Gene/Proteome Database (LMPD)
LMPD ID
LMP005434
Gene ID
Species
Homo sapiens (Human)
Gene Name
arylsulfatase G
Gene Symbol
Synonyms
-
Alternate Names
arylsulfatase G; ASG
Chromosome
17
Map Location
17q24.2
EC Number
3.1.6.-
Summary
The protein encoded by this gene belongs to the sulfatase enzyme family. Sulfatases hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules. This protein displays arylsulfatase activity at acidic pH, as is typical of lysosomal sulfatases, and has been shown to localize in the lysosomes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2012]
Orthologs
Proteins
| arylsulfatase G | |
|---|---|
| Refseq ID | NP_001254656 |
| Protein GI | 392050740 |
| UniProt ID | Q96EG1 |
| mRNA ID | NM_001267727 |
| Length | 525 |
| RefSeq Status | REVIEWED |
| MGWLFLKVLLAGVSFSGFLYPLVDFCISGKTRGQKPNFVIILADDMGWGDLGANWAETKDTANLDKMASEGMRFVDFHAAASTCSPSRASLLTGRLGLRNGVTRNFAVTSVGGLPLNETTLAEVLQQAGYVTGIIGKWHLGHHGSYHPNFRGFDYYFGIPYSHDMGCTDTPGYNHPPCPACPQGDGPSRNLQRDCYTDVALPLYENLNIVEQPVNLSSLAQKYAEKATQFIQRASTSGRPFLLYVALAHMHVPLPVTQLPAAPRGRSLYGAGLWEMDSLVGQIKDKVDHTVKENTFLWFTGDNGPWAQKCELAGSVGPFTGFWQTRQGGSPAKQTTWEGGHRVPALAYWPGRVPVNVTSTALLSVLDIFPTVVALAQASLPQGRRFDGVDVSEVLFGRSQPGHRVLFHPNSGAAGEFGALQTVRLERYKAFYITGGARACDGSTGPELQHKFPLIFNLEDDTAEAVPLERGGAEYQAVLPEVRKVLADVLQDIANDNISSADYTQDPSVTPCCNPYQIACRCQAA | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005783 | IDA:HGNC | C | endoplasmic reticulum |
| GO:0005788 | TAS:Reactome | C | endoplasmic reticulum lumen |
| GO:0005615 | IDA:UniProtKB | C | extracellular space |
| GO:0005764 | IDA:UniProtKB | C | lysosome |
| GO:0004065 | IDA:UniProtKB | F | arylsulfatase activity |
| GO:0046872 | IEA:UniProtKB-KW | F | metal ion binding |
| GO:0044267 | TAS:Reactome | P | cellular protein metabolic process |
| GO:0006687 | TAS:Reactome | P | glycosphingolipid metabolic process |
| GO:0043687 | TAS:Reactome | P | post-translational protein modification |
| GO:0044281 | TAS:Reactome | P | small molecule metabolic process |
| GO:0006665 | TAS:Reactome | P | sphingolipid metabolic process |
| GO:0006790 | IDA:UniProtKB | P | sulfur compound metabolic process |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| hsa04142 | Lysosome |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_116105 | Glycosphingolipid metabolism |
| REACT_19323 | Sphingolipid metabolism |
| REACT_121036 | The activation of arylsulfatases |
Domain Information
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Biophysicochemical Properties | Kinetic parameters: KM=4.2 mM for p-nitrocatechol sulfate ; Vmax=63.5 umol/min/mg enzyme toward p-nitrocatechol sulfate ; pH dependence: Optimum pH is 5.4. ; Temperature dependence: Most efficient at 45-50 degrees Celsius. ; |
| Cofactor | Name=Ca(2+); Xref=ChEBI |
| Enzyme Regulation | Inhibited by phosphate. The phosphate forms a covalent bond with the active site 3-oxoalanine. |
| Function | Displays arylsulfatase activity at acidic pH with pseudosubstrates, such as p-nitrocatechol sulfate and also, but with lower activity, p-nitrophenyl sulfate and 4- methylumbelliferyl sulfate. |
| Ptm | Glycosylated. |
| Ptm | N-glycosylated. |
| Ptm | The conversion to 3-oxoalanine (also known as C- formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. |
| Sequence Caution | Sequence=BAA76845.2; Type=Erroneous initiation; Evidence= ; |
| Similarity | Belongs to the sulfatase family. |
| Subcellular Location | Lysosome {ECO |
| Tissue Specificity | Widely expressed, with very low expression in brain, lung, heart and skeletal muscle. |
Identical and Related Proteins
Unique RefSeq proteins for LMP005434 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 392050740 | RefSeq | NP_001254656 | 525 | arylsulfatase G |
Identical Sequences to LMP005434 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:392050740 | GenBank | AFQ69841.1 | 525 | Sequence 27 from patent US 8227212 |
| GI:392050740 | GenBank | AIC50890.1 | 525 | ARSG, partial [synthetic construct] |
| GI:392050740 | GenBank | AIC62704.1 | 525 | ARSG, partial [synthetic construct] |
| GI:392050740 | RefSeq | XP_005257227.1 | 525 | PREDICTED: arylsulfatase G isoform X1 [Homo sapiens] |
| GI:392050740 | RefSeq | XP_006721839.1 | 525 | PREDICTED: arylsulfatase G isoform X4 [Homo sapiens] |
| GI:392050740 | RefSeq | XP_006721840.1 | 525 | PREDICTED: arylsulfatase G isoform X5 [Homo sapiens] |
Related Sequences to LMP005434 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:392050740 | DBBJ | BAA76845.2 | 551 | KIAA1001 protein, partial [Homo sapiens] |
| GI:392050740 | DBBJ | BAG09935.1 | 525 | arylsulfatase G precursor, partial [synthetic construct] |
| GI:392050740 | GenBank | ACJ96044.1 | 525 | Sequence 56 from patent US 7417115 |
| GI:392050740 | GenBank | ACJ96504.1 | 525 | Sequence 56 from patent US 7417123 |
| GI:392050740 | GenBank | ACR88913.1 | 525 | Sequence 56 from patent US 7521539 |
| GI:392050740 | GenBank | ACR89465.1 | 525 | Sequence 56 from patent US 7524497 |