Gene/Proteome Database (LMPD)
LMPD ID
LMP005083
Gene ID
Species
Homo sapiens (Human)
Gene Name
monoacylglycerol O-acyltransferase 1
Gene Symbol
Synonyms
DGAT2L; DGAT2L1; MGAT1
Alternate Names
2-acylglycerol O-acyltransferase 1; hDC2; diacylglycerol O-acyltransferase 2 like 1; acyl-CoA:monoacylglycerol acyltransferase 1; diacylglycerol O-acyltransferase candidate 2; diacylglycerol acyltransferase 2-like protein 1
Chromosome
2
Map Location
2q36.1
EC Number
2.3.1.22
Summary
Acyl-CoA:monoacylglycerol acyltransferase (MOGAT; EC 2.3.1.22) catalyzes the synthesis of diacylglycerols, the precursor of physiologically important lipids such as triacylglycerol and phospholipids (Yen et al., 2002 [PubMed 12077311]).[supplied by OMIM, Mar 2008]
Orthologs
Proteins
| 2-acylglycerol O-acyltransferase 1 | |
|---|---|
| Refseq ID | NP_477513 |
| Protein GI | 148746191 |
| UniProt ID | Q96PD6 |
| mRNA ID | NM_058165 |
| Length | 335 |
| RefSeq Status | VALIDATED |
| MKVEFAPLNIQLARRLQTVAVLQWVLKYLLLGPMSIGITVMLIIHNYLFLYIPYLMWLYFDWHTPERGGRRSSWIKNWTLWKHFKDYFPIHLIKTQDLDPSHNYIFGFHPHGIMAVGAFGNFSVNYSDFKDLFPGFTSYLHVLPLWFWCPVFREYVMSVGLVSVSKKSVSYMVSKEGGGNISVIVLGGAKESLDAHPGKFTLFIRQRKGFVKIALTHGASLVPVVSFGENELFKQTDNPEGSWIRTVQNKLQKIMGFALPLFHARGVFQYNFGLMTYRKAIHTVVGRPIPVRQTLNPTQEQIEELHQTYMEELRKLFEEHKGKYGIPEHETLVLK | |
Gene Information
Entrez Gene ID
Gene Name
monoacylglycerol O-acyltransferase 1
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005783 | IEA:UniProtKB-KW | C | endoplasmic reticulum |
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0003846 | IEA:UniProtKB-EC | F | 2-acylglycerol O-acyltransferase activity |
| GO:0004144 | IEA:Ensembl | F | diacylglycerol O-acyltransferase activity |
| GO:0006651 | IEA:Ensembl | P | diacylglycerol biosynthetic process |
| GO:0006071 | IEA:UniProtKB-KW | P | glycerol metabolic process |
| GO:0019432 | IEA:UniProtKB-UniPathway | P | triglyceride biosynthetic process |
BIOCYC Pathway Links
| BIOCYC Pathway ID | Description |
|---|---|
| TRIGLSYN-PWY | triacylglycerol biosynthesis |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR007130 | Diacylglycerol acyltransferase |
UniProt Annotations
Entry Information
Gene Name
monoacylglycerol O-acyltransferase 1
Protein Entry
MOGT1_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | Acyl-CoA + 2-acylglycerol = CoA + diacylglycerol. |
| Function | Catalyzes the formation of diacylglycerol from 2- monoacylglycerol and fatty acyl-CoA. Probably not involved in absorption of dietary fat in the small intestine (By similarity). |
| Pathway | Glycerolipid metabolism; triacylglycerol biosynthesis. |
| Sequence Caution | Sequence=AAX81987.1; Type=Erroneous gene model prediction; Evidence= ; |
| Similarity | Belongs to the diacylglycerol acyltransferase family. |
| Subcellular Location | Endoplasmic reticulum membrane {ECO |
Identical and Related Proteins
Unique RefSeq proteins for LMP005083 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 148746191 | RefSeq | NP_477513 | 335 | 2-acylglycerol O-acyltransferase 1 |
Identical Sequences to LMP005083 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:148746191 | GenBank | EAW70805.1 | 335 | monoacylglycerol O-acyltransferase 1, isoform CRA_a [Homo sapiens] |
| GI:148746191 | SwissProt | Q96PD6.2 | 335 | RecName: Full=2-acylglycerol O-acyltransferase 1; AltName: Full=Acyl-CoA:monoacylglycerol acyltransferase 1; Short=MGAT1; AltName: Full=Diacylglycerol O-acyltransferase candidate 2; Short=hDC2; AltName: Full=Diacylglycerol acyltransferase 2-like protein 1; AltName: Full=Monoacylglycerol O-acyltransferase 1 [Homo sapiens] |
| GI:148746191 | tpe | CAD89265.1 | 335 | TPA: acyl CoA:monoacylglycerol acyltransferase 2 [Homo sapiens] |
Related Sequences to LMP005083 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:148746191 | GenBank | AAI40228.1 | 334 | Monoacylglycerol O-acyltransferase 1, partial [synthetic construct] |
| GI:148746191 | GenBank | ABW44457.1 | 334 | Sequence 23 from patent US 7259002 |
| GI:148746191 | GenBank | AEC33345.1 | 334 | Sequence 8 from patent US 7862819 |
| GI:148746191 | GenBank | AED72413.1 | 334 | Sequence 22 from patent US 7910346 |
| GI:148746191 | GenBank | AEF63656.1 | 334 | Sequence 28 from patent US 7935863 |
| GI:148746191 | GenBank | AEF76535.1 | 334 | Sequence 28 from patent US 7939714 |