Gene/Proteome Database (LMPD)

LMPD ID
LMP005197
Gene ID
14228
Species
Mus musculus (Mouse)
Gene Name
FK506 binding protein 4
Gene Symbol
Fkbp4
Synonyms
59kDa; AL022792; AW208983; FKBP-4; FKBP-52; FKBP52; FKPB52; p59
Alternate Names
peptidyl-prolyl cis-trans isomerase FKBP4; HBI; FKBP59; rotamase; 52 kDa FKBP; PPIase FKBP4; 59 kDa immunophilin; immunophilin FKBP52; FK506-binding protein 4; HSP-binding immunophilin; 52 kDa FK506-binding protein
Chromosome
6
Map Location
6 F3|6
EC Number
5.2.1.8

Proteins

peptidyl-prolyl cis-trans isomerase FKBP4
Refseq ID NP_034349
Protein GI 6753882
UniProt ID P30416
mRNA ID NM_010219
Length 458
RefSeq Status PROVISIONAL
MTAEEMKAAENGAQSAPLPLEGVDISPKQDEGVLKVIKREGTGTETPMIGDRVFVHYTGWLLDGTKFDSSLDRKDKFSFDLGKGEVIKAWDIAVATMKVGEVCHITCKPEYAYGAAGSPPKIPPNATLVFEVELFEFKGEDLTEEEDGGIIRRIRTRGEGYARPNDGAMVEVALEGYHKDRLFDQRELCFEVGEGESLDLPCGLEEAIQRMEKGEHSIVYLKPSYAFGSVGKERFQIPPHAELRYEVRLKSFEKAKESWEMSSAEKLEQSNIVKERGTAYFKEGKYKQALLQYKKIVSWLEYESSFSGEEMQKVHALRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAVCQQRTRRQLAREKKLYANMFERLAEEEHKVKAEVAAGDHPTDAEMKGERNNVAENQSRVETEA

Gene Information

Entrez Gene ID
14228
Gene Name
FK506 binding protein 4
Gene Symbol
Fkbp4
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0044295 ISS:UniProtKB C axonal growth cone
GO:0005829 ISS:UniProtKB C cytosol
GO:0005789 IBA:RefGenome C endoplasmic reticulum membrane
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0005874 IEA:UniProtKB-KW C microtubule
GO:0005739 IEA:UniProtKB-KW C mitochondrion
GO:0043025 IEA:Ensembl C neuronal cell body
GO:0005634 IDA:MGI C nucleus
GO:0048471 IEA:Ensembl C perinuclear region of cytoplasm
GO:0005524 IDA:MGI F ATP binding
GO:0005528 IBA:RefGenome F FK506 binding
GO:0005525 IDA:MGI F GTP binding
GO:0035259 IDA:MGI F glucocorticoid receptor binding
GO:0031072 IDA:MGI F heat shock protein binding
GO:0003755 ISS:UniProtKB F peptidyl-prolyl cis-trans isomerase activity
GO:0051219 IDA:MGI F phosphoprotein binding
GO:0044822 IEA:Ensembl F poly(A) RNA binding
GO:0030521 IMP:MGI P androgen receptor signaling pathway
GO:0061077 ISS:UniProtKB P chaperone-mediated protein folding
GO:0006825 IEA:Ensembl P copper ion transport
GO:0007566 IMP:MGI P embryo implantation
GO:0046661 IMP:MGI P male sex differentiation
GO:0031115 IEA:Ensembl P negative regulation of microtubule polymerization
GO:0031111 ISS:UniProtKB P negative regulation of microtubule polymerization or depolymerization
GO:0010977 ISS:UniProtKB P negative regulation of neuron projection development
GO:0030850 IMP:MGI P prostate gland development
GO:0031503 IDA:MGI P protein complex localization
GO:0000413 IBA:RefGenome P protein peptidyl-prolyl isomerization
GO:0048608 IMP:MGI P reproductive structure development
GO:0006463 IDA:MGI P steroid hormone receptor complex assembly

KEGG Pathway Links

KEGG Pathway ID Description
ko04915 Estrogen signaling pathway
mmu04915 Estrogen signaling pathway

REACTOME Pathway Links

REACTOME Pathway ID Description
5894134 Attenuation phase
5894135 HSF1-dependent transactivation

Domain Information

InterPro Annotations

Accession Description
IPR023566 Peptidyl-prolyl cis-trans isomerase, FKBP-type
IPR001179 Peptidyl-prolyl cis-trans isomerase, FKBP-type, domain
IPR001440 Tetratricopeptide TPR1
IPR019734 Tetratricopeptide repeat
IPR013026 Tetratricopeptide repeat-containing domain
IPR011990 Tetratricopeptide-like helical domain

UniProt Annotations

Entry Information

Gene Name
FK506 binding protein 4
Protein Entry
FKBP4_MOUSE
UniProt ID
P30416
Species
Mouse

Comments

Comment Type Description
Catalytic Activity Peptidylproline (omega=180) = peptidylproline (omega=0).
Domain The C-terminal region (AA 375-458) is required to prevent tubulin polymerization. {ECO:0000250}.
Domain The PPIase activity is mainly due to the fisrt PPIase FKBP-type domain (1-138 AA). {ECO:0000250}.
Domain The TPR repeats mediate mitochondrial localization. {ECO:0000250}.
Domain The chaperone activity resides in the C-terminal region, mainly between amino acids 264 and 400. {ECO:0000250}.
Enzyme Regulation Inhibited by FK506. {ECO:0000250}.
Function Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria. {ECO:0000269|PubMed:11278753, ECO:0000269|PubMed:11751894, ECO:0000269|PubMed:8341706}.
Interaction P06537:Nr3c1; NbExp=3; IntAct=EBI-492746, EBI-492753;
Ptm Phosphorylation by CK2 results in loss of HSP90 binding activity.
Sequence Caution Sequence=CAA34914.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA34914.1; Type=Frameshift; Positions=16, 156, 204, 265; Evidence={ECO:0000305};
Similarity Contains 2 PPIase FKBP-type domains. {ECO:0000255|PROSITE-ProRule:PRU00277}.
Similarity Contains 3 TPR repeats. {ECO:0000255|PROSITE- ProRule:PRU00339}.
Subcellular Location Cytoplasm, cytosol. Mitochondrion {ECO:0000250}. Nucleus. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Shuttles from mitochondria to nucleus; co-localizes in mitochondria with the glucocorticoid receptor. {ECO:0000250}.
Subunit Homodimer (By similarity). Associates with HSP90AA1 and HSPA1A/HSPA1B in steroid hormone receptor complexes. Also interacts with peroxisomal phytanoyl-CoA alpha-hydroxylase (PHYH). Interacts with NR3C1 and dynein. Interacts with HSF1 in the HSP90 complex. Associates with tubulin. Interacts with MAPT/TAU. Interacts (via TPR domain) with S100A1, S100A2 and S100A6; the interaction is Ca(2+) dependent. Interaction with S100A1 and S100A2 (but not with S100A6) leads to inhibition of FKBP4-HSP90 interaction. Interacts with dynein; contributes to NR3C1 transport to the nucleus. {ECO:0000250, ECO:0000269|PubMed:11278753, ECO:0000269|PubMed:11751894, ECO:0000269|PubMed:9195923}.

Identical and Related Proteins

Unique RefSeq proteins for LMP005197 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6753882 RefSeq NP_034349 458 peptidyl-prolyl cis-trans isomerase FKBP4

Identical Sequences to LMP005197 proteins

Reference Database Accession Length Protein Name
GI:6753882 DBBJ BAC39057.1 458 unnamed protein product [Mus musculus]
GI:6753882 EMBL CAA50231.1 458 p59 immunophilin [Mus musculus]
GI:6753882 GenBank EDK99887.1 458 FK506 binding protein 4, isoform CRA_b [Mus musculus]
GI:6753882 SwissProt P30416.5 458 RecName: Full=Peptidyl-prolyl cis-trans isomerase FKBP4; Short=PPIase FKBP4; AltName: Full=52 kDa FK506-binding protein; Short=52 kDa FKBP; Short=FKBP-52; AltName: Full=59 kDa immunophilin; Short=p59; AltName: Full=FK506-binding protein 4; Short=FKBP-4; AltName: Full=FKBP59; AltName: Full=HSP-binding immunophilin; Short=HBI; AltName: Full=Immunophilin FKBP52; AltName: Full=Rotamase; Contains: RecName: Full=Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed [Mus musculus]

Related Sequences to LMP005197 proteins

Reference Database Accession Length Protein Name
GI:6753882 DBBJ BAE35690.1 458 unnamed protein product [Mus musculus]
GI:6753882 GenBank AAH03447.1 458 FK506 binding protein 4 [Mus musculus]
GI:6753882 GenBank EDK99886.1 455 FK506 binding protein 4, isoform CRA_a [Mus musculus]
GI:6753882 GenBank EDM01775.1 458 FK506 binding protein 4 [Rattus norvegicus]
GI:6753882 RefSeq NP_001178792.1 458 peptidyl-prolyl cis-trans isomerase FKBP4 [Rattus norvegicus]
GI:6753882 SwissProt Q9QVC8.3 458 RecName: Full=Peptidyl-prolyl cis-trans isomerase FKBP4; Short=PPIase FKBP4; AltName: Full=52 kDa FK506-binding protein; Short=52 kDa FKBP; Short=FKBP-52; AltName: Full=59 kDa immunophilin; Short=p59; AltName: Full=FK506-binding protein 4; Short=FKBP-4; AltName: Full=FKBP59; AltName: Full=HSP-binding immunophilin; Short=HBI; AltName: Full=Immunophilin FKBP52; AltName: Full=Rotamase; Contains: RecName: Full=Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed [Rattus norvegicus]