Gene/Proteome Database (LMPD)
LMPD ID
LMP005150
Gene ID
Species
Mus musculus (Mouse)
Gene Name
lipolysis stimulated lipoprotein receptor
Gene Symbol
Synonyms
ILDR3; Lisch7
Alternate Names
lipolysis-stimulated lipoprotein receptor; lipolysis stimulated receptor; lipolysis-stimulated receptor; liver-specific bHLH-Zip transcription factor; liver-specific gene on mouse chromosome 7 protein
Chromosome
7
Map Location
7 B1|7
Proteins
| lipolysis-stimulated lipoprotein receptor isoform 1 precursor | |
|---|---|
| Refseq ID | NP_059101 |
| Protein GI | 30794490 |
| UniProt ID | Q99KG5 |
| mRNA ID | NM_017405 |
| Length | 594 |
| RefSeq Status | VALIDATED |
| MAPAASACAGAPGSHPATTIFVCLFLIIYCPDRASAIQVTVPDPYHVVILFQPVTLHCTYQMSNTLTAPIVIWKYKSFCRDRVADAFSPASVDNQLNAQLAAGNPGYNPYVECQDSVRTVRVVATKQGNAVTLGDYYQGRRITITGNADLTFEQTAWGDSGVYYCSVVSAQDLDGNNEAYAELIVLGRTSEAPELLPGFRAGPLEDWLFVVVVCLASLLFFLLLGICWCQCCPHTCCCYVRCPCCPDKCCCPEALYAAGKAATSGVPSIYAPSIYTHLSPAKTPPPPPAMIPMRPPYGYPGDFDRTSSVGGHSSQVPLLREVDGSVSSEVRSGYRIQANQQDDSMRVLYYMEKELANFDPSRPGPPNGRVERAMSEVTSLHEDDWRSRPSRAPALTPIRDEEWNRHSPRSPRTWEQEPLQEQPRGGWGSGRPRARSVDALDDINRPGSTESGRSSPPSSGRRGRAYAPPRSRSRDDLYDPDDPRDLPHSRDPHYYDDLRSRDPRADPRSRQRSHDPRDAGFRSRDPQYDGRLLEEALKKKGAGERRRVYREEEEEEEEGHYPPAPPPYSETDSQASRERRMKKNLALSRESLVV | |
| sig_peptide: 1..36 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 3595 peptide sequence: MAPAASACAGAPGSHPATTIFVCLFLIIYCPDRASA sig_peptide: 1..36 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 3595 peptide sequence: MAPAASACAGAPGSHPATTIFVCLFLIIYCPDRASA sig_peptide: 1..35 inference: non-experimental evidence, no additional details recorded note: Potential; propagated from UniProtKB/Swiss-Prot (Q99KG5.1) calculated_mol_wt: 3524 peptide sequence: MAPAASACAGAPGSHPATTIFVCLFLIIYCPDRAS mat_peptide: 36..594 product: Lipolysis-stimulated lipoprotein receptor experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q99KG5.1) calculated_mol_wt: 62602 peptide sequence: AIQVTVPDPYHVVILFQPVTLHCTYQMSNTLTAPIVIWKYKSFCRDRVADAFSPASVDNQLNAQLAAGNPGYNPYVECQDSVRTVRVVATKQGNAVTLGDYYQGRRITITGNADLTFEQTAWGDSGVYYCSVVSAQDLDGNNEAYAELIVLGRTSEAPELLPGFRAGPLEDWLFVVVVCLASLLFFLLLGICWCQCCPHTCCCYVRCPCCPDKCCCPEALYAAGKAATSGVPSIYAPSIYTHLSPAKTPPPPPAMIPMRPPYGYPGDFDRTSSVGGHSSQVPLLREVDGSVSSEVRSGYRIQANQQDDSMRVLYYMEKELANFDPSRPGPPNGRVERAMSEVTSLHEDDWRSRPSRAPALTPIRDEEWNRHSPRSPRTWEQEPLQEQPRGGWGSGRPRARSVDALDDINRPGSTESGRSSPPSSGRRGRAYAPPRSRSRDDLYDPDDPRDLPHSRDPHYYDDLRSRDPRADPRSRQRSHDPRDAGFRSRDPQYDGRLLEEALKKKGAGERRRVYREEEEEEEEGHYPPAPPPYSETDSQASRERRMKKNLALSRESLVV | |
| lipolysis-stimulated lipoprotein receptor isoform 2 precursor | |
|---|---|
| Refseq ID | NP_001157656 |
| Protein GI | 255958261 |
| UniProt ID | Q99KG5 |
| mRNA ID | NM_001164184 |
| Length | 575 |
| RefSeq Status | VALIDATED |
| MAPAASACAGAPGSHPATTIFVCLFLIIYCPDRASAIQVTVPDPYHVVILFQPVTLHCTYQMSNTLTAPIVIWKYKSFCRDRVADAFSPASVDNQLNAQLAAGNPGYNPYVECQDSVRTVRVVATKQGNAVTLGDYYQGRRITITGNADLTFEQTAWGDSGVYYCSVVSAQDLDGNNEAYAELIVLDWLFVVVVCLASLLFFLLLGICWCQCCPHTCCCYVRCPCCPDKCCCPEALYAAGKAATSGVPSIYAPSIYTHLSPAKTPPPPPAMIPMRPPYGYPGDFDRTSSVGGHSSQVPLLREVDGSVSSEVRSGYRIQANQQDDSMRVLYYMEKELANFDPSRPGPPNGRVERAMSEVTSLHEDDWRSRPSRAPALTPIRDEEWNRHSPRSPRTWEQEPLQEQPRGGWGSGRPRARSVDALDDINRPGSTESGRSSPPSSGRRGRAYAPPRSRSRDDLYDPDDPRDLPHSRDPHYYDDLRSRDPRADPRSRQRSHDPRDAGFRSRDPQYDGRLLEEALKKKGAGERRRVYREEEEEEEEGHYPPAPPPYSETDSQASRERRMKKNLALSRESLVV | |
| lipolysis-stimulated lipoprotein receptor isoform 3 precursor | |
|---|---|
| Refseq ID | NP_001157657 |
| Protein GI | 255958263 |
| UniProt ID | Q99KG5 |
| mRNA ID | NM_001164185 |
| Length | 526 |
| RefSeq Status | VALIDATED |
| MAPAASACAGAPGSHPATTIFVCLFLIIYCPDRASAIQVTVPDPYHVVILFQPVTLHCTYQMSNTLTAPIVIWKYKSFCRDRVADAFSPASVDNQLNAQLAAGNPGYNPYVECQDSVRTVRVVATKQGNAVTLGDYYQGRRITITGNADLTFEQTAWGDSGVYYCSVVSAQDLDGNNEAYAELIVLVYAAGKAATSGVPSIYAPSIYTHLSPAKTPPPPPAMIPMRPPYGYPGDFDRTSSVGGHSSQVPLLREVDGSVSSEVRSGYRIQANQQDDSMRVLYYMEKELANFDPSRPGPPNGRVERAMSEVTSLHEDDWRSRPSRAPALTPIRDEEWNRHSPRSPRTWEQEPLQEQPRGGWGSGRPRARSVDALDDINRPGSTESGRSSPPSSGRRGRAYAPPRSRSRDDLYDPDDPRDLPHSRDPHYYDDLRSRDPRADPRSRQRSHDPRDAGFRSRDPQYDGRLLEEALKKKGAGERRRVYREEEEEEEEGHYPPAPPPYSETDSQASRERRMKKNLALSRESLVV | |
Gene Information
Entrez Gene ID
Gene Name
lipolysis stimulated lipoprotein receptor
Gene Symbol
Species
Mus musculus
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0042627 | IEA:UniProtKB-KW | C | chylomicron |
| GO:0070062 | IEA:Ensembl | C | extracellular vesicular exosome |
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0034362 | IEA:UniProtKB-KW | C | low-density lipoprotein particle |
| GO:0005886 | IDA:HGNC | C | plasma membrane |
| GO:0034361 | IEA:UniProtKB-KW | C | very-low-density lipoprotein particle |
| GO:0030228 | TAS:HGNC | F | lipoprotein particle receptor activity |
| GO:0030169 | TAS:HGNC | F | low-density lipoprotein particle binding |
| GO:0009790 | IMP:HGNC | P | embryo development |
| GO:0042953 | TAS:HGNC | P | lipoprotein transport |
| GO:0001889 | IMP:HGNC | P | liver development |
| GO:0006898 | TAS:GOC | P | receptor-mediated endocytosis |
| GO:0019216 | IEA:Ensembl | P | regulation of lipid metabolic process |
Domain Information
UniProt Annotations
Entry Information
Gene Name
lipolysis stimulated lipoprotein receptor
Protein Entry
LSR_MOUSE
UniProt ID
Species
Mouse
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q99KG5-1; Sequence=Displayed; Name=2; IsoId=Q99KG5-2; Sequence=VSP_019696; Name=3; IsoId=Q99KG5-3; Sequence=VSP_019695; |
| Developmental Stage | Expressed during embryogenesis (at protein level). Detected from E7.5 to E17. {ECO:0000269|PubMed:15265030}. |
| Disruption Phenotype | Death between E12.5 and E15.5 probably due to impaired liver and embryonic development. {ECO:0000269|PubMed:15265030}. |
| Function | Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells (By similarity). {ECO:0000250}. |
| Sequence Caution | Sequence=AAA92719.1; Type=Frameshift; Positions=2; Evidence={ECO:0000305}; |
| Similarity | Belongs to the immunoglobulin superfamily. LISCH7 family. {ECO:0000305}. |
| Similarity | Contains 1 Ig-like V-type (immunoglobulin-like) domain. {ECO:0000305}. |
| Subcellular Location | Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. |
| Subunit | Homotrimer or homotetramer. {ECO:0000250}. |
| Tissue Specificity | Specifically expressed in liver and to a lower extent in kidney (at protein level). Also detected in brain, testis, ovaries, adrenal gland, intestine, muscle, and lung. {ECO:0000269|PubMed:15265030}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP005150 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 30794490 | RefSeq | NP_059101 | 594 | lipolysis-stimulated lipoprotein receptor isoform 1 precursor |
| 255958261 | RefSeq | NP_001157656 | 575 | lipolysis-stimulated lipoprotein receptor isoform 2 precursor |
| 255958263 | RefSeq | NP_001157657 | 526 | lipolysis-stimulated lipoprotein receptor isoform 3 precursor |
Identical Sequences to LMP005150 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:255958261 | DBBJ | BAE27447.1 | 575 | unnamed protein product [Mus musculus] |
| GI:30794490 | GenBank | AAH04672.1 | 594 | Lipolysis stimulated lipoprotein receptor [Mus musculus] |
| GI:30794490 | GenBank | EDL23971.1 | 594 | lipolysis stimulated lipoprotein receptor, isoform CRA_a [Mus musculus] |
| GI:255958261 | GenBank | EDL23973.1 | 575 | lipolysis stimulated lipoprotein receptor, isoform CRA_c [Mus musculus] |
| GI:255958263 | GenBank | EDL23974.1 | 526 | lipolysis stimulated lipoprotein receptor, isoform CRA_d [Mus musculus] |
| GI:30794490 | SwissProt | Q99KG5.1 | 594 | RecName: Full=Lipolysis-stimulated lipoprotein receptor; AltName: Full=Lipolysis-stimulated receptor; AltName: Full=Liver-specific bHLH-Zip transcription factor; AltName: Full=Liver-specific gene on mouse chromosome 7 protein; Flags: Precursor [Mus musculus] |
Related Sequences to LMP005150 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:30794490 | GenBank | AAA92719.1 | 656 | Lisch7, partial [Mus musculus] |
| GI:255958261 | GenBank | AAH04672.1 | 594 | Lipolysis stimulated lipoprotein receptor [Mus musculus] |
| GI:30794490 | GenBank | AAQ83379.1 | 576 | lipolysis stimulated receptor, partial [Mus musculus] |
| GI:30794490 | GenBank | AAR67381.1 | 594 | Sequence 16 from patent US 6635431 |
| GI:255958261 | GenBank | AAR67382.1 | 575 | Sequence 17 from patent US 6635431 |
| GI:30794490 | GenBank | ABX97977.1 | 594 | Sequence 16 from patent US 7291709 |
| GI:255958261 | GenBank | ABX97978.1 | 575 | Sequence 17 from patent US 7291709 |
| GI:30794490 | GenBank | ACM96525.1 | 594 | Sequence 17 from patent US 7470669 |
| GI:255958261 | GenBank | ACM96526.1 | 575 | Sequence 18 from patent US 7470669 |
| GI:30794490 | GenBank | AED79457.1 | 594 | Sequence 16 from patent US 7919091 |
| GI:255958261 | GenBank | AED79458.1 | 575 | Sequence 17 from patent US 7919091 |
| GI:255958263 | RefSeq | XP_005081852.1 | 524 | PREDICTED: lipolysis-stimulated lipoprotein receptor isoform X3 [Mesocricetus auratus] |
| GI:255958263 | RefSeq | XP_005361265.1 | 576 | PREDICTED: lipolysis-stimulated lipoprotein receptor isoform X2 [Microtus ochrogaster] |
| GI:255958263 | RefSeq | XP_005361267.1 | 527 | PREDICTED: lipolysis-stimulated lipoprotein receptor isoform X4 [Microtus ochrogaster] |
| GI:255958263 | RefSeq | XP_006982135.1 | 575 | PREDICTED: lipolysis-stimulated lipoprotein receptor isoform X2 [Peromyscus maniculatus bairdii] |
| GI:255958263 | RefSeq | XP_006982136.1 | 526 | PREDICTED: lipolysis-stimulated lipoprotein receptor isoform X3 [Peromyscus maniculatus bairdii] |
| GI:255958263 | RefSeq | XP_007622523.1 | 527 | PREDICTED: lipolysis-stimulated lipoprotein receptor isoform X4 [Cricetulus griseus] |
| GI:255958261 | SwissProt | Q99KG5.1 | 594 | RecName: Full=Lipolysis-stimulated lipoprotein receptor; AltName: Full=Lipolysis-stimulated receptor; AltName: Full=Liver-specific bHLH-Zip transcription factor; AltName: Full=Liver-specific gene on mouse chromosome 7 protein; Flags: Precursor [Mus musculus] |