Gene/Proteome Database (LMPD)
LMPD ID
LMP006010
Gene ID
Species
Homo sapiens (Human)
Gene Name
solute carrier family 22 (organic cation/zwitterion transporter), member 4
Gene Symbol
Synonyms
OCTN1
Alternate Names
solute carrier family 22 member 4; ET transporter; ergothioneine transporter; integral membrane transport protein; organic cation/carnitine transporter 1; solute carrier family 22 (organic cation/ergothioneine transporter), member 4
Chromosome
5
Map Location
5q31.1
Summary
Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is an organic cation transporter and plasma integral membrane protein containing eleven putative transmembrane domains as well as a nucleotide-binding site motif. Transport by this protein is at least partially ATP-dependent. [provided by RefSeq, Jul 2008]
Orthologs
Proteins
| solute carrier family 22 member 4 | |
|---|---|
| Refseq ID | NP_003050 |
| Protein GI | 24497490 |
| UniProt ID | Q9H015 |
| mRNA ID | NM_003059 |
| Length | 551 |
| RefSeq Status | REVIEWED |
| MRDYDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCRVPDAANLSSAWRNNSVPLRLRDGREVPHSCSRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQDVYLSTVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKNVLFATMAVQTGFSFLQIFSISWEMFTVLFVIVGMGQISNYVVAFILGTEILGKSVRIIFSTLGVCTFFAVGYMLLPLFAYFIRDWRMLLLALTVPGVLCVPLWWFIPESPRWLISQRRFREAEDIIQKAAKMNNIAVPAVIFDSVEELNPLKQQKAFILDLFRTRNIAIMTIMSLLLWMLTSVGYFALSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRRYIIAAVLFWGGGVLLFIQLVPVDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIAPYFVYLGAYNRMLPYIVMGSLTVLIGILTLFFPESLGMTLPETLEQMQKVKWFRSGKKTRDSMETEENPKVLITAF | |
Gene Information
Entrez Gene ID
Gene Name
solute carrier family 22 (organic cation/zwitterion transporter), member 4
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0016324 | IDA:BHF-UCL | C | apical plasma membrane |
| GO:0005887 | TAS:ProtInc | C | integral component of plasma membrane |
| GO:0005739 | IDA:MGI | C | mitochondrion |
| GO:0005886 | IC:BHF-UCL | C | plasma membrane |
| GO:0005524 | IEA:UniProtKB-KW | F | ATP binding |
| GO:0015226 | IDA:MGI | F | carnitine transmembrane transporter activity |
| GO:0015491 | IDA:BHF-UCL | F | cation:cation antiporter activity |
| GO:0000166 | TAS:ProtInc | F | nucleotide binding |
| GO:0030165 | IPI:BHF-UCL | F | PDZ domain binding |
| GO:0015651 | IDA:BHF-UCL | F | quaternary ammonium group transmembrane transporter activity |
| GO:0008513 | TAS:ProtInc | F | secondary active organic cation transmembrane transporter activity |
| GO:0015293 | IEA:UniProtKB-KW | F | symporter activity |
| GO:0007589 | TAS:ProtInc | P | body fluid secretion |
| GO:0009437 | IEA:Ensembl | P | carnitine metabolic process |
| GO:1902603 | IDA:GOC | P | carnitine transmembrane transport |
| GO:0015879 | IDA:MGI | P | carnitine transport |
| GO:0098655 | IDA:GOC | P | cation transmembrane transport |
| GO:0015695 | TAS:ProtInc | P | organic cation transport |
| GO:0015697 | IDA:BHF-UCL | P | quaternary ammonium group transport |
| GO:0006814 | IEA:UniProtKB-KW | P | sodium ion transport |
| GO:0055085 | TAS:Reactome | P | transmembrane transport |
| GO:0006641 | IEA:Ensembl | P | triglyceride metabolic process |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_22345 | Organic cation/anion/zwitterion transport |
| REACT_22357 | Organic cation transport |
| REACT_19118 | SLC-mediated transmembrane transport |
| REACT_19305 | Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds |
Domain Information
UniProt Annotations
Entry Information
Gene Name
solute carrier family 22 (organic cation/zwitterion transporter), member 4
Protein Entry
S22A4_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Biophysicochemical Properties | Kinetic parameters: KM=0.470 mM for TEA (at 37 degrees Celsius and pH 7.4) ; Vmax=0.974 nmol/min/mg enzyme toward TEA (at 37 degrees Celsius and pH 7.4) {ECO |
| Caution | PubMed:9426230 reported that this protein does not transport carnitine, however, experiments were done with the Phe- 503 variant, which affects the ability to transport carnitine. PubMed:15459889 showed that, although weakly, it can also transport carnitine at some level. Its function in carnitine transport is therefore unclear. |
| Disease | Rheumatoid arthritis (RA) [MIM |
| Function | Sodium-ion dependent, low affinity carnitine transporter. Probably transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 1.78. A key substrate of this transporter seems to be ergothioneine (ET). |
| Induction | Overexpressed upon TNF treatment. |
| Similarity | Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. |
| Subcellular Location | Membrane; Multi-pass membrane protein. |
| Subunit | Interacts with PDZK1. |
| Tissue Specificity | Widely expressed. Highly expressed in whole blood, bone marrow, trachea and fetal liver. Weakly expressed in kidney, skeletal muscle, prostate, lung, pancreas, placenta, heart, uterus, spleen and spinal cord. Highly expressed in intestinal cell types affected by Crohn disease, including epithelial cells. Expressed in CD68 macrophage and CD43 T-cells but not in CD20 B-cells. Predominantly expressed in CD14 cells in peripheral blood mononuclear cells. {ECO |
Identical and Related Proteins
Unique RefSeq proteins for LMP006010 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 24497490 | RefSeq | NP_003050 | 551 | solute carrier family 22 member 4 |
Identical Sequences to LMP006010 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:24497490 | DBBJ | BAI47346.1 | 551 | solute carrier family 22 (organic cation/ergothioneine transporter), member 4, partial [synthetic construct] |
| GI:24497490 | GenBank | ADL99193.1 | 551 | Sequence 4 from patent US 7723019 |
| GI:24497490 | GenBank | AFO05920.1 | 551 | Sequence 558 from patent US 8216786 |
| GI:24497490 | GenBank | AGU22372.1 | 551 | Sequence 2 from patent US 8492106 |
| GI:24497490 | GenBank | AHD73497.1 | 551 | Sequence 10565 from patent US 8586006 |
| GI:24497490 | SwissProt | Q9H015.3 | 551 | RecName: Full=Solute carrier family 22 member 4; AltName: Full=Ergothioneine transporter; Short=ET transporter; AltName: Full=Organic cation/carnitine transporter 1 [Homo sapiens] |
Related Sequences to LMP006010 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:24497490 | DBBJ | BAA23356.1 | 551 | OCTN1 [Homo sapiens] |
| GI:24497490 | EMBL | CAX30724.1 | 551 | unnamed protein product [Homo sapiens] |
| GI:24497490 | GenBank | AAU99061.1 | 551 | Sequence 7 from patent US 6731505 |
| GI:24497490 | GenBank | AAU99062.1 | 551 | Sequence 38 from patent US 6731505 |
| GI:24497490 | GenBank | AAV24018.1 | 551 | Sequence 1 from patent US 6759514 |
| GI:24497490 | GenBank | AEH97779.1 | 551 | Sequence 1 from patent US 7947470 |