Gene/Proteome Database (LMPD)

LMPD ID
LMP005021
Gene ID
51304
Species
Homo sapiens (Human)
Gene Name
zinc finger, DHHC-type containing 3
Gene Symbol
ZDHHC3
Synonyms
DHHC-3; GODZ; ZNF373
Alternate Names
palmitoyltransferase ZDHHC3; DHHC1 protein; zinc finger protein 373; zinc finger, DHHC domain containing 3; golgi-specific DHHC Zinc Finger Protein; zinc finger DHHC domain-containing protein 3; Golgi apparatus-specific protein with DHHC zinc finger domain
Chromosome
3
Map Location
3p21.31
EC Number
2.3.1.225

Proteins

palmitoyltransferase ZDHHC3 isoform 1
Refseq ID NP_001128651
Protein GI 206597477
UniProt ID Q9NYG2
mRNA ID NM_001135179
Length 299
RefSeq Status VALIDATED
MMLIPTHHFRNIERKPEYLQPEKCVPPPYPGPVGTMWFIRDGCGIACAIVTWFLVLYAEFVVLFVMLIPSRDYVYSIINGIVFNLLAFLALASHCRAMLTDPGAVPKGNATKEFIESLQLKPGQVVYKCPKCCSIKPDRAHHCSVCKRCIRKMDHHCPWVNNCVGENNQKYFVLFTMYIALISLHALIMVGFHFLHCFEEDWTKCSSFSPPTTVILLILLCFEGLLFLIFTSVMFGTQVHSICTDETGIEQLKKEERRWAKKTKWMNMKAVFGHPFSLGWASPFATPDQGKADPYQYVV
palmitoyltransferase ZDHHC3 isoform 2
Refseq ID NP_057682
Protein GI 7706133
UniProt ID Q9NYG2
mRNA ID NM_016598
Length 327
RefSeq Status VALIDATED
MMLIPTHHFRNIERKPEYLQPEKCVPPPYPGPVGTMWFIRDGCGIACAIVTWFLVLYAEFVVLFVMLIPSRDYVYSIINGIVFNLLAFLALASHCRAMLTDPGAVPKGNATKEFIESLQLKPGQVVYKCPKCCSIKPDRAHHCSVCKRCIRKMDHHCPWVNNCVGENNQKYFVLFTMYIALISLHALIMVGFHFLHCFEEDWTTYGLNREEMAETGISLHEKMQPLNFSSTECSSFSPPTTVILLILLCFEGLLFLIFTSVMFGTQVHSICTDETGIEQLKKEERRWAKKTKWMNMKAVFGHPFSLGWASPFATPDQGKADPYQYVV

Gene Information

Entrez Gene ID
51304
Gene Name
zinc finger, DHHC-type containing 3
Gene Symbol
ZDHHC3
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IDA:UniProt C Golgi apparatus
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0016020 IDA:UniProtKB C membrane
GO:0016409 IDA:UniProt F palmitoyltransferase activity
GO:0019706 IEA:UniProtKB-EC F protein-cysteine S-palmitoyltransferase activity
GO:0008270 IEA:InterPro F zinc ion binding
GO:0018345 IDA:UniProt P protein palmitoylation
GO:0006605 IEA:Ensembl P protein targeting

Domain Information

InterPro Annotations

Accession Description
IPR001594 Zinc finger, DHHC-type, palmitoyltransferase

UniProt Annotations

Entry Information

Gene Name
zinc finger, DHHC-type containing 3
Protein Entry
ZDHC3_HUMAN
UniProt ID
Q9NYG2
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NYG2-1; Sequence=Displayed; Name=2; IsoId=Q9NYG2-2; Sequence=VSP_006934;
Catalytic Activity Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.
Domain The DHHC domain is required for palmitoyltransferase activity.
Function Palmitoyltransferase with broad specificity. Palmitoylates GABA receptors on their gamma subunit (GABRG1, GABRG2 and GABRG3), which regulates synaptic clustering and/or cell surface stability. Palmitoylates glutamate receptors GRIA1 and GRIA2, which leads to their retention in Golgi (By similarity).
Ptm Autopalmitoylated.
Similarity Belongs to the DHHC palmitoyltransferase family.
Similarity Contains 1 DHHC-type zinc finger.
Subcellular Location Golgi apparatus membrane ; Multi-pass membrane protein .

Identical and Related Proteins

Unique RefSeq proteins for LMP005021 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
206597477 RefSeq NP_001128651 299 palmitoyltransferase ZDHHC3 isoform 1
7706133 RefSeq NP_057682 327 palmitoyltransferase ZDHHC3 isoform 2

Identical Sequences to LMP005021 proteins

Reference Database Accession Length Protein Name
GI:7706133 GenBank AAF63570.1 327 DHHC1 protein [Homo sapiens]
GI:7706133 GenBank EAW64730.1 327 zinc finger, DHHC-type containing 3, isoform CRA_b [Homo sapiens]
GI:206597477 GenBank JAA03900.1 299 zinc finger, DHHC-type containing 3 [Pan troglodytes]
GI:206597477 GenBank JAA18675.1 299 zinc finger, DHHC-type containing 3 [Pan troglodytes]
GI:206597477 GenBank JAA32488.1 299 zinc finger, DHHC-type containing 3 [Pan troglodytes]
GI:206597477 GenBank JAA36631.1 299 zinc finger, DHHC-type containing 3 [Pan troglodytes]
GI:7706133 GenBank AGJ46255.1 327 Sequence 12 from patent US 8404655
GI:206597477 RefSeq XP_008959800.1 299 PREDICTED: palmitoyltransferase ZDHHC3 isoform X8 [Pan paniscus]
GI:206597477 SwissProt Q9NYG2.2 299 RecName: Full=Palmitoyltransferase ZDHHC3; AltName: Full=Protein DHHC1; AltName: Full=Zinc finger DHHC domain-containing protein 3; Short=DHHC-3; AltName: Full=Zinc finger protein 373 [Homo sapiens]

Related Sequences to LMP005021 proteins

Reference Database Accession Length Protein Name
GI:7706133 GenBank JAA03901.1 327 zinc finger, DHHC-type containing 3 [Pan troglodytes]
GI:7706133 GenBank JAA18676.1 327 zinc finger, DHHC-type containing 3 [Pan troglodytes]
GI:7706133 GenBank JAA32489.1 327 zinc finger, DHHC-type containing 3 [Pan troglodytes]
GI:7706133 GenBank JAA36632.1 327 zinc finger, DHHC-type containing 3 [Pan troglodytes]
GI:7706133 RefSeq XP_516405.2 327 PREDICTED: palmitoyltransferase ZDHHC3 isoform X7 [Pan troglodytes]
GI:206597477 RefSeq XP_003257011.1 299 PREDICTED: palmitoyltransferase ZDHHC3 isoform 1 [Nomascus leucogenys]
GI:206597477 RefSeq XP_003776314.1 299 PREDICTED: palmitoyltransferase ZDHHC3 isoform X4 [Pongo abelii]
GI:206597477 RefSeq XP_003926290.1 299 PREDICTED: palmitoyltransferase ZDHHC3 isoform X1 [Saimiri boliviensis boliviensis]
GI:206597477 RefSeq XP_004034028.1 299 PREDICTED: palmitoyltransferase ZDHHC3 isoform 1 [Gorilla gorilla gorilla]
GI:206597477 RefSeq XP_007982108.1 299 PREDICTED: palmitoyltransferase ZDHHC3 isoform X9 [Chlorocebus sabaeus]
GI:7706133 RefSeq XP_008959799.1 327 PREDICTED: palmitoyltransferase ZDHHC3 isoform X7 [Pan paniscus]
GI:206597477 RefSeq XP_010372687.1 299 PREDICTED: palmitoyltransferase ZDHHC3 isoform X2 [Rhinopithecus roxellana]