Gene/Proteome Database (LMPD)
LMPD ID
LMP005729
Gene ID
Species
Mus musculus (Mouse)
Gene Name
formyl peptide receptor 1
Gene Symbol
Synonyms
FPR; LXA4R; fMLF-R
Alternate Names
fMet-Leu-Phe receptor; fMLP receptor; lipoxin A4 receptor; N-formyl peptide receptor; N-formylpeptide chemoattractant receptor
Chromosome
17
Map Location
17 A3.2|17 10.63 cM
Proteins
fMet-Leu-Phe receptor | |
---|---|
Refseq ID | NP_038549 |
Protein GI | 7305065 |
UniProt ID | P33766 |
mRNA ID | NM_013521 |
Length | 364 |
RefSeq Status | VALIDATED |
MDTNMSLLMNKSAVNLMNVSGSTQSVSAGYIVLDVFSYLIFAVTFVLGVLGNGLVIWVAGFRMKHTVTTISYLNLAIADFCFTSTLPFYIASMVMGGHWPFGWFMCKFIYTVIDINLFGSVFLIALIALDRCICVLHPVWAQNHRTVSLAKKVIIVPWICAFLLTLPVIIRLTTVPNSRLGPGKTACTFDFSPWTKDPVEKRKVAVTMLTVRGIIRFIIGFSTPMSIVAICYGLITTKIHRQGLIKSSRPLRVLSFVVAAFFLCWCPFQVVALISTIQVRERLKNMTPGIVTALKITSPLAFFNSCLNPMLYVFMGQDFRERLIHSLPASLERALTEDSAQTSDTGTNLGTNSTSLSENTLNAM |
Gene Information
Gene Ontology (GO Annotations)
GO ID | Source | Type | Description |
---|---|---|---|
GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
GO:0005886 | IEA:UniProtKB-KW | C | plasma membrane |
GO:0004982 | IDA:MGI | F | N-formyl peptide receptor activity |
GO:0007186 | IDA:MGI | P | G-protein coupled receptor signaling pathway |
GO:0006935 | TAS:MGI | P | chemotaxis |
GO:0007200 | IDA:MGI | P | phospholipase C-activating G-protein coupled receptor signaling pathway |
KEGG Pathway Links
Domain Information
UniProt Annotations
Entry Information
Comments
Comment Type | Description |
---|---|
Function | High affinity receptor for N-formyl-methionyl peptides (FMLP), which are powerful neutrophils chemotactic factors. Stimulate chemotaxis in immune cells to site of infection or tissue damage upon recognition of several ligands, such as FMLP, or ligand involved in cell damage, disease or inflammation. |
Ptm | Phosphorylated; which is necessary for desensitization. {ECO:0000250}. |
Similarity | Belongs to the G-protein coupled receptor 1 family. {ECO:0000255|PROSITE-ProRule:PRU00521}. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Tissue Specificity | Expressed in neutrophils, dendritic cells, microglia, spleen, lung and liver. Low level of expression in the vomeronasal organ. {ECO:0000269|PubMed:19497865}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP005729 (as displayed in Record Overview)
Protein GI | Database | Accession | Length | Protein Name |
---|---|---|---|---|
7305065 | RefSeq | NP_038549 | 364 | fMet-Leu-Phe receptor |
Identical Sequences to LMP005729 proteins
Reference | Database | Accession | Length | Protein Name |
---|---|---|---|---|
GI:7305065 | DBBJ | BAE23472.1 | 364 | unnamed protein product [Mus musculus] |
GI:7305065 | GenBank | AAI40413.1 | 364 | Formyl peptide receptor 1, partial [synthetic construct] |
GI:7305065 | GenBank | EDL20512.1 | 364 | mCG20436 [Mus musculus] |
GI:7305065 | GenBank | AAI48697.1 | 364 | Formyl peptide receptor 1 [synthetic construct] |
GI:7305065 | GenBank | ABS90809.1 | 364 | Sequence 10 from patent US 7198912 |
GI:7305065 | GenBank | ACJ96430.1 | 364 | Sequence 10 from patent US 7417121 |
Related Sequences to LMP005729 proteins
Reference | Database | Accession | Length | Protein Name |
---|---|---|---|---|
GI:7305065 | GenBank | EDL99792.1 | 355 | formyl peptide receptor 1 (predicted) [Rattus norvegicus] |
GI:7305065 | RefSeq | NP_001099686.1 | 355 | fMet-Leu-Phe receptor [Rattus norvegicus] |
GI:7305065 | RefSeq | XP_003514680.1 | 362 | PREDICTED: fMet-Leu-Phe receptor [Cricetulus griseus] |
GI:7305065 | RefSeq | XP_005086703.1 | 363 | PREDICTED: fMet-Leu-Phe receptor [Mesocricetus auratus] |
GI:7305065 | RefSeq | XP_006228050.1 | 355 | PREDICTED: fMet-Leu-Phe receptor isoform X1 [Rattus norvegicus] |
GI:7305065 | RefSeq | XP_006994301.1 | 363 | PREDICTED: fMet-Leu-Phe receptor [Peromyscus maniculatus bairdii] |