Gene/Proteome Database (LMPD)

LMPD ID
LMP005209
Gene ID
30849
Species
Homo sapiens (Human)
Gene Name
phosphoinositide-3-kinase, regulatory subunit 4
Gene Symbol
PIK3R4
Synonyms
VPS15; p150
Alternate Names
phosphoinositide 3-kinase regulatory subunit 4; PI3-kinase p150 subunit; PI3-kinase regulatory subunit 4; phosphoinositide 3-kinase adaptor protein; phosphatidylinositol 3-kinase-associated p150; phosphoinositide-3-kinase, regulatory subunit 4, p150
Chromosome
3
Map Location
3q22.1
EC Number
2.7.11.1

Proteins

phosphoinositide 3-kinase regulatory subunit 4
Refseq ID NP_055417
Protein GI 23943912
UniProt ID Q99570
mRNA ID NM_014602
Length 1358
RefSeq Status VALIDATED
MGNQLAGIAPSQILSVESYFSDIHDFEYDKSLGSTRFFKVARAKHREGLVVVKVFAIQDPTLPLTSYKQELEELKIRLNSAQNCLPFQKASEKASEKAAMLFRQYVRDNLYDRISTRPFLNNIEKRWIAFQILTAVDQAHKSGVRHGDIKTENVMVTSWNWVLLTDFASFKPTYLPEDNPADFNYFFDTSRRRTCYIAPERFVDGGMFATELEYMRDPSTPLVDLNSNQRTRGELKRAMDIFSAGCVIAELFTEGVPLFDLSQLLAYRNGHFFPEQVLNKIEDHSIRELVTQMIHREPDKRLEAEDYLKQQRGNAFPEIFYTFLQPYMAQFAKETFLSADERILVIRKDLGNIIHNLCGHDLPEKAEGEPKENGLVILVSVITSCLQTLKYCDSKLAALELILHLAPRLSVEILLDRITPYLLHFSNDSVPRVRAEALRTLTKVLALVKEVPRNDINIYPEYILPGIAHLAQDDATIVRLAYAENIALLAETALRFLELVQLKNLNMENDPNNEEIDEVTHPNGNYDTELQALHEMVQQKVVTLLSDPENIVKQTLMENGITRLCVFFGRQKANDVLLSHMITFLNDKNDWHLRGAFFDSIVGVAAYVGWQSSSILKPLLQQGLSDAEEFVIVKALYALTCMCQLGLLQKPHVYEFASDIAPFLCHPNLWIRYGAVGFITVVARQISTADVYCKLMPYLDPYITQPIIQIERKLVLLSVLKEPVSRSIFDYALRSKDITSLFRHLHMRQKKRNGSLPDCPPPEDPAIAQLLKKLLSQGMTEEEEDKLLALKDFMMKSNKAKANIVDQSHLHDSSQKGVIDLAALGITGRQVDLVKTKQEPDDKRARKHVKQDSNVNEEWKSMFGSLDPPNMPQALPKGSDQEVIQTGKPPRSESSAGICVPLSTSSQVPEVTTVQNKKPVIPVLSSTILPSTYQIRITTCKTELQQLIQQKREQCNAERIAKQMMENAEWESKPPPPGWRPKGLLVAHLHEHKSAVNRIRVSDEHSLFATCSNDGTVKIWNSQKMEGKTTTTRSILTYSRIGGRVKTLTFCQGSHYLAIASDNGAVQLLGIEASKLPKSPKIHPLQSRILDQKEDGCVVDMHHFNSGAQSVLAYATVNGSLVGWDLRSSSNAWTLKHDLKSGLITSFAVDIHQCWLCIGTSSGTMACWDMRFQLPISSHCHPSRARIRRLSMHPLYQSWVIAAVQGNNEVSMWDMETGDRRFTLWASSAPPLSELQPSPHSVHGIYCSPADGNPILLTAGSDMKIRFWDLAYPERSYVVAGSTSSPSVSYYRKIIEGTEVVQEIQNKQKVGPSDDTPRRGPESLPVGHHDIITDVATFQTTQGFIVTASRDGIVKVWK

Gene Information

Entrez Gene ID
30849
Gene Name
phosphoinositide-3-kinase, regulatory subunit 4
Gene Symbol
PIK3R4
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005930 ISS:UniProtKB C axoneme
GO:0005829 TAS:Reactome C cytosol
GO:0005770 IDA:UniProtKB C late endosome
GO:0016020 IDA:UniProtKB C membrane
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0004672 NAS:UniProtKB F protein kinase activity
GO:0004674 IEA:UniProtKB-KW F protein serine/threonine kinase activity
GO:0045087 TAS:Reactome P innate immune response
GO:0008286 TAS:Reactome P insulin receptor signaling pathway
GO:0006661 TAS:Reactome P phosphatidylinositol biosynthetic process
GO:0006644 TAS:Reactome P phospholipid metabolic process
GO:0006468 NAS:UniProtKB P protein phosphorylation
GO:0044281 TAS:Reactome P small molecule metabolic process
GO:0034162 TAS:Reactome P toll-like receptor 9 signaling pathway
GO:0002224 TAS:Reactome P toll-like receptor signaling pathway

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_120756 Synthesis of PIPs at the early endosome membrane
REACT_120918 Synthesis of PIPs at the late endosome membrane

Domain Information

InterPro Annotations

Accession Description
IPR011989 Armadillo-like helical
IPR016024 Armadillo-type fold
IPR021133 HEAT, type 2
IPR000719 Protein kinase domain
IPR011009 Protein kinase-like domain
IPR008271 Serine/threonine-protein kinase, active site
IPR019775 WD40 repeat, conserved site
IPR017986 WD40-repeat-containing domain
IPR015943 WD40/YVTN repeat-like-containing domain
IPR001680 WD40_repeat

UniProt Annotations

Entry Information

Gene Name
phosphoinositide-3-kinase, regulatory subunit 4
Protein Entry
PI3R4_HUMAN
UniProt ID
Q99570
Species
Human

Comments

Comment Type Description
Catalytic Activity ATP + a protein = ADP + a phosphoprotein.
Cofactor Name=Mn(2+); Xref=ChEBI
Function Regulatory subunit of the PI3K complex. May regulate membrane trafficking late in the endocytic pathway.
Ptm Myristoylated.
Ptm Probably autophosphorylated. {ECO
Similarity Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Similarity Contains 1 protein kinase domain.
Similarity Contains 3 HEAT repeats. {ECO
Similarity Contains 7 WD repeats. {ECO
Subcellular Location Late endosome . Note=Localizes also to discrete punctae along the ciliary axoneme.
Subunit Heterodimer. This subunit, part of a complex composed of regulatory and catalytic subunits, associates with the phosphatidylinositol 3-kinase type 3 (PIK3C3). Forms a complex with BECN1, PIK3C3 and either UVRAG and KIAA0226/Rubicon, or with ATG14. In this complex, presence of UVRAG and ATG14 are mutually exclusive. Part of a complex composed by PIK3C3 and PIK3CB (By similarity). Interacts with RAB7A in the presence of PIK3C3/VPS34. {ECO
Tissue Specificity Ubiquitously expressed.

Identical and Related Proteins

Unique RefSeq proteins for LMP005209 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
23943912 RefSeq NP_055417 1358 phosphoinositide 3-kinase regulatory subunit 4

Identical Sequences to LMP005209 proteins

Reference Database Accession Length Protein Name
GI:23943912 DBBJ BAG10543.1 1358 phosphoinositide-3-kinase, regulatory subunit 4, partial [synthetic construct]
GI:23943912 EMBL CAV30715.1 1358 unnamed protein product [Homo sapiens]
GI:23943912 GenBank AAI27107.1 1358 Phosphoinositide-3-kinase, regulatory subunit 4 [Homo sapiens]
GI:23943912 GenBank EAW79222.1 1358 phosphoinositide-3-kinase, regulatory subunit 4, p150 [Homo sapiens]
GI:23943912 GenBank ADA36150.1 1358 Sequence 291 from patent US 7615626
GI:23943912 GenBank AGA37771.1 1358 Sequence 291 from patent US 8318137

Related Sequences to LMP005209 proteins

Reference Database Accession Length Protein Name
GI:23943912 GenBank AAI27106.1 1358 Phosphoinositide-3-kinase, regulatory subunit 4 [Homo sapiens]
GI:23943912 GenBank JAA10174.1 1358 phosphoinositide-3-kinase, regulatory subunit 4 [Pan troglodytes]
GI:23943912 GenBank JAA13158.1 1358 phosphoinositide-3-kinase, regulatory subunit 4 [Pan troglodytes]
GI:23943912 GenBank JAA28007.1 1358 phosphoinositide-3-kinase, regulatory subunit 4 [Pan troglodytes]
GI:23943912 GenBank JAA41571.1 1358 phosphoinositide-3-kinase, regulatory subunit 4 [Pan troglodytes]
GI:23943912 GenBank AIC56333.1 1358 PIK3R4, partial [synthetic construct]