Gene/Proteome Database (LMPD)

LMPD ID
LMP005002
Gene ID
67420
Species
Mus musculus (Mouse)
Gene Name
fatty acyl CoA reductase 1
Gene Symbol
Far1
Synonyms
2600011M19Rik; 2900034E22Rik; 3732409C05Rik; AI850429; Mlstd2
Alternate Names
fatty acyl-CoA reductase 1; male sterility domain containing 2
Chromosome
7
Map Location
7|7 F2
EC Number
1.2.1.n2

Proteins

fatty acyl-CoA reductase 1 isoform 1
Refseq ID NP_081655
Protein GI 68448551
UniProt ID Q922J9
mRNA ID NM_027379
Length 515
RefSeq Status VALIDATED
MVSIPEYYEGKNILLTGATGFLGKVLLEKLLRSCPRVNSVYVLVRQKAGQTPQERVEEILSSKLFDRLRDENPDFREKIIAINSELTQPKLALSEEDKEIIIDSTNVIFHCAATVRFNENLRDAVQLNVIATRQLILLAQQMKNLEVFMHVSTAYAYCNRKHIDEVVYPPPVDPKKLIDSLEWMDDGLVNDITPKLIGDRPNTYIYTKALAEYVVQQEGAKLNVAIVRPSIVGASWKEPFPGWIDNFNGPSGLFIAAGKGILRTMRASNNALADLVPVDVVVNTSLAAAWYSGVNRPRNIMVYNCTTGSTNPFHWGEVEYHVISTFKRNPLEQAFRRPNVNLTSNHLLYHYWIAVSHKAPAFLYDIYLRMTGRSPRMMKTITRLHKAMVFLEYFTSNSWVWNTDNVNMLMNQLNPEDKKTFNIDVRQLHWAEYIENYCMGTKKYVLNEEMSGLPAARKHLNKLRNIRYGFNTILVILIWRIFIARSQMARNIWYFVVSLCYKFLSYFRASSTMRY
fatty acyl-CoA reductase 1 isoform 2
Refseq ID NP_001272760
Protein GI 551894048
UniProt ID Q922J9
mRNA ID NM_001285831
Length 515
RefSeq Status VALIDATED
MVSIPEYYEGKNILLTGATGFLGKVLLEKLLRSCPRVNSVYVLVRQKAGQTPQERVEEILSSKLFDRLRDENPDFREKIIAINSELTQPKLALSEEDKEIIIDSTNVIFHCAATVRFNENLRDAVQLNVIATRQLILLAQQMKNLEVFMHVSTAYAYCNRKHIDEVVYPPPVDPKKLIDSLEWMDDGLVNDITPKLIGDRPNTYIYTKALAEYVVQQEGAKLNVAIVRPSIVGASWKEPFPGWIDNFNGPSGLFIAAGKGILRTMRASNNALADLVPVDVVVNTSLAAAWYSGVNRPRNIMVYNCTTGSTNPFHWGEVGDYLNHSFKMNPLNQVFRHPYVKFCSNNLMLHYWKGVKHTVPALLLDLALRLTGQKPWMMKTITRLHKAMVFLEYFTSNSWVWNTDNVNMLMNQLNPEDKKTFNIDVRQLHWAEYIENYCMGTKKYVLNEEMSGLPAARKHLNKLRNIRYGFNTILVILIWRIFIARSQMARNIWYFVVSLCYKFLSYFRASSTMRY

Gene Information

Entrez Gene ID
67420
Gene Name
fatty acyl CoA reductase 1
Gene Symbol
Far1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005778 IEA:Ensembl C peroxisomal membrane
GO:0005777 IDA:MGI C peroxisome
GO:0080019 IEA:InterPro F fatty-acyl-CoA reductase (alcohol-forming) activity
GO:0050062 IDA:MGI F long-chain-fatty-acyl-CoA reductase activity
GO:0008611 IEA:Ensembl P ether lipid biosynthetic process
GO:0046474 IEA:Ensembl P glycerophospholipid biosynthetic process
GO:0035336 IEA:Ensembl P long-chain fatty-acyl-CoA metabolic process
GO:0010025 IDA:UniProtKB P wax biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
ko04146 Peroxisome
mmu04146 Peroxisome

REACTOME Pathway Links

REACTOME Pathway ID Description
5892980 Peroxisomal lipid metabolism
5892979 Plasmalogen biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR026055 Fatty acyl-CoA reductase
IPR013120 Male sterility, NAD-binding
IPR016040 NAD(P)-binding domain

UniProt Annotations

Entry Information

Gene Name
fatty acyl CoA reductase 1
Protein Entry
FACR1_MOUSE
UniProt ID
Q922J9
Species
Mouse

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q922J9-1; Sequence=Displayed; Name=2; IsoId=Q922J9-2; Sequence=VSP_021678, VSP_021679; Name=3; IsoId=Q922J9-3; Sequence=VSP_021680; Note=No experimental confirmation available.; Name=4; IsoId=Q922J9-4; Sequence=VSP_021681; Note=No experimental confirmation available.;
Biophysicochemical Properties pH dependence: Optimum pH is 7.4. {ECO:0000269|PubMed:15220348};
Catalytic Activity Hexadecanal + CoA + NADP(+) = hexadecanoyl-CoA + NADPH.
Function Catalyzes the reduction of saturated fatty acyl-CoA with chain length C16 or C18 to fatty alcohols. {ECO:0000269|PubMed:15220348, ECO:0000269|PubMed:15220349}.
Similarity Belongs to the fatty acyl-CoA reductase family. {ECO:0000305}.
Subcellular Location Peroxisome membrane {ECO:0000305}; Single- pass membrane protein {ECO:0000305}.
Subunit Interacts (via C-terminus) with PEX19, the interaction is required for targeting to peroxisomes. {ECO:0000250|UniProtKB:Q8WVX9}.
Tissue Specificity Widely expressed. Expressed in all tissues examined. Highest expression seen in preputial gland. Expressed in the brain where large quantities of ether lipids are synthesized. {ECO:0000269|PubMed:15220348}.

Identical and Related Proteins

Unique RefSeq proteins for LMP005002 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
68448551 RefSeq NP_081655 515 fatty acyl-CoA reductase 1 isoform 1
551894048 RefSeq NP_001272760 515 fatty acyl-CoA reductase 1 isoform 2

Identical Sequences to LMP005002 proteins

Reference Database Accession Length Protein Name
GI:551894048 DBBJ BAC28423.1 515 unnamed protein product [Mus musculus]
GI:68448551 EMBL CCA94586.1 515 unnamed protein product [synthetic construct]
GI:551894048 GenBank EDL17053.1 515 male sterility domain containing 2, isoform CRA_c [Mus musculus]
GI:68448551 RefSeq XP_006508190.1 515 PREDICTED: fatty acyl-CoA reductase 1 isoform X1 [Mus musculus]
GI:68448551 RefSeq XP_006508191.1 515 PREDICTED: fatty acyl-CoA reductase 1 isoform X2 [Mus musculus]
GI:68448551 RefSeq XP_006508192.1 515 PREDICTED: fatty acyl-CoA reductase 1 isoform X3 [Mus musculus]
GI:68448551 RefSeq XP_006508193.1 515 PREDICTED: fatty acyl-CoA reductase 1 isoform X4 [Mus musculus]
GI:68448551 RefSeq XP_006508194.1 515 PREDICTED: fatty acyl-CoA reductase 1 isoform X5 [Mus musculus]

Related Sequences to LMP005002 proteins

Reference Database Accession Length Protein Name
GI:68448551 DBBJ BAB29388.1 520 unnamed protein product [Mus musculus]
GI:68448551 EMBL CCA94587.1 753 unnamed protein product [synthetic construct]
GI:551894048 GenBank AAH82015.1 515 Fatty acyl CoA reductase 1 [Rattus norvegicus]
GI:551894048 GenBank EDM17791.1 515 rCG39451, isoform CRA_a [Rattus norvegicus]
GI:68448551 GenBank EDM17792.1 515 rCG39451, isoform CRA_b [Rattus norvegicus]
GI:68448551 GenBank EDM17793.1 515 rCG39451, isoform CRA_b [Rattus norvegicus]
GI:551894048 RefSeq NP_001011933.1 515 fatty acyl-CoA reductase 1 [Rattus norvegicus]
GI:551894048 RefSeq XP_005075711.1 515 PREDICTED: fatty acyl-CoA reductase 1 isoform X4 [Mesocricetus auratus]
GI:68448551 RefSeq XP_006230079.1 515 PREDICTED: fatty acyl-CoA reductase 1 isoform X2 [Rattus norvegicus]
GI:68448551 RefSeq XP_006230080.1 515 PREDICTED: fatty acyl-CoA reductase 1 isoform X2 [Rattus norvegicus]
GI:551894048 RefSeq XP_006230082.1 515 PREDICTED: fatty acyl-CoA reductase 1 isoform X1 [Rattus norvegicus]
GI:551894048 SwissProt Q66H50.1 515 RecName: Full=Fatty acyl-CoA reductase 1; AltName: Full=Male sterility domain-containing protein 2 [Rattus norvegicus]