Gene/Proteome Database (LMPD)

LMPD ID
LMP006002
Gene ID
12491
Species
Mus musculus (Mouse)
Gene Name
CD36 antigen
Gene Symbol
Cd36
Synonyms
FAT; GPIV; Scarb3
Alternate Names
platelet glycoprotein 4; PAS-4; GPIIIB; PAS IV; glycoprotein IIIb; fatty acid translocase; platelet glycoprotein IV
Chromosome
5
Map Location
5 A3|5 8.11 cM

Proteins

platelet glycoprotein 4
Refseq ID NP_031669
Protein GI 227116343
UniProt ID Q08857
mRNA ID NM_007643
Length 472
RefSeq Status VALIDATED
MGCDRNCGLIAGAVIGAVLAVFGGILMPVGDMLIEKTIKREVVLEEGTTAFKNWVKTGTTVYRQFWIFDVQNPDDVAKNSSKIKVKQRGPYTYRVRYLAKENITQDPEDHTVSFVQPNGAIFEPSLSVGTEDDNFTVLNLAVAAAPHIYQNSFVQVVLNSLIKKSKSSMFQTRSLKELLWGYKDPFLSLVPYPISTTVGVFYPYNDTVDGVYKVFNGKDNISKVAIIESYKGKRNLSYWPSYCDMINGTDAASFPPFVEKSRTLRFFSSDICRSIYAVFGSEIDLKGIPVYRFVLPANAFASPLQNPDNHCFCTEKVISNNCTSYGVLDIGKCKEGKPVYISLPHFLHASPDVSEPIEGLHPNEDEHRTYLDVEPITGFTLQFAKRLQVNILVKPARKIEALKNLKRPYIVPILWLNETGTIGDEKAEMFKTQVTGKIKLLGMVEMALLGIGVVMFVAFMISYCACKSKNGK
platelet glycoprotein 4
Refseq ID NP_001153028
Protein GI 227116349
UniProt ID Q08857
mRNA ID NM_001159556
Length 472
RefSeq Status VALIDATED
Protein sequence is identical to GI:227116343 (mRNA isoform)
platelet glycoprotein 4
Refseq ID NP_001153030
Protein GI 227116353
UniProt ID Q08857
mRNA ID NM_001159558
Length 472
RefSeq Status VALIDATED
Protein sequence is identical to GI:227116343 (mRNA isoform)
platelet glycoprotein 4
Refseq ID NP_001153029
Protein GI 227116351
UniProt ID Q08857
mRNA ID NM_001159557
Length 472
RefSeq Status VALIDATED
Protein sequence is identical to GI:227116343 (mRNA isoform)
platelet glycoprotein 4
Refseq ID NP_001153027
Protein GI 227116347
UniProt ID Q08857
mRNA ID NM_001159555
Length 472
RefSeq Status VALIDATED
Protein sequence is identical to GI:227116343 (mRNA isoform)

Gene Information

Entrez Gene ID
12491
Gene Name
CD36 antigen
Gene Symbol
Cd36
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IDA:MGI C Golgi apparatus
GO:0009986 ISS:BHF-UCL C cell surface
GO:0009897 IDA:MGI C external side of plasma membrane
GO:0005615 IEA:Ensembl C extracellular space
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0045121 IDA:MGI C membrane raft
GO:0005886 IDA:MGI C plasma membrane
GO:0008035 IDA:MGI F high-density lipoprotein particle binding
GO:0008289 ISS:BHF-UCL F lipid binding
GO:0070892 IMP:MGI F lipoteichoic acid receptor activity
GO:0030169 IMP:BHF-UCL F low-density lipoprotein particle binding
GO:0005041 IMP:BHF-UCL F low-density lipoprotein receptor activity
GO:0043277 IMP:MGI P apoptotic cell clearance
GO:0019934 IEA:Ensembl P cGMP-mediated signaling
GO:0007155 IEA:UniProtKB-KW P cell adhesion
GO:0007166 IDA:BHF-UCL P cell surface receptor signaling pathway
GO:0071221 IMP:MGI P cellular response to bacterial lipopeptide
GO:0071447 IMP:BHF-UCL P cellular response to hydroperoxide
GO:0071222 IMP:MGI P cellular response to lipopolysaccharide
GO:0071223 IDA:MGI P cellular response to lipoteichoic acid
GO:0030301 IMP:BHF-UCL P cholesterol transport
GO:0050830 IMP:MGI P defense response to Gram-positive bacterium
GO:0019915 IMP:BHF-UCL P lipid storage
GO:0042953 IMP:BHF-UCL P lipoprotein transport
GO:0044539 IEA:Ensembl P long-chain fatty acid import
GO:0034383 IMP:BHF-UCL P low-density lipoprotein particle clearance
GO:0055096 IDA:BHF-UCL P low-density lipoprotein particle mediated signaling
GO:0010629 IMP:BHF-UCL P negative regulation of gene expression
GO:0044130 IMP:MGI P negative regulation of growth of symbiont in host
GO:0042992 IMP:BHF-UCL P negative regulation of transcription factor import into nucleus
GO:0000122 IMP:BHF-UCL P negative regulation of transcription from RNA polymerase II promoter
GO:0007263 IEA:Ensembl P nitric oxide mediated signal transduction
GO:0002221 IMP:GOC P pattern recognition receptor signaling pathway
GO:0006910 IDA:MGI P phagocytosis, recognition
GO:0034381 IMP:BHF-UCL P plasma lipoprotein particle clearance
GO:0015911 IEA:Ensembl P plasma membrane long-chain fatty acid transport
GO:0043123 IMP:MGI P positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043410 IMP:MGI P positive regulation of MAPK cascade
GO:0030194 IMP:BHF-UCL P positive regulation of blood coagulation
GO:2000334 IMP:BHF-UCL P positive regulation of blood microparticle formation
GO:0001954 IEA:Ensembl P positive regulation of cell-matrix adhesion
GO:0010886 IMP:BHF-UCL P positive regulation of cholesterol storage
GO:0032735 IMP:MGI P positive regulation of interleukin-12 production
GO:0032755 IMP:MGI P positive regulation of interleukin-6 production
GO:0060907 IMP:MGI P positive regulation of macrophage cytokine production
GO:0010744 IMP:BHF-UCL P positive regulation of macrophage derived foam cell differentiation
GO:0050731 IDA:BHF-UCL P positive regulation of peptidyl-tyrosine phosphorylation
GO:0060100 IDA:MGI P positive regulation of phagocytosis, engulfment
GO:2000379 IMP:BHF-UCL P positive regulation of reactive oxygen species metabolic process
GO:0032760 IMP:MGI P positive regulation of tumor necrosis factor production
GO:0006898 IMP:GOC P receptor-mediated endocytosis
GO:2000121 IMP:BHF-UCL P regulation of removal of superoxide radicals
GO:0043619 IC:BHF-UCL P regulation of transcription from RNA polymerase II promoter in response to oxidative stress
GO:0035634 IEP:UniProtKB P response to stilbenoid

KEGG Pathway Links

KEGG Pathway ID Description
mmu04152 AMPK signaling pathway
mmu04975 Fat digestion and absorption
mmu04145 Phagosome

Domain Information

InterPro Annotations

Accession Description
IPR005428 Adhesion molecule CD36
IPR002159 CD36 antigen

UniProt Annotations

Entry Information

Gene Name
CD36 antigen
Protein Entry
CD36_MOUSE
UniProt ID
Q08857
Species
Mouse

Comments

Comment Type Description
Disruption Phenotype Animals with a double knockout of APOE and CD36, fed a Western diet for 12 weeks, exhibit much lower levels of CXCL1, CXCL2 and CCL5 cytokine mRNA expression in the descending aorta and a corresponding decrease in atherosclerotic lesion formation, compared to APOE single knockout mice. {ECO:0000269|PubMed:20037584}.
Function Binds to collagen, thrombospondin, anionic phospholipids and oxidized low-density lipoprotein (oxLDL). May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport (By similarity). Receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic effects (By similarity). As a coreceptor for TLR4-TLR6, promotes inflammation in monocytes/macrophages. Upon ligand binding, such as oxLDL or amyloid-beta 42 binding, rapidly induces the formation of a heterodimer of TLR4 and TLR6, which is internalized and triggers inflammatory signals, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion. {ECO:0000250|UniProtKB:P16671, ECO:0000269|PubMed:20037584}.
Similarity Belongs to the CD36 family. {ECO:0000305}.
Subcellular Location Cell membrane; Multi-pass membrane protein. Note=Upon ligand-binding, internalized through dynamin-dependent endocytosis. {ECO:0000250|UniProtKB:P16671}.
Subunit Interacts with THBS1 and THBS2; the interactions mediate the THBS antiangiogenic activity. Upon interaction with a ligand, such as oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42, rapidly forms a complex with TLR4 and TLR6; the complex is internalized and triggers an inflammatory signal. Through its C- terminus, interacts with PTK2, PXN and LYN, but not with SRC. LYN kinase activity is required for facilitating TLR4-TLR6 heterodimerization and signal initiation. {ECO:0000250|UniProtKB:P16671, ECO:0000269|PubMed:15748999}.

Identical and Related Proteins

Unique RefSeq proteins for LMP006002 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
227116343 RefSeq NP_031669 472 platelet glycoprotein 4

Identical Sequences to LMP006002 proteins

Reference Database Accession Length Protein Name
GI:227116343 RefSeq XP_006535683.1 472 PREDICTED: platelet glycoprotein 4 isoform X1 [Mus musculus]
GI:227116343 RefSeq XP_006535684.1 472 PREDICTED: platelet glycoprotein 4 isoform X2 [Mus musculus]
GI:227116343 RefSeq XP_006535685.1 472 PREDICTED: platelet glycoprotein 4 isoform X3 [Mus musculus]
GI:227116343 RefSeq XP_006535686.1 472 PREDICTED: platelet glycoprotein 4 isoform X4 [Mus musculus]
GI:227116343 RefSeq XP_006535687.1 472 PREDICTED: platelet glycoprotein 4 isoform X5 [Mus musculus]
GI:227116343 RefSeq XP_006535688.1 472 PREDICTED: platelet glycoprotein 4 isoform X6 [Mus musculus]

Related Sequences to LMP006002 proteins

Reference Database Accession Length Protein Name
GI:227116343 DBBJ BAC35163.1 472 unnamed protein product [Mus musculus]
GI:227116343 DBBJ BAE29735.1 472 unnamed protein product [Mus musculus]
GI:227116343 DBBJ BAE42856.1 472 unnamed protein product [Mus musculus]
GI:227116343 EMBL CBH19822.1 472 unnamed protein product [Mus musculus]
GI:227116343 GenBank ACQ18445.1 472 Sequence 359 from patent US 7510850
GI:227116343 GenBank ADF22040.1 472 Sequence 19 from patent US 7674891