Gene/Proteome Database (LMPD)

LMPD ID
LMP005918
Gene ID
56338
Species
Mus musculus (Mouse)
Gene Name
thioredoxin interacting protein
Gene Symbol
Txnip
Synonyms
1200008J08Rik; AA682105; Hyplip1; THIF; Tbp-2; VDUP1
Alternate Names
thioredoxin-interacting protein; hyperlipidemia 1; thioredoxin binding protein-2; vitamin D3 up-regulated protein 1; upregulated by 1,25-dihydroxyvitamin D-3
Chromosome
3
Map Location
3 F2.2|3 41.93 cM

Proteins

thioredoxin-interacting protein isoform 1
Refseq ID NP_001009935
Protein GI 60687518
UniProt ID Q8BG60
mRNA ID NM_001009935
Length 397
RefSeq Status VALIDATED
MVMFKKIKSFEVVFNDPEKVYGSGEKVAGRVIVEVCEVTRVKAVRILACGVAKVLWMQGSQQCKQTLDYLRYEDTLLLEEQPTAGENEMVIMRPGNKYEYKFGFELPQGPLGTSFKGKYGCVDYWVKAFLDRPSQPTQEAKKNFEVMDLVDVNTPDLMAPVSAKKEKKVSCMFIPDGRVSVSARIDRKGFCEGDDISIHADFENTCSRIVVPKAAIVARHTYLANGQTKVFTQKLSSVRGNHIISGTCASWRGKSLRVQKIRPSILGCNILKVEYSLLIYVSVPGSKKVILDLPLVIGSRSGLSSRTSSMASRTSSEMSWIDLNIPDTPEAPPCYMDIIPEDHRLESPTTPLLDDVDDSQDSPIFMYAPEFQFMPPPTYTEVDPCVLNNNNNNNNVQ
thioredoxin-interacting protein isoform 2
Refseq ID NP_076208
Protein GI 254553444
UniProt ID Q8BG60
mRNA ID NM_023719
Length 396
RefSeq Status VALIDATED
MVMFKKIKSFEVVFNDPEKVYGSGEKVAGRVIVEVCEVTRVKAVRILACGVAKVLWMQGSQQCKQTLDYLRYEDTLLLEEQPTGENEMVIMRPGNKYEYKFGFELPQGPLGTSFKGKYGCVDYWVKAFLDRPSQPTQEAKKNFEVMDLVDVNTPDLMAPVSAKKEKKVSCMFIPDGRVSVSARIDRKGFCEGDDISIHADFENTCSRIVVPKAAIVARHTYLANGQTKVFTQKLSSVRGNHIISGTCASWRGKSLRVQKIRPSILGCNILKVEYSLLIYVSVPGSKKVILDLPLVIGSRSGLSSRTSSMASRTSSEMSWIDLNIPDTPEAPPCYMDIIPEDHRLESPTTPLLDDVDDSQDSPIFMYAPEFQFMPPPTYTEVDPCVLNNNNNNNNVQ

Gene Information

Entrez Gene ID
56338
Gene Name
thioredoxin interacting protein
Gene Symbol
Txnip
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IDA:MGI C cytoplasm
GO:0005829 TAS:Reactome C cytosol
GO:0005758 IEA:Ensembl C mitochondrial intermembrane space
GO:0005634 IEA:Ensembl C nucleus
GO:0004857 IDA:MGI F enzyme inhibitor activity
GO:0007049 IEA:UniProtKB-KW P cell cycle
GO:0071228 ISS:UniProtKB P cellular response to tumor cell
GO:0030216 IEA:Ensembl P keratinocyte differentiation
GO:0043086 IDA:GOC P negative regulation of catalytic activity
GO:0051782 ISS:UniProtKB P negative regulation of cell division
GO:0000122 IGI:MGI P negative regulation of transcription from RNA polymerase II promoter
GO:0048008 IMP:MGI P platelet-derived growth factor receptor signaling pathway
GO:0043065 IEA:Ensembl P positive regulation of apoptotic process
GO:0006606 IMP:MGI P protein import into nucleus
GO:0042127 IEA:Ensembl P regulation of cell proliferation
GO:0051592 IEA:Ensembl P response to calcium ion
GO:0042493 IEA:Ensembl P response to drug
GO:0032355 IEA:Ensembl P response to estradiol
GO:0009749 IEA:Ensembl P response to glucose
GO:0042542 IEA:Ensembl P response to hydrogen peroxide
GO:0009612 IEA:Ensembl P response to mechanical stimulus
GO:0006979 IDA:MGI P response to oxidative stress
GO:0032570 IEA:Ensembl P response to progesterone
GO:0006351 IEA:UniProtKB-KW P transcription, DNA-templated

REACTOME Pathway Links

REACTOME Pathway ID Description
5892920 Immune System
5893859 Inflammasomes
5893306 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
5893863 The NLRP3 inflammasome

Domain Information

InterPro Annotations

Accession Description
IPR011022 Arrestin C-terminal-like domain
IPR011021 Arrestin-like, N-terminal
IPR014756 Immunoglobulin E-set

UniProt Annotations

Entry Information

Gene Name
thioredoxin interacting protein
Protein Entry
TXNIP_MOUSE
UniProt ID
Q8BG60
Species
Mouse

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BG60-1; Sequence=Displayed; Name=2; IsoId=Q8BG60-2; Sequence=VSP_020653;
Disruption Phenotype Marked reduction in the numbers of natural killer cells, low levels of Il2rb expression in the precursor hematopoietic stem cells and severe lymphoid hyperplasia in the small intestine. {ECO:0000269|PubMed:15723808}.
Function May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1) (By similarity). Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. {ECO:0000250, ECO:0000269|PubMed:15723808, ECO:0000269|PubMed:15930262}.
Ptm Ubiquitinated; undergoes polyubiquitination catalyzed by ITCH resulting in proteasomal degradation. {ECO:0000250}.
Similarity Belongs to the arrestin family. {ECO:0000305}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:10843682}.
Subunit Homodimer; disulfide-linked. Interacts with TXN/thioredoxin through its redox-active site. Interacts with transcriptional repressors ZBTB16, ZBTB32 and HDAC1. Interacts (via C-terminus) with ITCH (via WW domains). Interacts with DDIT4 (By similarity). {ECO:0000250}.
Tissue Specificity Ubiquitously expressed. {ECO:0000269|PubMed:10843682}.

Identical and Related Proteins

Unique RefSeq proteins for LMP005918 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
60687518 RefSeq NP_001009935 397 thioredoxin-interacting protein isoform 1
254553444 RefSeq NP_076208 396 thioredoxin-interacting protein isoform 2

Identical Sequences to LMP005918 proteins

Reference Database Accession Length Protein Name
GI:254553444 DBBJ BAC38504.1 396 unnamed protein product [Mus musculus]
GI:254553444 DBBJ BAC40625.1 396 unnamed protein product [Mus musculus]
GI:60687518 DBBJ BAE42444.1 397 unnamed protein product [Mus musculus]
GI:254553444 DBBJ BAE42465.1 396 unnamed protein product [Mus musculus]
GI:60687518 DBBJ BAE42470.1 397 unnamed protein product [Mus musculus]
GI:60687518 DBBJ BAE42508.1 397 unnamed protein product [Mus musculus]
GI:60687518 DBBJ BAE33304.1 397 unnamed protein product [Mus musculus]
GI:60687518 DBBJ BAE42311.1 397 unnamed protein product [Mus musculus]
GI:60687518 SwissProt Q8BG60.1 397 RecName: Full=Thioredoxin-interacting protein; AltName: Full=Vitamin D3 up-regulated protein 1 [Mus musculus]

Related Sequences to LMP005918 proteins

Reference Database Accession Length Protein Name
GI:60687518 DBBJ BAB23444.1 397 unnamed protein product [Mus musculus]
GI:60687518 DBBJ BAC38504.1 396 unnamed protein product [Mus musculus]
GI:60687518 DBBJ BAC40625.1 396 unnamed protein product [Mus musculus]
GI:254553444 DBBJ BAC40834.1 397 unnamed protein product [Mus musculus]
GI:254553444 DBBJ BAC40850.1 397 unnamed protein product [Mus musculus]
GI:60687518 DBBJ BAE42465.1 396 unnamed protein product [Mus musculus]
GI:254553444 GenBank AAG32665.1 396 thioredoxin interacting factor [Mus musculus]
GI:254553444 GenBank AAG32666.1 396 thioredoxin interacting factor [Mus musculus]
GI:60687518 GenBank AAH11212.1 400 Txnip protein [Mus musculus]
GI:254553444 GenBank AAH31850.1 397 Thioredoxin interacting protein [Mus musculus]
GI:60687518 GenBank EDL38892.1 497 thioredoxin interacting protein, isoform CRA_a, partial [Mus musculus]
GI:254553444 GenBank EDL38893.1 475 thioredoxin interacting protein, isoform CRA_b [Mus musculus]