Gene/Proteome Database (LMPD)
LMPD ID
LMP005727
Gene ID
Species
Homo sapiens (Human)
Gene Name
sphingosine-1-phosphate phosphatase 2
Gene Symbol
Synonyms
SPP2
Alternate Names
sphingosine-1-phosphate phosphatase 2; hSPP2; SPPase2; sphingosine-1-phosphatase 2; sphingosine-1-phosphate phosphotase 2; sphingosine 1-phosphate phosphohydrolase 2
Chromosome
2
Map Location
2q36.1
EC Number
3.1.3.-
Summary
Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite that regulates diverse biologic processes. SGPP2 catalyzes the degradation of S1P (Ogawa et al., 2003 [PubMed 12411432]).[supplied by OMIM, Jun 2009]
Orthologs
Proteins
| sphingosine-1-phosphate phosphatase 2 | |
|---|---|
| Refseq ID | NP_689599 |
| Protein GI | 23510289 |
| UniProt ID | Q8IWX5 |
| mRNA ID | NM_152386 |
| Length | 399 |
| RefSeq Status | PROVISIONAL |
| MAELLRSLQDSQLVARFQRRCGLFPAPDEGPRENGADPTERAARVPGVEHLPAANGKGGEAPANGLRRAAAPEAYVQKYVVKNYFYYYLFQFSAALGQEVFYITFLPFTHWNIDPYLSRRLIIIWVLVMYIGQVAKDVLKWPRPSSPPVVKLEKRLIAEYGMPSTHAMAATAIAFTLLISTMDRYQYPFVLGLVMAVVFSTLVCLSRLYTGMHTVLDVLGGVLITALLIVLTYPAWTFIDCLDSASPLFPVCVIVVPFFLCYNYPVSDYYSPTRADTTTILAAGAGVTIGFWINHFFQLVSKPAESLPVIQNIPPLTTYMLVLGLTKFAVGIVLILLVRQLVQNLSLQVLYSWFKVVTRNKEARRRLEIEVPYKFVTYTSVGICATTFVPMLHRFLGLP | |
Gene Information
Entrez Gene ID
Gene Name
sphingosine-1-phosphate phosphatase 2
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005783 | IDA:UniProtKB | C | endoplasmic reticulum |
| GO:0005789 | TAS:Reactome | C | endoplasmic reticulum membrane |
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0042392 | IDA:UniProtKB | F | sphingosine-1-phosphate phosphatase activity |
| GO:0016311 | IDA:GOC | P | dephosphorylation |
| GO:0044281 | TAS:Reactome | P | small molecule metabolic process |
| GO:0030148 | TAS:Reactome | P | sphingolipid biosynthetic process |
| GO:0006665 | TAS:Reactome | P | sphingolipid metabolic process |
| GO:0006670 | IDA:UniProtKB | P | sphingosine metabolic process |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| hsa00600 | Sphingolipid metabolism |
BIOCYC Pathway Links
| BIOCYC Pathway ID | Description |
|---|---|
| PWY3DJ-11470 | sphingosine and sphingosine-1-phosphate metabolism |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_115810 | Sphingolipid de novo biosynthesis |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR000326 | Phosphatidic acid phosphatase type 2/haloperoxidase |
UniProt Annotations
Entry Information
Gene Name
sphingosine-1-phosphate phosphatase 2
Protein Entry
SGPP2_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8IWX5-1; Sequence=Displayed; Name=2; IsoId=Q8IWX5-2; Sequence=VSP_039385; Note=No experimental confirmation available.; |
| Function | Has specific phosphohydrolase activity towards sphingoid base 1-phosphates. Has high phosphohydrolase activity against dihydrosphingosine-1-phosphate and sphingosine-1-phosphate (S1P) in vitro. May play a role in attenuating intracellular sphingosine 1-phosphate (S1P) signaling. May play a role in pro-inflammatory signaling. {ECO |
| Induction | Strongly induced by TNF, also induced by bacterial lipopolycaccharides (LPS) in neutrophils, endothelial cells, and other cell types. Not induced by growth-related factors. |
| Similarity | Belongs to the type 2 lipid phosphate phosphatase family. |
| Subcellular Location | Endoplasmic reticulum membrane ; Multi-pass membrane protein . |
| Tissue Specificity | Expressed strongly in kidney and heart, followed by brain, colon, small intestine and lung. Not detected in skeletal muscle, thymus, spleen, liver, placenta, and peripheral blood leukocytes. |
Identical and Related Proteins
Unique RefSeq proteins for LMP005727 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 23510289 | RefSeq | NP_689599 | 399 | sphingosine-1-phosphate phosphatase 2 |
Identical Sequences to LMP005727 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:23510289 | DBBJ | BAG36970.1 | 399 | unnamed protein product [Homo sapiens] |
| GI:23510289 | GenBank | AAN28731.1 | 399 | sphingosine 1-phosphate phosphohydrolase 2 [Homo sapiens] |
| GI:23510289 | GenBank | AAI34343.1 | 399 | Sphingosine-1-phosphate phosphotase 2 [Homo sapiens] |
| GI:23510289 | GenBank | AIC57671.1 | 399 | SGPP2, partial [synthetic construct] |
| GI:23510289 | SwissProt | Q8IWX5.1 | 399 | RecName: Full=Sphingosine-1-phosphate phosphatase 2; Short=SPPase2; Short=Spp2; Short=hSPP2; AltName: Full=Sphingosine-1-phosphatase 2 [Homo sapiens] |
Related Sequences to LMP005727 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:23510289 | GenBank | AAI06905.1 | 396 | SGPP2 protein, partial [Homo sapiens] |
| GI:23510289 | GenBank | AAI06906.1 | 396 | SGPP2 protein, partial [Homo sapiens] |
| GI:23510289 | RefSeq | XP_001107876.1 | 399 | PREDICTED: sphingosine-1-phosphate phosphatase 2 isoform 2 [Macaca mulatta] |
| GI:23510289 | RefSeq | XP_526109.2 | 399 | PREDICTED: sphingosine-1-phosphate phosphatase 2 [Pan troglodytes] |
| GI:23510289 | RefSeq | XP_004033321.1 | 393 | PREDICTED: sphingosine-1-phosphate phosphatase 2 [Gorilla gorilla gorilla] |
| GI:23510289 | RefSeq | XP_005574481.1 | 399 | PREDICTED: sphingosine-1-phosphate phosphatase 2 [Macaca fascicularis] |