Gene/Proteome Database (LMPD)

LMPD ID
LMP005837
Gene ID
52064
Species
Mus musculus (Mouse)
Gene Name
coenzyme Q5 homolog, methyltransferase (yeast)
Gene Symbol
Coq5
Synonyms
1810014G04Rik; D5Ertd33e
Alternate Names
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; ubiquinone biosynthesis methyltransferase COQ5, mitochondrial
Chromosome
5
Map Location
5 F|5 56.03 cM
EC Number
2.1.1.201

Proteins

2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial precursor
Refseq ID NP_080780
Protein GI 13385992
UniProt ID Q9CXI0
mRNA ID NM_026504
Length 327
RefSeq Status PROVISIONAL
MAAPRCCVLWRVCGRGWWRATGHCRLPGCHRSWPWATLGTRSLSQEKRAAETHFGFETVSEGEKGSKVYQVFENVAKKYDLMNDMMSLGIHRAWKDLLIRKMHPLPGTQLLDMAGGTGDIAFRFLSYVQAQHQRRQRRQLRTQQNLSWEEIAKKYQNEEDSLGGSLATVCDINREMLKVGKQKALDQGHTAGLAWVLGDAEELPFDDDSFDVYTIAFGIRNVTHIDQALQEAHRVLKPGGRFLCLEFGQVNDPLISRLYDLYSFQVIPVIGEVIAGDWKSYQYLVESIRKFPNQEDFKDMIEDAGFQRVTYENLTTGIVAIHSGFKL
transit_peptide: 1..49 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (Potential); propagated from UniProtKB/Swiss-Prot (Q9CXI0.2) calculated_mol_wt: 5653 peptide sequence: MAAPRCCVLWRVCGRGWWRATGHCRLPGCHRSWPWATLGTRSLSQEKRA mat_peptide: 50..327 product: 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q9CXI0.2) calculated_mol_wt: 31701 peptide sequence: AETHFGFETVSEGEKGSKVYQVFENVAKKYDLMNDMMSLGIHRAWKDLLIRKMHPLPGTQLLDMAGGTGDIAFRFLSYVQAQHQRRQRRQLRTQQNLSWEEIAKKYQNEEDSLGGSLATVCDINREMLKVGKQKALDQGHTAGLAWVLGDAEELPFDDDSFDVYTIAFGIRNVTHIDQALQEAHRVLKPGGRFLCLEFGQVNDPLISRLYDLYSFQVIPVIGEVIAGDWKSYQYLVESIRKFPNQEDFKDMIEDAGFQRVTYENLTTGIVAIHSGFKL

Gene Information

Entrez Gene ID
52064
Gene Name
coenzyme Q5 homolog, methyltransferase (yeast)
Gene Symbol
Coq5
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005739 IDA:MGI C mitochondrion
GO:0008168 IEA:UniProtKB-KW F methyltransferase activity
GO:0006744 IEA:UniProtKB-UniPathway P ubiquinone biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu01100 Metabolic pathways
mmu00130 Ubiquinone and other terpenoid-quinone biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
5894069 Ubiquinol biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase
IPR004033 UbiE/COQ5 methyltransferase
IPR023576 UbiE/COQ5 methyltransferase, conserved site

UniProt Annotations

Entry Information

Gene Name
coenzyme Q5 homolog, methyltransferase (yeast)
Protein Entry
COQ5_MOUSE
UniProt ID
Q9CXI0
Species
Mouse

Comments

Comment Type Description
Catalytic Activity S-adenosyl-L-methionine + 2-methoxy-6-all- trans-polyprenyl-1,4-benzoquinol = S-adenosyl-L-homocysteine + 6- methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol.
Function Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). {ECO:0000250}.
Pathway Cofactor biosynthesis; ubiquinone biosynthesis.
Sequence Caution Sequence=BAB26525.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};
Similarity Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiE family. {ECO:0000305}.
Subcellular Location Mitochondrion {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP005837 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
13385992 RefSeq NP_080780 327 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial precursor

Identical Sequences to LMP005837 proteins

Reference Database Accession Length Protein Name
GI:13385992 DBBJ BAB25069.1 327 unnamed protein product [Mus musculus]
GI:13385992 DBBJ BAC32564.1 327 unnamed protein product [Mus musculus]
GI:13385992 DBBJ BAC34194.1 327 unnamed protein product [Mus musculus]
GI:13385992 GenBank AAH52345.1 327 Coenzyme Q5 homolog, methyltransferase (yeast) [Mus musculus]
GI:13385992 GenBank EDL19869.1 327 coenzyme Q5 homolog, methyltransferase (yeast) [Mus musculus]
GI:13385992 SwissProt Q9CXI0.2 327 RecName: Full=2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; AltName: Full=Ubiquinone biosynthesis methyltransferase COQ5; Flags: Precursor [Mus musculus]

Related Sequences to LMP005837 proteins

Reference Database Accession Length Protein Name
GI:13385992 DBBJ BAB26525.1 298 unnamed protein product [Mus musculus]
GI:13385992 DBBJ BAB29289.1 327 unnamed protein product [Mus musculus]
GI:13385992 GenBank EGW10589.1 327 Ubiquinone biosynthesis methyltransferase COQ5, mitochondrial [Cricetulus griseus]
GI:13385992 RefSeq XP_003503565.1 327 PREDICTED: 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial isoform X1 [Cricetulus griseus]
GI:13385992 RefSeq XP_005079029.1 327 PREDICTED: 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial [Mesocricetus auratus]
GI:13385992 RefSeq XP_005344360.1 327 PREDICTED: 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial [Microtus ochrogaster]