protein Name
GI:262527265 DBBJ BAG52266.1 484 unnamed protein product [Homo sapiens]
GI:262527265 DBBJ BAH13385.1 484 unnamed protein product [Homo sapiens]
GI:21704287 DBBJ BAJ17766.1 496 sialidase 4, partial [synthetic construct]
GI:21704287 GenBank AAH12899.2 496 Sialidase 4 [Homo sapiens]
GI:21704287 GenBank AAX82022.1 496 unknown [Homo sapiens]
GI:262527265 GenBank EAW71295.1 484 sialidase 4, isoform CRA_b [Homo sapiens]
GI:262527263 GenBank EAW71296.1 497 sialidase 4, isoform CRA_c [Homo sapiens]
GI:21704287 GenBank EAW71297.1 496 sialidase 4, isoform CRA_d [Homo sapiens]
GI:262527265 RefSeq NP_001161073.1 484 sialidase-4 isoform 3 [Homo sapiens]
GI:262527265 RefSeq NP_001161074.1 484 sialidase-4 isoform 3 [Homo sapiens]
GI:262527265 SwissProt Q8WWR8.3 484 RecName: Full=Sialidase-4; AltName: Full=N-acetyl-alpha-neuraminidase 4 [Homo sapiens]

Related Sequences to LMP004984 proteins

Reference Database Accession Length Protein Name
GI:21704287 DBBJ BAF82765.1 496 unnamed protein product [Homo sapiens]
GI:262527263 DBBJ BAF82765.1 496 unnamed protein product [Homo sapiens]
GI:262527263 DBBJ BAJ17766.1 496 sialidase 4, partial [synthetic construct]
GI:262527265 DBBJ BAJ17766.1 496 sialidase 4, partial [synthetic construct]
GI:262527265 GenBank AAH12899.2 496 Sialidase 4 [Homo sapiens]
GI:262527263 GenBank AAH12899.2 496 Sialidase 4 [Homo sapiens]
GI:262527265 GenBank AAX82022.1 496 unknown [Homo sapiens]
GI:262527263 GenBank AAX82022.1 496 unknown [Homo sapiens]
GI:21704287 GenBank AAI05975.1 496 Sialidase 4 [Homo sapiens]
GI:21704287 GenBank AAI17215.1 496 Sialidase 4 [Homo sapiens]
GI:262527265 GenBank EAW71294.1 510 sialidase 4, isoform CRA_a [Homo sapiens]
GI:262527263 GenBank EAW71297.1 496 sialidase 4, isoform CRA_d [Homo sapiens]
GI:262527265 GenBank EAW71297.1 496 sialidase 4, isoform CRA_d [Homo sapiens]
GI:21704287 GenBank ADR83030.1 496 sialidase 4, partial [synthetic construct]
GI:21704287 GenBank AIC57666.1 496 NEU4, partial [synthetic construct]
GI:262527263 RefSeq NP_542779.2 496 sialidase-4 isoform 1 [Homo sapiens]
GI:262527265 RefSeq NP_542779.2 496 sialidase-4 isoform 1 [Homo sapiens]
GI:21704287 RefSeq NP_001161071.1 497 sialidase-4 isoform 2 [Homo sapiens]