Gene/Proteome Database (LMPD)

LMPD ID
LMP005157
Gene ID
72077
Species
Mus musculus (Mouse)
Gene Name
glucosaminyl (N-acetyl) transferase 3, mucin type
Gene Symbol
Gcnt3
Synonyms
2010013H22Rik; 2210021I22Rik; 2210401J11Rik
Alternate Names
beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3; C2GnT-M; C2GnT-mucin type; core 2 beta-1,6-N-acetylglucosaminyltransferase II; mucus-type core 2 beta-1,6-N-acetylglucosaminyltransferase
Chromosome
9
Map Location
9 D|9
EC Number
2.4.1.102

Proteins

beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3
Refseq ID NP_082363
Protein GI 124430729
UniProt ID Q5JCT0
mRNA ID NM_028087
Length 437
RefSeq Status PROVISIONAL
MTSWQRLCWHYRLWTLGCYMLLAILALKLSLRLKCDFDAMDLDSEEFQSQYCRDLLYKTLKLPAKSSINCSGVIRGEQKAVTQALLNNLEIKKKQQLFTEADYLRMTADCEHFKTKRKFIQVPLSKEEASFPIAYSMVVHEKIENFERLLRAVYTPQNVYCVHMDQKSSEPFKQAVRAIVSCFPNVFIASKLVSVVYASWSRVQADLNCMEDLLQSPVPWKYLLNTCGTDFPIKTNAEMVKALKLLKGQNSMESEVPPPHKKSRWKYHYEVTDTLHMTSKRKTPPPNNLTMFTGNAYMVASRDFIEHVFSNSKARQLIEWVKDTYSPDEHLWATLQRASWMPGSDPLHRKFDLSDMRAIARLTKWYDHEGDIENGAPYTSCSGIHQRAVCVYGSGDLHWILQNHHLLANKFDPKVDDNVLQCLEEYLRHKAIYGTEL

Gene Information

Entrez Gene ID
72077
Gene Name
glucosaminyl (N-acetyl) transferase 3, mucin type
Gene Symbol
Gcnt3
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IEA:UniProtKB-KW C Golgi apparatus
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0008109 IEA:UniProtKB-EC F N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity
GO:0047225 IMP:MGI F acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity
GO:0003829 IEA:UniProtKB-EC F beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity
GO:0002426 IMP:MGI P immunoglobulin production in mucosal tissue
GO:0050892 IMP:MGI P intestinal absorption
GO:0060993 IGI:MGI P kidney morphogenesis
GO:0006486 IEA:UniProtKB-UniPathway P protein glycosylation
GO:0048729 IGI:MGI P tissue morphogenesis

KEGG Pathway Links

KEGG Pathway ID Description
mmu01100 Metabolic pathways
ko00512 Mucin type O-Glycan biosynthesis
mmu00512 Mucin type O-Glycan biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR003406 Glycosyl transferase, family 14

UniProt Annotations

Entry Information

Gene Name
glucosaminyl (N-acetyl) transferase 3, mucin type
Protein Entry
GCNT3_MOUSE
UniProt ID
Q5JCT0
Species
Mouse

Comments

Comment Type Description
Catalytic Activity UDP-N-acetyl-D-glucosamine + beta-D- galactosyl-1,3-N-acetyl-D-galactosaminyl-R = UDP + beta-D- galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D- galactosaminyl-R.
Catalytic Activity UDP-N-acetyl-D-glucosamine + beta-D- galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D- glucosaminyl-1,6-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R.
Function Glycosyltransferase that can synthesize all known mucin beta 6 N-acetylglucosaminides. Mediates core 2 and core 4 O-glycan branching, 2 important steps in mucin-type biosynthesis. Has also I-branching enzyme activity by converting linear into branched poly-N-acetyllactosaminoglycans, leading to introduce the blood group I antigen during embryonic development (By similarity). {ECO:0000250}.
Pathway Protein modification; protein glycosylation.
Ptm N-glycosylated. {ECO:0000250}.
Sequence Caution Sequence=AAH18297.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB25548.1; Type=Erroneous termination; Positions=35; Note=Translated as Cys.; Evidence={ECO:0000305};
Similarity Belongs to the glycosyltransferase 14 family. {ECO:0000305}.
Subcellular Location Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Web Resource Name=Functional Glycomics Gateway - GTase; Note=core 2 beta 6 GlcNAc T3; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_575";

Identical and Related Proteins

Unique RefSeq proteins for LMP005157 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
124430729 RefSeq NP_082363 437 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3

Identical Sequences to LMP005157 proteins

Reference Database Accession Length Protein Name
GI:124430729 GenBank ABM91120.1 437 mucus-type core 2 beta-1,6-N-acetylglucosaminyltransferase [Mus musculus]
GI:124430729 GenBank EDL26189.1 437 glucosaminyl (N-acetyl) transferase 3, mucin type, isoform CRA_b [Mus musculus]
GI:124430729 RefSeq XP_006511526.1 437 PREDICTED: beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 isoform X1 [Mus musculus]
GI:124430729 RefSeq XP_006511527.1 437 PREDICTED: beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 isoform X2 [Mus musculus]
GI:124430729 RefSeq XP_006511528.1 437 PREDICTED: beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 isoform X3 [Mus musculus]
GI:124430729 SwissProt Q5JCT0.2 437 RecName: Full=Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3; AltName: Full=C2GnT-mucin type; Short=C2GnT-M; AltName: Full=Mucus-type core 2 beta-1,6-N-acetylglucosaminyltransferase [Mus musculus]

Related Sequences to LMP005157 proteins

Reference Database Accession Length Protein Name
GI:124430729 DBBJ BAC53607.1 437 beta-1,6-N-acetylglucosaminyltransferase [Rattus norvegicus]
GI:124430729 GenBank AAK72480.1 437 core 2 beta-1,6-N-acetylglucosaminyltransferase II [Mus musculus]
GI:124430729 GenBank EDL26188.1 436 glucosaminyl (N-acetyl) transferase 3, mucin type, isoform CRA_a [Mus musculus]
GI:124430729 RefSeq NP_775434.1 437 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 [Rattus norvegicus]
GI:124430729 RefSeq XP_006243428.1 437 PREDICTED: beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 isoform X1 [Rattus norvegicus]
GI:124430729 RefSeq XP_008764442.1 437 PREDICTED: beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 isoform X1 [Rattus norvegicus]