Gene/Proteome Database (LMPD)

LMPD ID
LMP005977
Gene ID
254531
Species
Homo sapiens (Human)
Gene Name
lysophosphatidylcholine acyltransferase 4
Gene Symbol
LPCAT4
Synonyms
AGPAT7; AYTL3; LPAAT-eta; LPEAT2
Alternate Names
lysophospholipid acyltransferase LPCAT4; 1-AGPAT 7; plasmalogen synthase; acyltransferase like 3; acyltransferase-like 3; 1-AGP acyltransferase 7; PLSC domain containing protein; 1-acylglycerophosphoserine O-acyltransferase; 1-acylglycerophosphocholine O-acyltransferase; lysophosphatidylethanolamine acyltransferase 2; 1-alkylglycerophosphocholine O-acetyltransferase; 1-alkenylglycerophosphoethanolamine O-acyltransferase; acyl-CoA:lysophosphatidylethanolamine acyltransferase 2; 1-acylglycerol-3-phosphate O-acyltransferase 7 (lysophosphatidic acid acyltransferase, eta)
Chromosome
15
Map Location
15q14
EC Number
2.3.1.23
Summary
Members of the 1-acylglycerol-3-phosphate O-acyltransferase (EC 2.3.1.51) family, such as AGPAT7, catalyze the conversion of lysophosphatidic acid (LPA) to phosphatidic acid (PA), a precursor in the biosynthesis of all glycerolipids. Both LPA and PA are involved in signal transduction (Ye et al., 2005 [PubMed 16243729]).[supplied by OMIM, May 2008]
Orthologs
View orthologs and multiple alignments for LPCAT4

Proteins

lysophospholipid acyltransferase LPCAT4
Refseq ID NP_705841
Protein GI 87116681
UniProt ID Q643R3
mRNA ID NM_153613
Length 524
RefSeq Status VALIDATED
MSQGSPGDWAPLDPTPGPPASPNPFVHELHLSRLQRVKFCLLGALLAPIRVLLAFIVLFLLWPFAWLQVAGLSEEQLQEPITGWRKTVCHNGVLGLSRLLFFLLGFLRIRVRGQRASRLQAPVLVAAPHSTFFDPIVLLPCDLPKVVSRAENLSVPVIGALLRFNQAILVSRHDPASRRRVVEEVRRRATSGGKWPQVLFFPEGTCSNKKALLKFKPGAFIAGVPVQPVLIRYPNSLDTTSWAWRGPGVLKVLWLTASQPCSIVDVEFLPVYHPSPEESRDPTLYANNVQRVMAQALGIPATECEFVGSLPVIVVGRLKVALEPQLWELGKVLRKAGLSAGYVDAGAEPGRSRMISQEEFARQLQLSDPQTVAGAFGYFQQDTKGLVDFRDVALALAALDGGRSLEELTRLAFELFAEEQAEGPNRLLYKDGFSTILHLLLGSPHPAATALHAELCQAGSSQGLSLCQFQNFSLHDPLYGKLFSTYLRPPHTSRGTSQTPNASSPGNPTALANGTVQAPKQKGD

Gene Information

Entrez Gene ID
254531
Gene Name
lysophosphatidylcholine acyltransferase 4
Gene Symbol
LPCAT4
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IDA:MGI C endoplasmic reticulum
GO:0005789 TAS:Reactome C endoplasmic reticulum membrane
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0016020 IDA:UniProtKB C membrane
GO:0047184 IEA:UniProtKB-EC F 1-acylglycerophosphocholine O-acyltransferase activity
GO:0047166 IEA:UniProtKB-EC F 1-alkenylglycerophosphoethanolamine O-acyltransferase activity
GO:0047192 IEA:UniProtKB-EC F 1-alkylglycerophosphocholine O-acetyltransferase activity
GO:0005509 IEA:InterPro F calcium ion binding
GO:0071617 IDA:MGI F lysophospholipid acyltransferase activity
GO:0044255 TAS:Reactome P cellular lipid metabolic process
GO:0046474 TAS:Reactome P glycerophospholipid biosynthetic process
GO:0006654 TAS:Reactome P phosphatidic acid biosynthetic process
GO:0036151 TAS:Reactome P phosphatidylcholine acyl-chain remodeling
GO:0036152 TAS:Reactome P phosphatidylethanolamine acyl-chain remodeling
GO:0036148 TAS:Reactome P phosphatidylglycerol acyl-chain remodeling
GO:0036150 TAS:Reactome P phosphatidylserine acyl-chain remodeling
GO:0006644 IDA:MGI P phospholipid metabolic process
GO:0044281 TAS:Reactome P small molecule metabolic process
GO:0019432 TAS:Reactome P triglyceride biosynthetic process

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_120829 Acyl chain remodelling of PC
REACT_121369 Acyl chain remodelling of PE
REACT_121324 Acyl chain remodelling of PG
REACT_121384 Acyl chain remodelling of PS

Domain Information

InterPro Annotations

Accession Description
IPR011992 EF-hand domain pair
IPR002123 Phospholipid/glycerol acyltransferase

UniProt Annotations

Entry Information

Gene Name
lysophosphatidylcholine acyltransferase 4
Protein Entry
LPCT4_HUMAN
UniProt ID
Q643R3
Species
Human

Comments

Comment Type Description
Biophysicochemical Properties Kinetic parameters: KM=80 uM for lysophosphatidylethanolamine ; KM=20 uM for oleoyl-CoA ; Vmax=270 pmol/min/mg enzyme with lysophosphatidylethanolamine and oleoyl-CoA as substrates ;
Catalytic Activity Acetyl-CoA + 1-alkyl-sn-glycero-3- phosphocholine = CoA + 2-acetyl-1-alkyl-sn-glycero-3- phosphocholine.
Catalytic Activity Acyl-CoA + 1-acyl-sn-glycero-3- phosphatidylserine = CoA + 1,2-diacyl-sn-glycero-3- phosphatidylserine.
Catalytic Activity Acyl-CoA + 1-acyl-sn-glycero-3- phosphoethanolamine = CoA + 1,2-diacyl-sn-glycero-3- phosphoethanolamine.
Catalytic Activity Acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine = CoA + 1,2-diacyl-sn-glycero-3-phosphocholine.
Catalytic Activity Acyl-CoA + 1-alkenylglycerophosphoethanolamine = CoA + 1-alkenyl-2-acylglycerophosphoethanolamine.
Function Displays acyl-CoA-dependent lysophospholipid acyltransferase activity with a subset of lysophospholipids as substrates; converts lysophosphatidylethanolamine to phosphatidylethanolamine, lysophosphatidylcholine to phosphatidycholine, 1-alkenyl-lysophatidylethanolamine to 1- alkenyl-phosphatidylethanolamine, lysophosphatidylglycerol and alkyl-lysophosphatidylcholine to phosphatidylglycerol and alkyl- phosphatidylcholine, respectively. In contrast, has no lysophosphatidylinositol, glycerol-3-phosphate, diacylglycerol or lysophosphatidic acid acyltransferase activity. Prefers long chain acyl-CoAs (C16, C18) as acyl donors.
Pathway Lipid metabolism; phospholipid metabolism.
Sequence Caution Sequence=AAC19156.1; Type=Frameshift; Positions=328; Evidence= ; Sequence=AAC19156.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence= ; Sequence=AAN33178.1; Type=Frameshift; Positions=198; Evidence= ; Sequence=AAP97722.1; Type=Frameshift; Positions=188, 198; Evidence= ;
Similarity Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
Subcellular Location Endoplasmic reticulum membrane ; Multi- pass membrane protein {ECO
Tissue Specificity Widely expressed with predominant level in brain.

Identical and Related Proteins

Unique RefSeq proteins for LMP005977 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
87116681 RefSeq NP_705841 524 lysophospholipid acyltransferase LPCAT4

Identical Sequences to LMP005977 proteins

Reference Database Accession Length Protein Name
GI:87116681 DBBJ BAF82962.1 524 unnamed protein product [Homo sapiens]
GI:87116681 GenBank AAH92463.1 524 Lysophosphatidylcholine acyltransferase 4 [Homo sapiens]
GI:87116681 GenBank EAW92306.1 524 1-acylglycerol-3-phosphate O-acyltransferase 7 (lysophosphatidic acid acyltransferase, eta), isoform CRA_a [Homo sapiens]
GI:87116681 GenBank AFO18218.1 524 Sequence 32 from patent US 8206947
GI:87116681 GenBank AIC53487.1 524 LPCAT4, partial [synthetic construct]
GI:87116681 SwissProt Q643R3.1 524 RecName: Full=Lysophospholipid acyltransferase LPCAT4; AltName: Full=1-acylglycerol-3-phosphate O-acyltransferase 7; Short=1-AGP acyltransferase 7; Short=1-AGPAT 7; AltName: Full=1-acylglycerophosphocholine O-acyltransferase; AltName: Full=1-acylglycerophosphoserine O-acyltransferase; AltName: Full=1-alkenylglycerophosphoethanolamine O-acyltransferase; AltName: Full=1-alkylglycerophosphocholine O-acetyltransferase; AltName: Full=Acyltransferase-like 3; AltName: Full=Lysophosphatidylcholine acyltransferase 4; AltName: Full=Lysophosphatidylethanolamine acyltransferase 2; AltName: Full=Plasmalogen synthase [Homo sapiens]

Related Sequences to LMP005977 proteins

Reference Database Accession Length Protein Name
GI:87116681 GenBank AEP61172.1 567 Sequence 166 from patent US 8026065
GI:87116681 GenBank JAA30924.1 524 lysophosphatidylcholine acyltransferase 4 [Pan troglodytes]
GI:87116681 GenBank JAA39971.1 524 lysophosphatidylcholine acyltransferase 4 [Pan troglodytes]
GI:87116681 RefSeq XP_510281.2 524 PREDICTED: lysophospholipid acyltransferase LPCAT4 [Pan troglodytes]
GI:87116681 RefSeq XP_003804988.1 524 PREDICTED: lysophospholipid acyltransferase LPCAT4 [Pan paniscus]
GI:87116681 RefSeq XP_004055974.1 524 PREDICTED: lysophospholipid acyltransferase LPCAT4 [Gorilla gorilla gorilla]