Gene/Proteome Database (LMPD)
Proteins
| ubiquinone biosynthesis monooxygenase COQ6 precursor | |
|---|---|
| Refseq ID | NP_766170 |
| Protein GI | 283135186 |
| UniProt ID | Q8R1S0 |
| mRNA ID | NM_172582 |
| Length | 476 |
| RefSeq Status | VALIDATED |
| MAARIGSMAGLLCVRWWSSAQLAARGGPLVASQRWAGSSADTVYDVVVSGGGLVGSAMACALGHDIHFHDKKILLLEAGPKKALEKLSETYSNRVSSISPGSTTLLSSFGAWDHICNMRCKAFRRMQVWDSCSEALIMFDRDNLDDMGYIVENDVIMYALTKQLEAVADRVKVLYESKAVGYSWPGAFSMADSSPWVHITLGDGSTLQTKLLIGADGHKSGVRQAAGIQNVSWKYDQSAVVATLHLSEATENNVAWQRFLPSGPIALLPLSDTLSSLVWSTSHEHAAELVSMDEEEFVDAINSAFWSDVHHTDFVDSASAMVRHAVALLKPTKVSARQLPPSIAKVDAKSRALFPLGLGHAAEYVRPRVALIGDAAHRIHPLAGQGVNMGFGDISSLVHHLSTAAFNGKDLGSMSHLTGYETDRQRHNTALLAATDLLKRLYSTSATPLVLLRTWGLQATNAVSPLKEQIMAFASK | |
| sig_peptide: 1..20 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2167 peptide sequence: MAARIGSMAGLLCVRWWSSA | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0042995 | IEA:UniProtKB-KW | C | cell projection |
| GO:0005794 | IEA:UniProtKB-KW | C | Golgi apparatus |
| GO:0005739 | IDA:MGI | C | mitochondrion |
| GO:0050660 | IEA:InterPro | F | flavin adenine dinucleotide binding |
| GO:0016709 | IEA:InterPro | F | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen |
| GO:0006744 | IEA:UniProtKB-UniPathway | P | ubiquinone biosynthetic process |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| mmu00130 | Ubiquinone and other terpenoid-quinone biosynthesis |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR003042 | Aromatic-ring hydroxylase-like |
| IPR002938 | Monooxygenase, FAD-binding |
| IPR010971 | Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/UbiI/COQ6 |
| IPR018168 | Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6, conserved site |
| IPR000689 | Ubiquinone biosynthesis monooxygenase, COQ6-type |
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Cofactor | Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000305}; |
| Developmental Stage | At 12.5 dpc, expressed in the metanephric mesenchyme. At 16.5 dpc, expressed in the condensing metanephric mesenchyme surrounding the ureter tips. At 18.5 dpc, expressed in whole kidney. {ECO:0000269|PubMed:21540551}. |
| Pathway | Cofactor biosynthesis; ubiquinone biosynthesis. |
| Similarity | Belongs to the UbiH/COQ6 family. {ECO:0000305}. |
| Subcellular Location | Golgi apparatus {ECO:0000269|PubMed:21540551}. Cell projection {ECO:0000250}. Note=Localizes to podocyte cell processes. {ECO:0000250}. |
| Subunit | Interacts with ADCK4 and COQ7. {ECO:0000250}. |
| Tissue Specificity | Expressed in the kidney, in podocytes. {ECO:0000269|PubMed:21540551}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP005117 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 283135186 | RefSeq | NP_766170 | 476 | ubiquinone biosynthesis monooxygenase COQ6 precursor |
Identical Sequences to LMP005117 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:283135186 | DBBJ | BAE20853.1 | 476 | unnamed protein product [Mus musculus] |
| GI:283135186 | GenBank | AAI32171.1 | 476 | Coenzyme Q6 homolog (yeast) [Mus musculus] |
| GI:283135186 | GenBank | AAI32169.1 | 476 | Coenzyme Q6 homolog (yeast) [Mus musculus] |
| GI:283135186 | GenBank | EDL02790.1 | 476 | coenzyme Q6 homolog (yeast), isoform CRA_c [Mus musculus] |
| GI:283135186 | RefSeq | XP_006515762.1 | 476 | PREDICTED: ubiquinone biosynthesis monooxygenase COQ6 isoform X1 [Mus musculus] |
| GI:283135186 | SwissProt | Q8R1S0.3 | 476 | RecName: Full=Ubiquinone biosynthesis monooxygenase COQ6; AltName: Full=Coenzyme Q10 monooxygenase 6 [Mus musculus] |
Related Sequences to LMP005117 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:283135186 | DBBJ | BAC37039.1 | 476 | unnamed protein product [Mus musculus] |
| GI:283135186 | EMBL | CBN59493.1 | 469 | unnamed protein product [Mus musculus] |
| GI:283135186 | GenBank | AAH24135.1 | 470 | Coq6 protein, partial [Mus musculus] |
| GI:283135186 | GenBank | AAH51055.1 | 475 | Coq6 protein, partial [Mus musculus] |
| GI:283135186 | RefSeq | NP_001011983.1 | 476 | ubiquinone biosynthesis monooxygenase COQ6 precursor [Rattus norvegicus] |
| GI:283135186 | SwissProt | Q68FU7.1 | 476 | RecName: Full=Ubiquinone biosynthesis monooxygenase COQ6 [Rattus norvegicus] |