Gene/Proteome Database (LMPD)
LMPD ID
LMP005682
Gene ID
Species
Homo sapiens (Human)
Gene Name
glycerophosphodiester phosphodiesterase domain containing 5
Gene Symbol
Synonyms
GDE2; PP1665
Alternate Names
glycerophosphodiester phosphodiesterase domain-containing protein 5; glycerophosphodiester phosphodiesterase 2
Chromosome
11
Map Location
11q13.4-q13.5
EC Number
3.1.-.-
Summary
Glycerophosphodiester phosphodiesterases (GDPDs; EC 3.1.4.46), such as GDPD5, are involved in glycerol metabolism (Lang et al., 2008 [PubMed 17578682]).[supplied by OMIM, Jan 2010]
Orthologs
Proteins
| glycerophosphodiester phosphodiesterase domain-containing protein 5 | |
|---|---|
| Refseq ID | NP_110419 |
| Protein GI | 189571657 |
| UniProt ID | Q8WTR4 |
| mRNA ID | NM_030792 |
| Length | 605 |
| RefSeq Status | VALIDATED |
| MVRHQPLQYYEPQLCLSCLTGIYGCRWKRYQRSHDDTTPWERLWFLLLTFTFGLTLTWLYFWWEVHNDYDEFNWYLYNRMGYWSDWPVPILVTTAAAFAYIAGLLVLALCHIAVGQQMNLHWLHKIGLVVILASTVVAMSAVAQLWEDEWEVLLISLQGTAPFLHVGAVAAVTMLSWIVAGQFARAERTSSQVTILCTFFTVVFALYLAPLTISSPCIMEKKDLGPKPALIGHRGAPMLAPEHTLMSFRKALEQKLYGLQADITISLDGVPFLMHDTTLRRTTNVEEEFPELARRPASMLNWTTLQRLNAGQWFLKTDPFWTASSLSPSDHREAQNQSICSLAELLELAKGNATLLLNLRDPPREHPYRSSFINVTLEAVLHSGFPQHQVMWLPSRQRPLVRKVAPGFQQTSGSKEAVASLRRGHIQRLNLRYTQVSRQELRDYASWNLSVNLYTVNAPWLFSLLWCAGVPSVTSDNSHALSQVPSPLWIMPPDEYCLMWVTADLVSFTLIVGIFVLQKWRLGGIRSYNPEQIMLSAAVRRTSRDVSIMKEKLIFSEISDGVEVSDVLSVCSDNSYDTYANSTATPVGPRGGGSHTKTLIERSGR | |
Gene Information
Entrez Gene ID
Gene Name
glycerophosphodiester phosphodiesterase domain containing 5
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0042995 | IEA:UniProtKB-KW | C | cell projection |
| GO:0005737 | IEA:UniProtKB-KW | C | cytoplasm |
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0008889 | IEA:InterPro | F | glycerophosphodiester phosphodiesterase activity |
| GO:0021895 | IEA:Ensembl | P | cerebral cortex neuron differentiation |
| GO:0006071 | IEA:InterPro | P | glycerol metabolic process |
| GO:0006629 | IEA:InterPro | P | lipid metabolic process |
| GO:0045746 | IEA:Ensembl | P | negative regulation of Notch signaling pathway |
| GO:0031175 | IEA:Ensembl | P | neuron projection development |
| GO:0045666 | IEA:Ensembl | P | positive regulation of neuron differentiation |
| GO:0048505 | IEA:Ensembl | P | regulation of timing of cell differentiation |
| GO:0021522 | IEA:Ensembl | P | spinal cord motor neuron differentiation |
Domain Information
UniProt Annotations
Entry Information
Gene Name
glycerophosphodiester phosphodiesterase domain containing 5
Protein Entry
GDPD5_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q8WTR4-1; Sequence=Displayed; Name=2; IsoId=Q8WTR4-2; Sequence=VSP_020816; Name=3; IsoId=Q8WTR4-3; Sequence=VSP_020815; Name=4; IsoId=Q8WTR4-4; Sequence=VSP_020814; Name=5; IsoId=Q8WTR4-5; Sequence=VSP_020813; |
| Function | Promotes neurite formation. Cooperates with PRDX1 to drive postmitotic motor neuron differentiation. The glycerophosphodiester phosphodiesterase activity may be required for its role in neuronal differentiation. May contribute to the osmotic regulation of cellular glycerophosphocholine. |
| Ptm | Intramolecular disulfide bond between Cys-25 and Cys-571 is reduced by PRDX1. |
| Sequence Caution | Sequence=AAP97686.1; Type=Erroneous initiation; Evidence= ; Sequence=BAC11242.1; Type=Erroneous initiation; Evidence= ; |
| Similarity | Belongs to the glycerophosphoryl diester phosphodiesterase family. |
| Similarity | Contains 1 GP-PDE domain. |
| Subcellular Location | Endomembrane system ; Multi- pass membrane protein . Cytoplasm, perinuclear region {ECO |
| Subunit | Interacts with PRDX1; forms a mixed-disulfide with PRDX1, leading to disrupt intramolecular disulfide bond between Cys-25 and Cys-571. |
Identical and Related Proteins
Unique RefSeq proteins for LMP005682 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 189571657 | RefSeq | NP_110419 | 605 | glycerophosphodiester phosphodiesterase domain-containing protein 5 |
Identical Sequences to LMP005682 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:189571657 | RefSeq | XP_006718760.1 | 605 | PREDICTED: glycerophosphodiester phosphodiesterase domain-containing protein 5 isoform X4 [Homo sapiens] |
| GI:189571657 | SwissProt | Q8WTR4.2 | 605 | RecName: Full=Glycerophosphodiester phosphodiesterase domain-containing protein 5; AltName: Full=Glycerophosphodiester phosphodiesterase 2 [Homo sapiens] |
Related Sequences to LMP005682 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:189571657 | EMBL | CAC37749.1 | 605 | unnamed protein product [Homo sapiens] |
| GI:189571657 | GenBank | AAL55858.1 | 605 | unknown [Homo sapiens] |
| GI:189571657 | GenBank | AAL55884.1 | 605 | unknown [Homo sapiens] |
| GI:189571657 | GenBank | EAW74967.1 | 605 | glycerophosphodiester phosphodiesterase domain containing 5, isoform CRA_a [Homo sapiens] |
| GI:189571657 | GenBank | EAW74969.1 | 605 | glycerophosphodiester phosphodiesterase domain containing 5, isoform CRA_a [Homo sapiens] |
| GI:189571657 | GenBank | EAW74970.1 | 605 | glycerophosphodiester phosphodiesterase domain containing 5, isoform CRA_a [Homo sapiens] |