Gene/Proteome Database (LMPD)

LMPD ID
LMP005578
Gene ID
17250
Species
Mus musculus (Mouse)
Gene Name
ATP-binding cassette, sub-family C (CFTR/MRP), member 1
Gene Symbol
Abcc1
Synonyms
Abcc1a; Abcc1b; MRP; Mdrap; Mrp1
Chromosome
16
Map Location
16 A1|16
Summary
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein plays an essential role in the defense against toxic compounds and serves as the major high-affinity transporter of leukotriene C4. The encoded protein may also play an essential role in steroid hormone homeostasis as a transporter for steroid hormones and their metabolites. [provided by RefSeq, Nov 2011]
Orthologs
View orthologs and multiple alignments for Abcc1

Proteins

multidrug resistance-associated protein 1
Refseq ID NP_032602
Protein GI 6678848
UniProt ID O35379
mRNA ID NM_008576
Length 1528
RefSeq Status REVIEWED
MALRSFCSADGSDPLWDWNVTWHTSNPDFTKCFQNTVLTWVPCFYLWSCFPLYFFYLSRHDRGYIQMTHLNKTKTALGFFLWIICWADLFYSFWERSQGVLRAPVLLVSPTLLGITMLLATFLIQLERRKGVQSSGIMLTFWLVALLCALAILRSKIISALKKDAHVDVFRDSTFYLYFTLVLVQLVLSCFSDCSPLFSETVHDRNPCPESSASFLSRITFWWITGMMVHGYRQPLESSDLWSLNKEDTSEEVVPVLVNNWKKECDKSRKQPVRIVYAPPKDPSKPKGSSQLDVNEEVEALIVKSPHKDREPSLFKVLYKTFGPYFLMSFLYKALHDLMMFAGPKILELIINFVNDREAPDWQGYFYTALLFVSACLQTLALHQYFHICFVSGMRIKTAVVGAVYRKALLITNAARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYFLWLSLGPSVLAGVAVMILMVPLNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFQDKVMSIRQEELKVLKKSAYLAAVGTFTWVCTPFLVALSTFAVFVTVDERNILDAKKAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRSIKSGEGNSITVKNATFTWARGEPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVTLKGSVAYVPQQAWIQNDSLRENILFGHPLQENYYKAVMEACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNSDIYLFDDPLSAVDAHVGKHIFEKVVGPMGLLKNKTRILVTHGISYLPQVDVIIVMSGGKISEMGSYQELLDRDGAFAEFLRTYANAEQDLASEDDSVSGSGKESKPVENGMLVTDTVGKHLQRHLSNSSSHSGDTSQQHSSIAELQKAGAKEETWKLMEADKAQTGQVQLSVYWNYMKAIGLFITFLSIFLFLCNHVSALASNYWLSLWTDDPPVVNGTQANRNFRLSVYGALGILQGAAIFGYSMAVSIGGIFASRRLHLDLLYNVLRSPMSFFERTPSGNLVNRFSKELDTVDSMIPQVIKMFMGSLFSVIGAVIIILLATPIAAVIIPPLGLVYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQITAYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSTWPHSGRVEFRDYCLRYREDLDLVLKHINVTIEGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGVNIAKIGLHNLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWMALELAHLKGFVSALPDKLNHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDNLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEVRECGAPSELLQQRGIFYSMAKDAGLV

Gene Information

Entrez Gene ID
17250
Gene Name
ATP-binding cassette, sub-family C (CFTR/MRP), member 1
Gene Symbol
Abcc1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0005887 IDA:MGI C integral component of plasma membrane
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0042626 IEA:InterPro F ATPase activity, coupled to transmembrane movement of substances

Domain Information

InterPro Annotations

Accession Description
IPR003593 AAA+ ATPase domain
IPR011527 ABC transporter type 1, transmembrane domain
IPR017871 ABC transporter, conserved site
IPR003439 ABC_transporter-like
IPR005292 Multi drug resistance-associated protein
IPR027417 P-loop containing nucleoside triphosphate hydrolase

UniProt Annotations

Entry Information

Gene Name
ATP-binding cassette, sub-family C (CFTR/MRP), member 1
Protein Entry
MRP1_MOUSE
UniProt ID
O35379
Species
Mouse

Comments

Comment Type Description
Similarity Belongs to the ABC transporter superfamily.
Similarity Contains ABC transmembrane type-1 domains.
Similarity Contains ABC transmembrane type-domains.

Identical and Related Proteins

Unique RefSeq proteins for LMP005578 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6678848 RefSeq NP_032602 1528 multidrug resistance-associated protein 1

Identical Sequences to LMP005578 proteins

Reference Database Accession Length Protein Name
GI:6678848 DBBJ BAC26654.1 1528 unnamed protein product [Mus musculus]
GI:6678848 GenBank AAE40250.1 1528 Sequence 6 from patent US 6001563
GI:6678848 GenBank ABE18307.1 1528 Sequence 88 from patent US 6989232
GI:6678848 GenBank AAH90617.1 1528 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 [Mus musculus]
GI:6678848 GenBank EDK97393.1 1528 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 [Mus musculus]
GI:6678848 SwissProt O35379.1 1528 RecName: Full=Multidrug resistance-associated protein 1; AltName: Full=ATP-binding cassette sub-family C member 1; AltName: Full=Leukotriene C(4) transporter; Short=LTC4 transporter [Mus musculus]

Related Sequences to LMP005578 proteins

Reference Database Accession Length Protein Name
GI:6678848 GenBank AAN86532.1 1532 multidrug resistance-associated protein 1 [Rattus norvegicus]
GI:6678848 GenBank AAO85437.1 1532 ATP-binding cassette protein C1 [Rattus norvegicus]
GI:6678848 RefSeq NP_071617.2 1532 multidrug resistance-associated protein 1 [Rattus norvegicus]
GI:6678848 RefSeq XP_006521902.1 1595 PREDICTED: multidrug resistance-associated protein 1 isoform X1 [Mus musculus]
GI:6678848 RefSeq XP_006983921.1 1527 PREDICTED: multidrug resistance-associated protein 1 isoform X1 [Peromyscus maniculatus bairdii]
GI:6678848 SwissProt Q8CG09.2 1532 RecName: Full=Multidrug resistance-associated protein 1; AltName: Full=ATP-binding cassette sub-family C member 1; AltName: Full=Leukotriene C(4) transporter; Short=LTC4 transporter [Rattus norvegicus]