Gene/Proteome Database (LMPD)
LMPD ID
LMP005756
Gene ID
Species
Homo sapiens (Human)
Gene Name
G protein-coupled receptor 68
Gene Symbol
Synonyms
GPR12A; OGR1
Alternate Names
ovarian cancer G-protein coupled receptor 1; G-protein coupled receptor 68; sphingosylphosphorylcholine receptor; ovarian cancer G protein-coupled receptor, 1
Chromosome
14
Map Location
14q31
Proteins
| ovarian cancer G-protein coupled receptor 1 | |
|---|---|
| Refseq ID | NP_003476 |
| Protein GI | 295054323 |
| UniProt ID | Q15743 |
| mRNA ID | NM_003485 |
| Length | 365 |
| RefSeq Status | VALIDATED |
| MGNITADNSSMSCTIDHTIHQTLAPVVYVTVLVVGFPANCLSLYFGYLQIKARNELGVYLCNLTVADLFYICSLPFWLQYVLQHDNWSHGDLSCQVCGILLYENIYISVGFLCCISVDRYLAVAHPFRFHQFRTLKAAVGVSVVIWAKELLTSIYFLMHEEVIEDENQHRVCFEHYPIQAWQRAINYYRFLVGFLFPICLLLASYQGILRAVRRSHGTQKSRKDQIQRLVLSTVVIFLACFLPYHVLLLVRSVWEASCDFAKGVFNAYHFSLLLTSFNCVADPVLYCFVSETTHRDLARLRGACLAFLTCSRTGRAREAYPLGAPEASGKSGAQGEEPELLTKLHPAFQTPNSPGSGGFPTGRLA | |
| ovarian cancer G-protein coupled receptor 1 | |
|---|---|
| Refseq ID | NP_001171147 |
| Protein GI | 295054325 |
| UniProt ID | Q15743 |
| mRNA ID | NM_001177676 |
| Length | 365 |
| RefSeq Status | VALIDATED |
| Protein sequence is identical to GI:295054323 (mRNA isoform) | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005887 | TAS:ProtInc | C | integral component of plasma membrane |
| GO:0005886 | TAS:Reactome | C | plasma membrane |
| GO:0004930 | TAS:ProtInc | F | G-protein coupled receptor activity |
| GO:0007186 | TAS:ProtInc | P | G-protein coupled receptor signaling pathway |
| GO:0071467 | IEA:Ensembl | P | cellular response to pH |
| GO:0006954 | TAS:ProtInc | P | inflammatory response |
| GO:0045656 | IEA:Ensembl | P | negative regulation of monocyte differentiation |
| GO:0035774 | IEA:Ensembl | P | positive regulation of insulin secretion involved in cellular response to glucose stimulus |
| GO:2001206 | IEA:Ensembl | P | positive regulation of osteoclast development |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_19184 | GPCR downstream signaling |
| REACT_21340 | GPCR ligand binding |
Domain Information
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Caution | Was originally (PubMed:10806476) thought to be a receptor for sphingosylphosphorylcholine (SPC). However, this work has been retracted (PubMed:16508674). {ECO |
| Function | Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca(2+) mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Function also as a metastasis suppressor gene in prostate cancer (By similarity). |
| Sequence Caution | Sequence=AAH96071.1; Type=Erroneous initiation; Evidence= ; Sequence=AAH96072.1; Type=Erroneous initiation; Evidence= ; Sequence=AAH96073.1; Type=Erroneous initiation; Evidence= ; Sequence=AAH96074.1; Type=Erroneous initiation; Evidence= ; Sequence=AAH98567.1; Type=Erroneous initiation; Evidence= ; Sequence=AAT38917.1; Type=Erroneous initiation; Evidence= ; Sequence=ACG60649.1; Type=Erroneous initiation; Evidence= ; Sequence=EAW81447.1; Type=Erroneous initiation; Evidence= ; |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Subcellular Location | Cell membrane; Multi-pass membrane protein. |
| Tissue Specificity | Found at low level in a wide range of tissues, but significantly expressed in lung, kidney, bone and nervous system. |
| Web Resource | Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/GPR68ID40745ch14q32.html"; |
Identical and Related Proteins
Unique RefSeq proteins for LMP005756 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 295054323 | RefSeq | NP_003476 | 365 | ovarian cancer G-protein coupled receptor 1 |
Identical Sequences to LMP005756 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:295054323 | GenBank | AAH67472.1 | 365 | GPR68 protein, partial [Homo sapiens] |
| GI:295054323 | GenBank | AAH69592.1 | 365 | GPR68 protein [Homo sapiens] |
| GI:295054323 | GenBank | ABA17146.1 | 365 | Sequence 6 from patent US 6919176 |
| GI:295054323 | GenBank | ACH30153.1 | 365 | Sequence 118 from patent US 7410777 |
| GI:295054323 | GenBank | ADQ31978.1 | 365 | G protein-coupled receptor 68, partial [synthetic construct] |
| GI:295054323 | RefSeq | NP_001171147.1 | 365 | ovarian cancer G-protein coupled receptor 1 [Homo sapiens] |
Related Sequences to LMP005756 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:295054323 | GenBank | AAE25349.1 | 531 | Sequence 2 from patent US 5912335 |
| GI:295054323 | RefSeq | XP_005268167.1 | 375 | PREDICTED: ovarian cancer G-protein coupled receptor 1 isoform X1 [Homo sapiens] |
| GI:295054323 | RefSeq | XP_005268168.1 | 375 | PREDICTED: ovarian cancer G-protein coupled receptor 1 isoform X2 [Homo sapiens] |
| GI:295054323 | RefSeq | XP_005268169.1 | 375 | PREDICTED: ovarian cancer G-protein coupled receptor 1 isoform X3 [Homo sapiens] |
| GI:295054323 | RefSeq | XP_006720325.1 | 375 | PREDICTED: ovarian cancer G-protein coupled receptor 1 isoform X4 [Homo sapiens] |
| GI:295054323 | RefSeq | XP_006720326.1 | 375 | PREDICTED: ovarian cancer G-protein coupled receptor 1 isoform X5 [Homo sapiens] |