Gene/Proteome Database (LMPD)

LMPD ID
LMP005842
Gene ID
217837
Species
Mus musculus (Mouse)
Gene Name
inositol 1,3,4-triphosphate 5/6 kinase
Gene Symbol
Itpk1
Synonyms
BC031182
Alternate Names
inositol-tetrakisphosphate 1-kinase; ins(1,3,4)P(3) 5/6-kinase; inositol-triphosphate 5/6-kinase; inositol 1,3,4-trisphosphate 5/6-kinase
Chromosome
12
Map Location
12 E|12
EC Number
2.7.1.134

Proteins

inositol-tetrakisphosphate 1-kinase
Refseq ID NP_766172
Protein GI 29789389
UniProt ID Q8BYN3
mRNA ID NM_172584
Length 419
RefSeq Status PROVISIONAL
MQTFLKGKRVGYWLSEKKVKKLNFQAFAELCRKRGIEVVQLNLSRPIEEQGPLDVIIHKLTDVILEADQNDSQSLELVHRFQEYIDAHPETIVLDPLPAIRTLLDRSKSYELIRKIEAYMKDDRICSPPFMELTSLCGEDTMRLLEQNGLAFPFICKTRVAHGTNSHEMAIVFNQEGLNAIQPPCVVQNFINHNAVLYKVFVVGESYTVVQRPSLKNFSAGTSDRESIFFNSHNVSKPESSSVLTELDKIEGVFERPSDEVIRELSRALRQALGVSLFGIDIIINNQTGQHAVIDVNAFPGYEGVSEFFTDLLNHIATVLQGQSTGGAATEEVAPLRHNRLLAEPAGSLAGERTCSASPGCCGSMKGQDTPWKTETEAGNMGAGASAKLPHQRLGCTTGVSPSFQQHCVASLATKASSQ

Gene Information

Entrez Gene ID
217837
Gene Name
inositol 1,3,4-triphosphate 5/6 kinase
Gene Symbol
Itpk1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005622 IEA:InterPro C intracellular
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0016787 IEA:UniProtKB-KW F hydrolase activity
GO:0047325 IEA:UniProtKB-EC F inositol tetrakisphosphate 1-kinase activity
GO:0052726 IEA:UniProtKB-EC F inositol-1,3,4-trisphosphate 5-kinase activity
GO:0052725 IEA:UniProtKB-EC F inositol-1,3,4-trisphosphate 6-kinase activity
GO:0016853 IEA:UniProtKB-KW F isomerase activity
GO:0000287 IEA:InterPro F magnesium ion binding
GO:0032957 IEA:InterPro P inositol trisphosphate metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu00562 Inositol phosphate metabolism
mmu01100 Metabolic pathways

REACTOME Pathway Links

REACTOME Pathway ID Description
5894025 Synthesis of IP3 and IP4 in the cytosol
5894029 Synthesis of pyrophosphates in the cytosol

Domain Information

InterPro Annotations

Accession Description
IPR011761 ATP-grasp fold
IPR008656 Inositol-tetrakisphosphate 1-kinase

UniProt Annotations

Entry Information

Gene Name
inositol 1,3,4-triphosphate 5/6 kinase
Protein Entry
ITPK1_MOUSE
UniProt ID
Q8BYN3
Species
Mouse

Comments

Comment Type Description
Catalytic Activity ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate.
Catalytic Activity ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate.
Catalytic Activity ATP + 1D-myo-inositol 3,4,5,6- tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6- pentakisphosphate.
Cofactor Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Note=Binds 2 magnesium ions per subunit. {ECO:0000250};
Function Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Also acts as an inositol polyphosphate phosphatase that dephosphorylate Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 to Ins(1,3,4)P3, and Ins(1,3,4,5,6)P5 to Ins(3,4,5,6)P4. May also act as an isomerase that interconverts the inositol tetrakisphosphate isomers Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP and magnesium. Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain (By similarity). {ECO:0000250}.
Ptm Acetylation by EP300 and CREBBP destabilizes ITPK1, and down- regulates enzymatic activity. Deacetylated by SIRT1 (By similarity). {ECO:0000250}.
Similarity Belongs to the ITPK1 family. {ECO:0000305}.
Similarity Contains 1 ATP-grasp domain. {ECO:0000255|PROSITE- ProRule:PRU00409}.
Subunit Monomer. Interacts with GPS1/COPS1 (By similarity). {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP005842 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
29789389 RefSeq NP_766172 419 inositol-tetrakisphosphate 1-kinase

Identical Sequences to LMP005842 proteins

Reference Database Accession Length Protein Name
GI:29789389 DBBJ BAC30166.1 419 unnamed protein product [Mus musculus]
GI:29789389 GenBank AAH56464.1 419 Inositol 1,3,4-triphosphate 5/6 kinase [Mus musculus]
GI:29789389 SwissProt Q8BYN3.1 419 RecName: Full=Inositol-tetrakisphosphate 1-kinase; AltName: Full=Inositol 1,3,4-trisphosphate 5/6-kinase; Short=Inositol-triphosphate 5/6-kinase; Short=Ins(1,3,4)P(3) 5/6-kinase [Mus musculus]

Related Sequences to LMP005842 proteins

Reference Database Accession Length Protein Name
GI:29789389 GenBank EDL18855.1 409 inositol 1,3,4-triphosphate 5/6 kinase, isoform CRA_a [Mus musculus]
GI:29789389 RefSeq NP_001178914.1 421 inositol-tetrakisphosphate 1-kinase [Rattus norvegicus]
GI:29789389 RefSeq XP_005068442.1 419 PREDICTED: inositol-tetrakisphosphate 1-kinase [Mesocricetus auratus]
GI:29789389 RefSeq XP_005343536.1 419 PREDICTED: inositol-tetrakisphosphate 1-kinase [Microtus ochrogaster]
GI:29789389 RefSeq XP_006990956.1 419 PREDICTED: inositol-tetrakisphosphate 1-kinase [Peromyscus maniculatus bairdii]
GI:29789389 RefSeq XP_008819938.1 422 PREDICTED: inositol-tetrakisphosphate 1-kinase isoform X2 [Nannospalax galili]