Gene/Proteome Database (LMPD)

LMPD ID
LMP005502
Gene ID
12012
Species
Mus musculus (Mouse)
Gene Name
bile acid-Coenzyme A: amino acid N-acyltransferase
Gene Symbol
Baat
Synonyms
AI118337; AI158864; BAT
Alternate Names
bile acid-CoA:amino acid N-acyltransferase; BACAT; taurine N-acyltransferase; glycine N-choloyltransferase; long-chain fatty-acyl-CoA hydrolase; bile acid-Coenzyme A dehydrogenase: amino acid n-acyltransferase
Chromosome
4
Map Location
4 B1|4 26.51 cM
EC Number
2.3.1.65

Proteins

bile acid-CoA:amino acid N-acyltransferase
Refseq ID NP_031545
Protein GI 110225339
UniProt ID Q91X34
mRNA ID NM_007519
Length 420
RefSeq Status VALIDATED
MAKLTAVPLSALVDEPVHIQVTGLAPFQVVCLQASLKDEKGNLFSSQAFYRASEVGEVDLEHDPSLGGDYMGVHPMGLFWSLKPEKLLGRLIKRDVMNSPYQIHIKACHPYFPLQDIVVSPPLDSLTLERWYVAPGVKRIQVKESRIRGALFLPPGEGPFPGVIDLFGGAGGLMEFRASLLASRGFATLALAYWNYDDLPSRLEKVDLEYFEEGVEFLLRHPKVLGPGVGILSVCIGAEIGLSMAINLKQIRATVLINGPNFVSQSPHVYHGQVYPPVPSNEEFVVTNALGLVEFYRTFQETADKDSKYCFPIEKAHGHFLFVVGEDDKNLNSKVHANQAIAQLMKNGKKNWTLLSYPGAGHLIEPPYTPLCQASRMPILIPSLSWGGEVIPHAAAQEHSWKEIQKFLKQHLLPDLSSQL

Gene Information

Entrez Gene ID
12012
Gene Name
bile acid-Coenzyme A: amino acid N-acyltransferase
Gene Symbol
Baat
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 IDA:UniProtKB C cytosol
GO:0005777 IEA:UniProtKB-KW C peroxisome
GO:0016410 IDA:MGI F N-acyltransferase activity
GO:0052689 IEA:UniProtKB-KW F carboxylic ester hydrolase activity
GO:0047963 IEA:UniProtKB-EC F glycine N-choloyltransferase activity
GO:0052815 IEA:Ensembl F medium-chain acyl-CoA hydrolase activity
GO:0016290 IEA:UniProtKB-EC F palmitoyl-CoA hydrolase activity
GO:0052817 IEA:Ensembl F very long chain acyl-CoA hydrolase activity
GO:0006637 IEA:Ensembl P acyl-CoA metabolic process
GO:0006699 IEA:Ensembl P bile acid biosynthetic process
GO:0002152 IEA:Ensembl P bile acid conjugation
GO:0008206 IDA:MGI P bile acid metabolic process
GO:0006631 IEA:UniProtKB-KW P fatty acid metabolic process
GO:0006544 IEA:Ensembl P glycine metabolic process
GO:0001889 IEA:Ensembl P liver development
GO:0031100 IEA:Ensembl P organ regeneration
GO:0019530 IEA:Ensembl P taurine metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu04976 Bile secretion
mmu04146 Peroxisome
mmu00120 Primary bile acid biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR006862 Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase
IPR016662 Acyl-CoA thioesterase, long chain
IPR029058 Alpha/Beta hydrolase fold
IPR014940 BAAT/Acyl-CoA thioester hydrolase C-terminal

UniProt Annotations

Entry Information

Gene Name
bile acid-Coenzyme A: amino acid N-acyltransferase
Protein Entry
BAAT_MOUSE
UniProt ID
Q91X34
Species
Mouse

Comments

Comment Type Description
Biophysicochemical Properties Kinetic parameters: KM=1.9 mM for taurine;
Catalytic Activity Choloyl-CoA + glycine = CoA + glycocholate. {ECO:0000269|PubMed:9215542}.
Catalytic Activity Palmitoyl-CoA + H(2)O = CoA + palmitate. {ECO:0000269|PubMed:9215542}.
Function Involved in bile acid metabolism. In liver hepatocytes catalyzes the second step in the conjugation of C24 bile acids (choloneates) to taurine before excretion into bile canaliculi. The major components of bile are cholic acid and chenodeoxycholic acid. In a first step the bile acids are converted to an acyl-CoA thioester, either in peroxisomes (primary bile acids deriving from the cholesterol pathway), or cytoplasmic at the endoplasmic reticulum (secondary bile acids). May catalyze the conjugation of primary or secondary bile acids, or both. The conjugation increases the detergent properties of bile acids in the intestine, which facilitates lipid and fat-soluble vitamin absorption. In turn, bile acids are deconjugated by bacteria in the intestine and are recycled back to the liver for reconjugation (secondary bile acids). May also act as an acyl-CoA thioesterase that regulates intracellular levels of free fatty acids. In vitro, catalyzes the hydrolysis of long- and very long-chain saturated acyl-CoAs to the free fatty acid and coenzyme A (CoASH), and conjugates glycine to these acyl-CoAs (By similarity). {ECO:0000250}.
Miscellaneous Mouse BAAT seems to be selective for taurine conjugation of cholyl CoA. In mouse only taurine-conjugated bile acids are found in bile.
Sequence Caution Sequence=AAB58325.1; Type=Frameshift; Positions=40, 44; Evidence={ECO:0000305}; Sequence=BAC25534.1; Type=Frameshift; Positions=63; Evidence={ECO:0000305};
Similarity Belongs to the C/M/P thioester hydrolase family. {ECO:0000305}.
Subcellular Location Cytoplasm {ECO:0000250}. Peroxisome {ECO:0000250}. Note=Cytoplasmic or/and peroxisomal. {ECO:0000250}.
Subunit Monomer. {ECO:0000250}.
Tissue Specificity Highly expressed in liver, kidney, gallbladder, proximal intestine and distal intestine. Weakly expressed in adrenal gland, lung, brain and muscle. {ECO:0000269|PubMed:12810727, ECO:0000269|PubMed:9215542}.

Identical and Related Proteins

Unique RefSeq proteins for LMP005502 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
110225339 RefSeq NP_031545 420 bile acid-CoA:amino acid N-acyltransferase

Identical Sequences to LMP005502 proteins

Reference Database Accession Length Protein Name
GI:110225339 GenBank EDL02319.1 420 bile acid-Coenzyme A: amino acid N-acyltransferase [Mus musculus]
GI:110225339 SwissProt Q91X34.1 420 RecName: Full=Bile acid-CoA:amino acid N-acyltransferase; Short=BACAT; Short=BAT; AltName: Full=Glycine N-choloyltransferase; AltName: Full=Long-chain fatty-acyl-CoA hydrolase [Mus musculus]

Related Sequences to LMP005502 proteins

Reference Database Accession Length Protein Name
GI:110225339 DBBJ BAA07901.1 420 Kan-1 [Rattus norvegicus]
GI:110225339 GenBank AAB58325.1 420 bile acid CoA: amino acid N-acyltransferase [Mus musculus]
GI:110225339 GenBank AAH88153.1 420 Bile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase) [Rattus norvegicus]
GI:110225339 GenBank EDL78183.1 420 bile acid-Coenzyme A: amino acid N-acyltransferase [Rattus norvegicus]
GI:110225339 RefSeq NP_058996.2 420 bile acid-CoA:amino acid N-acyltransferase [Rattus norvegicus]
GI:110225339 SwissProt Q63276.2 420 RecName: Full=Bile acid-CoA:amino acid N-acyltransferase; Short=BACAT; Short=BAT; AltName: Full=Glycine N-choloyltransferase; AltName: Full=Kan-1; AltName: Full=Long-chain fatty-acyl-CoA hydrolase [Rattus norvegicus]