Gene/Proteome Database (LMPD)

LMPD ID
LMP005760
Gene ID
23180
Species
Homo sapiens (Human)
Gene Name
raftlin, lipid raft linker 1
Gene Symbol
RFTN1
Synonyms
PIB10; PIG9; RAFTLIN
Alternate Names
raftlin; raft-linking protein; proliferation-inducing protein 9; proliferation-inducing protein 10; cell migration-inducing gene 2 protein
Chromosome
3
Map Location
3p24.3

Proteins

raftlin
Refseq ID NP_055965
Protein GI 41872577
UniProt ID Q14699
mRNA ID NM_015150
Length 578
RefSeq Status VALIDATED
MGCGLNKLEKRDEKRPGNIYSTLKRPQVETKIDVSYEYRFLEFTTLSAAELPGSSAVRLASLRDLPAQLLELYQQGFSLAALHPFVQPTHEREKTPLEHIFRAILIKKTDRSQKTDLHNEGYILELDCCSSLDHPTDQKLIPEFIKKIQEAASQGLKFVGVIPQYHSSVNSAGSSAPVSTANSTEDARDAKNARGDHASLENEKPGTGDVCSAPAGRNQSPEPSSGPRGEVPLAKQPSSPSGEGDGGELSPQGVSKTLDGPESNPLEVHEEPLSGKMEIFTLFNKPKSHQKCRQYYPVTIPLHVSKNGQTVSGLDANWLEHMSDHFRKGGMLVNAVFYLGIVNDSLHGLTDGVFIFEAVSTEDSKTIQGYDAIVVEQWTVLEGVEVQTDYVPLLNSLAAYGWQLTCVLPTPVVKTTSEGSVSTKQIVFLQRPCLPQKIKKKESKFQWRFSREEMHNRQMRKSKGKLSARDKQQAEENEKNLEDQSSKAGDMGNCVSGQQQEGGVSEEMKGPVQEDKGEQLSPGGLLCGVGVEGEAVQNGPASHSRALVGICTGHSNPGEDARDGDAEEVRELGTVEEN

Gene Information

Entrez Gene ID
23180
Gene Name
raftlin, lipid raft linker 1
Gene Symbol
RFTN1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IDA:MGI C cytoplasm
GO:0005768 IDA:MGI C endosome
GO:0070062 IDA:UniProt C extracellular vesicular exosome
GO:0045121 IDA:UniProt C membrane raft
GO:0005886 IDA:UniProt C plasma membrane
GO:0043234 IDA:MGI C protein complex
GO:0003725 IDA:MGI F double-stranded RNA binding
GO:0050853 IMP:UniProt P B cell receptor signaling pathway
GO:0033227 IMP:MGI P dsRNA transport
GO:0040007 IMP:UniProt P growth
GO:0032620 ISS:UniProt P interleukin-17 production
GO:0001765 IMP:UniProt P membrane raft assembly
GO:1903044 ISS:UniProt P protein localization to membrane raft
GO:0032596 ISS:UniProt P protein transport into membrane raft
GO:0043330 IMP:MGI P response to exogenous dsRNA
GO:0002457 ISS:UniProt P T cell antigen processing and presentation
GO:0050852 ISS:UniProt P T cell receptor signaling pathway
GO:0034138 IMP:MGI P toll-like receptor 3 signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR028169 Raftlin family

UniProt Annotations

Entry Information

Gene Name
raftlin, lipid raft linker 1
Protein Entry
RFTN1_HUMAN
UniProt ID
Q14699
Species
Human

Comments

Comment Type Description
Function May play a pivotal role in the formation and/or maintenance of lipid rafts. May regulate B-cell antigen receptor- mediated signaling.
Sequence Caution Sequence=AAH51336.1; Type=Erroneous initiation; Evidence= ; Sequence=AAH69209.1; Type=Erroneous initiation; Evidence= ; Sequence=BAA07644.1; Type=Erroneous initiation; Evidence= ;
Similarity Belongs to the raftlin family.
Subcellular Location Cell membrane ; Lipid-anchor . Note=Associates with lipid rafts.
Tissue Specificity Specifically expressed by B-cells (at protein level).

Identical and Related Proteins

Unique RefSeq proteins for LMP005760 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
41872577 RefSeq NP_055965 578 raftlin

Identical Sequences to LMP005760 proteins

Reference Database Accession Length Protein Name
GI:41872577 DBBJ BAG09597.1 578 raftlin, partial [synthetic construct]
GI:41872577 GenBank AHD73366.1 578 Sequence 10434 from patent US 8586006
GI:41872577 GenBank AIC50920.1 578 RFTN1, partial [synthetic construct]
GI:41872577 RefSeq XP_005265042.1 578 PREDICTED: raftlin isoform X1 [Homo sapiens]
GI:41872577 RefSeq XP_005265043.1 578 PREDICTED: raftlin isoform X2 [Homo sapiens]
GI:41872577 RefSeq XP_006713132.1 578 PREDICTED: raftlin isoform X5 [Homo sapiens]

Related Sequences to LMP005760 proteins

Reference Database Accession Length Protein Name
GI:41872577 DBBJ BAA07644.1 648 KIAA0084, partial [Homo sapiens]
GI:41872577 DBBJ BAG65235.1 792 unnamed protein product [Homo sapiens]
GI:41872577 GenBank AAH51336.1 597 Raftlin, lipid raft linker 1, partial [Homo sapiens]
GI:41872577 GenBank AAO91814.1 578 cell migration-inducing gene 2 [Homo sapiens]
GI:41872577 GenBank AAH69209.1 597 Raftlin, lipid raft linker 1, partial [Homo sapiens]
GI:41872577 GenBank AAH98270.2 578 Raftlin, lipid raft linker 1 [Homo sapiens]