Gene/Proteome Database (LMPD)

LMPD ID
LMP005582
Gene ID
433323
Species
Mus musculus (Mouse)
Gene Name
sphingosine-1-phosphate phosphotase 2
Gene Symbol
Sgpp2
Synonyms
SPPase2; Spp2
Alternate Names
sphingosine-1-phosphate phosphatase 2; sphingosine-1-phosphatase 2
Chromosome
1
Map Location
1 C4|1
EC Number
3.1.3.-

Proteins

sphingosine-1-phosphate phosphatase 2
Refseq ID NP_001004173
Protein GI 51921345
UniProt ID Q810K3
mRNA ID NM_001004173
Length 354
RefSeq Status VALIDATED
MAELLRSLRDSQLVARFQRRCGLFPAREASGEEHVVKNYFYYYLFRFSAALGQEVFYITFLPFTHWNIDPNLSRRLVVIWVLVMYIGQVAKDILKWPRPSFPPVVRLEKRIIAEYGMPSTHAMAATAISFTLLISTMDRYQYPFILGLMMAVVFSTLVCLSRLYTGMHTVLDILGGVLITAVLIALTYPAWTLIDSLDSASPLFPVCVIVVPFLLCYNYPVSDYYSPTRADTTTIVAAGAGVTLGFWINHFFQLVSKPTPSLPVIQNIPPLTTDMLVLGLTKFMVGIMLILLVRQLVQKLSLQVLFSWFKVVTRNKEARRRLEIEVPYKFVTYTSVGICATTFVPMLHRFLGLL

Gene Information

Entrez Gene ID
433323
Gene Name
sphingosine-1-phosphate phosphotase 2
Gene Symbol
Sgpp2
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0042392 IEA:Ensembl F sphingosine-1-phosphate phosphatase activity
GO:0006670 IEA:Ensembl P sphingosine metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ko00600 Sphingolipid metabolism
mmu00600 Sphingolipid metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
5893777 Sphingolipid de novo biosynthesis
5893778 Sphingolipid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase

UniProt Annotations

Entry Information

Gene Name
sphingosine-1-phosphate phosphotase 2
Protein Entry
SGPP2_MOUSE
UniProt ID
Q810K3
Species
Mouse

Comments

Comment Type Description
Developmental Stage Developmentally regulated. Expression during kidney development increases around 8 fold from E11.5 and adult. Highest expression is found in the ureteric bud. {ECO:0000269|PubMed:19073640}.
Function Has specific phosphohydrolase activity towards sphingoid base 1-phosphates. Has high phosphohydrolase activity against dihydrosphingosine-1-phosphate and sphingosine-1-phosphate (S1P) in vitro. May play a role in attenuating intracellular sphingosine 1-phosphate (S1P) signaling. May play a role in pro-inflammatory signaling (By similarity). {ECO:0000250}.
Similarity Belongs to the type 2 lipid phosphate phosphatase family. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP005582 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
51921345 RefSeq NP_001004173 354 sphingosine-1-phosphate phosphatase 2

Identical Sequences to LMP005582 proteins

Reference Database Accession Length Protein Name
GI:51921345 GenBank AAH49995.1 354 Sgpp2 protein [Mus musculus]
GI:51921345 GenBank AAI47844.1 354 Sphingosine-1-phosphate phosphotase 2 [Mus musculus]
GI:51921345 GenBank AAI47851.1 354 Sphingosine-1-phosphate phosphotase 2 [Mus musculus]
GI:51921345 RefSeq XP_006496568.1 354 PREDICTED: sphingosine-1-phosphate phosphatase 2 isoform X1 [Mus musculus]
GI:51921345 SwissProt Q810K3.1 354 RecName: Full=Sphingosine-1-phosphate phosphatase 2; Short=SPPase2; Short=Spp2; AltName: Full=Sphingosine-1-phosphatase 2 [Mus musculus]

Related Sequences to LMP005582 proteins

Reference Database Accession Length Protein Name
GI:51921345 GenBank ERE86545.1 382 sphingosine-1-phosphate phosphatase 2-like protein [Cricetulus griseus]
GI:51921345 RefSeq NP_001178740.1 354 sphingosine-1-phosphate phosphatase 2 [Rattus norvegicus]
GI:51921345 RefSeq XP_005361609.1 359 PREDICTED: sphingosine-1-phosphate phosphatase 2 [Microtus ochrogaster]
GI:51921345 RefSeq XP_005330593.1 354 PREDICTED: sphingosine-1-phosphate phosphatase 2 isoform X2 [Ictidomys tridecemlineatus]
GI:51921345 RefSeq XP_006972188.1 354 PREDICTED: sphingosine-1-phosphate phosphatase 2 [Peromyscus maniculatus bairdii]
GI:51921345 RefSeq XP_008824034.1 379 PREDICTED: sphingosine-1-phosphate phosphatase 2 [Nannospalax galili]