Gene/Proteome Database (LMPD)

LMPD ID
LMP005543
Gene ID
227095
Species
Mus musculus (Mouse)
Gene Name
3-hydroxyisobutyryl-Coenzyme A hydrolase
Gene Symbol
Hibch
Synonyms
2610509I15Rik; AI648812
Alternate Names
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; HIBYL-COA-H; HIB-CoA hydrolase
Chromosome
1
Map Location
1 C1.1|1
EC Number
3.1.2.4

Proteins

3-hydroxyisobutyryl-CoA hydrolase, mitochondrial precursor
Refseq ID NP_666220
Protein GI 22122625
UniProt ID Q8QZS1
mRNA ID NM_146108
Length 385
RefSeq Status PROVISIONAL
MGQPYAWRLLSRVSSFRRASVILQHLRMSMHTEAAEVLLERRGCGGVITLNRPKFLNALSLNMIRQIYPQLKTWEQDPDTFLIIIKGAGGKAFCAGGDIKALSEAKKARQNLTQDLFREEYILNNAIASCQKPYVALIDGITMGGGVGLSVHGQFRVATERSLFAMPETGIGLFPDVGGGYFLPRLQGKLGYFLALTGYRLKGRDVHRAGIATHFVDSEKLRVLEEELLALKSPSAEDVAGVLESYHAKSKMDQDKSIIFEEHMDKINSCFSANTVEQIIENLRQDGSPFAIEQMKVINKMSPTSLKITLRQLMEGSSKTLQEVLIMEYRITQACMEGHDFHEGVRAVLIDKDQTPKWKPANLKDVTDEDLNSYFKSLGSSDLKF
transit_peptide: 1..32 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (By similarity); propagated from UniProtKB/Swiss-Prot (Q8QZS1.1) calculated_mol_wt: 3817 peptide sequence: MGQPYAWRLLSRVSSFRRASVILQHLRMSMHT mat_peptide: 33..385 product: 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q8QZS1.1) calculated_mol_wt: 39239 peptide sequence: EAAEVLLERRGCGGVITLNRPKFLNALSLNMIRQIYPQLKTWEQDPDTFLIIIKGAGGKAFCAGGDIKALSEAKKARQNLTQDLFREEYILNNAIASCQKPYVALIDGITMGGGVGLSVHGQFRVATERSLFAMPETGIGLFPDVGGGYFLPRLQGKLGYFLALTGYRLKGRDVHRAGIATHFVDSEKLRVLEEELLALKSPSAEDVAGVLESYHAKSKMDQDKSIIFEEHMDKINSCFSANTVEQIIENLRQDGSPFAIEQMKVINKMSPTSLKITLRQLMEGSSKTLQEVLIMEYRITQACMEGHDFHEGVRAVLIDKDQTPKWKPANLKDVTDEDLNSYFKSLGSSDLKF

Gene Information

Entrez Gene ID
227095
Gene Name
3-hydroxyisobutyryl-Coenzyme A hydrolase
Gene Symbol
Hibch
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0005739 IDA:MGI C mitochondrion
GO:0003860 IEA:UniProtKB-EC F 3-hydroxyisobutyryl-CoA hydrolase activity
GO:0006574 IEA:UniProtKB-UniPathway P valine catabolic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu01200 Carbon metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
5892792 Branched-chain amino acid catabolism

Domain Information

InterPro Annotations

Accession Description
IPR029045 ClpP/crotonase-like domain
IPR014748 Crontonase, C-terminal

UniProt Annotations

Entry Information

Gene Name
3-hydroxyisobutyryl-Coenzyme A hydrolase
Protein Entry
HIBCH_MOUSE
UniProt ID
Q8QZS1
Species
Mouse

Comments

Comment Type Description
Catalytic Activity 3-hydroxy-2-methylpropanoyl-CoA + H(2)O = CoA + 3-hydroxy-2-methylpropanoate.
Function Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA (By similarity). {ECO:0000250}.
Pathway Amino-acid degradation; L-valine degradation.
Similarity Belongs to the enoyl-CoA hydratase/isomerase family. {ECO:0000305}.
Subcellular Location Mitochondrion {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP005543 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
22122625 RefSeq NP_666220 385 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial precursor

Identical Sequences to LMP005543 proteins

Reference Database Accession Length Protein Name
GI:22122625 DBBJ BAC36138.1 385 unnamed protein product [Mus musculus]
GI:22122625 GenBank AAH26437.1 385 3-hydroxyisobutyryl-Coenzyme A hydrolase [Mus musculus]
GI:22122625 SwissProt Q8QZS1.1 385 RecName: Full=3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; AltName: Full=3-hydroxyisobutyryl-coenzyme A hydrolase; Short=HIB-CoA hydrolase; Short=HIBYL-CoA-H; Flags: Precursor [Mus musculus]

Related Sequences to LMP005543 proteins

Reference Database Accession Length Protein Name
GI:22122625 GenBank EDK99981.1 386 3-hydroxyisobutyryl-Coenzyme A hydrolase, partial [Mus musculus]
GI:22122625 GenBank EDL99105.1 385 3-hydroxyisobutyryl-Coenzyme A hydrolase [Rattus norvegicus]
GI:22122625 RefSeq XP_006244957.1 385 PREDICTED: 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial isoform X1 [Rattus norvegicus]
GI:22122625 RefSeq XP_003514109.2 385 PREDICTED: 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial isoform X1 [Cricetulus griseus]
GI:22122625 RefSeq XP_007635559.1 385 PREDICTED: 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial isoform X2 [Cricetulus griseus]
GI:22122625 SwissProt Q5XIE6.2 385 RecName: Full=3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; AltName: Full=3-hydroxyisobutyryl-coenzyme A hydrolase; Short=HIB-CoA hydrolase; Short=HIBYL-CoA-H; Flags: Precursor [Rattus norvegicus]