Gene/Proteome Database (LMPD)

LMPD ID
LMP005881
Gene ID
2686
Species
Homo sapiens (Human)
Gene Name
gamma-glutamyltransferase 7
Gene Symbol
GGT7
Synonyms
D20S101; GGT4; GGTL3; GGTL5; dJ18C9.2
Chromosome
20
Map Location
20q11.22
Summary
This gene is a member of a gene family that encodes enzymes involved in both the metabolism of glutathione and in the transpeptidation of amino acids. Changes in the activity of gamma-glutamyltransferase may signal preneoplastic or toxic conditions in the liver or kidney. The protein encoded by this gene consists of a heavy and a light chain, and it can interact with CT120, a plasma membrane-associated protein that is possibly involved in lung carcinogenesis. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for GGT7

Proteins

gamma-glutamyltransferase 7
Refseq ID NP_821158
Protein GI 109148539
UniProt ID Q9UJ14
mRNA ID NM_178026
Length 662
RefSeq Status REVIEWED
MAAENEASQESALGAYSPVDYMSITSFPRLPEDEPAPAAPLRGRKDEDAFLGDPDTDPDSFLKSARLQRLPSSSSEMGSQDGSPLRETRKDPFSAAAAECSCRQDGLTVIVTACLTFATGVTVALVMQIYFGDPQIFQQGAVVTDAARCTSLGIEVLSKQGSSVDAAVAAALCLGIVAPHSSGLGGGGVMLVHDIRRNESHLIDFRESAPGALREETLQRSWETKPGLLVGVPGMVKGLHEAHQLYGRLPWSQVLAFAAAVAQDGFNVTHDLARALAEQLPPNMSERFRETFLPSGRPPLPGSLLHRPDLAEVLDVLGTSGPAAFYAGGNLTLEMVAEAQHAGGVITEEDFSNYSALVEKPVCGVYRGHLVLSPPPPHTGPALISALNILEGFNLTSLVSREQALHWVAETLKIALALASRLGDPVYDSTITESMDDMLSKVEAAYLRGHINDSQAAPAPLLPVYELDGAPTAAQVLIMGPDDFIVAMVSSLNQPFGSGLITPSGILLNSQMLDFSWPNRTANHSAPSLENSVQPGKRPLSFLLPTVVRPAEGLCGTYLALGANGAARGLSGLTQVLLNVLTLNRNLSDSLARGRLHPDLQSNLLQVDSEFTEEEIEFLEARGHHVEKVDVLSWVHGSRRTNNFIIAVKDPRSPDAAGATIL

Gene Information

Entrez Gene ID
2686
Gene Name
gamma-glutamyltransferase 7
Gene Symbol
GGT7
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0003840 IEA:InterPro F gamma-glutamyltransferase activity
GO:0006749 IEA:InterPro P glutathione metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa00460 Cyanoamino acid metabolism
hsa00480 Glutathione metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_228214 Aflatoxin activation and detoxification
REACT_6960 Glutathione synthesis and recycling

Domain Information

InterPro Annotations

Accession Description
IPR000101 Gamma-glutamyltranspeptidase
IPR029055 Nucleophile aminohydrolases, N-terminal

UniProt Annotations

Entry Information

Gene Name
gamma-glutamyltransferase 7
Protein Entry
GGT7_HUMAN
UniProt ID
Q9UJ14
Species
Human

Identical and Related Proteins

Unique RefSeq proteins for LMP005881 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
109148539 RefSeq NP_821158 662 gamma-glutamyltransferase 7

Identical Sequences to LMP005881 proteins

Reference Database Accession Length Protein Name
GI:109148539 EMBL CAD38482.1 662 unnamed protein product [Homo sapiens]
GI:109148539 GenBank EAW76250.1 662 gamma-glutamyltransferase-like 3, isoform CRA_b [Homo sapiens]
GI:109148539 GenBank ACN05176.1 662 Sequence 11 from patent US 7485308
GI:109148539 GenBank JAA22992.1 662 gamma-glutamyltransferase 7 [Pan troglodytes]
GI:109148539 GenBank JAA33415.1 662 gamma-glutamyltransferase 7 [Pan troglodytes]
GI:109148539 SwissProt Q9UJ14.2 662 RecName: Full=Gamma-glutamyltransferase 7; Short=GGT 7; AltName: Full=Gamma-glutamyltransferase-like 3; AltName: Full=Gamma-glutamyltransferase-like 5; AltName: Full=Gamma-glutamyltranspeptidase 7; AltName: Full=Glutathione hydrolase 7; Contains: RecName: Full=Gamma-glutamyltransferase 7 heavy chain; Contains: RecName: Full=Gamma-glutamyltransferase 7 light chain; Flags: Precursor [Homo sapiens]

Related Sequences to LMP005881 proteins

Reference Database Accession Length Protein Name
GI:109148539 GenBank EAW76252.1 666 gamma-glutamyltransferase-like 3, isoform CRA_d [Homo sapiens]
GI:109148539 GenBank JAA20323.1 662 gamma-glutamyltransferase 7 [Pan troglodytes]
GI:109148539 GenBank AIC54449.1 662 GGT7, partial [synthetic construct]
GI:109148539 RefSeq XP_003904868.1 662 PREDICTED: gamma-glutamyltransferase 7 isoform X1 [Papio anubis]
GI:109148539 RefSeq XP_004062091.1 662 PREDICTED: gamma-glutamyltransferase 7 [Gorilla gorilla gorilla]
GI:109148539 RefSeq XP_008019719.1 662 PREDICTED: gamma-glutamyltransferase 7 isoform X1 [Chlorocebus sabaeus]