Gene/Proteome Database (LMPD)
LMPD ID
LMP005424
Gene ID
Species
Homo sapiens (Human)
Gene Name
phosphatidylinositol 3-kinase, catalytic subunit type 3
Gene Symbol
Synonyms
VPS34; hVps34
Alternate Names
phosphatidylinositol 3-kinase catalytic subunit type 3; PI3K type 3; PI3-kinase type 3; PtdIns-3-kinase type 3; phosphoinositide-3-kinase, class 3; phosphatidylinositol 3-kinase p100 subunit
Chromosome
18
Map Location
18q12.3
EC Number
2.7.1.137
Proteins
phosphatidylinositol 3-kinase catalytic subunit type 3 | |
---|---|
Refseq ID | NP_002638 |
Protein GI | 34761064 |
UniProt ID | Q8NEB9 |
mRNA ID | NM_002647 |
Length | 887 |
RefSeq Status | VALIDATED |
MGEAEKFHYIYSCDLDINVQLKIGSLEGKREQKSYKAVLEDPMLKFSGLYQETCSDLYVTCQVFAEGKPLALPVRTSYKAFSTRWNWNEWLKLPVKYPDLPRNAQVALTIWDVYGPGKAVPVGGTTVSLFGKYGMFRQGMHDLKVWPNVEADGSEPTKTPGRTSSTLSEDQMSRLAKLTKAHRQGHMVKVDWLDRLTFREIEMINESEKRSSNFMYLMVEFRCVKCDDKEYGIVYYEKDGDESSPILTSFELVKVPDPQMSMENLVESKHHKLARSLRSGPSDHDLKPNAATRDQLNIIVSYPPTKQLTYEEQDLVWKFRYYLTNQEKALTKFLKCVNWDLPQEAKQALELLGKWKPMDVEDSLELLSSHYTNPTVRRYAVARLRQADDEDLLMYLLQLVQALKYENFDDIKNGLEPTKKDSQSSVSENVSNSGINSAEIDSSQIITSPLPSVSSPPPASKTKEVPDGENLEQDLCTFLISRACKNSTLANYLYWYVIVECEDQDTQQRDPKTHEMYLNVMRRFSQALLKGDKSVRVMRSLLAAQQTFVDRLVHLMKAVQRESGNRKKKNERLQALLGDNEKMNLSDVELIPLPLEPQVKIRGIIPETATLFKSALMPAQLFFKTEDGGKYPVIFKHGDDLRQDQLILQIISLMDKLLRKENLDLKLTPYKVLATSTKHGFMQFIQSVPVAEVLDTEGSIQNFFRKYAPSENGPNGISAEVMDTYVKSCAGYCVITYILGVGDRHLDNLLLTKTGKLFHIDFGYILGRDPKPLPPPMKLNKEMVEGMGGTQSEQYQEFRKQCYTAFLHLRRYSNLILNLFSLMVDANIPDIALEPDKTVKKVQDKFRLDLSDEEAVHYMQSLIDESVHALFAAVVEQIHKFAQYWRK |
Gene Information
Entrez Gene ID
Gene Name
phosphatidylinositol 3-kinase, catalytic subunit type 3
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
GO ID | Source | Type | Description |
---|---|---|---|
GO:0005930 | ISS:UniProtKB | C | axoneme |
GO:0005829 | TAS:Reactome | C | cytosol |
GO:0005770 | IDA:UniProtKB | C | late endosome |
GO:0016020 | IDA:UniProtKB | C | membrane |
GO:0030496 | IDA:UniProtKB | C | midbody |
GO:0045335 | IEA:Ensembl | C | phagocytic vesicle |
GO:0005942 | IBA:RefGenome | C | phosphatidylinositol 3-kinase complex |
GO:0016303 | IMP:UniProtKB | F | 1-phosphatidylinositol-3-kinase activity |
GO:0005524 | IEA:UniProtKB-KW | F | ATP binding |
GO:0004672 | IEA:Ensembl | F | protein kinase activity |
GO:0000045 | IEA:Ensembl | P | autophagic vacuole assembly |
GO:0000910 | IMP:UniProtKB | P | cytokinesis |
GO:0045022 | IMP:UniProtKB | P | early endosome to late endosome transport |
GO:0007032 | IEA:Ensembl | P | endosome organization |
GO:0045087 | TAS:Reactome | P | innate immune response |
GO:0008286 | TAS:Reactome | P | insulin receptor signaling pathway |
GO:0006661 | TAS:Reactome | P | phosphatidylinositol biosynthetic process |
GO:0036092 | IMP:GOC | P | phosphatidylinositol-3-phosphate biosynthetic process |
GO:0048015 | IEA:Ensembl | P | phosphatidylinositol-mediated signaling |
GO:0006644 | TAS:Reactome | P | phospholipid metabolic process |
GO:0016485 | IEA:Ensembl | P | protein processing |
GO:0050708 | IEA:Ensembl | P | regulation of protein secretion |
GO:0043201 | IEA:Ensembl | P | response to leucine |
GO:0044281 | TAS:Reactome | P | small molecule metabolic process |
GO:0034162 | TAS:Reactome | P | toll-like receptor 9 signaling pathway |
GO:0002224 | TAS:Reactome | P | toll-like receptor signaling pathway |
KEGG Pathway Links
KEGG Pathway ID | Description |
---|---|
hsa05152 | Tuberculosis |
Domain Information
InterPro Annotations
Accession | Description |
---|---|
IPR016024 | Armadillo-type fold |
IPR000008 | C2 domain |
IPR000403 | Phosphatidylinositol 3-/4-kinase, catalytic domain |
IPR002420 | Phosphatidylinositol 3-kinase, C2 domain |
IPR008290 | Phosphatidylinositol 3-kinase, Vps34 type |
IPR018936 | Phosphatidylinositol 3/4-kinase, conserved site |
IPR015433 | Phosphatidylinositol Kinase |
IPR001263 | Phosphoinositide 3-kinase, accessory (PIK) domain |
IPR011009 | Protein kinase-like domain |
UniProt Annotations
Entry Information
Gene Name
phosphatidylinositol 3-kinase, catalytic subunit type 3
Protein Entry
PK3C3_HUMAN
UniProt ID
Species
Human
Comments
Comment Type | Description |
---|---|
Catalytic Activity | ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate. |
Cofactor | Name=Mn(2+); Xref=ChEBI |
Function | Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes. {ECO |
Interaction | Q14457:BECN1; NbExp=14; IntAct=EBI-1056470, EBI-949378; |
Similarity | Belongs to the PI3/PI4-kinase family. |
Similarity | Contains 1 C2 PI3K-type domain. {ECO |
Similarity | Contains 1 PI3K/PI4K domain. {ECO |
Similarity | Contains 1 PIK helical domain. {ECO |
Subcellular Location | Midbody. Late endosome. Note=Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme. |
Subunit | Heterodimer. This subunit, part of a complex composed of regulatory and catalytic subunits, associates with regulatory subunit PIK3R4. Forms a complex with BECN1, PIK3R4 and either UVRAG and KIAA0226/Rubicon, or with ATG14. In this complex, presence of UVRAG and ATG14 are mutually exclusive. Part of a complex composed of PIK3R4 and PIK3CB (By similarity). Interacts with RAB7A in the presence of PIK3R4. Interacts with BECN1P1/BECN2. {ECO |
Tissue Specificity | Ubiquitously expressed, with a highest expression in skeletal muscle. |
Identical and Related Proteins
Unique RefSeq proteins for LMP005424 (as displayed in Record Overview)
Protein GI | Database | Accession | Length | Protein Name |
---|---|---|---|---|
34761064 | RefSeq | NP_002638 | 887 | phosphatidylinositol 3-kinase catalytic subunit type 3 |
Identical Sequences to LMP005424 proteins
Reference | Database | Accession | Length | Protein Name |
---|---|---|---|---|
GI:34761064 | GenBank | JAA09283.1 | 887 | phosphoinositide-3-kinase, class 3 [Pan troglodytes] |
GI:34761064 | GenBank | JAA13351.1 | 887 | phosphoinositide-3-kinase, class 3 [Pan troglodytes] |
GI:34761064 | GenBank | JAA29776.1 | 887 | phosphoinositide-3-kinase, class 3 [Pan troglodytes] |
GI:34761064 | GenBank | JAA39989.1 | 887 | phosphoinositide-3-kinase, class 3 [Pan troglodytes] |
GI:34761064 | GenBank | AHD78234.1 | 887 | Sequence 25571 from patent US 8586006 |
GI:34761064 | RefSeq | XP_003830260.1 | 887 | PREDICTED: phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [Pan paniscus] |
Related Sequences to LMP005424 proteins
Reference | Database | Accession | Length | Protein Name |
---|---|---|---|---|
GI:34761064 | GenBank | AAX43278.1 | 888 | phosphoinositide-3-kinase class 3, partial [synthetic construct] |
GI:34761064 | GenBank | AFE64002.1 | 887 | phosphatidylinositol 3-kinase catalytic subunit type 3 [Macaca mulatta] |
GI:34761064 | GenBank | AFH27474.1 | 887 | phosphatidylinositol 3-kinase catalytic subunit type 3 [Macaca mulatta] |
GI:34761064 | GenBank | AFI35288.1 | 887 | phosphatidylinositol 3-kinase catalytic subunit type 3 [Macaca mulatta] |
GI:34761064 | RefSeq | XP_002828227.1 | 887 | PREDICTED: phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [Pongo abelii] |
GI:34761064 | RefSeq | XP_005586880.1 | 887 | PREDICTED: phosphatidylinositol 3-kinase catalytic subunit type 3 [Macaca fascicularis] |