Gene/Proteome Database (LMPD)

LMPD ID
LMP005258
Gene ID
8801
Species
Homo sapiens (Human)
Gene Name
succinate-CoA ligase, GDP-forming, beta subunit
Gene Symbol
SUCLG2
Synonyms
GBETA
Alternate Names
succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial; SCS-betaG; succinyl-CoA synthetase beta-G chain; succinyl-CoA synthetase, beta-G chain; GTP-specific succinyl-CoA synthetase beta subunit; GTP-specific succinyl-CoA synthetase subunit beta; succinyl-CoA ligase, GDP-forming, beta chain, mitochondrial
Chromosome
3
Map Location
3p14.1
EC Number
6.2.1.4
Summary
This gene encodes a GTP-specific beta subunit of succinyl-CoA synthetase. Succinyl-CoA synthetase catalyzes the reversible reaction involving the formation of succinyl-CoA and succinate. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 5 and 12. [provided by RefSeq, Apr 2010]
Orthologs
View orthologs and multiple alignments for SUCLG2

Proteins

succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial isoform 1 precursor
Refseq ID NP_001171070
Protein GI 294862256
UniProt ID Q96I99
mRNA ID NM_001177599
Length 440
RefSeq Status REVIEWED
MASPVAAQAGKLLRALALRPRFLAAGSQAVQLTSRRWLNLQEYQSKKLMSDNGVRVQRFFVADTANEALEAAKRLNAKEIVLKAQILAGGRGKGVFNSGLKGGVHLTKDPNVVGQLAKQMIGYNLATKQTPKEGVKVNKVMVAEALDISRETYLAILMDRSCNGPVLVGSPQGGVDIEEVAASNPELIFKEQIDIFEGIKDSQAQRMAENLGFVGPLKSQAADQITKLYNLFLKIDATQVEVNPFGETPEGQVVCFDAKINFDDNAEFRQKDIFAMDDKSENEPIENEAAKYDLKYIGLDGNIACFVNGAGLAMATCDIIFLNGGKPANFLDLGGGVKEAQVYQAFKLLTADPKVEAILVNIFGGIVNCAIIANGITKACRELELKVPLVVRLEGTFMEKKGSYMHIKQETGNSNENITGIQENVAHQNLSKCAISIFLC
succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial isoform 2 precursor
Refseq ID NP_003839
Protein GI 157779135
UniProt ID Q96I99
mRNA ID NM_003848
Length 432
RefSeq Status REVIEWED
MASPVAAQAGKLLRALALRPRFLAAGSQAVQLTSRRWLNLQEYQSKKLMSDNGVRVQRFFVADTANEALEAAKRLNAKEIVLKAQILAGGRGKGVFNSGLKGGVHLTKDPNVVGQLAKQMIGYNLATKQTPKEGVKVNKVMVAEALDISRETYLAILMDRSCNGPVLVGSPQGGVDIEEVAASNPELIFKEQIDIFEGIKDSQAQRMAENLGFVGPLKSQAADQITKLYNLFLKIDATQVEVNPFGETPEGQVVCFDAKINFDDNAEFRQKDIFAMDDKSENEPIENEAAKYDLKYIGLDGNIACFVNGAGLAMATCDIIFLNGGKPANFLDLGGGVKEAQVYQAFKLLTADPKVEAILVNIFGGIVNCAIIANGITKACRELELKVPLVVRLEGTNVQEAQKILNNSGLPITSAIDLEDAAKKAVASVAKK
transit_peptide: 1..16 inference: protein motif:TargetP:1.0 calculated_mol_wt: 1597 peptide sequence: MASPVAAQAGKLLRAL mat_peptide: 17..440 product: succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial isoform 1 calculated_mol_wt: 46153 peptide sequence: ALRPRFLAAGSQAVQLTSRRWLNLQEYQSKKLMSDNGVRVQRFFVADTANEALEAAKRLNAKEIVLKAQILAGGRGKGVFNSGLKGGVHLTKDPNVVGQLAKQMIGYNLATKQTPKEGVKVNKVMVAEALDISRETYLAILMDRSCNGPVLVGSPQGGVDIEEVAASNPELIFKEQIDIFEGIKDSQAQRMAENLGFVGPLKSQAADQITKLYNLFLKIDATQVEVNPFGETPEGQVVCFDAKINFDDNAEFRQKDIFAMDDKSENEPIENEAAKYDLKYIGLDGNIACFVNGAGLAMATCDIIFLNGGKPANFLDLGGGVKEAQVYQAFKLLTADPKVEAILVNIFGGIVNCAIIANGITKACRELELKVPLVVRLEGTFMEKKGSYMHIKQETGNSNENITGIQENVAHQNLSKCAISIFLC transit_peptide: 1..16 inference: protein motif:TargetP:1.0 calculated_mol_wt: 1597 peptide sequence: MASPVAAQAGKLLRAL mat_peptide: 17..432 product: succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial isoform 2 calculated_mol_wt: 44932 peptide sequence: ALRPRFLAAGSQAVQLTSRRWLNLQEYQSKKLMSDNGVRVQRFFVADTANEALEAAKRLNAKEIVLKAQILAGGRGKGVFNSGLKGGVHLTKDPNVVGQLAKQMIGYNLATKQTPKEGVKVNKVMVAEALDISRETYLAILMDRSCNGPVLVGSPQGGVDIEEVAASNPELIFKEQIDIFEGIKDSQAQRMAENLGFVGPLKSQAADQITKLYNLFLKIDATQVEVNPFGETPEGQVVCFDAKINFDDNAEFRQKDIFAMDDKSENEPIENEAAKYDLKYIGLDGNIACFVNGAGLAMATCDIIFLNGGKPANFLDLGGGVKEAQVYQAFKLLTADPKVEAILVNIFGGIVNCAIIANGITKACRELELKVPLVVRLEGTNVQEAQKILNNSGLPITSAIDLEDAAKKAVASVAKK

Gene Information

Entrez Gene ID
8801
Gene Name
succinate-CoA ligase, GDP-forming, beta subunit
Gene Symbol
SUCLG2
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005759 TAS:Reactome C mitochondrial matrix
GO:0005739 IDA:HPA C mitochondrion
GO:0005886 IDA:HPA C plasma membrane
GO:0045244 IEA:Ensembl C succinate-CoA ligase complex (GDP-forming)
GO:0005524 IEA:InterPro F ATP binding
GO:0019003 IEA:Ensembl F GDP binding
GO:0005525 IEA:UniProtKB-KW F GTP binding
GO:0004776 NAS:UniProtKB F succinate-CoA ligase (GDP-forming) activity
GO:0044237 TAS:Reactome P cellular metabolic process
GO:0044281 TAS:Reactome P small molecule metabolic process
GO:0006105 IEA:Ensembl P succinate metabolic process
GO:0006104 NAS:UniProtKB P succinyl-CoA metabolic process
GO:0006099 TAS:Reactome P tricarboxylic acid cycle

KEGG Pathway Links

KEGG Pathway ID Description
hsa01200 Carbon metabolism
hsa00020 Citrate cycle (TCA cycle)

Domain Information

InterPro Annotations

Accession Description
IPR005811 ATP-citrate lyase/succinyl-CoA ligase
IPR013815 ATP-grasp fold, subdomain 1
IPR013816 ATP-grasp fold, subdomain 2
IPR013650 ATP-grasp fold, succinyl-CoA synthetase-type
IPR005809 Succinyl-CoA synthetase, beta subunit
IPR017866 Succinyl-CoA synthetase, beta subunit, conserved site
IPR016102 Succinyl-CoA synthetase-like

UniProt Annotations

Entry Information

Gene Name
succinate-CoA ligase, GDP-forming, beta subunit
Protein Entry
SUCB2_HUMAN
UniProt ID
Q96I99
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96I99-1; Sequence=Displayed; Name=2; IsoId=Q96I99-2; Sequence=VSP_042013; Note=No experimental confirmation available.;
Catalytic Activity GTP + succinate + CoA = GDP + phosphate + succinyl-CoA.
Function Catalyzes the GTP-dependent ligation of succinate and CoA to form succinyl-CoA.
Pathway Carbohydrate metabolism; tricarboxylic acid cycle.
Sequence Caution Sequence=AAH07716.3; Type=Erroneous initiation; Evidence= ; Sequence=AAH47024.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence= ; Sequence=AAH47024.1; Type=Erroneous termination; Positions=31; Note=Translated as Gln.; Evidence= ;
Similarity Belongs to the succinate/malate CoA ligase beta subunit family.
Similarity Contains 1 ATP-grasp domain.
Subcellular Location Mitochondrion.
Subunit Heterodimer of an alpha and a beta subunit.
Tissue Specificity Mainly expressed in liver, kidney, heart, spleen and skeletal muscle. Also found in intestine and colon, and in low amounts in lung, brain, prostate, testis and ovary.

Identical and Related Proteins

Unique RefSeq proteins for LMP005258 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
294862256 RefSeq NP_001171070 440 succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial isoform 1 precursor
157779135 RefSeq NP_003839 432 succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial isoform 2 precursor

Identical Sequences to LMP005258 proteins

Reference Database Accession Length Protein Name
GI:157779135 GenBank EAW65456.1 432 succinate-CoA ligase, GDP-forming, beta subunit, isoform CRA_a [Homo sapiens]
GI:157779135 GenBank EAW65457.1 432 succinate-CoA ligase, GDP-forming, beta subunit, isoform CRA_a [Homo sapiens]
GI:157779135 GenBank AED45406.1 432 Sequence 1038 from patent US 7892730
GI:157779135 SwissProt Q96I99.2 432 RecName: Full=Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial; AltName: Full=GTP-specific succinyl-CoA synthetase subunit beta; AltName: Full=Succinyl-CoA synthetase beta-G chain; Short=SCS-betaG; Flags: Precursor [Homo sapiens]

Related Sequences to LMP005258 proteins

Reference Database Accession Length Protein Name
GI:157779135 GenBank AAE30555.1 432 Sequence 3 from patent US 5965369
GI:157779135 GenBank AAH68602.1 432 SUCLG2 protein [Homo sapiens]
GI:294862256 GenBank AED45406.1 432 Sequence 1038 from patent US 7892730
GI:294862256 GenBank EHH16246.1 440 hypothetical protein EGK_11505 [Macaca mulatta]
GI:294862256 GenBank EHH51199.1 411 hypothetical protein EGM_10535, partial [Macaca fascicularis]
GI:157779135 GenBank JAA16856.1 432 succinate-CoA ligase, GDP-forming, beta subunit [Pan troglodytes]
GI:157779135 RefSeq XP_516570.2 432 PREDICTED: succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial [Pan troglodytes]
GI:294862256 RefSeq NP_003839.2 432 succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial isoform 2 precursor [Homo sapiens]
GI:157779135 RefSeq XP_003279643.1 432 PREDICTED: succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial isoform 1 [Nomascus leucogenys]
GI:294862256 RefSeq XP_003279644.1 444 PREDICTED: succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial isoform 2 [Nomascus leucogenys]
GI:157779135 RefSeq XP_010360507.1 432 PREDICTED: succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial isoform X1 [Rhinopithecus roxellana]
GI:294862256 SwissProt Q96I99.2 432 RecName: Full=Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial; AltName: Full=GTP-specific succinyl-CoA synthetase subunit beta; AltName: Full=Succinyl-CoA synthetase beta-G chain; Short=SCS-betaG; Flags: Precursor [Homo sapiens]