Gene/Proteome Database (LMPD)

LMPD ID
LMP005988
Gene ID
57515
Species
Homo sapiens (Human)
Gene Name
serine incorporator 1
Gene Symbol
SERINC1
Synonyms
TDE1L; TDE2; TMS-2; TMS2
Alternate Names
serine incorporator 1; tumor differentially expressed 2; tumor differentially expressed protein 2
Chromosome
6
Map Location
6q22.31

Proteins

serine incorporator 1 precursor
Refseq ID NP_065806
Protein GI 24308213
UniProt ID Q9NRX5
mRNA ID NM_020755
Length 453
RefSeq Status PROVISIONAL
MGSVLGLCSMASWIPCLCGSAPCLLCRCCPSGNNSTVTRLIYALFLLVGVCVACVMLIPGMEEQLNKIPGFCENEKGVVPCNILVGYKAVYRLCFGLAMFYLLLSLLMIKVKSSSDPRAAVHNGFWFFKFAAAIAIIIGAFFIPEGTFTTVWFYVGMAGAFCFILIQLVLLIDFAHSWNESWVEKMEEGNSRCWYAALLSATALNYLLSLVAIVLFFVYYTHPASCSENKAFISVNMLLCVGASVMSILPKIQESQPRSGLLQSSVITVYTMYLTWSAMTNEPETNCNPSLLSIIGYNTTSTVPKEGQSVQWWHAQGIIGLILFLLCVFYSSIRTSNNSQVNKLTLTSDESTLIEDGGARSDGSLEDGDDVHRAVDNERDGVTYSYSFFHFMLFLASLYIMMTLTNWYRYEPSREMKSQWTAVWVKISSSWIGIVLYVWTLVAPLVLTNRDFD
sig_peptide: 1..19 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1928 peptide sequence: MGSVLGLCSMASWIPCLCG

Gene Information

Entrez Gene ID
57515
Gene Name
serine incorporator 1
Gene Symbol
SERINC1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005789 ISS:HGNC C endoplasmic reticulum membrane
GO:0070062 IDA:UniProt C extracellular vesicular exosome
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005886 ISS:HGNC C plasma membrane
GO:0015194 ISS:HGNC F L-serine transmembrane transporter activity
GO:0015825 ISS:HGNC P L-serine transport
GO:0006658 ISS:HGNC P phosphatidylserine metabolic process
GO:0008654 IEA:UniProtKB-KW P phospholipid biosynthetic process
GO:0051347 ISS:HGNC P positive regulation of transferase activity
GO:0006665 ISS:HGNC P sphingolipid metabolic process

Domain Information

InterPro Annotations

Accession Description
IPR029552 Serine incorporator 1
IPR005016 Serine incorporator/TMS membrane protein

UniProt Annotations

Entry Information

Gene Name
serine incorporator 1
Protein Entry
SERC1_HUMAN
UniProt ID
Q9NRX5
Species
Human

Comments

Comment Type Description
Function Enhances the incorporation of serine into phosphatidylserine and sphingolipids.
Interaction Q06710:PAX8; NbExp=2; IntAct=EBI-2683145, EBI-2683132;
Sequence Caution Sequence=BAA86567.1; Type=Erroneous initiation; Evidence= ;
Similarity Belongs to the TDE1 family.
Subcellular Location Endoplasmic reticulum membrane {ECO
Subunit Interacts with SPTLC1.

Identical and Related Proteins

Unique RefSeq proteins for LMP005988 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
24308213 RefSeq NP_065806 453 serine incorporator 1 precursor

Identical Sequences to LMP005988 proteins

Reference Database Accession Length Protein Name
GI:24308213 GenBank AHD73447.1 453 Sequence 10515 from patent US 8586006
GI:24308213 GenBank AIC63527.1 453 SERINC1, partial [synthetic construct]
GI:24308213 RefSeq XP_005551759.1 453 PREDICTED: serine incorporator 1 [Macaca fascicularis]
GI:24308213 RefSeq XP_008005385.1 453 PREDICTED: serine incorporator 1 [Chlorocebus sabaeus]
GI:24308213 RefSeq XP_009204454.1 453 PREDICTED: serine incorporator 1 [Papio anubis]
GI:24308213 RefSeq XP_010373719.1 453 PREDICTED: serine incorporator 1 [Rhinopithecus roxellana]

Related Sequences to LMP005988 proteins

Reference Database Accession Length Protein Name
GI:24308213 DBBJ BAA86567.1 472 KIAA1253 protein, partial [Homo sapiens]
GI:24308213 EMBL CAH91227.1 453 hypothetical protein [Pongo abelii]
GI:24308213 EMBL CAH93497.1 453 hypothetical protein [Pongo abelii]
GI:24308213 PIR - 457 hypothetical protein DKFZp434H0413.1 - human (fragment) [Homo sapiens]
GI:24308213 RefSeq NP_001125724.1 453 serine incorporator 1 precursor [Pongo abelii]
GI:24308213 SwissProt Q5R419.1 453 RecName: Full=Serine incorporator 1; AltName: Full=Tumor differentially expressed protein 2 [Pongo abelii]