Gene/Proteome Database (LMPD)
LMPD ID
LMP005176
Gene ID
Species
Mus musculus (Mouse)
Gene Name
glucuronidase, beta
Gene Symbol
Synonyms
AI747421; Gur; Gus; Gus-r; Gus-s; Gus-t; Gus-u; Gut; asd; g
Alternate Names
beta-glucuronidase; adipose storage deficiency
Chromosome
5
Map Location
5 G1.3|5 68.32 cM
EC Number
3.2.1.31
Proteins
| beta-glucuronidase precursor | |
|---|---|
| Refseq ID | NP_034498 |
| Protein GI | 6754098 |
| UniProt ID | P12265 |
| mRNA ID | NM_010368 |
| Length | 648 |
| RefSeq Status | PROVISIONAL |
| MSLKWSACWVALGQLLCSCALALKGGMLFPKESPSRELKALDGLWHFRADLSNNRLQGFEQQWYRQPLRESGPVLDMPVPSSFNDITQEAALRDFIGWVWYEREAILPRRWTQDTDMRVVLRINSAHYYAVVWVNGIHVVEHEGGHLPFEADISKLVQSGPLTTCRITIAINNTLTPHTLPPGTIVYKTDTSMYPKGYFVQDTSFDFFNYAGLHRSVVLYTTPTTYIDDITVITNVEQDIGLVTYWISVQGSEHFQLEVQLLDEGGKVVAHGTGNQGQLQVPSANLWWPYLMHEHPAYMYSLEVKVTTTESVTDYYTLPIGIRTVAVTKSKFLINGKPFYFQGVNKHEDSDIRGKGFDWPLLVKDFNLLRWLGANSFRTSHYPYSEEVLQLCDRYGIVVIDECPGVGIVLPQSFGNESLRHHLEVMEELVRRDKNHPAVVMWSVANEPSSALKPAAYYFKTLITHTKALDLTRPVTFVSNAKYDADLGAPYVDVICVNSYFSWYHDYGHLEVIQPQLNSQFENWYKTHQKPIIQSEYGADAIPGIHEDPPRMFSEEYQKAVLENYHSVLDQKRKEYVVGELIWNFADFMTNQSPLRVIGNKKGIFTRQRQPKTSAFILRERYWRIANETGGHGSGPRTQCFGSRPFTF | |
| sig_peptide: 1..22 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2355 peptide sequence: MSLKWSACWVALGQLLCSCALA mat_peptide: 23..648 product: beta-glucuronidase EC_number: 3.2.1.31 calculated_mol_wt: 71859 peptide sequence: LKGGMLFPKESPSRELKALDGLWHFRADLSNNRLQGFEQQWYRQPLRESGPVLDMPVPSSFNDITQEAALRDFIGWVWYEREAILPRRWTQDTDMRVVLRINSAHYYAVVWVNGIHVVEHEGGHLPFEADISKLVQSGPLTTCRITIAINNTLTPHTLPPGTIVYKTDTSMYPKGYFVQDTSFDFFNYAGLHRSVVLYTTPTTYIDDITVITNVEQDIGLVTYWISVQGSEHFQLEVQLLDEGGKVVAHGTGNQGQLQVPSANLWWPYLMHEHPAYMYSLEVKVTTTESVTDYYTLPIGIRTVAVTKSKFLINGKPFYFQGVNKHEDSDIRGKGFDWPLLVKDFNLLRWLGANSFRTSHYPYSEEVLQLCDRYGIVVIDECPGVGIVLPQSFGNESLRHHLEVMEELVRRDKNHPAVVMWSVANEPSSALKPAAYYFKTLITHTKALDLTRPVTFVSNAKYDADLGAPYVDVICVNSYFSWYHDYGHLEVIQPQLNSQFENWYKTHQKPIIQSEYGADAIPGIHEDPPRMFSEEYQKAVLENYHSVLDQKRKEYVVGELIWNFADFMTNQSPLRVIGNKKGIFTRQRQPKTSAFILRERYWRIANETGGHGSGPRTQCFGSRPFTF | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005783 | IEA:UniProtKB-KW | C | endoplasmic reticulum |
| GO:0070062 | IEA:Ensembl | C | extracellular vesicular exosome |
| GO:0005764 | IDA:MGI | C | lysosome |
| GO:0004566 | IDA:MGI | F | beta-glucuronidase activity |
| GO:0005975 | IDA:MGI | P | carbohydrate metabolic process |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| mmu04142 | Lysosome |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR008979 | Galactose-binding domain-like |
| IPR017853 | Glycoside hydrolase superfamily |
| IPR013781 | Glycoside hydrolase, catalytic domain |
| IPR006101 | Glycoside hydrolase, family 2 |
| IPR006103 | Glycoside hydrolase, family 2, TIM barrel |
| IPR023232 | Glycoside hydrolase, family 2, active site |
| IPR023230 | Glycoside hydrolase, family 2, conserved site |
| IPR006102 | Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich |
| IPR013812 | Glycoside hydrolase, family 2/20, immunoglobulin-like beta-sandwich domain |
| IPR006104 | Glycosyl hydrolases family 2, sugar binding domain |
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | A beta-D-glucuronoside + H(2)O = D-glucuronate + an alcohol. |
| Enzyme Regulation | Inhibited by L-aspartic acid. {ECO:0000250}. |
| Function | Plays an important role in the degradation of dermatan and keratan sulfates. |
| Similarity | Belongs to the glycosyl hydrolase 2 family. {ECO:0000305}. |
| Subcellular Location | Lysosome {ECO:0000269|PubMed:2394691}. Endoplasmic reticulum {ECO:0000269|PubMed:2394691}. Note=A small proportion is found in the endoplasmic reticulum. |
| Subunit | Homotetramer. |
Identical and Related Proteins
Unique RefSeq proteins for LMP005176 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 6754098 | RefSeq | NP_034498 | 648 | beta-glucuronidase precursor |
Identical Sequences to LMP005176 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:6754098 | DBBJ | BAE36917.1 | 648 | unnamed protein product [Mus musculus] |
| GI:6754098 | DBBJ | BAE35155.1 | 648 | unnamed protein product [Mus musculus] |
| GI:6754098 | DBBJ | BAE23021.1 | 648 | unnamed protein product [Mus musculus] |
| GI:6754098 | DBBJ | BAE29265.1 | 648 | unnamed protein product [Mus musculus] |
| GI:6754098 | GenBank | EDL19485.1 | 648 | glucuronidase, beta, isoform CRA_a [Mus musculus] |
| GI:6754098 | SwissProt | P12265.2 | 648 | RecName: Full=Beta-glucuronidase; Flags: Precursor [Mus musculus] |
Related Sequences to LMP005176 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:6754098 | DBBJ | BAE34865.1 | 648 | unnamed protein product [Mus musculus] |
| GI:6754098 | DBBJ | BAE35384.1 | 648 | unnamed protein product [Mus musculus] |
| GI:6754098 | GenBank | AAA63308.1 | 648 | beta-glucoronidase [Mus musculus domesticus] |
| GI:6754098 | GenBank | AAA63309.1 | 648 | beta-glucoronidase [Mus musculus domesticus] |
| GI:6754098 | GenBank | AAA37696.1 | 648 | beta-glucuronidase precursor [Mus musculus] |
| GI:6754098 | GenBank | AAA98623.1 | 648 | beta-glucuronidase [Mus musculus domesticus] |