Gene/Proteome Database (LMPD)
LMPD ID
LMP005110
Gene ID
Species
Homo sapiens (Human)
Gene Name
inositol polyphosphate-4-phosphatase, type I, 107kDa
Gene Symbol
Synonyms
INPP4; TVAS1
Alternate Names
type I inositol 3,4-bisphosphate 4-phosphatase; type I inositol-3,4-bisphosphate 4-phosphatase; inositol polyphosphate-4-phosphatase, type I, 107kD
Chromosome
2
Map Location
2q11.2
EC Number
3.1.3.66
Summary
This gene encodes an Mg++ independent enzyme that hydrolyzes the 4-position phosphate from the inositol ring of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate, and inositol 3,4-bisphosphate. Multiple transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Aug 2008]
Orthologs
Proteins
| type I inositol 3,4-bisphosphate 4-phosphatase isoform a | |
|---|---|
| Refseq ID | NP_004018 |
| Protein GI | 4755140 |
| UniProt ID | Q96PE3 |
| mRNA ID | NM_004027 |
| Length | 938 |
| RefSeq Status | REVIEWED |
| MTAREHSPRHGARARAMQRASTIDVAADMLGLSLAGNIQDPDEPILEFSLACSELHTPSLDRKPNSFVAVSVTTPPQAFWTKHAQTEIIEGTNNPIFLSSIAFFQDSLINQMTQVKLSVYDVKDRSQGTMYLLGSGTFIVKDLLQDRHHRLHLTLRSAESDRVGNITVIGWQMEEKSDQRPPVTRSVDTVNGRMVLPVDESLTEALGIRSKYASLRKDTLLKSVFGGAICRMYRFPTTDGNHLRILEQMAESVLSLHVPRQFVKLLLEEDAARVCELEELGELSPCWESLRRQIVTQYQTIILTYQENLTDLHQYRGPSFKASSLKADKKLEFVPTNLHIQRMRVQDDGGSDQNYDIVTIGAPAAHCQGFKSGGLRKKLHKFEETKKHFEECCTSSGCQSIIYIPQDVVRAKEIIAQINTLKTQVSYYAERLSRAAKDRSATGLERTLAILADKTRQLVTVCDCKLLANSIHGLNAARPDYIASKASPTSTEEEQVMLRNDQDTLMARWTGRNSRSSLQVDWHEEEWEKVWLNVDKSLECIIQRVDKLLQKERLHGEGCEDVFPCAGSCTSKKDCSPPPEESSPGEWSEALYPLLTTLTDCVAMMSDKAKKAMVFLLMQDSAPTIATYLSLQYRRDVVFCQTLTALICGFIIKLRNCLHDDGFLRQLYTIGLLAQFESLLSTYGEELAMLEDMSLGIMDLRNVTFKVTQATSSASADMLPVITGNRDGFNVRVPLPGPLFDALPREIQSGMLLRVQPVLFNVGINEQQTLAERFGDTSLQEVINVESLVRLNSYFEQFKEVLPEDCLPRSRSQTCLPELLRFLGQNVHARKNKNVDILWQAAEICRRLNGVRFTSCKSAKDRTAMSVTLEQCLILQHEHGMAPQVFTQALECMRSEGCRRENTMKNVGSRKYAFNSLQLKAFPKHYRPPEGTYGKVET | |
| type I inositol 3,4-bisphosphate 4-phosphatase isoform b | |
|---|---|
| Refseq ID | NP_001557 |
| Protein GI | 4504705 |
| UniProt ID | Q96PE3 |
| mRNA ID | NM_001566 |
| Length | 954 |
| RefSeq Status | REVIEWED |
| MTAREHSPRHGARARAMQRASTIDVAADMLGLSLAGNIQDPDEPILEFSLACSELHTPSLDRKPNSFVAVSVTTPPQAFWTKHAQTEIIEGTNNPIFLSSIAFFQDSLINQMTQVKLSVYDVKDRSQGTMYLLGSGTFIVKDLLQDRHHRLHLTLRSAESDRVGNITVIGWQMEEKSDQRPPVTRSVDTVNGRMVLPVDESLTEALGIRSKYASLRKDTLLKSVFGGAICRMYRFPTTDGNHLRILEQMAESVLSLHVPRQFVKLLLEEDAARVCELEELGELSPCWESLRRQIVTQYQTIILTYQENLTDLHQYRGPSFKASSLKADKKLEFVPTNLHIQRMRVQDDGGSDQNYDIVTIGAPAAHCQGFKSGGLRKKLHKFEETKKHFEECCTSSGCQSIIYIPQDVVRAKEIIAQINTLKTQVSYYAERLSRAAKDRSATGLERTLAILADKTRQLVTVCDCKLLANSIHGLNAARPDYIASKASPTSTEEEQVMLRNDQDTLMARWTGRNSRSSLQVDWHEEEWEKVWLNVDKSLECIIQRVDKLLQKERLHGEGCEDVFPCAGSCTSKKDCSPPPEESSPGEWSEALYPLLTTLTDCVAMMSDKAKKAMVFLLMQDSAPTIATYLSLQYRRDVVFCQTLTALICGFIIKLRNCLHDDGFLRQLYTIGLLAQFESLLSTYGEELAMLEDMSLGIMDLRNVTFKVTQATSSASADMLPVITGNRDGFNVRVPLPGPLFDALPREIQSGMLLRVQPVLFNVGINEQQTLAERFGDTSLQEVINVESLVRLNSYFEQFKEVLPEDCLPRSRSQTCLPELLRFLGQNVHARKNKNVDILWQAAEICRRLNGVRFTSCKSAKDRTAMSVTLEQCLILQHEHGMAPQVFTQALECMRSIGTREVVTQKNLSGLVPIRDLRLDPSLLCSIPLLALSPNLLIVWLFLSIAYLVTKLRCK | |
| type I inositol 3,4-bisphosphate 4-phosphatase isoform c | |
|---|---|
| Refseq ID | NP_001127697 |
| Protein GI | 197116361 |
| UniProt ID | Q96PE3 |
| mRNA ID | NM_001134225 |
| Length | 972 |
| RefSeq Status | REVIEWED |
| MTAREHSPRHGARARAMQRASTIDVAADMLGLSLAGNIQDPDEPILEFSLACSELHTPSLDRKPNSFVAVSVTTPPQAFWTKHAQTEIIEGTNNPIFLSSIAFFQDSLINQMTQVKLSVYDVKDRSQGTMYLLGSGTFIVKDLLQDRHHRLHLTLRSAESDRVGNITVIGWQMEEKSDQRPPVTRSVDTVNGRMVLPVDESLTEALGIRSKYASLRKDTLLKSVFGGAICRMYRFPTTDGNHLRILEQMAESVLSLHVPRQFVKLLLEEDAARVCELEELGELSPCWESLRRQIVTQYQTIILTYQENLTDLHQYRGPSFKASSLKADKKLEFVPTNLHIQRMRVQDDGGSDQNYDIVTIGAPAAHCQGFKSGGLRKKLHKFEETKKHTSSGCQSIIYIPQDVVRAKEIIAQINTLKTQVSYYAERLSRAAKDRSATGLERTLAILADKTRQLVTVCDCKLLANSIHGLNAARPDYIASKASPTSTEEEQVMLRNDQDTLMARWTGRNSRSSLQVDWHEEEWEKVWLNVDKSLECIIQRVDKLLQKERLHGEGCEDVFPCAGSCTSKKGNPDSHAYWIRPEDPFCDVPSSPCPSTMPSTACHPHLTTHCSPPPEESSPGEWSEALYPLLTTLTDCVAMMSDKAKKAMVFLLMQDSAPTIATYLSLQYRRDVVFCQTLTALICGFIIKLRNCLHDDGFLRQLYTIGLLAQFESLLSTYGEELAMLEDMSLGIMDLRNVTFKVTQATSSASADMLPVITGNRDGFNVRVPLPGPLFDALPREIQSGMLLRVQPVLFNVGINEQQTLAERFGDTSLQEVINVESLVRLNSYFEQFKEVLPEDCLPRSRSQTCLPELLRFLGQNVHARKNKNVDILWQAAEICRRLNGVRFTSCKSAKDRTAMSVTLEQCLILQHEHGMAPQVFTQALECMRSEGCRRENTMKNVGSRKYAFNSLQLKAFPKHYRPPEGTYGKVET | |
| type I inositol 3,4-bisphosphate 4-phosphatase isoform d | |
|---|---|
| Refseq ID | NP_001127696 |
| Protein GI | 197116359 |
| UniProt ID | Q96PE3 |
| mRNA ID | NM_001134224 |
| Length | 977 |
| RefSeq Status | REVIEWED |
| MTAREHSPRHGARARAMQRASTIDVAADMLGLSLAGNIQDPDEPILEFSLACSELHTPSLDRKPNSFVAVSVTTPPQAFWTKHAQTEIIEGTNNPIFLSSIAFFQDSLINQMTQVKLSVYDVKDRSQGTMYLLGSGTFIVKDLLQDRHHRLHLTLRSAESDRVGNITVIGWQMEEKSDQRPPVTRSVDTVNGRMVLPVDESLTEALGIRSKYASLRKDTLLKSVFGGAICRMYRFPTTDGNHLRILEQMAESVLSLHVPRQFVKLLLEEDAARVCELEELGELSPCWESLRRQIVTQYQTIILTYQENLTDLHQYRGPSFKASSLKADKKLEFVPTNLHIQRMRVQDDGGSDQNYDIVTIGAPAAHCQGFKSGGLRKKLHKFEETKKHFEECCTSSGCQSIIYIPQDVVRAKEIIAQINTLKTQVSYYAERLSRAAKDRSATGLERTLAILADKTRQLVTVCDCKLLANSIHGLNAARPDYIASKASPTSTEEEQVMLRNDQDTLMARWTGRNSRSSLQVDWHEEEWEKVWLNVDKSLECIIQRVDKLLQKERLHGEGCEDVFPCAGSCTSKKGNPDSHAYWIRPEDPFCDVPSSPCPSTMPSTACHPHLTTHCSPPPEESSPGEWSEALYPLLTTLTDCVAMMSDKAKKAMVFLLMQDSAPTIATYLSLQYRRDVVFCQTLTALICGFIIKLRNCLHDDGFLRQLYTIGLLAQFESLLSTYGEELAMLEDMSLGIMDLRNVTFKVTQATSSASADMLPVITGNRDGFNVRVPLPGPLFDALPREIQSGMLLRVQPVLFNVGINEQQTLAERFGDTSLQEVINVESLVRLNSYFEQFKEVLPEDCLPRSRSQTCLPELLRFLGQNVHARKNKNVDILWQAAEICRRLNGVRFTSCKSAKDRTAMSVTLEQCLILQHEHGMAPQVFTQALECMRSEGCRRENTMKNVGSRKYAFNSLQLKAFPKHYRPPEGTYGKVET | |
Gene Information
Entrez Gene ID
Gene Name
inositol polyphosphate-4-phosphatase, type I, 107kDa
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005829 | TAS:Reactome | C | cytosol |
| GO:0016316 | IEA:UniProtKB-EC | F | phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity |
| GO:0034597 | IEA:UniProtKB-EC | F | phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity |
| GO:0043647 | TAS:Reactome | P | inositol phosphate metabolic process |
| GO:0006661 | TAS:Reactome | P | phosphatidylinositol biosynthetic process |
| GO:0006644 | TAS:Reactome | P | phospholipid metabolic process |
| GO:0007165 | TAS:ProtInc | P | signal transduction |
| GO:0044281 | TAS:Reactome | P | small molecule metabolic process |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_150352 | Synthesis of IP2, IP, and Ins in the cytosol |
| REACT_120756 | Synthesis of PIPs at the early endosome membrane |
| REACT_121025 | Synthesis of PIPs at the plasma membrane |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR000008 | C2 domain |
UniProt Annotations
Entry Information
Gene Name
inositol polyphosphate-4-phosphatase, type I, 107kDa
Protein Entry
INP4A_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=Alpha-3; IsoId=Q96PE3-1; Sequence=Displayed; Name=2; Synonyms=Alpha-1; IsoId=Q96PE3-2; Sequence=VSP_015241; Name=3; IsoId=Q96PE3-3; Sequence=VSP_015240; Name=4; Synonyms=Beta; IsoId=Q96PE3-4; Sequence=VSP_015241, VSP_015242; Note=Inactive.; |
| Catalytic Activity | 1-phosphatidyl-myo-inositol 3,4-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate. |
| Function | Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4- trisphosphate and inositol 3,4-bisphosphate. |
| Pathway | Signal transduction; phosphatidylinositol signaling pathway. |
| Similarity | Belongs to the inositol 3,4-bisphosphate 4-phosphatase family. |
| Similarity | Contains 1 C2 domain. |
| Tissue Specificity | Isoform 1 is expressed in the platelets, MEG- 01 megakaryocytes and Jurkat T-cells. Isoform 2 is expressed in the brain. |
Identical and Related Proteins
Unique RefSeq proteins for LMP005110 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 4755140 | RefSeq | NP_004018 | 938 | type I inositol 3,4-bisphosphate 4-phosphatase isoform a |
| 4504705 | RefSeq | NP_001557 | 954 | type I inositol 3,4-bisphosphate 4-phosphatase isoform b |
| 197116361 | RefSeq | NP_001127697 | 972 | type I inositol 3,4-bisphosphate 4-phosphatase isoform c |
| 197116359 | RefSeq | NP_001127696 | 977 | type I inositol 3,4-bisphosphate 4-phosphatase isoform d |
Identical Sequences to LMP005110 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:4755140 | GenBank | AAB01068.1 | 938 | inositol polyphosphate 4-phosphatase [Homo sapiens] |
| GI:4504705 | GenBank | AAB72150.1 | 954 | inositol polyphosphate 4-phosphatase type I-beta [Homo sapiens] |
| GI:197116359 | GenBank | AAK58870.1 | 977 | inositol polyphosphate 4-phosphatase type I alpha 3 [Homo sapiens] |
| GI:197116361 | GenBank | AAX93230.1 | 972 | unknown [Homo sapiens] |
| GI:197116361 | GenBank | EAX01904.1 | 972 | inositol polyphosphate-4-phosphatase, type I, 107kDa, isoform CRA_a [Homo sapiens] |
| GI:197116361 | GenBank | ADA53463.1 | 972 | Sequence 1293 from patent US 7625699 |
| GI:197116359 | GenBank | AED82370.1 | 977 | Sequence 1107 from patent US 7919467 |
| GI:4504705 | GenBank | AHD74038.1 | 954 | Sequence 12958 from patent US 8586006 |
| GI:4755140 | GenBank | AHD74039.1 | 938 | Sequence 12959 from patent US 8586006 |
| GI:4504705 | RefSeq | XP_001157143.1 | 954 | PREDICTED: type I inositol 3,4-bisphosphate 4-phosphatase isoform X4 [Pan troglodytes] |
| GI:4755140 | RefSeq | XP_003949911.1 | 938 | PREDICTED: type I inositol 3,4-bisphosphate 4-phosphatase isoform X6 [Pan troglodytes] |
| GI:197116359 | SwissProt | Q96PE3.1 | 977 | RecName: Full=Type I inositol 3,4-bisphosphate 4-phosphatase; AltName: Full=Inositol polyphosphate 4-phosphatase type I [Homo sapiens] |
Related Sequences to LMP005110 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:197116361 | GenBank | AAH28361.1 | 972 | INPP4A protein [Homo sapiens] |
| GI:197116361 | GenBank | JAA01050.1 | 972 | inositol polyphosphate-4-phosphatase, type I, 107kDa [Pan troglodytes] |
| GI:197116361 | GenBank | JAA12874.1 | 972 | inositol polyphosphate-4-phosphatase, type I, 107kDa [Pan troglodytes] |
| GI:197116361 | GenBank | JAA26333.1 | 972 | inositol polyphosphate-4-phosphatase, type I, 107kDa [Pan troglodytes] |
| GI:197116361 | GenBank | JAA41022.1 | 972 | inositol polyphosphate-4-phosphatase, type I, 107kDa [Pan troglodytes] |
| GI:4755140 | RefSeq | XP_002757450.1 | 938 | PREDICTED: type I inositol 3,4-bisphosphate 4-phosphatase isoform X12 [Callithrix jacchus] |
| GI:4504705 | RefSeq | XP_002757451.1 | 954 | PREDICTED: type I inositol 3,4-bisphosphate 4-phosphatase isoform X9 [Callithrix jacchus] |
| GI:4504705 | RefSeq | XP_003279279.1 | 954 | PREDICTED: type I inositol 3,4-bisphosphate 4-phosphatase isoform 2 [Nomascus leucogenys] |
| GI:197116359 | RefSeq | XP_003806177.1 | 977 | PREDICTED: type I inositol 3,4-bisphosphate 4-phosphatase isoform X6 [Pan paniscus] |
| GI:4755140 | RefSeq | XP_003806178.1 | 938 | PREDICTED: type I inositol 3,4-bisphosphate 4-phosphatase isoform X13 [Pan paniscus] |
| GI:197116361 | RefSeq | XP_003949910.1 | 972 | PREDICTED: type I inositol 3,4-bisphosphate 4-phosphatase isoform X3 [Pan troglodytes] |
| GI:197116359 | RefSeq | XP_004031519.1 | 977 | PREDICTED: type I inositol 3,4-bisphosphate 4-phosphatase isoform 2 [Gorilla gorilla gorilla] |
| GI:4755140 | RefSeq | XP_004031520.1 | 938 | PREDICTED: type I inositol 3,4-bisphosphate 4-phosphatase isoform 3 [Gorilla gorilla gorilla] |
| GI:4504705 | RefSeq | XP_004031521.1 | 954 | PREDICTED: type I inositol 3,4-bisphosphate 4-phosphatase isoform 4 [Gorilla gorilla gorilla] |
| GI:197116359 | RefSeq | XP_005575099.1 | 977 | PREDICTED: type I inositol 3,4-bisphosphate 4-phosphatase isoform X5 [Macaca fascicularis] |
| GI:4755140 | RefSeq | XP_005575104.1 | 938 | PREDICTED: type I inositol 3,4-bisphosphate 4-phosphatase isoform X10 [Macaca fascicularis] |
| GI:197116359 | RefSeq | XP_006712566.1 | 978 | PREDICTED: type I inositol 3,4-bisphosphate 4-phosphatase isoform X5 [Homo sapiens] |
| GI:4755140 | RefSeq | XP_006712570.1 | 939 | PREDICTED: type I inositol 3,4-bisphosphate 4-phosphatase isoform X9 [Homo sapiens] |
| GI:197116359 | RefSeq | XP_008006290.1 | 977 | PREDICTED: type I inositol 3,4-bisphosphate 4-phosphatase isoform X5 [Chlorocebus sabaeus] |
| GI:4504705 | RefSeq | XP_008006293.1 | 954 | PREDICTED: type I inositol 3,4-bisphosphate 4-phosphatase isoform X8 [Chlorocebus sabaeus] |
| GI:4755140 | RefSeq | XP_008006298.1 | 938 | PREDICTED: type I inositol 3,4-bisphosphate 4-phosphatase isoform X12 [Chlorocebus sabaeus] |
| GI:4504705 | RefSeq | XP_008948697.1 | 954 | PREDICTED: type I inositol 3,4-bisphosphate 4-phosphatase isoform X9 [Pan paniscus] |
| GI:4504705 | RefSeq | XP_008978355.1 | 954 | PREDICTED: type I inositol 3,4-bisphosphate 4-phosphatase isoform X9 [Callithrix jacchus] |
| GI:197116359 | RefSeq | XP_009441219.1 | 977 | PREDICTED: type I inositol 3,4-bisphosphate 4-phosphatase isoform X2 [Pan troglodytes] |