Gene/Proteome Database (LMPD)

LMPD ID
LMP005661
Gene ID
7994
Species
Homo sapiens (Human)
Gene Name
K(lysine) acetyltransferase 6A
Gene Symbol
KAT6A
Synonyms
MOZ; MYST3; RUNXBP2; ZC2HC6A; ZNF220
Chromosome
8
Map Location
8p11
EC Number
2.3.1.48

Proteins

histone acetyltransferase KAT6A
Refseq ID NP_001092882
Protein GI 150378463
UniProt ID Q92794
mRNA ID NM_001099412
Length 2004
RefSeq Status VALIDATED
MVKLANPLYTEWILEAIKKVKKQKQRPSEERICNAVSSSHGLDRKTVLEQLELSVKDGTILKVSNKGLNSYKDPDNPGRIALPKPRNHGKLDNKQNVDWNKLIKRAVEGLAESGGSTLKSIERFLKGQKDVSALFGGSAASGFHQQLRLAIKRAIGHGRLLKDGPLYRLNTKATNVDGKESCESLSCLPPVSLLPHEKDKPVAEPIPICSFCLGTKEQNREKKPEELISCADCGNSGHPSCLKFSPELTVRVKALRWQCIECKTCSSCRDQGKNADNMLFCDSCDRGFHMECCDPPLTRMPKGMWICQICRPRKKGRKLLQKKAAQIKRRYTNPIGRPKNRLKKQNTVSKGPFSKVRTGPGRGRKRKITLSSQSASSSSEEGYLERIDGLDFCRDSNVSLKFNKKTKGLIDGLTKFFTPSPDGRKARGEVVDYSEQYRIRKRGNRKSSTSDWPTDNQDGWDGKQENEERLFGSQEIMTEKDMELFRDIQEQALQKVGVTGPPDPQVRCPSVIEFGKYEIHTWYSSPYPQEYSRLPKLYLCEFCLKYMKSRTILQQHMKKCGWFHPPANEIYRKNNISVFEVDGNVSTIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVLTQNDVKGCHLVGYFSKEKHCQQKYNVSCIMILPQYQRKGYGRFLIDFSYLLSKREGQAGSPEKPLSDLGRLSYMAYWKSVILECLYHQNDKQISIKKLSKLTGICPQDITSTLHHLRMLDFRSDQFVIIRREKLIQDHMAKLQLNLRPVDVDPECLRWTPVIVSNSVVSEEEEEEAEEGENEEPQCQERELEISVGKSVSHENKEQDSYSVESEKKPEVMAPVSSTRLSKQVLPHDSLPANSQPSRRGRWGRKNRKTQERFGDKDSKLLLEETSSAPQEQYGECGEKSEATQEQYTESEEQLVASEEQPSQDGKPDLPKRRLSEGVEPWRGQLKKSPEALKCRLTEGSERLPRRYSEGDRAVLRGFSESSEEEEEPESPRSSSPPILTKPTLKRKKPFLHRRRRVRKRKHHNSSVVTETISETTEVLDEPFEDSDSERPMPRLEPTFEIDEEEEEEDENELFPREYFRRLSSQDVLRCQSSSKRKSKDEEEDEESDDADDTPILKPVSLLRKRDVKNSPLEPDTSTPLKKKKGWPKGKSRKPIHWKKRPGRKPGFKLSREIMPVSTQACVIEPIVSIPKAGRKPKIQESEETVEPKEDMPLPEERKEEEEMQAEAEEAEEGEEEDAASSEVPAASPADSSNSPETETKEPEVEEEEEKPRVSEEQRQSEEEQQELEEPEPEEEEDAAAETAQNDDHDADDEDDGHLESTKKKELEEQPTREDVKEEPGVQESFLDANMQKSREKIKDKEETELDSEEEQPSHDTSVVSEQMAGSEDDHEEDSHTKEELIELKEEEEIPHSELDLETVQAVQSLTQEESSEHEGAYQDCEETLAACQTLQSYTQADEDPQMSMVEDCHASEHNSPISSVQSHPSQSVRSVSSPNVPALESGYTQISPEQGSLSAPSMQNMETSPMMDVPSVSDHSQQVVDSGFSDLGSIESTTENYENPSSYDSTMGGSICGNSSSQSSCSYGGLSSSSSLTQSSCVVTQQMASMGSSCSMMQQSSVQPAANCSIKSPQSCVVERPPSNQQQQPPPPPPQQPQPPPPQPQPAPQPPPPQQQPQQQPQPQPQQPPPPPPPQQQPPLSQCSMNNSFTPAPMIMEIPESGSTGNISIYERIPGDFGAGSYSQPSATFSLAKLQQLTNTIMDPHAMPYSHSPAVTSYATSVSLSNTGLAQLAPSHPLAGTPQAQATMTPPPNLASTTMNLTSPLLQCNMSATNIGIPHTQRLQGQMPVKGHISIRSKSAPLPSAAAHQQQLYGRSPSAVAMQAGPRALAVQRGMNMGVNLMPTPAYNVNSMNMNTLNAMNSYRMTQPMMNSSYHSNPAYMNQTAQYPMQMQMGMMGSQAYTQQPMQPNPHGNMMYTGPSHHSYMNAAGVPKQSLNGPYMRR
histone acetyltransferase KAT6A
Refseq ID NP_001092883
Protein GI 150378543
UniProt ID Q92794
mRNA ID NM_001099413
Length 2004
RefSeq Status VALIDATED
Protein sequence is identical to GI:150378463 (mRNA isoform)
histone acetyltransferase KAT6A
Refseq ID NP_006757
Protein GI 150378493
UniProt ID Q92794
mRNA ID NM_006766
Length 2004
RefSeq Status VALIDATED
Protein sequence is identical to GI:150378463 (mRNA isoform)

Gene Information

Entrez Gene ID
7994
Gene Name
K(lysine) acetyltransferase 6A
Gene Symbol
KAT6A
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0000786 IEA:InterPro C nucleosome
GO:0005634 IEA:Ensembl C nucleus
GO:0003677 IEA:InterPro F DNA binding
GO:0003682 IEA:Ensembl F chromatin binding
GO:0004402 IEA:UniProtKB-EC F histone acetyltransferase activity
GO:0008270 IEA:InterPro F zinc ion binding
GO:0035909 IEA:Ensembl P aorta morphogenesis
GO:0035162 IEA:Ensembl P embryonic hemopoiesis
GO:0060325 IEA:Ensembl P face morphogenesis
GO:0003007 IEA:Ensembl P heart morphogenesis
GO:0043966 IEA:Ensembl P histone H3 acetylation
GO:0043433 IEA:Ensembl P negative regulation of sequence-specific DNA binding transcription factor activity
GO:0006334 IEA:InterPro P nucleosome assembly
GO:0035019 IEA:Ensembl P somatic stem cell maintenance

KEGG Pathway Links

KEGG Pathway ID Description
hsa04550 Signaling pathways regulating pluripotency of stem cells
ko04550 Signaling pathways regulating pluripotency of stem cells

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_172633 Chromatin modifying enzymes
REACT_172610 HATs acetylate histones

Domain Information

InterPro Annotations

Accession Description
IPR016181 Acyl-CoA N-acyltransferase
IPR005818 Linker histone H1/H5, domain H15
IPR002717 MOZ/SAS-like protein
IPR011991 Winged helix-turn-helix DNA-binding domain
IPR011011 Zinc finger, FYVE/PHD-type
IPR019787 Zinc finger, PHD-finger
IPR001965 Zinc finger, PHD-type
IPR001841 Zinc finger, RING-type
IPR013083 Zinc finger, RING/FYVE/PHD-type

UniProt Annotations

Entry Information

Gene Name
K(lysine) acetyltransferase 6A
Protein Entry
KAT6A_HUMAN
UniProt ID
Q92794
Species
Human

Comments

Comment Type Description
Catalytic Activity Acetyl-CoA + [histone] = CoA + acetyl- [histone].
Similarity Belongs to the MYST (SAS/MOZ) family.
Subcellular Location Nucleus .

Identical and Related Proteins

Unique RefSeq proteins for LMP005661 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
150378463 RefSeq NP_001092882 2004 histone acetyltransferase KAT6A

Identical Sequences to LMP005661 proteins

Reference Database Accession Length Protein Name
GI:150378463 DBBJ BAG72649.1 2004 MYST histone acetyltransferase (monocytic leukemia) 3, partial [synthetic construct]
GI:150378463 GenBank EAW63239.1 2004 MYST histone acetyltransferase (monocytic leukemia) 3, isoform CRA_a [Homo sapiens]
GI:150378463 GenBank AAI72379.1 2004 MYST histone acetyltransferase (monocytic leukemia) 3 [synthetic construct]
GI:150378463 RefSeq NP_006757.2 2004 histone acetyltransferase KAT6A [Homo sapiens]
GI:150378463 RefSeq NP_001092883.1 2004 histone acetyltransferase KAT6A [Homo sapiens]
GI:150378463 SwissProt Q92794.2 2004 RecName: Full=Histone acetyltransferase KAT6A; AltName: Full=MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3; Short=MYST-3; AltName: Full=Monocytic leukemia zinc finger protein; AltName: Full=Runt-related transcription factor-binding protein 2; AltName: Full=Zinc finger protein 220 [Homo sapiens]

Related Sequences to LMP005661 proteins

Reference Database Accession Length Protein Name
GI:150378463 GenBank EFJ32520.1 747 hypothetical protein SELMODRAFT_407465 [Selaginella moellendorffii]
GI:150378463 GenBank EGT50526.1 695 hypothetical protein CAEBREN_04973 [Caenorhabditis brenneri]
GI:150378463 RefSeq XP_002966493.1 747 hypothetical protein SELMODRAFT_407465 [Selaginella moellendorffii]
GI:150378463 RefSeq XP_003415192.1 634 PREDICTED: prelamin-A/C isoform 2 [Loxodonta africana]
GI:150378463 RefSeq XP_003512974.1 461 PREDICTED: histone acetyltransferase KAT5 isoform X5 [Cricetulus griseus]
GI:150378463 RefSeq XP_007608886.1 461 PREDICTED: histone acetyltransferase KAT5 isoform X5 [Cricetulus griseus]