Gene/Proteome Database (LMPD)

LMPD ID
LMP005499
Gene ID
283
Species
Homo sapiens (Human)
Gene Name
angiogenin, ribonuclease, RNase A family, 5
Gene Symbol
ANG
Synonyms
ALS9; HEL168; RAA1; RNASE4; RNASE5
Alternate Names
angiogenin; RNase 5; ribonuclease 5; ribonuclease A A1; epididymis luminal protein 168
Chromosome
14
Map Location
14q11.1-q11.2
EC Number
3.1.27.-
Summary
The protein encoded by this gene is an exceedingly potent mediator of new blood vessel formation. It hydrolyzes cellular tRNAs resulting in decreased protein synthesis and is similar to pancreatic ribonuclease. In addition, the mature peptide has antimicrobial activity against some bacteria and fungi, including S. pneumoniae and C. albicans. Alternative splicing results in two transcript variants encoding the same protein. This gene and the gene that encodes ribonuclease, RNase A family, 4 share promoters and 5' exons. Each gene splices to a unique downstream exon that contains its complete coding region. [provided by RefSeq, Aug 2014]
Orthologs
View orthologs and multiple alignments for ANG

Proteins

angiogenin precursor
Refseq ID NP_001091046
Protein GI 148277046
UniProt ID P03950
mRNA ID NM_001097577
Length 147
RefSeq Status REVIEWED
MVMGLGVLLLVFVLGLGLTPPTLAQDNSRYTHFLTQHYDAKPQGRDDRYCESIMRRRGLTSPCKDINTFIHGNKRSIKAICENKNGNPHRENLRISKSSFQVTTCKLHGGSPWPPCQYRATAGFRNVVVACENGLPVHLDQSIFRRP
angiogenin precursor
Refseq ID NP_001136
Protein GI 4557313
UniProt ID P03950
mRNA ID NM_001145
Length 147
RefSeq Status REVIEWED
Protein sequence is identical to GI:148277046 (mRNA isoform)
sig_peptide: 1..24 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2425 peptide sequence: MVMGLGVLLLVFVLGLGLTPPTLA mat_peptide: 25..147 product: angiogenin experiment: DESCRIPTION:antimicrobial peptide[PMID: 12548285] calculated_mol_wt: 14143 peptide sequence: QDNSRYTHFLTQHYDAKPQGRDDRYCESIMRRRGLTSPCKDINTFIHGNKRSIKAICENKNGNPHRENLRISKSSFQVTTCKLHGGSPWPPCQYRATAGFRNVVVACENGLPVHLDQSIFRRP sig_peptide: 1..24 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2425 peptide sequence: MVMGLGVLLLVFVLGLGLTPPTLA mat_peptide: 25..147 product: angiogenin experiment: DESCRIPTION:antimicrobial peptide[PMID: 12548285] calculated_mol_wt: 14143 peptide sequence: QDNSRYTHFLTQHYDAKPQGRDDRYCESIMRRRGLTSPCKDINTFIHGNKRSIKAICENKNGNPHRENLRISKSSFQVTTCKLHGGSPWPPCQYRATAGFRNVVVACENGLPVHLDQSIFRRP

Gene Information

Entrez Gene ID
283
Gene Name
angiogenin, ribonuclease, RNase A family, 5
Gene Symbol
ANG
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0032311 IPI:UniProtKB C angiogenin-PRI complex
GO:0005605 IDA:UniProtKB C basal lamina
GO:0005615 IDA:UniProtKB C extracellular space
GO:0070062 IDA:UniProt C extracellular vesicular exosome
GO:0030426 ISS:UniProtKB C growth cone
GO:0043025 ISS:UniProtKB C neuronal cell body
GO:0005730 ISS:UniProtKB C nucleolus
GO:0005634 IDA:UniProtKB C nucleus
GO:0003779 IDA:UniProtKB F actin binding
GO:0005507 IDA:UniProtKB F copper ion binding
GO:0003677 IC:UniProtKB F DNA binding
GO:0004519 TAS:UniProtKB F endonuclease activity
GO:0008201 IDA:UniProtKB F heparin binding
GO:0042277 IDA:UniProtKB F peptide binding
GO:0005102 IDA:UniProtKB F receptor binding
GO:0004540 IDA:UniProtKB F ribonuclease activity
GO:0019843 TAS:UniProtKB F rRNA binding
GO:0030041 ISS:UniProtKB P actin filament polymerization
GO:0032431 IMP:UniProtKB P activation of phospholipase A2 activity
GO:0007202 IMP:UniProtKB P activation of phospholipase C activity
GO:0032148 IMP:UniProtKB P activation of protein kinase B activity
GO:0001525 IMP:UniProtKB P angiogenesis
GO:0007154 NAS:UniProtKB P cell communication
GO:0008219 IEA:UniProtKB-KW P cell death
GO:0016477 IMP:UniProtKB P cell migration
GO:0006651 IDA:UniProtKB P diacylglycerol biosynthetic process
GO:0042592 NAS:UniProtKB P homeostatic process
GO:0048662 IDA:UniProtKB P negative regulation of smooth muscle cell proliferation
GO:0017148 IEA:UniProtKB-KW P negative regulation of translation
GO:0090305 TAS:GOC P nucleic acid phosphodiester bond hydrolysis
GO:0001556 NAS:UniProtKB P oocyte maturation
GO:0001541 NAS:UniProtKB P ovarian follicle development
GO:0001890 NAS:UniProtKB P placenta development
GO:0001938 IDA:UniProtKB P positive regulation of endothelial cell proliferation
GO:0042327 IDA:UniProtKB P positive regulation of phosphorylation
GO:0050714 IDA:UniProtKB P positive regulation of protein secretion
GO:0009725 IDA:UniProtKB P response to hormone
GO:0001666 IDA:UniProtKB P response to hypoxia
GO:0090501 IDA:GOC P RNA phosphodiester bond hydrolysis
GO:0009303 IMP:UniProtKB P rRNA transcription

Domain Information

InterPro Annotations

Accession Description
IPR001427 Pancreatic ribonuclease
IPR023411 Ribonuclease A, active site
IPR023412 Ribonuclease A-domain

UniProt Annotations

Entry Information

Gene Name
angiogenin, ribonuclease, RNase A family, 5
Protein Entry
ANGI_HUMAN
UniProt ID
P03950
Species
Human

Comments

Comment Type Description
Caution It is uncertain whether Met-1 or Met-3 is the initiator.
Developmental Stage Low level expression in the developing fetus, increased in the neonate, and maximal in the adult.
Disease Amyotrophic lateral sclerosis 9 (ALS9) [MIM
Function Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo. {ECO
Interaction P35609:ACTN2; NbExp=4; IntAct=EBI-525291, EBI-77797; P19883:FST; NbExp=3; IntAct=EBI-525291, EBI-1571188; P13489:RNH1; NbExp=2; IntAct=EBI-525291, EBI-1237106;
Sequence Caution Sequence=AAH20704.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ;
Similarity Belongs to the pancreatic ribonuclease family.
Subcellular Location Secreted, extracellular space, extracellular matrix, basement membrane. Nucleus, nucleolus. Note=Rapidly endocytosed by target cells and translocated to the nucleus where it accumulates in the nucleolus and binds to DNA.
Subunit Interacts with and forms a tight 1:1 complex with RNH1. Dimerization of two such complexes may occur. {ECO
Tissue Specificity Expressed predominantly in the liver. Also detected in endothelial cells and spinal cord neurons.
Web Resource Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/ANGID635ch14q11.html";
Web Resource Name=Functional Glycomics Gateway - Glycan Binding; Note=Angiogenin; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_other_803";
Web Resource Name=R&D Systems' cytokine mini-reviews: Angiogenin; URL="http://www.rndsystems.com/molecule_detail.aspx?m=1054";

Identical and Related Proteins

Unique RefSeq proteins for LMP005499 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
148277046 RefSeq NP_001091046 147 angiogenin precursor

Identical Sequences to LMP005499 proteins

Reference Database Accession Length Protein Name
GI:148277046 GenBank AEH74419.1 147 Sequence 9 from patent US 7955805
GI:148277046 GenBank AGU27885.1 147 Sequence 16 from patent US 8497070
GI:148277046 GenBank AGU27918.1 147 Sequence 8 from patent US 8497078
GI:148277046 GenBank AHE01106.1 147 Sequence 56022 from patent US 8586006
GI:148277046 GenBank AIC48263.1 147 ANG, partial [synthetic construct]
GI:148277046 tpe CDG31911.1 147 TPA: ribonuclease A A1 [Homo sapiens]

Related Sequences to LMP005499 proteins

Reference Database Accession Length Protein Name
GI:148277046 EMBL CAI93403.1 147 unnamed protein product [Homo sapiens]
GI:148277046 GenBank AAL67714.1 147 angiogenin, partial [Homo sapiens]
GI:148277046 GenBank ABH92283.1 147 Sequence 254 from patent US 7060479
GI:148277046 GenBank ABW56222.1 147 Sequence 254 from patent US 7271243
GI:148277046 RefSeq XP_004054892.1 147 PREDICTED: angiogenin isoform 1 [Gorilla gorilla gorilla]
GI:148277046 RefSeq XP_004054893.1 147 PREDICTED: angiogenin isoform 2 [Gorilla gorilla gorilla]