Gene/Proteome Database (LMPD)

LMPD ID
LMP005318
Gene ID
27400
Species
Mus musculus (Mouse)
Gene Name
hydroxysteroid (17-beta) dehydrogenase 6
Gene Symbol
Hsd17b6
Synonyms
17betaHSD9; Hsd17b9; Rdh8
Alternate Names
17-beta-hydroxysteroid dehydrogenase type 6; 17-beta-HSD6; 17-beta-HSD9; 17-beta-HSD 6; 3-alpha->beta-HSE; 3-alpha->beta-hydroxysteroid epimerase; hydroxysteroid 17-beta dehydrogenase 9; hydroxysteroid (17-beta) dehydrogenase 9; oxidative 3-alpha hydroxysteroid dehydrogenase
Chromosome
10
Map Location
10 D3|10
EC Number
1.1.1.105

Proteins

17-beta-hydroxysteroid dehydrogenase type 6 precursor
Refseq ID NP_038814
Protein GI 7305165
UniProt ID Q9R092
mRNA ID NM_013786
Length 317
RefSeq Status PROVISIONAL
MWFYLVTLVGLYHLLRWYRERQVVSHLQDKYVFITGCDSGFGNLLARQLDRRGMRVLAACLTEKGAEELRNKTSDRLETVILDVTKTESIVAATQWVKERVGDRGLWGLVNNAGVLQPFAYIEWYRPEDYMPIFQVNLIGLTQVTISMLFLVKKARGRIVNVSSALGRVALFGGFYSCSKYGVEAFSDVLRHEVQDFGVKVSIIEPGSFKTEMTDAELTIERTKKVWEAAPEHIKESYGQQFFDDFCSTTKRELMKCSRNLSLVTDCMEHALTSTHPRTRYSAGWDAKFFFIPLSYLPASLVDYLLAISRGKPAQAA
sig_peptide: 1..17 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2211 peptide sequence: MWFYLVTLVGLYHLLRW mat_peptide: 18..317 product: 17-beta-hydroxysteroid dehydrogenase type 6 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q9R092.1) calculated_mol_wt: 33910 peptide sequence: YRERQVVSHLQDKYVFITGCDSGFGNLLARQLDRRGMRVLAACLTEKGAEELRNKTSDRLETVILDVTKTESIVAATQWVKERVGDRGLWGLVNNAGVLQPFAYIEWYRPEDYMPIFQVNLIGLTQVTISMLFLVKKARGRIVNVSSALGRVALFGGFYSCSKYGVEAFSDVLRHEVQDFGVKVSIIEPGSFKTEMTDAELTIERTKKVWEAAPEHIKESYGQQFFDDFCSTTKRELMKCSRNLSLVTDCMEHALTSTHPRTRYSAGWDAKFFFIPLSYLPASLVDYLLAISRGKPAQAA

Gene Information

Entrez Gene ID
27400
Gene Name
hydroxysteroid (17-beta) dehydrogenase 6
Gene Symbol
Hsd17b6
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0005768 IEA:UniProtKB-KW C endosome
GO:0016020 IEA:UniProtKB-KW C membrane
GO:0004303 IEA:UniProtKB-EC F estradiol 17-beta-dehydrogenase activity
GO:0004745 IEA:UniProtKB-EC F retinol dehydrogenase activity
GO:0047035 IEA:UniProtKB-EC F testosterone dehydrogenase (NAD+) activity
GO:0008202 IEA:UniProtKB-KW P steroid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu01100 Metabolic pathways
mmu00830 Retinol metabolism
ko00140 Steroid hormone biosynthesis
mmu00140 Steroid hormone biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR002347 Glucose/ribitol dehydrogenase
IPR016040 NAD(P)-binding domain
IPR002198 Short-chain dehydrogenase/reductase SDR
IPR020904 Short-chain dehydrogenase/reductase, conserved site

UniProt Annotations

Entry Information

Gene Name
hydroxysteroid (17-beta) dehydrogenase 6
Protein Entry
H17B6_MOUSE
UniProt ID
Q9R092
Species
Mouse

Comments

Comment Type Description
Catalytic Activity 17-beta-estradiol + NAD(P)(+) = estrone + NAD(P)H.
Catalytic Activity All-trans-retinol-[cellular-retinol-binding- protein] + NAD(+) = all-trans-retinal-[cellular-retinol-binding- protein] + NADH.
Catalytic Activity Testosterone + NAD(+) = androstenedione + NADH.
Function NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3- alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). {ECO:0000269|PubMed:10537158}.
Similarity Belongs to the short-chain dehydrogenases/reductases (SDR) family. {ECO:0000305}.
Subcellular Location Microsome membrane {ECO:0000269|PubMed:10537158}; Peripheral membrane protein {ECO:0000269|PubMed:10537158}; Lumenal side {ECO:0000269|PubMed:10537158}. Early endosome membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Lumenal side {ECO:0000305}.
Tissue Specificity Detected in liver. {ECO:0000269|PubMed:10537158}.

Identical and Related Proteins

Unique RefSeq proteins for LMP005318 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
7305165 RefSeq NP_038814 317 17-beta-hydroxysteroid dehydrogenase type 6 precursor

Identical Sequences to LMP005318 proteins

Reference Database Accession Length Protein Name
GI:7305165 DBBJ BAB25536.1 317 unnamed protein product [Mus musculus]
GI:7305165 GenBank AAF04761.1 317 trans-retinol/estrogen dehydrogenase [Mus musculus]
GI:7305165 GenBank AAH21836.1 317 Hydroxysteroid (17-beta) dehydrogenase 6 [Mus musculus]
GI:7305165 GenBank EDL24532.1 317 hydroxysteroid (17-beta) dehydrogenase 9, isoform CRA_a [Mus musculus]
GI:7305165 SwissProt Q9R092.1 317 RecName: Full=17-beta-hydroxysteroid dehydrogenase type 6; Short=17-beta-HSD 6; Short=17-beta-HSD6; AltName: Full=17-beta-HSD9; AltName: Full=3-alpha->beta-hydroxysteroid epimerase; Short=3-alpha->beta-HSE; AltName: Full=Oxidative 3-alpha hydroxysteroid dehydrogenase; Flags: Precursor [Mus musculus]

Related Sequences to LMP005318 proteins

Reference Database Accession Length Protein Name
GI:7305165 GenBank AAB88253.1 327 oxidative 17 beta hydroxysteroid dehydrogenase type 6 [Rattus norvegicus]
GI:7305165 GenBank AAH91114.1 327 Hydroxysteroid (17-beta) dehydrogenase 6 [Rattus norvegicus]
GI:7305165 GenBank EDL24533.1 321 hydroxysteroid (17-beta) dehydrogenase 9, isoform CRA_b, partial [Mus musculus]
GI:7305165 RefSeq NP_775427.1 327 17-beta-hydroxysteroid dehydrogenase type 6 [Rattus norvegicus]
GI:7305165 RefSeq XP_006240801.2 317 PREDICTED: 17-beta-hydroxysteroid dehydrogenase type 6 isoform X1 [Rattus norvegicus]
GI:7305165 RefSeq XP_008768115.1 317 PREDICTED: 17-beta-hydroxysteroid dehydrogenase type 6 [Rattus norvegicus]