Gene/Proteome Database (LMPD)

LMPD ID
LMP005417
Gene ID
84513
Species
Homo sapiens (Human)
Gene Name
phosphatidic acid phosphatase type 2 domain containing 1B
Gene Symbol
PPAPDC1B
Synonyms
DPPL1; HTPAP
Alternate Names
phosphatidate phosphatase PPAPDC1B; diacylglycerol pyrophosphate like 1; phosphatidic acid phosphatase type 2 domain-containing protein 1B
Chromosome
8
Map Location
8p11.23
EC Number
3.1.3.4

Proteins

phosphatidate phosphatase PPAPDC1B isoform 1
Refseq ID NP_001096029
Protein GI 156523237
UniProt ID Q8NEB5
mRNA ID NM_001102559
Length 264
RefSeq Status VALIDATED
MGKAAAAVAFGAEVGVRLALFAAFLVTELLPPFQRLIQPEEMWLYRNPYVEAEYFPTKPMFVIAFLSPLSLIFLAKFLKKADTRDSRQACLAASLALALNGVFTNTIKLIVGRPRPDFFYRCFPDGLAHSDLMCTGDKDVVNEGRKSFPSGHSSFAFAGLAFASFYLAGKLHCFTPQGRGKSWRFCAFLSPLLFAAVIALSRTCDYKHHWQDVLVGSMIGMTFAYVCYRQYYPPLTDAECHKPFQDKLVLSTAQKPGDSYCFDI
phosphatidate phosphatase PPAPDC1B isoform 2
Refseq ID NP_115872
Protein GI 156523235
UniProt ID Q8NEB5
mRNA ID NM_032483
Length 216
RefSeq Status VALIDATED
MGKAAAAVAFGAEVGVRLALFAAFLVTELLPPFQRLIQPEEMWLYRNPYVEAEYFPTKPMFVIAFLSPLSLIFLAKFLKKADTRDSRQACLAASLALALNGVFTNTIKLIVGRPRPDFFYRCFPDGLAHSDLMCTGDKDVVNEGRKSFPSGHSSFAFAGLAFASFYLAGKLHCFTPQGRGKSWRFCAFLSPLLFAAVIALSRTCDYKHHWQGPFKW
phosphatidate phosphatase PPAPDC1B isoform 3
Refseq ID NP_001096030
Protein GI 156523239
UniProt ID Q8NEB5
mRNA ID NM_001102560
Length 176
RefSeq Status VALIDATED
MGKAAAAVAFGAEVGVRLALFAAFLVTELLPPFQRLIQPEEMWLYRNPYVEAEYFPTKPMFVIAFLSPLSLIFLAKFLKKADTRDSRQACLAASLALALNGVFTNTIKLIVGRPRPDFFYRCFPDGLAHSDLMCTGDKDVVNEGRKSFPSGHSSCMNIIWTLPYACFHIIEFNLES

Gene Information

Entrez Gene ID
84513
Gene Name
phosphatidic acid phosphatase type 2 domain containing 1B
Gene Symbol
PPAPDC1B
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 TAS:UniProtKB C cytoplasm
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005886 TAS:UniProtKB C plasma membrane
GO:0008195 IDA:UniProtKB F phosphatidate phosphatase activity
GO:0046839 IDA:UniProtKB P phospholipid dephosphorylation

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_160123 Fcgamma receptor (FCGR) dependent phagocytosis
REACT_6900 Immune System
REACT_6802 Innate Immune System
REACT_160158 Role of phospholipids in phagocytosis

Domain Information

InterPro Annotations

Accession Description
IPR028668 Phosphatidate phosphatase PPAPDC1A/PPAPDC1B
IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase

UniProt Annotations

Entry Information

Gene Name
phosphatidic acid phosphatase type 2 domain containing 1B
Protein Entry
PPC1B_HUMAN
UniProt ID
Q8NEB5
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8NEB5-1; Sequence=Displayed; Name=2; IsoId=Q8NEB5-2; Sequence=VSP_025241, VSP_025242; Name=3; IsoId=Q8NEB5-3; Sequence=VSP_040055; Name=4; IsoId=Q8NEB5-4; Sequence=VSP_054076, VSP_054077; Note=No experimental confirmation available. Gene prediction based on EST data.;
Biophysicochemical Properties Kinetic parameters: KM=41 uM for diacylglycerol pyrophosphate ; KM=277 uM for phosphatidate ; KM=295 uM for lysophosphatidate ;
Catalytic Activity A 1,2-diacylglycerol 3-phosphate + H(2)O = a 1,2-diacyl-sn-glycerol + phosphate.
Enzyme Regulation Inhibited by N-ethylmaleimide.
Function Displays magnesium-independent phosphatidate phosphatase activity in vitro. Catalyzes the conversion of phosphatidic acid to diacylglycerol. May be a metastatic suppressor for hepatocellular carcinoma. {ECO
Sequence Caution Sequence=AAI06015.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ; Sequence=AAK14924.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ;
Similarity Belongs to the PA-phosphatase related phosphoesterase family.
Subcellular Location Membrane ; Multi-pass membrane protein .
Tissue Specificity Ubiquitous.

Identical and Related Proteins

Unique RefSeq proteins for LMP005417 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
156523237 RefSeq NP_001096029 264 phosphatidate phosphatase PPAPDC1B isoform 1
156523235 RefSeq NP_115872 216 phosphatidate phosphatase PPAPDC1B isoform 2
156523239 RefSeq NP_001096030 176 phosphatidate phosphatase PPAPDC1B isoform 3

Identical Sequences to LMP005417 proteins

Reference Database Accession Length Protein Name
GI:156523237 GenBank JAA03048.1 264 phosphatidic acid phosphatase type 2 domain containing 1B [Pan troglodytes]
GI:156523235 GenBank JAA03049.1 216 phosphatidic acid phosphatase type 2 domain containing 1B [Pan troglodytes]
GI:156523239 GenBank JAA03050.1 176 phosphatidic acid phosphatase type 2 domain containing 1B [Pan troglodytes]
GI:156523237 GenBank JAA23695.1 264 phosphatidic acid phosphatase type 2 domain containing 1B [Pan troglodytes]
GI:156523237 GenBank JAA23696.1 264 phosphatidic acid phosphatase type 2 domain containing 1B [Pan troglodytes]
GI:156523237 GenBank JAA23697.1 264 phosphatidic acid phosphatase type 2 domain containing 1B [Pan troglodytes]
GI:156523237 GenBank JAA23698.1 264 phosphatidic acid phosphatase type 2 domain containing 1B [Pan troglodytes]
GI:156523239 GenBank JAA23699.1 176 phosphatidic acid phosphatase type 2 domain containing 1B [Pan troglodytes]
GI:156523235 GenBank JAA23700.1 216 phosphatidic acid phosphatase type 2 domain containing 1B [Pan troglodytes]
GI:156523237 RefSeq XP_003830775.1 264 PREDICTED: phosphatidate phosphatase PPAPDC1B isoform X1 [Pan paniscus]
GI:156523239 RefSeq XP_004046957.1 176 PREDICTED: phosphatidate phosphatase PPAPDC1B [Gorilla gorilla gorilla]
GI:156523235 RefSeq XP_008954398.1 216 PREDICTED: phosphatidate phosphatase PPAPDC1B isoform X3 [Pan paniscus]

Related Sequences to LMP005417 proteins

Reference Database Accession Length Protein Name
GI:156523235 GenBank EAW63326.1 218 phosphatidic acid phosphatase type 2 domain containing 1B, isoform CRA_b, partial [Homo sapiens]
GI:156523237 RefSeq XP_003269633.1 267 PREDICTED: phosphatidate phosphatase PPAPDC1B isoform 1 [Nomascus leucogenys]
GI:156523235 RefSeq XP_003269634.1 226 PREDICTED: phosphatidate phosphatase PPAPDC1B isoform 2 [Nomascus leucogenys]
GI:156523237 RefSeq XP_003902706.1 266 PREDICTED: phosphatidate phosphatase PPAPDC1B isoform X2 [Papio anubis]
GI:156523239 RefSeq XP_005273718.1 221 PREDICTED: phosphatidate phosphatase PPAPDC1B isoform X1 [Homo sapiens]
GI:156523235 RefSeq XP_005273718.1 221 PREDICTED: phosphatidate phosphatase PPAPDC1B isoform X1 [Homo sapiens]
GI:156523237 RefSeq XP_005563145.1 265 PREDICTED: phosphatidate phosphatase PPAPDC1B isoform X2 [Macaca fascicularis]
GI:156523239 RefSeq XP_005563145.1 265 PREDICTED: phosphatidate phosphatase PPAPDC1B isoform X2 [Macaca fascicularis]
GI:156523237 RefSeq XP_007960386.1 315 PREDICTED: phosphatidate phosphatase PPAPDC1B isoform X1 [Chlorocebus sabaeus]
GI:156523235 RefSeq XP_007960389.1 271 PREDICTED: phosphatidate phosphatase PPAPDC1B isoform X4 [Chlorocebus sabaeus]
GI:156523237 RefSeq XP_519712.3 313 PREDICTED: phosphatidate phosphatase PPAPDC1B isoform X1 [Pan troglodytes]
GI:156523239 RefSeq XP_519712.3 313 PREDICTED: phosphatidate phosphatase PPAPDC1B isoform X1 [Pan troglodytes]
GI:156523239 RefSeq XP_001170536.2 265 PREDICTED: phosphatidate phosphatase PPAPDC1B isoform X3 [Pan troglodytes]
GI:156523235 RefSeq XP_001170536.2 265 PREDICTED: phosphatidate phosphatase PPAPDC1B isoform X3 [Pan troglodytes]
GI:156523239 RefSeq XP_010383587.1 328 PREDICTED: phosphatidate phosphatase PPAPDC1B isoform X1 [Rhinopithecus roxellana]
GI:156523239 RefSeq XP_010383588.1 314 PREDICTED: phosphatidate phosphatase PPAPDC1B isoform X2 [Rhinopithecus roxellana]
GI:156523237 RefSeq XP_010383588.1 314 PREDICTED: phosphatidate phosphatase PPAPDC1B isoform X2 [Rhinopithecus roxellana]
GI:156523235 RefSeq XP_010383592.1 265 PREDICTED: phosphatidate phosphatase PPAPDC1B isoform X5 [Rhinopithecus roxellana]