Gene/Proteome Database (LMPD)

LMPD ID
LMP006074
Gene ID
10628
Species
Homo sapiens (Human)
Gene Name
thioredoxin interacting protein
Gene Symbol
TXNIP
Synonyms
EST01027; HHCPA78; THIF; VDUP1
Alternate Names
thioredoxin-interacting protein; thioredoxin binding protein 2; thioredoxin-binding protein 2; vitamin D3 up-regulated protein 1; upregulated by 1,25-dihydroxyvitamin D-3
Chromosome
1
Map Location
1q21.1

Proteins

thioredoxin-interacting protein
Refseq ID NP_006463
Protein GI 171184421
UniProt ID Q9H3M7
mRNA ID NM_006472
Length 391
RefSeq Status VALIDATED
MVMFKKIKSFEVVFNDPEKVYGSGEKVAGRVIVEVCEVTRVKAVRILACGVAKVLWMQGSQQCKQTSEYLRYEDTLLLEDQPTGENEMVIMRPGNKYEYKFGFELPQGPLGTSFKGKYGCVDYWVKAFLDRPSQPTQETKKNFEVVDLVDVNTPDLMAPVSAKKEKKVSCMFIPDGRVSVSARIDRKGFCEGDEISIHADFENTCSRIVVPKAAIVARHTYLANGQTKVLTQKLSSVRGNHIISGTCASWRGKSLRVQKIRPSILGCNILRVEYSLLIYVSVPGSKKVILDLPLVIGSRSGLSSRTSSMASRTSSEMSWVDLNIPDTPEAPPCYMDVIPEDHRLESPTTPLLDDMDGSQDSPIFMYAPEFKFMPPPTYTEVDPCILNNNVQ

Gene Information

Entrez Gene ID
10628
Gene Name
thioredoxin interacting protein
Gene Symbol
TXNIP
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IDA:UniProtKB C cytoplasm
GO:0005829 TAS:Reactome C cytosol
GO:0005758 IEA:Ensembl C mitochondrial intermembrane space
GO:0005634 IEA:Ensembl C nucleus
GO:0004857 IEA:Ensembl F enzyme inhibitor activity
GO:0031625 IPI:UniProtKB F ubiquitin protein ligase binding
GO:0007049 IEA:UniProtKB-KW P cell cycle
GO:0071228 IDA:UniProtKB P cellular response to tumor cell
GO:0045087 TAS:Reactome P innate immune response
GO:0030216 IDA:UniProtKB P keratinocyte differentiation
GO:0051782 IDA:UniProtKB P negative regulation of cell division
GO:0000122 IEA:Ensembl P negative regulation of transcription from RNA polymerase II promoter
GO:0035872 TAS:Reactome P nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0048008 IEA:Ensembl P platelet-derived growth factor receptor signaling pathway
GO:0043065 IEA:Ensembl P positive regulation of apoptotic process
GO:0006606 IEA:Ensembl P protein import into nucleus
GO:0042127 IEA:Ensembl P regulation of cell proliferation
GO:0051592 IEA:Ensembl P response to calcium ion
GO:0042493 IEA:Ensembl P response to drug
GO:0032355 IEA:Ensembl P response to estradiol
GO:0009749 IEA:Ensembl P response to glucose
GO:0042542 IEA:Ensembl P response to hydrogen peroxide
GO:0009612 IEA:Ensembl P response to mechanical stimulus
GO:0032570 IEA:Ensembl P response to progesterone
GO:0006351 IEA:UniProtKB-KW P transcription, DNA-templated

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_75900 Inflammasomes
REACT_6802 Innate Immune System
REACT_75913 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
REACT_75808 The NLRP3 inflammasome

Domain Information

InterPro Annotations

Accession Description
IPR011022 Arrestin C-terminal-like domain
IPR011021 Arrestin-like, N-terminal
IPR014756 Immunoglobulin E-set

UniProt Annotations

Entry Information

Gene Name
thioredoxin interacting protein
Protein Entry
TXNIP_HUMAN
UniProt ID
Q9H3M7
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9H3M7-1; Sequence=Displayed; Name=2; IsoId=Q9H3M7-2; Sequence=VSP_054401; Note=No experimental confirmation available.;
Function May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over- expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1). {ECO
Induction By 1,25-dihydroxyvitamin D-3 and TGFB1. Down-regulated in response to oxidative stress. {ECO
Ptm Ubiquitinated; undergoes polyubiquitination catalyzed by ITCH resulting in proteasomal degradation.
Similarity Belongs to the arrestin family.
Subcellular Location Cytoplasm .
Subunit Homodimer; disulfide-linked. Interacts with TXN/thioredoxin through its redox-active site. Interacts with transcriptional repressors ZBTB16, ZBTB32 and HDAC1. Interacts (via C-terminus) with ITCH (via WW domains). Interacts with DDIT4. {ECO

Identical and Related Proteins

Unique RefSeq proteins for LMP006074 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
171184421 RefSeq NP_006463 391 thioredoxin-interacting protein

Identical Sequences to LMP006074 proteins

Reference Database Accession Length Protein Name
GI:171184421 GenBank JAA32413.1 391 thioredoxin interacting protein [Pan troglodytes]
GI:171184421 GenBank JAA32414.1 391 thioredoxin interacting protein [Pan troglodytes]
GI:171184421 GenBank JAA32415.1 391 thioredoxin interacting protein [Pan troglodytes]
GI:171184421 GenBank JAA32416.1 391 thioredoxin interacting protein [Pan troglodytes]
GI:171184421 GenBank AIC50678.1 391 TXNIP, partial [synthetic construct]
GI:171184421 RefSeq NP_001258601.1 391 thioredoxin-interacting protein [Pan troglodytes]

Related Sequences to LMP006074 proteins

Reference Database Accession Length Protein Name
GI:171184421 EMBL CAD29008.1 391 unnamed protein product [Homo sapiens]
GI:171184421 EMBL CAD43676.1 391 unnamed protein product [Homo sapiens]
GI:171184421 EMBL CAD57059.1 391 unnamed protein product [Homo sapiens]
GI:171184421 GenBank AAB31977.2 391 brain-expressed HHCPA78 homolog VDUP1 [Homo sapiens]
GI:171184421 GenBank AAT01927.2 391 thioredoxin binding protein 2, partial [Homo sapiens]
GI:171184421 GenBank AHD72352.1 391 Sequence 7850 from patent US 8586006