Gene/Proteome Database (LMPD)

LMPD ID
LMP006052
Gene ID
51635
Species
Homo sapiens (Human)
Gene Name
dehydrogenase/reductase (SDR family) member 7
Gene Symbol
DHRS7
Synonyms
SDR34C1; retDSR4; retSDR4
Alternate Names
dehydrogenase/reductase SDR family member 7; retinal short-chain dehydrogenase/reductase 4; short chain dehydrogenase/reductase family 34C, member 1
Chromosome
14
Map Location
14q23.1
EC Number
1.1.-.-
Summary
Short-chain dehydrogenases/reductases (SDRs), such as DHRS7, catalyze the oxidation/reduction of a wide range of substrates, including retinoids and steroids (Haeseleer and Palczewski, 2000 [PubMed 10800688]).[supplied by OMIM, Jun 2009]
Orthologs
View orthologs and multiple alignments for DHRS7

Proteins

dehydrogenase/reductase SDR family member 7 precursor
Refseq ID NP_057113
Protein GI 7706318
UniProt ID Q9Y394
mRNA ID NM_016029
Length 339
RefSeq Status VALIDATED
MNWELLLWLLVLCALLLLLVQLLRFLRADGDLTLLWAEWQGRRPEWELTDMVVWVTGASSGIGEELAYQLSKLGVSLVLSARRVHELERVKRRCLENGNLKEKDILVLPLDLTDTGSHEAATKAVLQEFGRIDILVNNGGMSQRSLCMDTSLDVYRKLIELNYLGTVSLTKCVLPHMIERKQGKIVTVNSILGIISVPLSIGYCASKHALRGFFNGLRTELATYPGIIVSNICPGPVQSNIVENSLAGEVTKTIGNNGDQSHKMTTSRCVRLMLISMANDLKEVWISEQPFLLVTYLWQYMPTWAWWITNKMGKKRIENFKSGVDADSSYFKIFKTKHD
sig_peptide: 1..28 inference: non-experimental evidence, no additional details recorded note: Potential; propagated from UniProtKB/Swiss-Prot (Q9Y394.1) calculated_mol_wt: 3380 peptide sequence: MNWELLLWLLVLCALLLLLVQLLRFLRA mat_peptide: 29..339 product: Dehydrogenase/reductase SDR family member 7 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q9Y394.1) calculated_mol_wt: 34937 peptide sequence: DGDLTLLWAEWQGRRPEWELTDMVVWVTGASSGIGEELAYQLSKLGVSLVLSARRVHELERVKRRCLENGNLKEKDILVLPLDLTDTGSHEAATKAVLQEFGRIDILVNNGGMSQRSLCMDTSLDVYRKLIELNYLGTVSLTKCVLPHMIERKQGKIVTVNSILGIISVPLSIGYCASKHALRGFFNGLRTELATYPGIIVSNICPGPVQSNIVENSLAGEVTKTIGNNGDQSHKMTTSRCVRLMLISMANDLKEVWISEQPFLLVTYLWQYMPTWAWWITNKMGKKRIENFKSGVDADSSYFKIFKTKHD

Gene Information

Entrez Gene ID
51635
Gene Name
dehydrogenase/reductase (SDR family) member 7
Gene Symbol
DHRS7
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016020 IDA:UniProtKB C membrane
GO:0016491 IEA:UniProtKB-KW F oxidoreductase activity

Domain Information

InterPro Annotations

Accession Description
IPR002347 Glucose/ribitol dehydrogenase
IPR016040 NAD(P)-binding domain
IPR002198 Short-chain dehydrogenase/reductase SDR
IPR020904 Short-chain dehydrogenase/reductase, conserved site

UniProt Annotations

Entry Information

Gene Name
dehydrogenase/reductase (SDR family) member 7
Protein Entry
DHRS7_HUMAN
UniProt ID
Q9Y394
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Y394-1; Sequence=Displayed; Name=2; IsoId=Q9Y394-2; Sequence=VSP_008103; Note=No experimental confirmation available.;
Similarity Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Identical and Related Proteins

Unique RefSeq proteins for LMP006052 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
7706318 RefSeq NP_057113 339 dehydrogenase/reductase SDR family member 7 precursor

Identical Sequences to LMP006052 proteins

Reference Database Accession Length Protein Name
GI:7706318 GenBank AED38914.1 339 Sequence 637 from patent US 7883858
GI:7706318 GenBank AED39458.1 339 Sequence 1798 from patent US 7883858
GI:7706318 GenBank AEI18843.1 339 Sequence 172 from patent US 7960100
GI:7706318 GenBank AEI18844.1 339 Sequence 173 from patent US 7960100
GI:7706318 GenBank AEI18845.1 339 Sequence 174 from patent US 7960100
GI:7706318 GenBank AIC51542.1 339 DHRS7, partial [synthetic construct]

Related Sequences to LMP006052 proteins

Reference Database Accession Length Protein Name
GI:7706318 GenBank JAA10521.1 339 dehydrogenase/reductase (SDR family) member 7 [Pan troglodytes]
GI:7706318 GenBank JAA18180.1 339 dehydrogenase/reductase (SDR family) member 7 [Pan troglodytes]
GI:7706318 GenBank JAA27524.1 339 dehydrogenase/reductase (SDR family) member 7 [Pan troglodytes]
GI:7706318 GenBank JAA41648.1 339 dehydrogenase/reductase (SDR family) member 7 [Pan troglodytes]
GI:7706318 RefSeq XP_005267814.1 472 PREDICTED: dehydrogenase/reductase SDR family member 7 isoform X1 [Homo sapiens]
GI:7706318 RefSeq XP_008955244.1 339 PREDICTED: dehydrogenase/reductase SDR family member 7 [Pan paniscus]