Gene/Proteome Database (LMPD)

LMPD ID
LMP006065
Gene ID
327942
Species
Mus musculus (Mouse)
Gene Name
phosphatidylinositol glycan anchor biosynthesis, class L
Gene Symbol
Pigl
Synonyms
Gm737
Alternate Names
N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase; PIG-L; phosphatidylinositol glycan, class L; phosphatidylinositol-glycan biosynthesis class L protein; ortholog of human and rat phosphatidylinositol glycan class L PIGL
Chromosome
11
Map Location
11 B2|11
EC Number
3.5.1.89

Proteins

N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase
Refseq ID NP_001034625
Protein GI 88014552
UniProt ID Q5SX19
mRNA ID NM_001039536
Length 252
RefSeq Status PROVISIONAL
MELVGFLCVAVAVLTWGFLRVWNSAERMRSPEQAGLPGAGSRALVVIAHPDDEAMFFAPTMLGLARLEQQVSLLCFSSGNYYNQGEIRKKELLQSCAVLGIPPSRVMIIDKRDFPDDPEVQWDTELVASTLLQHIHANGTDLVVTFDAEGVSGHSNHIALYKAVRALHSGGKLPKGCSVLTLQSVNALRKYAFLLDLPWTLLSPQDVLFVLTSKEVAQAKKAMSCHRSQLLWFRYLYVLFSRYMRINSLRFL

Gene Information

Entrez Gene ID
327942
Gene Name
phosphatidylinositol glycan anchor biosynthesis, class L
Gene Symbol
Pigl
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0000225 IEA:UniProtKB-EC F N-acetylglucosaminylphosphatidylinositol deacetylase activity
GO:0006506 IEA:UniProtKB-UniPathway P GPI anchor biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu00563 Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
mmu01100 Metabolic pathways

REACTOME Pathway Links

REACTOME Pathway ID Description
5893244 Synthesis of glycosylphosphatidylinositol (GPI)

Domain Information

InterPro Annotations

Accession Description
IPR003737 N-acetylglucosaminyl phosphatidylinositol deacetylase-related
IPR024078 Putative deacetylase LmbE-like domain

UniProt Annotations

Entry Information

Gene Name
phosphatidylinositol glycan anchor biosynthesis, class L
Protein Entry
PIGL_MOUSE
UniProt ID
Q5SX19
Species
Mouse

Comments

Comment Type Description
Catalytic Activity 6-(N-acetyl-alpha-D-glucosaminyl)-1- phosphatidyl-1D-myo-inositol + H(2)O = 6-(alpha-D-glucosaminyl)-1- phosphatidyl-1D-myo-inositol + acetate.
Function Involved in the second step of GPI biosynthesis. De-N- acetylation of N-acetylglucosaminyl-phosphatidylinositol (By similarity). {ECO:0000250}.
Pathway Glycolipid biosynthesis; glycosylphosphatidylinositol- anchor biosynthesis.
Similarity Belongs to the PIGL family. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP006065 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
88014552 RefSeq NP_001034625 252 N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase

Identical Sequences to LMP006065 proteins

Reference Database Accession Length Protein Name
GI:88014552 DBBJ BAE34385.1 252 unnamed protein product [Mus musculus]
GI:88014552 GenBank EDL10346.1 252 mCG23380, isoform CRA_b [Mus musculus]
GI:88014552 SwissProt Q5SX19.1 252 RecName: Full=N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase; AltName: Full=Phosphatidylinositol-glycan biosynthesis class L protein; Short=PIG-L [Mus musculus]

Related Sequences to LMP006065 proteins

Reference Database Accession Length Protein Name
GI:88014552 DBBJ BAA20869.1 252 PIG-L [Rattus norvegicus]
GI:88014552 GenBank AAH74020.1 252 Pigl protein [Rattus norvegicus]
GI:88014552 GenBank EDM04707.1 252 phosphatidylinositol glycan, class L [Rattus norvegicus]
GI:88014552 GenBank AED45473.1 285 Sequence 1239 from patent US 7892730
GI:88014552 RefSeq NP_620256.1 252 N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase [Rattus norvegicus]
GI:88014552 SwissProt O35790.1 252 RecName: Full=N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase; AltName: Full=Phosphatidylinositol-glycan biosynthesis class L protein; Short=PIG-L [Rattus norvegicus]