Gene/Proteome Database (LMPD)

LMPD ID
LMP005931
Gene ID
12972
Species
Mus musculus (Mouse)
Gene Name
crystallin, zeta
Gene Symbol
Cryz
Synonyms
Sez9
Alternate Names
quinone oxidoreductase; zeta-crystallin; quinone reductase; NADPH:quinone reductase
Chromosome
3
Map Location
3 H4|3
EC Number
1.6.5.5

Proteins

quinone oxidoreductase
Refseq ID NP_034098
Protein GI 33859530
UniProt ID P47199
mRNA ID NM_009968
Length 331
RefSeq Status VALIDATED
MATGQKLMRAIRVFEFGGPEVLKLQSDVVVPVPQSHQVLIKVHACGVNPVETYIRSGAYSRKPALPYTPGSDVAGIIESVGDKVSAFKKGDRVFCYSTVSGGYAEFALAADDTIYPLPETLNFRQGAALGIPYFTACRALFHSARARAGESVLVHGASGGVGLATCQIARAHGLKVLGTAGSEEGKKLVLQNGAHEVFNHKEANYIDKIKMSVGDKDKGVDVIIEMLANENLSNDLKLLSHGGRVVVVGCRGPIEINPRDTMAKETSIIGVSLSSSTKEEFQQFAGLLQAGIEKGWVKPVIGSEYPLEKAAQAHEDIIHGSGKTGKMILLL

Gene Information

Entrez Gene ID
12972
Gene Name
crystallin, zeta
Gene Symbol
Cryz
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IEA:Ensembl C Golgi apparatus
GO:0005829 ISS:UniProtKB C cytosol
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0050661 ISO:MGI F NADP binding
GO:0070402 ISS:UniProtKB F NADPH binding
GO:0003960 ISS:UniProtKB F NADPH:quinone reductase activity
GO:0003730 ISS:UniProtKB F mRNA 3'-UTR binding
GO:0008270 IEA:InterPro F zinc ion binding
GO:0051289 IEA:Ensembl P protein homotetramerization
GO:0042178 ISS:UniProtKB P xenobiotic catabolic process

Domain Information

InterPro Annotations

Accession Description
IPR013154 Alcohol dehydrogenase GroES-like
IPR002085 Alcohol dehydrogenase superfamily, zinc-type
IPR013149 Alcohol dehydrogenase, C-terminal
IPR011032 GroES (chaperonin 10)-like
IPR016040 NAD(P)-binding domain
IPR002364 Quinone oxidoreductase/zeta-crystallin, conserved site

UniProt Annotations

Entry Information

Gene Name
crystallin, zeta
Protein Entry
QOR_MOUSE
UniProt ID
P47199
Species
Mouse

Comments

Comment Type Description
Catalytic Activity NADPH + 2 quinone = NADP(+) + 2 semiquinone.
Function Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species and enhances their stability. NADPH binding interferes with mRNA binding (By similarity). {ECO:0000250}.
Similarity Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. {ECO:0000305}.
Subcellular Location Cytoplasm {ECO:0000250}.
Subunit Homotetramer. {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP005931 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
33859530 RefSeq NP_034098 331 quinone oxidoreductase

Identical Sequences to LMP005931 proteins

Reference Database Accession Length Protein Name
GI:33859530 GenBank AAB30620.2 331 zeta-crystallin [Mus musculus]
GI:33859530 GenBank EDL11887.1 331 crystallin, zeta, isoform CRA_a [Mus musculus]
GI:33859530 GenBank EDL11889.1 331 crystallin, zeta, isoform CRA_a [Mus musculus]
GI:33859530 GenBank ACJ91544.1 331 Sequence 9 from patent US 7414025
GI:33859530 GenBank ADR88543.1 331 Sequence 9 from patent US 7741073
GI:33859530 RefSeq XP_006501036.1 331 PREDICTED: quinone oxidoreductase isoform X1 [Mus musculus]

Related Sequences to LMP005931 proteins

Reference Database Accession Length Protein Name
GI:33859530 DBBJ BAE22081.1 331 unnamed protein product [Mus musculus]
GI:33859530 GenBank AAH03800.1 331 Cryz protein [Mus musculus]
GI:33859530 GenBank AAH43076.1 331 Crystallin, zeta [Mus musculus]
GI:33859530 GenBank EDL11888.1 333 crystallin, zeta, isoform CRA_b, partial [Mus musculus]
GI:33859530 GenBank EDL82539.1 329 rCG28670, isoform CRA_a [Rattus norvegicus]
GI:33859530 GenBank EDL82540.1 329 rCG28670, isoform CRA_a [Rattus norvegicus]