Gene/Proteome Database (LMPD)

LMPD ID
LMP006175
Gene ID
59031
Species
Mus musculus (Mouse)
Gene Name
carbohydrate sulfotransferase 12
Gene Symbol
Chst12
Synonyms
AI595374; C4S-2; C4ST2
Alternate Names
carbohydrate sulfotransferase 12; chondroitin 4-sulfotransferase 2; chondroitin 4-O-sulfotransferase 2
Chromosome
5
Map Location
5 G2|5
EC Number
2.8.2.5

Proteins

carbohydrate sulfotransferase 12
Refseq ID NP_067503
Protein GI 157266279
UniProt ID Q99LL3
mRNA ID NM_021528
Length 419
RefSeq Status VALIDATED
MTKPRLFRLWLVLGSALMILLIIVYWDNVGTAHFYLHTSLSRPHILEPLPTQGLVEENVFTSDVDEFLDTLLSSDAKHNDLSRRKTEQPPVPAPSKPVLSHMEENVRGYDWSTHDAHQNPDRDRQQAERRSLLRDFCANASLAFPTKDRSFDDIPNYELNHLIVDDRHGVIYCYVPKVACTNWKRVMIVLSESLLDRGSPYRDPLDIPREHVHNTSTHLTFNKFWRRYGKFSRHLMKVKLKKYTKFLFVRDPFVRLISAFRSKFELENEEFYRKFAVPMLRLYANHTSLPASVSEAFSAGLKVSFANFIQYLLDPHTEKLAPFNEHWRQVYRLCHPCQIDYDFVGKLETLDEDAAQLLRFLKVDSQLHFPPSYRNRTASSWEEDWFANIPLAWRQQLYKLYEADFVLFGYPKPENLLRD

Gene Information

Entrez Gene ID
59031
Gene Name
carbohydrate sulfotransferase 12
Gene Symbol
Chst12
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IEA:UniProtKB-KW C Golgi apparatus
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0047756 ISS:UniProtKB F chondroitin 4-sulfotransferase activity
GO:0016051 IEA:InterPro P carbohydrate biosynthetic process
GO:0030206 ISS:UniProtKB P chondroitin sulfate biosynthetic process
GO:0030208 ISS:UniProtKB P dermatan sulfate biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
ko00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
mmu00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate

REACTOME Pathway Links

REACTOME Pathway ID Description
5894037 Chondroitin sulfate biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR018011 Carbohydrate sulfotransferase-related
IPR005331 Sulfotransferase

UniProt Annotations

Entry Information

Gene Name
carbohydrate sulfotransferase 12
Protein Entry
CHSTC_MOUSE
UniProt ID
Q99LL3
Species
Mouse

Comments

Comment Type Description
Catalytic Activity 3'-phosphoadenylyl sulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate.
Function Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin and desulfated dermatan sulfate. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Activity toward partially desulfated dermatan sulfate is however lower. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor (By similarity). {ECO:0000250}.
Similarity Belongs to the sulfotransferase 2 family. {ECO:0000305}.
Subcellular Location Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP006175 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
157266279 RefSeq NP_067503 419 carbohydrate sulfotransferase 12

Identical Sequences to LMP006175 proteins

Reference Database Accession Length Protein Name
GI:157266279 DBBJ BAE24951.1 419 unnamed protein product [Mus musculus]
GI:157266279 DBBJ BAE41826.1 419 unnamed protein product [Mus musculus]
GI:157266279 DBBJ BAE42314.1 419 unnamed protein product [Mus musculus]
GI:157266279 GenBank EDL19118.1 419 mCG14487 [Mus musculus]
GI:157266279 RefSeq XP_006504788.1 419 PREDICTED: carbohydrate sulfotransferase 12 isoform X1 [Mus musculus]
GI:157266279 SwissProt Q99LL3.2 419 RecName: Full=Carbohydrate sulfotransferase 12; AltName: Full=Chondroitin 4-O-sulfotransferase 2; AltName: Full=Chondroitin 4-sulfotransferase 2; Short=C4ST-2; Short=C4ST2 [Mus musculus]

Related Sequences to LMP006175 proteins

Reference Database Accession Length Protein Name
GI:157266279 GenBank AAH03201.1 419 Carbohydrate sulfotransferase 12 [Mus musculus]
GI:157266279 GenBank EDL89730.1 419 rCG42530 [Rattus norvegicus]
GI:157266279 GenBank ADL85573.1 419 Sequence 14056 from patent US 7700359
GI:157266279 GenBank AFO09857.1 419 Sequence 14056 from patent US 8221983
GI:157266279 RefSeq NP_001032864.1 419 carbohydrate sulfotransferase 12 [Rattus norvegicus]
GI:157266279 RefSeq XP_008767193.1 419 PREDICTED: carbohydrate sulfotransferase 12 isoform X1 [Rattus norvegicus]