Gene/Proteome Database (LMPD)

LMPD ID
LMP005534
Gene ID
22876
Species
Homo sapiens (Human)
Gene Name
inositol polyphosphate-5-phosphatase F
Gene Symbol
INPP5F
Synonyms
MSTPO47; SAC2; hSAC2
Alternate Names
phosphatidylinositide phosphatase SAC2; Sac domain-containing inositol phosphatase 2; sac domain-containing phosphoinositide 5-phosphatase 2
Chromosome
10
Map Location
10q26.11
EC Number
3.1.3.-
Summary
The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase and contains a Sac domain. The activity of this protein is specific for phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]
Orthologs
View orthologs and multiple alignments for INPP5F

Proteins

phosphatidylinositide phosphatase SAC2 isoform 1
Refseq ID NP_055752
Protein GI 7662414
UniProt ID Q9Y2H2
mRNA ID NM_014937
Length 1132
RefSeq Status REVIEWED
MELFQAKDHYILQQGERALWCSRRDGGLQLRPATDLLLAWNPICLGLVEGVIGKIQLHSDLPWWLILIRQKALVGKLPGDHEVCKVTKIAVLSLSEMEPQDLELELCKKHHFGINKPEKIIPSPDDSKFLLKTFTHIKSNVSAPNKKKVKESKEKEKLERRLLEELLKMFMDSESFYYSLTYDLTNSVQRQSTGERDGRPLWQKVDDRFFWNKYMIQDLTEIGTPDVDFWIIPMIQGFVQIEELVVNYTESSDDEKSSPETPPQESTCVDDIHPRFLVALISRRSRHRAGMRYKRRGVDKNGNVANYVETEQLIHVHNHTLSFVQTRGSVPVFWSQVGYRYNPRPRLDRSEKETVAYFCAHFEEQLNIYKKQVIINLVDQAGREKIIGDAYLKQVLLFNNSHLTYVSFDFHEHCRGMKFENVQTLTDAIYDIILDMKWCWVDEAGVICKQEGIFRVNCMDCLDRTNVVQAAIARVVMEQQLKKLGVMPPEQPLPVKCNRIYQIMWANNGDSISRQYAGTAALKGDFTRTGERKLAGVMKDGVNSANRYYLNRFKDAYRQAVIDLMQGIPVTEDLYSIFTKEKEHEALHKENQRSHQELISQLLQSYMKLLLPDDEKFHGGWALIDCDPSLIDATHRDVDVLLLLSNSAYYVAYYDDEVDKVNQYQRLSLENLEKIEIGPEPTLFGKPKFSCMRLHYRYKEASGYFHTLRAVMRNPEEDGKDTLQCIAEMLQITKQAMGSDLPIIEKKLERKSSKPHEDIIGIRSQNQGSLAQGKNFLMSKFSSLNQKVKQTKSNVNIGNLRKLGNFTKPEMKVNFLKPNLKVNLWKSDSSLETMENTGVMDKVQAESDGDMSSDNDSYHSDEFLTNSKSDEDRQLANSLESVGPIDYVLPSCGIIASAPRLGSRSQSLSSTDSSVHAPSEITVAHGSGLGKGQESPLKKSPSAGDVHILTGFAKPMDIYCHRFVQDAQNKVTHLSETRSVSQQASQERNQMTNQVSNETQSESTEQTPSRPSQLDVSLSATGPQFLSVEPAHSVASQKTPTSASSMLELETGLHVTPSPSESSSSRAVSPFAKIRSSMVQVASITQAGLTHGINFAVSKVQKSPPEPEIINQVQQNELKKMFIQCQTRIIQI
phosphatidylinositide phosphatase SAC2 isoform 2
Refseq ID NP_001230123
Protein GI 342307080
UniProt ID Q9Y2H2
mRNA ID NM_001243194
Length 522
RefSeq Status REVIEWED
MCHDVIFMAWLKQQFSECTLIDATHRDVDVLLLLSNSAYYVAYYDDEVDKVNQYQRLSLENLEKIEIGPEPTLFGKPKFSCMRLHYRYKEASGYFHTLRAVMRNPEEDGKDTLQCIAEMLQITKQAMGSDLPIIEKKLERKSSKPHEDIIGIRSQNQGSLAQGKNFLMSKFSSLNQKVKQTKSNVNIGNLRKLGNFTKPEMKVNFLKPNLKVNLWKSDSSLETMENTGVMDKVQAESDGDMSSDNDSYHSDEFLTNSKSDEDRQLANSLESVGPIDYVLPSCGIIASAPRLGSRSQSLSSTDSSVHAPSEITVAHGSGLGKGQESPLKKSPSAGDVHILTGFAKPMDIYCHRFVQDAQNKVTHLSETRSVSQQASQERNQMTNQVSNETQSESTEQTPSRPSQLDVSLSATGPQFLSVEPAHSVASQKTPTSASSMLELETGLHVTPSPSESSSSRAVSPFAKIRSSMVQVASITQAGLTHGINFAVSKVQKSPPEPEIINQVQQNELKKMFIQCQTRIIQI
phosphatidylinositide phosphatase SAC2 isoform 3
Refseq ID NP_001230124
Protein GI 342307082
UniProt ID Q9Y2H2
mRNA ID NM_001243195
Length 219
RefSeq Status REVIEWED
MELFQAKDHYILQQGERALWCSRRDGGLQLRPATDLLLAWNPICLGLVEGVIGKIQLHSDLPWWLILIRQKALVGKLPGDHEVCKVTKIAVLSLSEMEPQDLELELCKKHHFGINKPEKIIPSPDDSKFLLKTFTHIKSNVSAPNKKKVKESKEKEKLERRLLEELLKMFMDSESFYYSLTYDLTNSVQRQSTGERDGRPLWQKVPLTARRAGFALGKK

Gene Information

Entrez Gene ID
22876
Gene Name
inositol polyphosphate-5-phosphatase F
Gene Symbol
INPP5F
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0042578 IEA:InterPro F phosphoric ester hydrolase activity
GO:0014898 IEA:Ensembl P cardiac muscle hypertrophy in response to stress
GO:0031161 IEA:Ensembl P phosphatidylinositol catabolic process
GO:0048015 IEA:Ensembl P phosphatidylinositol-mediated signaling
GO:0051896 IEA:Ensembl P regulation of protein kinase B signaling

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-6368 3-phosphoinositide degradation
PWY-6368 3-phosphoinositide degradation
PWY-6363 D-myo-inositol (1,4,5)-trisphosphate degradation
PWY-6358 superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism

Domain Information

InterPro Annotations

Accession Description
IPR022158 Inositol_phosphatase
IPR002013 SAC domain

UniProt Annotations

Entry Information

Gene Name
inositol polyphosphate-5-phosphatase F
Protein Entry
SAC2_HUMAN
UniProt ID
Q9Y2H2
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9Y2H2-1; Sequence=Displayed; Name=2; IsoId=Q9Y2H2-2; Sequence=VSP_033268, VSP_033269; Name=3; IsoId=Q9Y2H2-3; Sequence=VSP_033266, VSP_033267; Name=4; IsoId=Q9Y2H2-4; Sequence=VSP_046366, VSP_046367; Note=No experimental confirmation available.;
Biophysicochemical Properties Kinetic parameters: KM=14.3 uM for PtdIns(4,5)P2 (at pH 6.0) ;
Function Inositol 5-phosphatase which acts on phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Hydrolyzes phosphatidylinositol 4,5- bisphosphate most effectively. Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation.
Miscellaneous Inositol polyphosphate 5-phosphatases usually have 2 conserved motifs that are essential for 5-phosphatase activity. However, INPP5F does not contain such motifs, and phosphatase activity seems to exist in the SAC domain, suggesting a new type of phosphoinositide 5-phosphatase.
Sequence Caution Sequence=BAA76810.2; Type=Erroneous initiation; Evidence= ;
Similarity Contains 1 SAC domain. {ECO
Tissue Specificity Ubiquitous.

Identical and Related Proteins

Unique RefSeq proteins for LMP005534 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
7662414 RefSeq NP_055752 1132 phosphatidylinositide phosphatase SAC2 isoform 1
342307080 RefSeq NP_001230123 522 phosphatidylinositide phosphatase SAC2 isoform 2
342307082 RefSeq NP_001230124 219 phosphatidylinositide phosphatase SAC2 isoform 3

Identical Sequences to LMP005534 proteins

Reference Database Accession Length Protein Name
GI:7662414 DBBJ BAG11265.1 1132 inositol polyphosphate-5-phosphatase F, partial [synthetic construct]
GI:342307082 GenBank AAH52367.1 219 Inositol polyphosphate-5-phosphatase F [Homo sapiens]
GI:342307082 GenBank AAH82755.1 219 Inositol polyphosphate-5-phosphatase F [Homo sapiens]
GI:342307082 GenBank EAW49379.1 219 inositol polyphosphate-5-phosphatase F, isoform CRA_a [Homo sapiens]
GI:7662414 GenBank EAW49380.1 1132 inositol polyphosphate-5-phosphatase F, isoform CRA_b [Homo sapiens]
GI:7662414 GenBank EAW49381.1 1132 inositol polyphosphate-5-phosphatase F, isoform CRA_b [Homo sapiens]
GI:7662414 GenBank AHD70873.1 1132 Sequence 4341 from patent US 8586006
GI:7662414 SwissProt Q9Y2H2.3 1132 RecName: Full=Phosphatidylinositide phosphatase SAC2; AltName: Full=Inositol polyphosphate 5-phosphatase F; AltName: Full=Sac domain-containing inositol phosphatase 2; AltName: Full=Sac domain-containing phosphoinositide 5-phosphatase 2; Short=hSAC2 [Homo sapiens]

Related Sequences to LMP005534 proteins

Reference Database Accession Length Protein Name
GI:7662414 DBBJ BAA76810.2 1150 KIAA0966 protein, partial [Homo sapiens]
GI:342307082 DBBJ BAG11265.1 1132 inositol polyphosphate-5-phosphatase F, partial [synthetic construct]
GI:342307080 DBBJ BAG52363.1 522 unnamed protein product [Homo sapiens]
GI:7662414 GenBank AAI11494.1 1132 Inositol polyphosphate-5-phosphatase F [Homo sapiens]
GI:342307082 GenBank EAW49380.1 1132 inositol polyphosphate-5-phosphatase F, isoform CRA_b [Homo sapiens]
GI:342307082 GenBank EAW49381.1 1132 inositol polyphosphate-5-phosphatase F, isoform CRA_b [Homo sapiens]
GI:7662414 GenBank AED82297.1 1132 Sequence 1034 from patent US 7919467
GI:7662414 GenBank JAA09933.1 1133 inositol polyphosphate-5-phosphatase F [Pan troglodytes]
GI:7662414 GenBank JAA31645.1 1133 inositol polyphosphate-5-phosphatase F [Pan troglodytes]
GI:7662414 GenBank JAA38792.1 1133 inositol polyphosphate-5-phosphatase F [Pan troglodytes]
GI:342307080 GenBank JAA38796.1 523 inositol polyphosphate-5-phosphatase F [Pan troglodytes]
GI:342307082 GenBank AHD70873.1 1132 Sequence 4341 from patent US 8586006
GI:342307082 RefSeq NP_055752.1 1132 phosphatidylinositide phosphatase SAC2 isoform 1 [Homo sapiens]
GI:342307080 RefSeq NP_001124997.1 523 phosphatidylinositide phosphatase SAC2 [Pongo abelii]
GI:342307080 RefSeq XP_003312836.1 523 PREDICTED: phosphatidylinositide phosphatase SAC2 isoform X3 [Pan troglodytes]
GI:342307080 RefSeq XP_004050235.1 523 PREDICTED: phosphatidylinositide phosphatase SAC2-like [Gorilla gorilla gorilla]
GI:342307080 RefSeq XP_008949223.1 523 PREDICTED: phosphatidylinositide phosphatase SAC2 isoform X3 [Pan paniscus]
GI:342307082 SwissProt Q9Y2H2.3 1132 RecName: Full=Phosphatidylinositide phosphatase SAC2; AltName: Full=Inositol polyphosphate 5-phosphatase F; AltName: Full=Sac domain-containing inositol phosphatase 2; AltName: Full=Sac domain-containing phosphoinositide 5-phosphatase 2; Short=hSAC2 [Homo sapiens]