Gene/Proteome Database (LMPD)

LMPD ID
LMP005424
Gene ID
5289
Species
Homo sapiens (Human)
Gene Name
phosphatidylinositol 3-kinase, catalytic subunit type 3
Gene Symbol
PIK3C3
Synonyms
VPS34; hVps34
Alternate Names
phosphatidylinositol 3-kinase catalytic subunit type 3; PI3K type 3; PI3-kinase type 3; PtdIns-3-kinase type 3; phosphoinositide-3-kinase, class 3; phosphatidylinositol 3-kinase p100 subunit
Chromosome
18
Map Location
18q12.3
EC Number
2.7.1.137

Proteins

phosphatidylinositol 3-kinase catalytic subunit type 3
Refseq ID NP_002638
Protein GI 34761064
UniProt ID Q8NEB9
mRNA ID NM_002647
Length 887
RefSeq Status VALIDATED
MGEAEKFHYIYSCDLDINVQLKIGSLEGKREQKSYKAVLEDPMLKFSGLYQETCSDLYVTCQVFAEGKPLALPVRTSYKAFSTRWNWNEWLKLPVKYPDLPRNAQVALTIWDVYGPGKAVPVGGTTVSLFGKYGMFRQGMHDLKVWPNVEADGSEPTKTPGRTSSTLSEDQMSRLAKLTKAHRQGHMVKVDWLDRLTFREIEMINESEKRSSNFMYLMVEFRCVKCDDKEYGIVYYEKDGDESSPILTSFELVKVPDPQMSMENLVESKHHKLARSLRSGPSDHDLKPNAATRDQLNIIVSYPPTKQLTYEEQDLVWKFRYYLTNQEKALTKFLKCVNWDLPQEAKQALELLGKWKPMDVEDSLELLSSHYTNPTVRRYAVARLRQADDEDLLMYLLQLVQALKYENFDDIKNGLEPTKKDSQSSVSENVSNSGINSAEIDSSQIITSPLPSVSSPPPASKTKEVPDGENLEQDLCTFLISRACKNSTLANYLYWYVIVECEDQDTQQRDPKTHEMYLNVMRRFSQALLKGDKSVRVMRSLLAAQQTFVDRLVHLMKAVQRESGNRKKKNERLQALLGDNEKMNLSDVELIPLPLEPQVKIRGIIPETATLFKSALMPAQLFFKTEDGGKYPVIFKHGDDLRQDQLILQIISLMDKLLRKENLDLKLTPYKVLATSTKHGFMQFIQSVPVAEVLDTEGSIQNFFRKYAPSENGPNGISAEVMDTYVKSCAGYCVITYILGVGDRHLDNLLLTKTGKLFHIDFGYILGRDPKPLPPPMKLNKEMVEGMGGTQSEQYQEFRKQCYTAFLHLRRYSNLILNLFSLMVDANIPDIALEPDKTVKKVQDKFRLDLSDEEAVHYMQSLIDESVHALFAAVVEQIHKFAQYWRK

Gene Information

Entrez Gene ID
5289
Gene Name
phosphatidylinositol 3-kinase, catalytic subunit type 3
Gene Symbol
PIK3C3
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005930 ISS:UniProtKB C axoneme
GO:0005829 TAS:Reactome C cytosol
GO:0005770 IDA:UniProtKB C late endosome
GO:0016020 IDA:UniProtKB C membrane
GO:0030496 IDA:UniProtKB C midbody
GO:0045335 IEA:Ensembl C phagocytic vesicle
GO:0005942 IBA:RefGenome C phosphatidylinositol 3-kinase complex
GO:0016303 IMP:UniProtKB F 1-phosphatidylinositol-3-kinase activity
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0004672 IEA:Ensembl F protein kinase activity
GO:0000045 IEA:Ensembl P autophagic vacuole assembly
GO:0000910 IMP:UniProtKB P cytokinesis
GO:0045022 IMP:UniProtKB P early endosome to late endosome transport
GO:0007032 IEA:Ensembl P endosome organization
GO:0045087 TAS:Reactome P innate immune response
GO:0008286 TAS:Reactome P insulin receptor signaling pathway
GO:0006661 TAS:Reactome P phosphatidylinositol biosynthetic process
GO:0036092 IMP:GOC P phosphatidylinositol-3-phosphate biosynthetic process
GO:0048015 IEA:Ensembl P phosphatidylinositol-mediated signaling
GO:0006644 TAS:Reactome P phospholipid metabolic process
GO:0016485 IEA:Ensembl P protein processing
GO:0050708 IEA:Ensembl P regulation of protein secretion
GO:0043201 IEA:Ensembl P response to leucine
GO:0044281 TAS:Reactome P small molecule metabolic process
GO:0034162 TAS:Reactome P toll-like receptor 9 signaling pathway
GO:0002224 TAS:Reactome P toll-like receptor signaling pathway

KEGG Pathway Links

KEGG Pathway ID Description
hsa05152 Tuberculosis

Domain Information

InterPro Annotations

Accession Description
IPR016024 Armadillo-type fold
IPR000008 C2 domain
IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
IPR002420 Phosphatidylinositol 3-kinase, C2 domain
IPR008290 Phosphatidylinositol 3-kinase, Vps34 type
IPR018936 Phosphatidylinositol 3/4-kinase, conserved site
IPR015433 Phosphatidylinositol Kinase
IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domain
IPR011009 Protein kinase-like domain

UniProt Annotations

Entry Information

Gene Name
phosphatidylinositol 3-kinase, catalytic subunit type 3
Protein Entry
PK3C3_HUMAN
UniProt ID
Q8NEB9
Species
Human

Comments

Comment Type Description
Catalytic Activity ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate.
Cofactor Name=Mn(2+); Xref=ChEBI
Function Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes. {ECO
Interaction Q14457:BECN1; NbExp=14; IntAct=EBI-1056470, EBI-949378;
Similarity Belongs to the PI3/PI4-kinase family.
Similarity Contains 1 C2 PI3K-type domain. {ECO
Similarity Contains 1 PI3K/PI4K domain. {ECO
Similarity Contains 1 PIK helical domain. {ECO
Subcellular Location Midbody. Late endosome. Note=Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme.
Subunit Heterodimer. This subunit, part of a complex composed of regulatory and catalytic subunits, associates with regulatory subunit PIK3R4. Forms a complex with BECN1, PIK3R4 and either UVRAG and KIAA0226/Rubicon, or with ATG14. In this complex, presence of UVRAG and ATG14 are mutually exclusive. Part of a complex composed of PIK3R4 and PIK3CB (By similarity). Interacts with RAB7A in the presence of PIK3R4. Interacts with BECN1P1/BECN2. {ECO
Tissue Specificity Ubiquitously expressed, with a highest expression in skeletal muscle.

Identical and Related Proteins

Unique RefSeq proteins for LMP005424 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
34761064 RefSeq NP_002638 887 phosphatidylinositol 3-kinase catalytic subunit type 3

Identical Sequences to LMP005424 proteins

Reference Database Accession Length Protein Name
GI:34761064 GenBank JAA09283.1 887 phosphoinositide-3-kinase, class 3 [Pan troglodytes]
GI:34761064 GenBank JAA13351.1 887 phosphoinositide-3-kinase, class 3 [Pan troglodytes]
GI:34761064 GenBank JAA29776.1 887 phosphoinositide-3-kinase, class 3 [Pan troglodytes]
GI:34761064 GenBank JAA39989.1 887 phosphoinositide-3-kinase, class 3 [Pan troglodytes]
GI:34761064 GenBank AHD78234.1 887 Sequence 25571 from patent US 8586006
GI:34761064 RefSeq XP_003830260.1 887 PREDICTED: phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [Pan paniscus]

Related Sequences to LMP005424 proteins

Reference Database Accession Length Protein Name
GI:34761064 GenBank AAX43278.1 888 phosphoinositide-3-kinase class 3, partial [synthetic construct]
GI:34761064 GenBank AFE64002.1 887 phosphatidylinositol 3-kinase catalytic subunit type 3 [Macaca mulatta]
GI:34761064 GenBank AFH27474.1 887 phosphatidylinositol 3-kinase catalytic subunit type 3 [Macaca mulatta]
GI:34761064 GenBank AFI35288.1 887 phosphatidylinositol 3-kinase catalytic subunit type 3 [Macaca mulatta]
GI:34761064 RefSeq XP_002828227.1 887 PREDICTED: phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [Pongo abelii]
GI:34761064 RefSeq XP_005586880.1 887 PREDICTED: phosphatidylinositol 3-kinase catalytic subunit type 3 [Macaca fascicularis]