Gene/Proteome Database (LMPD)
LMPD ID
LMP005072
Gene ID
Species
Homo sapiens (Human)
Gene Name
oxysterol binding protein 2
Gene Symbol
Synonyms
HLM; ORP-4; ORP4; OSBPL1; OSBPL4
Alternate Names
oxysterol-binding protein 2; OSBP-related protein 4; oxysterol binding protein-like 1; oxysterol-binding protein-related protein 4
Chromosome
22
Map Location
22q12.2
Summary
The protein encoded by this gene contains a pleckstrin homology (PH) domain and an oxysterol-binding region. It binds oxysterols such as 7-ketocholesterol and may inhibit their cytotoxicity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2013]
Orthologs
Proteins
| oxysterol-binding protein 2 isoform a | |
|---|---|
| Refseq ID | NP_110385 |
| Protein GI | 13540513 |
| UniProt ID | Q969R2 |
| mRNA ID | NM_030758 |
| Length | 916 |
| RefSeq Status | REVIEWED |
| MGKAAAPSRGGGCGGRSRGLSSLFTVVPCLSCHTAAPGMSASTSGSGPEPKPQPQPVPEPERGPLSEQVSEAVSEAVPRSEPVSETTSEPEPGAGQPSELLQGSRPGSESSSGVGAGPFTKAASEPLSRAVGSATFLRPESGSLPALKPLPLLRPGQAKTPLGVPMSGTGTTSSAPLALLPLDSFEGWLLKWTNYLKGYQRRWFVLGNGLLSYYRNQGEMAHTCRGTINLSTAHIDTEDSCGILLTSGARSYHLKASSEVDRQQWITALELAKAKAVRVMNTHSDDSGDDDEATTPADKSELHHTLKNLSLKLDDLSTCNDLIAKHGAALQRSLTELDGLKIPSESGEKLKVVNERATLFRITSNAMINACRDFLELAEIHSRKWQRALQYEQEQRVHLEETIEQLAKQHNSLERAFHSAPGRPANPSKSFIEGSLLTPKGEDSEEDEDTEYFDAMEDSTSFITVITEAKEDSRKAEGSTGTSSVDWSSADNVLDGASLVPKGSSKVKRRVRIPNKPNYSLNLWSIMKNCIGRELSRIPMPVNFNEPLSMLQRLTEDLEYHHLLDKAVHCTSSVEQMCLVAAFSVSSYSTTVHRIAKPFNPMLGETFELDRLDDMGLRSLCEQVSHHPPSAAHYVFSKHGWSLWQEITISSKFRGKYISIMPLGAIHLEFQASGNHYVWRKSTSTVHNIIVGKLWIDQSGDIEIVNHKTNDRCQLKFLPYSYFSKEAARKVTGVVSDSQGKAHYVLSGSWDEQMECSKVMHSSPSSPSSDGKQKTVYQTLSAKLLWKKYPLPENAENMYYFSELALTLNEHEEGVAPTDSRLRPDQRLMEKGRWDEANTEKQRLEEKQRLSRRRRLEACGPGSSCSSEEEKEADAYTPLWFEKRLDPLTGEMACVYKGGYWEAKEKQDWHMCPNIF | |
| oxysterol-binding protein 2 isoform c | |
|---|---|
| Refseq ID | NP_001269667 |
| Protein GI | 544346311 |
| UniProt ID | Q969R2 |
| mRNA ID | NM_001282738 |
| Length | 750 |
| RefSeq Status | REVIEWED |
| MHRQRTRTMSSLAAKRLGMNRRPAGSGGGGGEAATWGHRFWRPQERPTDRNQGEMAHTCRGTINLSTAHIDTEDSCGILLTSGARSYHLKASSEVDRQQWITALELAKAKAVRVMNTHSDDSGDDDEATTPADKSELHHTLKNLSLKLDDLSTCNDLIAKHGAALQRSLTELDGLKIPSESGEKLKVVNERATLFRITSNAMINACRDFLELAEIHSRKWQRALQYEQEQRVHLEETIEQLAKQHNSLERAFHSAPGRPANPSKSFIEGSLLTPKGEDSEEDEDTEYFDAMEDSTSFITVITEAKEDRKAEGSTGTSSVDWSSADNVLDGASLVPKGSSKVKRRVRIPNKPNYSLNLWSIMKNCIGRELSRIPMPVNFNEPLSMLQRLTEDLEYHHLLDKAVHCTSSVEQMCLVAAFSVSSYSTTVHRIAKPFNPMLGETFELDRLDDMGLRSLCEQVSHHPPSAAHYVFSKHGWSLWQEITISSKFRGKYISIMPLGAIHLEFQASGNHYVWRKSTSTVHNIIVGKLWIDQSGDIEIVNHKTNDRCQLKFLPYSYFSKEAARKVTGVVSDSQGKAHYVLSGSWDEQMECSKVMHSSPSSPSSDGKQKTVYQTLSAKLLWKKYPLPENAENMYYFSELALTLNEHEEGVAPTDSRLRPDQRLMEKGRWDEANTEKQRLEEKQRLSRRRRLEACGPGSSCSSEEEKEADAYTPLWFEKRLDPLTGEMACVYKGGYWEAKEKQDWHMCPNIF | |
| oxysterol-binding protein 2 isoform d | |
|---|---|
| Refseq ID | NP_001269668 |
| Protein GI | 544346313 |
| UniProt ID | Q969R2 |
| mRNA ID | NM_001282739 |
| Length | 915 |
| RefSeq Status | REVIEWED |
| MGKAAAPSRGGGCGGRSRGLSSLFTVVPCLSCHTAAPGMSASTSGSGPEPKPQPQPVPEPERGPLSEQVSEAVSEAVPRSEPVSETTSEPEPGAGQPSELLQGSRPGSESSSGVGAGPFTKAASEPLSRAVGSATFLRPESGSLPALKPLPLLRPGQAKTPLGVPMSGTGTTSSAPLALLPLDSFEGWLLKWTNYLKGYQRRWFVLGNGLLSYYRNQGEMAHTCRGTINLSTAHIDTEDSCGILLTSGARSYHLKASSEVDRQQWITALELAKAKAVRVMNTHSDDSGDDDEATTPADKSELHHTLKNLSLKLDDLSTCNDLIAKHGAALQRSLTELDGLKIPSESGEKLKVVNERATLFRITSNAMINACRDFLELAEIHSRKWQRALQYEQEQRVHLEETIEQLAKQHNSLERAFHSAPGRPANPSKSFIEGSLLTPKGEDSEEDEDTEYFDAMEDSTSFITVITEAKEDRKAEGSTGTSSVDWSSADNVLDGASLVPKGSSKVKRRVRIPNKPNYSLNLWSIMKNCIGRELSRIPMPVNFNEPLSMLQRLTEDLEYHHLLDKAVHCTSSVEQMCLVAAFSVSSYSTTVHRIAKPFNPMLGETFELDRLDDMGLRSLCEQVSHHPPSAAHYVFSKHGWSLWQEITISSKFRGKYISIMPLGAIHLEFQASGNHYVWRKSTSTVHNIIVGKLWIDQSGDIEIVNHKTNDRCQLKFLPYSYFSKEAARKVTGVVSDSQGKAHYVLSGSWDEQMECSKVMHSSPSSPSSDGKQKTVYQTLSAKLLWKKYPLPENAENMYYFSELALTLNEHEEGVAPTDSRLRPDQRLMEKGRWDEANTEKQRLEEKQRLSRRRRLEACGPGSSCSSEEEKEADAYTPLWFEKRLDPLTGEMACVYKGGYWEAKEKQDWHMCPNIF | |
| oxysterol-binding protein 2 isoform e | |
|---|---|
| Refseq ID | NP_001269669 |
| Protein GI | 544346315 |
| UniProt ID | Q969R2 |
| mRNA ID | NM_001282740 |
| Length | 549 |
| RefSeq Status | REVIEWED |
| MINACRDFLELAEIHSRKWQRALQYEQEQRVHLEETIEQLAKQHNSLERAFHSAPGRPANPSKSFIEGSLLTPKGEDSEEDEDTEYFDAMEDSTSFITVITEAKEDRKAEGSTGTSSVDWSSADNVLDGASLVPKGSSKVKRRVRIPNKPNYSLNLWSIMKNCIGRELSRIPMPVNFNEPLSMLQRLTEDLEYHHLLDKAVHCTSSVEQMCLVAAFSVSSYSTTVHRIAKPFNPMLGETFELDRLDDMGLRSLCEQVSHHPPSAAHYVFSKHGWSLWQEITISSKFRGKYISIMPLGAIHLEFQASGNHYVWRKSTSTVHNIIVGKLWIDQSGDIEIVNHKTNDRCQLKFLPYSYFSKEAARKVTGVVSDSQGKAHYVLSGSWDEQMECSKVMHSSPSSPSSDGKQKTVYQTLSAKLLWKKYPLPENAENMYYFSELALTLNEHEEGVAPTDSRLRPDQRLMEKGRWDEANTEKQRLEEKQRLSRRRRLEACGPGSSCSSEEEKEADAYTPLWFEKRLDPLTGEMACVYKGGYWEAKEKQDWHMCPNIF | |
| oxysterol-binding protein 2 isoform f | |
|---|---|
| Refseq ID | NP_001269670 |
| Protein GI | 544346315 |
| UniProt ID | Q969R2 |
| mRNA ID | NM_001282741 |
| Length | 549 |
| RefSeq Status | REVIEWED |
| MINACRDFLELAEIHSRKWQRALQYEQEQRVHLEETIEQLAKQHNSLERAFHSAPGRPANPSKSFIEGSLLTPKGEDSEEDEDTEYFDAMEDSTSFITVITEAKEDRKAEGSTGTSSVDWSSADNVLDGASLVPKGSSKVKRRVRIPNKPNYSLNLWSIMKNCIGRELSRIPMPVNFNEPLSMLQRLTEDLEYHHLLDKAVHCTSSVEQMCLVAAFSVSSYSTTVHRIAKPFNPMLGETFELDRLDDMGLRSLCEQVSHHPPSAAHYVFSKHGWSLWQEITISSKFRGKYISIMPLGAIHLEFQASGNHYVWRKSTSTVHNIIVGKLWIDQSGDIEIVNHKTNDRCQLKFLPYSYFSKEAARKVTGVVSDSQGKAHYVLSGSWDEQMECSKVMHSSPSSPSSDGKQKTVYQTLSAKLLWKKYPLPENAENMYYFSELALTLNEHEEGVAPTDSRLRPDQRLMEKGRWDEANTEKQRLEEKQRLSRRRRLEACGPGSSCSSEEEKEADAYTPLWFEKRLDPLTGEMACVYKGGYWEAKEKQDWHMCPNIF | |
| oxysterol-binding protein 2 isoform g | |
|---|---|
| Refseq ID | NP_001269671 |
| Protein GI | 544346319 |
| UniProt ID | Q969R2 |
| mRNA ID | NM_001282742 |
| Length | 460 |
| RefSeq Status | REVIEWED |
| MEDSTSFITVITEAKEDRKAEGSTGTSSVDWSSADNVLDGASLVPKGSSKVKRRVRIPNKPNYSLNLWSIMKNCIGRELSRIPMPVNFNEPLSMLQRLTEDLEYHHLLDKAVHCTSSVEQMCLVAAFSVSSYSTTVHRIAKPFNPMLGETFELDRLDDMGLRSLCEQVSHHPPSAAHYVFSKHGWSLWQEITISSKFRGKYISIMPLGAIHLEFQASGNHYVWRKSTSTVHNIIVGKLWIDQSGDIEIVNHKTNDRCQLKFLPYSYFSKEAARKVTGVVSDSQGKAHYVLSGSWDEQMECSKVMHSSPSSPSSDGKQKTVYQTLSAKLLWKKYPLPENAENMYYFSELALTLNEHEEGVAPTDSRLRPDQRLMEKGRWDEANTEKQRLEEKQRLSRRRRLEACGPGSSCSSEEEKEADAYTPLWFEKRLDPLTGEMACVYKGGYWEAKEKQDWHMCPNIF | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0016020 | IEA:UniProtKB-KW | C | membrane |
| GO:0015485 | IDA:BHF-UCL | F | cholesterol binding |
| GO:0006869 | IEA:UniProtKB-KW | P | lipid transport |
Domain Information
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=6; Name=1; IsoId=Q969R2-1; Sequence=Displayed; Name=2; IsoId=Q969R2-2; Sequence=VSP_054520; Note=No experimental confirmation available.; Name=3; IsoId=Q969R2-3; Sequence=VSP_054886, VSP_054887, VSP_054520; Note=No experimental confirmation available.; Name=4; IsoId=Q969R2-4; Sequence=VSP_055263, VSP_054520; Note=No experimental confirmation available.; Name=5; IsoId=Q969R2-5; Sequence=VSP_055262, VSP_054520; Note=No experimental confirmation available.; Name=6; IsoId=Q969R2-6; Sequence=VSP_055751, VSP_055752; |
| Function | Binds 7-ketocholesterol. |
| Sequence Caution | Sequence=AAK56864.1; Type=Erroneous initiation; Evidence= ; Sequence=AAK56865.1; Type=Erroneous initiation; Evidence= ; Sequence=BAB33334.2; Type=Erroneous initiation; Evidence= ; |
| Similarity | Belongs to the OSBP family. |
| Similarity | Contains 1 PH domain. {ECO |
| Subcellular Location | Membrane; Peripheral membrane protein. |
| Tissue Specificity | Expressed mainly in retina, testis, and fetal liver. |
Identical and Related Proteins
Unique RefSeq proteins for LMP005072 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 13540513 | RefSeq | NP_110385 | 916 | oxysterol-binding protein 2 isoform a |
| 544346311 | RefSeq | NP_001269667 | 750 | oxysterol-binding protein 2 isoform c |
| 544346313 | RefSeq | NP_001269668 | 915 | oxysterol-binding protein 2 isoform d |
| 544346315 | RefSeq | NP_001269669 | 549 | oxysterol-binding protein 2 isoform e |
| 544346315 | RefSeq | NP_001269670 | 549 | oxysterol-binding protein 2 isoform f |
| 544346319 | RefSeq | NP_001269671 | 460 | oxysterol-binding protein 2 isoform g |
Identical Sequences to LMP005072 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:544346315 | DBBJ | BAC04091.1 | 549 | unnamed protein product [Homo sapiens] |
| GI:544346315 | DBBJ | BAC04091.1 | 549 | unnamed protein product [Homo sapiens] |
| GI:544346311 | DBBJ | BAG59156.1 | 750 | unnamed protein product [Homo sapiens] |
| GI:544346319 | DBBJ | BAG62075.1 | 460 | unnamed protein product [Homo sapiens] |
| GI:13540513 | GenBank | AAG53406.1 | 916 | OSBP-related protein 4 [Homo sapiens] |
| GI:544346315 | GenBank | ABA67837.1 | 549 | Sequence 3479 from patent US 6943241 |
| GI:544346315 | GenBank | ABA67837.1 | 549 | Sequence 3479 from patent US 6943241 |
| GI:544346313 | GenBank | AAI18915.1 | 915 | Oxysterol binding protein 2 [Homo sapiens] |
| GI:13540513 | GenBank | EAW59916.1 | 916 | oxysterol binding protein 2, isoform CRA_a [Homo sapiens] |
| GI:13540513 | GenBank | AHD69590.1 | 916 | Sequence 604 from patent US 8586006 |
| GI:13540513 | SwissProt | Q969R2.2 | 916 | RecName: Full=Oxysterol-binding protein 2; AltName: Full=Oxysterol-binding protein-related protein 4; Short=ORP-4; Short=OSBP-related protein 4 [Homo sapiens] |
Related Sequences to LMP005072 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:544346319 | DBBJ | BAC04091.1 | 549 | unnamed protein product [Homo sapiens] |
| GI:544346311 | DBBJ | BAD18525.1 | 743 | unnamed protein product [Homo sapiens] |
| GI:13540513 | DBBJ | BAB33334.2 | 920 | KIAA1664 protein, partial [Homo sapiens] |
| GI:544346313 | DBBJ | BAB33334.2 | 920 | KIAA1664 protein, partial [Homo sapiens] |
| GI:13540513 | DBBJ | BAG10478.1 | 916 | oxysterol-binding protein 2, partial [synthetic construct] |
| GI:544346315 | DBBJ | BAG59156.1 | 750 | unnamed protein product [Homo sapiens] |
| GI:544346315 | DBBJ | BAG59156.1 | 750 | unnamed protein product [Homo sapiens] |
| GI:544346313 | GenBank | AAG53406.1 | 916 | OSBP-related protein 4 [Homo sapiens] |
| GI:544346319 | GenBank | ABA67837.1 | 549 | Sequence 3479 from patent US 6943241 |
| GI:13540513 | GenBank | AAI18915.1 | 915 | Oxysterol binding protein 2 [Homo sapiens] |
| GI:544346315 | GenBank | AAI18915.1 | 915 | Oxysterol binding protein 2 [Homo sapiens] |
| GI:544346315 | GenBank | AAI18915.1 | 915 | Oxysterol binding protein 2 [Homo sapiens] |
| GI:544346319 | GenBank | AAI18915.1 | 915 | Oxysterol binding protein 2 [Homo sapiens] |
| GI:544346313 | GenBank | EAW59916.1 | 916 | oxysterol binding protein 2, isoform CRA_a [Homo sapiens] |
| GI:544346313 | GenBank | AHD69590.1 | 916 | Sequence 604 from patent US 8586006 |
| GI:544346313 | RefSeq | NP_110385.1 | 916 | oxysterol-binding protein 2 isoform a [Homo sapiens] |
| GI:544346311 | RefSeq | XP_003317247.1 | 750 | PREDICTED: oxysterol-binding protein 2 isoform X2 [Pan troglodytes] |
| GI:544346315 | RefSeq | XP_003317247.1 | 750 | PREDICTED: oxysterol-binding protein 2 isoform X2 [Pan troglodytes] |
| GI:544346315 | RefSeq | XP_003317247.1 | 750 | PREDICTED: oxysterol-binding protein 2 isoform X2 [Pan troglodytes] |
| GI:13540513 | RefSeq | XP_004063354.1 | 917 | PREDICTED: oxysterol-binding protein 2 isoform 1 [Gorilla gorilla gorilla] |
| GI:544346311 | RefSeq | XP_004063355.1 | 750 | PREDICTED: oxysterol-binding protein 2 isoform 2 [Gorilla gorilla gorilla] |
| GI:544346315 | RefSeq | NP_001269667.1 | 750 | oxysterol-binding protein 2 isoform c [Homo sapiens] |
| GI:544346319 | RefSeq | NP_001269667.1 | 750 | oxysterol-binding protein 2 isoform c [Homo sapiens] |
| GI:544346315 | RefSeq | NP_001269667.1 | 750 | oxysterol-binding protein 2 isoform c [Homo sapiens] |
| GI:544346319 | RefSeq | NP_001269668.1 | 915 | oxysterol-binding protein 2 isoform d [Homo sapiens] |
| GI:544346315 | RefSeq | NP_001269668.1 | 915 | oxysterol-binding protein 2 isoform d [Homo sapiens] |
| GI:544346315 | RefSeq | NP_001269668.1 | 915 | oxysterol-binding protein 2 isoform d [Homo sapiens] |
| GI:13540513 | RefSeq | NP_001269668.1 | 915 | oxysterol-binding protein 2 isoform d [Homo sapiens] |
| GI:544346319 | RefSeq | NP_001269669.1 | 549 | oxysterol-binding protein 2 isoform e [Homo sapiens] |
| GI:544346311 | RefSeq | XP_006724267.1 | 743 | PREDICTED: oxysterol-binding protein 2 isoform X5 [Homo sapiens] |
| GI:544346311 | RefSeq | XP_006724268.1 | 742 | PREDICTED: oxysterol-binding protein 2 isoform X6 [Homo sapiens] |
| GI:544346315 | RefSeq | XP_006724268.1 | 742 | PREDICTED: oxysterol-binding protein 2 isoform X6 [Homo sapiens] |
| GI:544346315 | RefSeq | XP_006724268.1 | 742 | PREDICTED: oxysterol-binding protein 2 isoform X6 [Homo sapiens] |
| GI:13540513 | RefSeq | XP_007973622.1 | 915 | PREDICTED: oxysterol-binding protein 2 isoform X3 [Chlorocebus sabaeus] |
| GI:544346311 | RefSeq | XP_009436449.1 | 1021 | PREDICTED: oxysterol-binding protein 2 isoform X1 [Pan troglodytes] |
| GI:544346313 | SwissProt | Q969R2.2 | 916 | RecName: Full=Oxysterol-binding protein 2; AltName: Full=Oxysterol-binding protein-related protein 4; Short=ORP-4; Short=OSBP-related protein 4 [Homo sapiens] |