Gene/Proteome Database (LMPD)

LMPD ID
LMP005403
Gene ID
214572
Species
Mus musculus (Mouse)
Gene Name
protein arginine N-methyltransferase 7
Gene Symbol
Prmt7
Synonyms
4933402B05Rik; BC006705
Alternate Names
protein arginine N-methyltransferase 7; histone-arginine N-methyltransferase PRMT7; [Myelin basic protein]-arginine N-methyltransferase PRMT7
Chromosome
8
Map Location
8 D3|8
EC Number
2.1.1.-

Proteins

protein arginine N-methyltransferase 7
Refseq ID NP_663379
Protein GI 21703808
UniProt ID Q922X9
mRNA ID NM_145404
Length 692
RefSeq Status PROVISIONAL
MKVFCGRANPTTGSLEWLEEDEHYDYHQEIARSSYADMLHDKDRNIKYYQGIRAAVSRVKDRGQKALVLDIGTGTGLLSMMAVTAGADFCYAIEVFKPMAEAAVKIVERNGFSDKIKVINKHSTEVTVGPDGDLPCRANILITELFDTELIGEGALPSYEHAHKHLVQEDCEAVPHRATVYAQLVESRRMWSWNKLFPVRVRTSLGEQVIVPPSELERCPGAPSVCDIQLNQVSPADFTVLSDVLPMFSVDFSKQVSSSAACHSRQFVPLASGQAQVVLSWWDIEMDPEGKIKCTMAPFWAQTDPQELQWRDHWMQCVYFLPQEEPVVQGSPRCLVAHHDDYCVWYSLQRTSPDENDSAYQVRPVCDCQAHLLWNRPRFGEINDQDRTDHYAQALRTVLLPGSVCLCVSDGSLLSMLAHHLGAEQVFTVESSVASYRLMKRIFKVNHLEDKISVINKRPELLTAADLEGKKVSLLLGEPFFTTSLLPWHNLYFWYVRTSVDQHLAPGAVVMPQAASLHAVIVEFRDLWRIRSPCGDCEGFDVHIMDDMIKHSLDFRESREAEPHPLWEYPCRSLSKPQEILTFDFQQPIPQQPMQSKGTMELTRPGKSHGAVLWMEYQLTPDSTISTGLINPAEDKGDCCWNPHCKQAVYFLSTTLDLRVPLNGPRSVSYVVEFHPLTGDITMEFRLADTLS

Gene Information

Entrez Gene ID
214572
Gene Name
protein arginine N-methyltransferase 7
Gene Symbol
Prmt7
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 ISS:UniProtKB C cytosol
GO:0005730 IEA:Ensembl C nucleolus
GO:0005634 ISS:UniProtKB C nucleus
GO:0005886 IEA:Ensembl C plasma membrane
GO:0008757 ISS:HGNC F S-adenosylmethionine-dependent methyltransferase activity
GO:0016277 ISS:HGNC F [myelin basic protein]-arginine N-methyltransferase activity
GO:0044020 IDA:UniProtKB F histone methyltransferase activity (H4-R3 specific)
GO:0008469 ISS:HGNC F histone-arginine N-methyltransferase activity
GO:0035242 IBA:RefGenome F protein-arginine omega-N asymmetric methyltransferase activity
GO:0035241 ISS:HGNC F protein-arginine omega-N monomethyltransferase activity
GO:0035243 IDA:UniProtKB F protein-arginine omega-N symmetric methyltransferase activity
GO:0043021 IEA:Ensembl F ribonucleoprotein complex binding
GO:0043046 IDA:UniProtKB P DNA methylation involved in gamete generation
GO:0030154 IEA:UniProtKB-KW P cell differentiation
GO:0043985 IDA:GOC P histone H4-R3 methylation
GO:0034969 IDA:UniProtKB P histone arginine methylation
GO:0016571 ISS:HGNC P histone methylation
GO:0018216 ISS:HGNC P peptidyl-arginine methylation
GO:0019919 IBA:RefGenome P peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
GO:0006349 IDA:UniProtKB P regulation of gene expression by genetic imprinting
GO:0006355 IBA:RefGenome P regulation of transcription, DNA-templated
GO:0000387 ISS:UniProtKB P spliceosomal snRNP assembly
GO:0006351 IEA:UniProtKB-KW P transcription, DNA-templated

REACTOME Pathway Links

REACTOME Pathway ID Description
5894120 Chromatin modifying enzymes
5894121 Chromatin organization
5894122 RMTs methylate histone arginines

Domain Information

InterPro Annotations

Accession Description
IPR025799 Protein arginine N-methyltransferase
IPR014644 Protein arginine N-methyltransferase PRMT7
IPR010456 Ribosomal L11 methyltransferase, PrmA
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase

UniProt Annotations

Entry Information

Gene Name
protein arginine N-methyltransferase 7
Protein Entry
ANM7_MOUSE
UniProt ID
Q922X9
Species
Mouse

Comments

Comment Type Description
Catalytic Activity S-adenosyl-L-methionine + [myelin basic protein]-arginine = S-adenosyl-L-homocysteine + [myelin basic protein]-N(omega)-methyl-arginine.
Catalytic Activity S-adenosyl-L-methionine + arginine-[histone] = S-adenosyl-L-homocysteine + N(omega)-methyl-arginine-[histone].
Developmental Stage Present in undifferentiated embryonic stem and germ cells; expression is lost when cells differentiate. In the developing testis, it is expressed at all stages. Present in all cells within the developing tubule, including gonocytes and spermatogonia (at protein level). It the developing kidney, it is confined to the nephrogenic zone in the cortical region, where the tips of the ureteric bud induce de novo formation of epithelia in the metanephric mesenchyme and early glomeruli. Expression is around 8-fold lower in adult kidneys. {ECO:0000269|PubMed:15699352, ECO:0000269|PubMed:17048991, ECO:0000269|PubMed:18449859}.
Function Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo (By similarity). {ECO:0000250}.
Sequence Caution Sequence=BAD32582.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Similarity Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N- methyltransferase family. PRMT7 subfamily. {ECO:0000255|PROSITE- ProRule:PRU01015}.
Similarity Contains 2 SAM-dependent MTase PRMT-type domains. {ECO:0000255|PROSITE-ProRule:PRU01015}.
Subcellular Location Cytoplasm, cytosol {ECO:0000250}. Nucleus {ECO:0000250}.
Subunit Homodimer and heterodimer. Interacts with PRMT5 and SNRPD3 (By similarity). Interacts with CTCFL. {ECO:0000250, ECO:0000269|PubMed:17048991}.

Identical and Related Proteins

Unique RefSeq proteins for LMP005403 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
21703808 RefSeq NP_663379 692 protein arginine N-methyltransferase 7

Identical Sequences to LMP005403 proteins

Reference Database Accession Length Protein Name
GI:21703808 DBBJ BAE32467.1 692 unnamed protein product [Mus musculus]
GI:21703808 GenBank AAT76979.1 692 arginine methyltransferase 7 [Mus musculus]
GI:21703808 GenBank ABH88217.1 692 Sequence 35 from patent US 7060437
GI:21703808 GenBank EDL11358.1 692 protein arginine N-methyltransferase 7, isoform CRA_b [Mus musculus]
GI:21703808 PDB 4C4A 692 Chain A, Crystal Structure Of Mouse Protein Arginine Methyltransferase 7 In Complex With Sah
GI:21703808 SwissProt Q922X9.1 692 RecName: Full=Protein arginine N-methyltransferase 7; AltName: Full=Histone-arginine N-methyltransferase PRMT7; AltName: Full=[Myelin basic protein]-arginine N-methyltransferase PRMT7 [Mus musculus]

Related Sequences to LMP005403 proteins

Reference Database Accession Length Protein Name
GI:21703808 DBBJ BAD32582.1 707 mKIAA1933 protein, partial [Mus musculus]
GI:21703808 GenBank AAH57177.1 692 Protein arginine N-methyltransferase 7 [Mus musculus]
GI:21703808 GenBank AAH85121.1 693 Protein arginine methyltransferase 7 [Rattus norvegicus]
GI:21703808 GenBank EDL11357.1 696 protein arginine N-methyltransferase 7, isoform CRA_a, partial [Mus musculus]
GI:21703808 RefSeq NP_001014175.1 693 protein arginine N-methyltransferase 7 [Rattus norvegicus]
GI:21703808 SwissProt Q5U4E8.1 693 RecName: Full=Protein arginine N-methyltransferase 7; AltName: Full=Histone-arginine N-methyltransferase PRMT7; AltName: Full=[Myelin basic protein]-arginine N-methyltransferase PRMT7 [Rattus norvegicus]