Gene/Proteome Database (LMPD)

LMPD ID
LMP005427
Gene ID
56886
Species
Homo sapiens (Human)
Gene Name
UDP-glucose glycoprotein glucosyltransferase 1
Gene Symbol
UGGT1
Synonyms
HUGT1; UGCGL1; UGT1
Chromosome
2
Map Location
2q14.3
EC Number
2.4.1.-
Summary
UDP-glucose:glycoprotein glucosyltransferase (UGT) is a soluble protein of the endoplasmic reticulum (ER) that selectively reglucosylates unfolded glycoproteins, thus providing quality control for protein transport out of the ER.[supplied by OMIM, Oct 2009]
Orthologs
View orthologs and multiple alignments for UGGT1

Proteins

UDP-glucose:glycoprotein glucosyltransferase 1 precursor
Refseq ID NP_064505
Protein GI 9910280
UniProt ID Q9NYU2
mRNA ID NM_020120
Length 1555
RefSeq Status VALIDATED
MGCKGDASGACAAGALPVTGVCYKMGVLVVLTVLWLFSSVKADSKAITTSLTTKWFSTPLLLEASEFLAEDSQEKFWNFVEASQNIGSSDHDGTDYSYYHAILEAAFQFLSPLQQNLFKFCLSLRSYSATIQAFQQIAADEPPPEGCNSFFSVHGKKTCESDTLEALLLTASERPKPLLFKGDHRYPSSNPESPVVIFYSEIGSEEFSNFHRQLISKSNAGKINYVFRHYIFNPRKEPVYLSGYGVELAIKSTEYKAKDDTQVKGTEVNTTVIGENDPIDEVQGFLFGKLRDLHPDLEGQLKELRKHLVESTNEMAPLKVWQLQDLSFQTAARILASPVELALVVMKDLSQNFPTKARAITKTAVSSELRTEVEENQKYFKGTLGLQPGDSALFINGLHMDLDTQDIFSLFDVLRNEARVMEGLHRLGIEGLSLHNVLKLNIQPSEADYAVDIRSPAISWVNNLEVDSRYNSWPSSLQELLRPTFPGVIRQIRKNLHNMVFIVDPAHETTAELMNTAEMFLSNHIPLRIGFIFVVNDSEDVDGMQDAGVAVLRAYNYVAQEVDDYHAFQTLTHIYNKVRTGEKVKVEHVVSVLEKKYPYVEVNSILGIDSAYDRNRKEARGYYEQTGVGPLPVVLFNGMPFEREQLDPDELETITMHKILETTTFFQRAVYLGELPHDQDVVEYIMNQPNVVPRINSRILTAERDYLDLTASNNFFVDDYARFTILDSQGKTAAVANSMNYLTKKGMSSKEIYDDSFIRPVTFWIVGDFDSPSGRQLLYDAIKHQKSSNNVRISMINNPAKEISYENTQISRAIWAALQTQTSNAAKNFITKMAKEGAAEALAAGADIAEFSVGGMDFSLFKEVFESSKMDFILSHAVYCRDVLKLKKGQRAVISNGRIIGPLEDSELFNQDDFHLLENIILKTSGQKIKSHIQQLRVEEDVASDLVMKVDALLSAQPKGDPRIEYQFFEDRHSAIKLRPKEGETYFDVVAVVDPVTREAQRLAPLLLVLAQLINMNLRVFMNCQSKLSDMPLKSFYRYVLEPEISFTSDNSFAKGPIAKFLDMPQSPLFTLNLNTPESWMVESVRTPYDLDNIYLEEVDSVVAAEYELEYLLLEGHCYDITTGQPPRGLQFTLGTSANPVIVDTIVMANLGYFQLKANPGAWILRLRKGRSEDIYRIYSHDGTDSPPDADEVVIVLNNFKSKIIKVKVQKKADMVNEDLLSDGTSENESGFWDSFKWGFTGQKTEEVKQDKDDIINIFSVASGHLYERFLRIMMLSVLKNTKTPVKFWFLKNYLSPTFKEFIPYMANEYNFQYELVQYKWPRWLHQQTEKQRIIWGYKILFLDVLFPLVVDKFLFVDADQIVRTDLKELRDFNLDGAPYGYTPFCDSRREMDGYRFWKSGYWASHLAGRKYHISALYVVDLKKFRKIAAGDRLRGQYQGLSQDPNSLSNLDQDLPNNMIHQVPIKSLPQEWLWCETWCDDASKKRAKTIDLCNNPMTKEPKLEAAVRIVPEWQDYDQEIKQLQIRFQKEKETGALYKEKTKEPSREGPQKREEL
sig_peptide: 1..42 inference: non-experimental evidence, no additional details recorded note: By similarity; propagated from UniProtKB/Swiss-Prot (Q9NYU2.3) calculated_mol_wt: 4175 peptide sequence: MGCKGDASGACAAGALPVTGVCYKMGVLVVLTVLWLFSSVKA mat_peptide: 43..1555 product: UDP-glucose:glycoprotein glucosyltransferase 1 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q9NYU2.3) calculated_mol_wt: 173033 peptide sequence: DSKAITTSLTTKWFSTPLLLEASEFLAEDSQEKFWNFVEASQNIGSSDHDGTDYSYYHAILEAAFQFLSPLQQNLFKFCLSLRSYSATIQAFQQIAADEPPPEGCNSFFSVHGKKTCESDTLEALLLTASERPKPLLFKGDHRYPSSNPESPVVIFYSEIGSEEFSNFHRQLISKSNAGKINYVFRHYIFNPRKEPVYLSGYGVELAIKSTEYKAKDDTQVKGTEVNTTVIGENDPIDEVQGFLFGKLRDLHPDLEGQLKELRKHLVESTNEMAPLKVWQLQDLSFQTAARILASPVELALVVMKDLSQNFPTKARAITKTAVSSELRTEVEENQKYFKGTLGLQPGDSALFINGLHMDLDTQDIFSLFDVLRNEARVMEGLHRLGIEGLSLHNVLKLNIQPSEADYAVDIRSPAISWVNNLEVDSRYNSWPSSLQELLRPTFPGVIRQIRKNLHNMVFIVDPAHETTAELMNTAEMFLSNHIPLRIGFIFVVNDSEDVDGMQDAGVAVLRAYNYVAQEVDDYHAFQTLTHIYNKVRTGEKVKVEHVVSVLEKKYPYVEVNSILGIDSAYDRNRKEARGYYEQTGVGPLPVVLFNGMPFEREQLDPDELETITMHKILETTTFFQRAVYLGELPHDQDVVEYIMNQPNVVPRINSRILTAERDYLDLTASNNFFVDDYARFTILDSQGKTAAVANSMNYLTKKGMSSKEIYDDSFIRPVTFWIVGDFDSPSGRQLLYDAIKHQKSSNNVRISMINNPAKEISYENTQISRAIWAALQTQTSNAAKNFITKMAKEGAAEALAAGADIAEFSVGGMDFSLFKEVFESSKMDFILSHAVYCRDVLKLKKGQRAVISNGRIIGPLEDSELFNQDDFHLLENIILKTSGQKIKSHIQQLRVEEDVASDLVMKVDALLSAQPKGDPRIEYQFFEDRHSAIKLRPKEGETYFDVVAVVDPVTREAQRLAPLLLVLAQLINMNLRVFMNCQSKLSDMPLKSFYRYVLEPEISFTSDNSFAKGPIAKFLDMPQSPLFTLNLNTPESWMVESVRTPYDLDNIYLEEVDSVVAAEYELEYLLLEGHCYDITTGQPPRGLQFTLGTSANPVIVDTIVMANLGYFQLKANPGAWILRLRKGRSEDIYRIYSHDGTDSPPDADEVVIVLNNFKSKIIKVKVQKKADMVNEDLLSDGTSENESGFWDSFKWGFTGQKTEEVKQDKDDIINIFSVASGHLYERFLRIMMLSVLKNTKTPVKFWFLKNYLSPTFKEFIPYMANEYNFQYELVQYKWPRWLHQQTEKQRIIWGYKILFLDVLFPLVVDKFLFVDADQIVRTDLKELRDFNLDGAPYGYTPFCDSRREMDGYRFWKSGYWASHLAGRKYHISALYVVDLKKFRKIAAGDRLRGQYQGLSQDPNSLSNLDQDLPNNMIHQVPIKSLPQEWLWCETWCDDASKKRAKTIDLCNNPMTKEPKLEAAVRIVPEWQDYDQEIKQLQIRFQKEKETGALYKEKTKEPSREGPQKREEL

Gene Information

Entrez Gene ID
56886
Gene Name
UDP-glucose glycoprotein glucosyltransferase 1
Gene Symbol
UGGT1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IDA:UniProtKB C endoplasmic reticulum
GO:0005788 TAS:Reactome C endoplasmic reticulum lumen
GO:0005793 ISS:UniProtKB C endoplasmic reticulum-Golgi intermediate compartment
GO:0070062 IDA:UniProt C extracellular vesicular exosome
GO:0003980 IDA:UniProtKB F UDP-glucose:glycoprotein glucosyltransferase activity
GO:0051082 IDA:UniProtKB F unfolded protein binding
GO:0051084 TAS:UniProtKB P 'de novo' posttranslational protein folding
GO:0044267 TAS:Reactome P cellular protein metabolic process
GO:0043687 TAS:Reactome P post-translational protein modification
GO:0018279 TAS:Reactome P protein N-linked glycosylation via asparagine
GO:0006457 TAS:Reactome P protein folding

KEGG Pathway Links

KEGG Pathway ID Description
hsa04141 Protein processing in endoplasmic reticulum
ko04141 Protein processing in endoplasmic reticulum

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_23810 Calnexin/calreticulin cycle
REACT_25091 ER Quality Control Compartment (ERQC)

Domain Information

InterPro Annotations

Accession Description
IPR029044 Nucleotide-diphospho-sugar transferases
IPR009448 UDP-glucose:Glycoprotein Glucosyltransferase

UniProt Annotations

Entry Information

Gene Name
UDP-glucose glycoprotein glucosyltransferase 1
Protein Entry
Q9NYU2_HUMAN
UniProt ID
Q9NYU2
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NYU2-1; Sequence=Displayed; Name=2; IsoId=Q9NYU2-2; Sequence=VSP_036508;
Cofactor Name=Ca(2+); Xref=ChEBI
Domain The N-terminal non-catalytic domain is assumed to mediate recognition of proteins with partial folding defects.
Function Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation.
Induction By tunicamycin and A23187. Induced 3-4 fold 10 hours after treatment.
Pathway Protein modification; protein glycosylation.
Sequence Caution Sequence=AAY14885.1; Type=Erroneous gene model prediction; Evidence= ; Sequence=BAB14632.1; Type=Erroneous initiation; Evidence= ;
Similarity Belongs to the glycosyltransferase 8 family.
Subcellular Location Endoplasmic reticulum lumen {ECO
Subunit Monomer as well as in a tight complex with SEP15 (By similarity). Interacts with METTL23. {ECO
Tissue Specificity Higher levels in pancreas, skeletal muscle, kidney, and brain. Low levels in lung and heart.
Web Resource Name=GGDB; Note=GlycoGene database; URL="http://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=UGGT1";

Identical and Related Proteins

Unique RefSeq proteins for LMP005427 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
9910280 RefSeq NP_064505 1555 UDP-glucose:glycoprotein glucosyltransferase 1 precursor

Identical Sequences to LMP005427 proteins

Reference Database Accession Length Protein Name
GI:9910280 GenBank AAF66232.1 1555 UDP-glucose:glycoprotein glucosyltransferase 1 precursor [Homo sapiens]
GI:9910280 GenBank ACM81452.1 1555 Sequence 6950 from patent US 6812339
GI:9910280 SwissProt Q9NYU2.3 1555 RecName: Full=UDP-glucose:glycoprotein glucosyltransferase 1; Short=UGT1; Short=hUGT1; AltName: Full=UDP--Glc:glycoprotein glucosyltransferase; AltName: Full=UDP-glucose ceramide glucosyltransferase-like 1; Flags: Precursor [Homo sapiens]

Related Sequences to LMP005427 proteins

Reference Database Accession Length Protein Name
GI:9910280 EMBL CAD34799.1 1555 unnamed protein product [Homo sapiens]
GI:9910280 GenBank JAA06510.1 1556 UDP-glucose glycoprotein glucosyltransferase 1 [Pan troglodytes]
GI:9910280 GenBank JAA13307.1 1556 UDP-glucose glycoprotein glucosyltransferase 1 [Pan troglodytes]
GI:9910280 GenBank JAA25670.1 1556 UDP-glucose glycoprotein glucosyltransferase 1 [Pan troglodytes]
GI:9910280 GenBank JAA43469.1 1556 UDP-glucose glycoprotein glucosyltransferase 1 [Pan troglodytes]
GI:9910280 RefSeq XP_001141314.1 1556 PREDICTED: UDP-glucose:glycoprotein glucosyltransferase 1 isoform X1 [Pan troglodytes]