Gene/Proteome Database (LMPD)

LMPD ID
LMP005729
Gene ID
14293
Species
Mus musculus (Mouse)
Gene Name
formyl peptide receptor 1
Gene Symbol
Fpr1
Synonyms
FPR; LXA4R; fMLF-R
Alternate Names
fMet-Leu-Phe receptor; fMLP receptor; lipoxin A4 receptor; N-formyl peptide receptor; N-formylpeptide chemoattractant receptor
Chromosome
17
Map Location
17 A3.2|17 10.63 cM

Proteins

fMet-Leu-Phe receptor
Refseq ID NP_038549
Protein GI 7305065
UniProt ID P33766
mRNA ID NM_013521
Length 364
RefSeq Status VALIDATED
MDTNMSLLMNKSAVNLMNVSGSTQSVSAGYIVLDVFSYLIFAVTFVLGVLGNGLVIWVAGFRMKHTVTTISYLNLAIADFCFTSTLPFYIASMVMGGHWPFGWFMCKFIYTVIDINLFGSVFLIALIALDRCICVLHPVWAQNHRTVSLAKKVIIVPWICAFLLTLPVIIRLTTVPNSRLGPGKTACTFDFSPWTKDPVEKRKVAVTMLTVRGIIRFIIGFSTPMSIVAICYGLITTKIHRQGLIKSSRPLRVLSFVVAAFFLCWCPFQVVALISTIQVRERLKNMTPGIVTALKITSPLAFFNSCLNPMLYVFMGQDFRERLIHSLPASLERALTEDSAQTSDTGTNLGTNSTSLSENTLNAM

Gene Information

Entrez Gene ID
14293
Gene Name
formyl peptide receptor 1
Gene Symbol
Fpr1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005886 IEA:UniProtKB-KW C plasma membrane
GO:0004982 IDA:MGI F N-formyl peptide receptor activity
GO:0006935 TAS:MGI P chemotaxis
GO:0007186 IDA:MGI P G-protein coupled receptor signaling pathway
GO:0007200 IDA:MGI P phospholipase C-activating G-protein coupled receptor signaling pathway

KEGG Pathway Links

KEGG Pathway ID Description
mmu04015 Rap1 signaling pathway
mmu05150 Staphylococcus aureus infection

Domain Information

InterPro Annotations

Accession Description
IPR027345 Formyl peptide receptor 1
IPR000826 Formyl peptide receptor-related
IPR017452 GPCR, rhodopsin-like, 7TM
IPR000276 G protein-coupled receptor, rhodopsin-like

UniProt Annotations

Entry Information

Gene Name
formyl peptide receptor 1
Protein Entry
FPR1_MOUSE
UniProt ID
P33766
Species
Mouse

Comments

Comment Type Description
Function High affinity receptor for N-formyl-methionyl peptides (FMLP), which are powerful neutrophils chemotactic factors. Stimulate chemotaxis in immune cells to site of infection or tissue damage upon recognition of several ligands, such as FMLP, or ligand involved in cell damage, disease or inflammation.
Ptm Phosphorylated; which is necessary for desensitization. {ECO:0000250}.
Similarity Belongs to the G-protein coupled receptor 1 family. {ECO:0000255|PROSITE-ProRule:PRU00521}.
Subcellular Location Cell membrane; Multi-pass membrane protein.
Tissue Specificity Expressed in neutrophils, dendritic cells, microglia, spleen, lung and liver. Low level of expression in the vomeronasal organ. {ECO:0000269|PubMed:19497865}.

Identical and Related Proteins

Unique RefSeq proteins for LMP005729 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
7305065 RefSeq NP_038549 364 fMet-Leu-Phe receptor

Identical Sequences to LMP005729 proteins

Reference Database Accession Length Protein Name
GI:7305065 DBBJ BAE23472.1 364 unnamed protein product [Mus musculus]
GI:7305065 GenBank AAI40413.1 364 Formyl peptide receptor 1, partial [synthetic construct]
GI:7305065 GenBank EDL20512.1 364 mCG20436 [Mus musculus]
GI:7305065 GenBank AAI48697.1 364 Formyl peptide receptor 1 [synthetic construct]
GI:7305065 GenBank ABS90809.1 364 Sequence 10 from patent US 7198912
GI:7305065 GenBank ACJ96430.1 364 Sequence 10 from patent US 7417121

Related Sequences to LMP005729 proteins

Reference Database Accession Length Protein Name
GI:7305065 GenBank EDL99792.1 355 formyl peptide receptor 1 (predicted) [Rattus norvegicus]
GI:7305065 RefSeq NP_001099686.1 355 fMet-Leu-Phe receptor [Rattus norvegicus]
GI:7305065 RefSeq XP_003514680.1 362 PREDICTED: fMet-Leu-Phe receptor [Cricetulus griseus]
GI:7305065 RefSeq XP_005086703.1 363 PREDICTED: fMet-Leu-Phe receptor [Mesocricetus auratus]
GI:7305065 RefSeq XP_006228050.1 355 PREDICTED: fMet-Leu-Phe receptor isoform X1 [Rattus norvegicus]
GI:7305065 RefSeq XP_006994301.1 363 PREDICTED: fMet-Leu-Phe receptor [Peromyscus maniculatus bairdii]