Gene/Proteome Database (LMPD)
LMPD ID
LMP006180
Gene ID
Species
Homo sapiens (Human)
Gene Name
sphingosine-1-phosphate phosphatase 1
Gene Symbol
Synonyms
SPPase1
Alternate Names
sphingosine-1-phosphate phosphatase 1; spp1; hSPP1; hSPPase1; sphingosine-1-phosphatase 1
Chromosome
14
Map Location
14q23.2
EC Number
3.1.3.-
Summary
Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite that regulates diverse biologic processes. SGPP1 catalyzes the degradation of S1P via salvage and recycling of sphingosine into long-chain ceramides (Mandala et al., 2000 [PubMed 10859351]; Le Stunff et al., 2007 [PubMed 17895250]).[supplied by OMIM, Jun 2009]
Orthologs
Proteins
| sphingosine-1-phosphate phosphatase 1 | |
|---|---|
| Refseq ID | NP_110418 |
| Protein GI | 13540569 |
| UniProt ID | Q9BX95 |
| mRNA ID | NM_030791 |
| Length | 441 |
| RefSeq Status | PROVISIONAL |
| MSLRQRLAQLVGRLQDPQKVARFQRLCGVEAPPRRSADRREDEKAEAPLAGDPRLRGRQPGAPGGPQPPGSDRNQCPAKPDGGGAPNGVRNGLAAELGPASPRRAGALRRNSLTGEEGQLARVSNWPLYCLFCFGTELGNELFYILFFPFWIWNLDPLVGRRLVVIWVLVMYLGQCTKDIIRWPRPASPPVVKLEVFYNSEYSMPSTHAMSGTAIPISMVLLTYGRWQYPLIYGLILIPCWCSLVCLSRIYMGMHSILDIIAGFLYTILILAVFYPFVDLIDNFNQTHKYAPFIIIGLHLALGIFSFTLDTWSTSRGDTAEILGSGAGIACGSHVTYNMGLVLDPSLDTLPLAGPPITVTLFGKAILRILIGMVFVLIIRDVMKKITIPLACKIFNIPCDDIRKARQHMEVELPYRYITYGMVGFSITFFVPYIFFFIGIS | |
Gene Information
Entrez Gene ID
Gene Name
sphingosine-1-phosphate phosphatase 1
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005789 | TAS:Reactome | C | endoplasmic reticulum membrane |
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0042392 | IEA:Ensembl | F | sphingosine-1-phosphate phosphatase activity |
| GO:0097191 | IEA:Ensembl | P | extrinsic apoptotic signaling pathway |
| GO:0097193 | IEA:Ensembl | P | intrinsic apoptotic signaling pathway |
| GO:0044281 | TAS:Reactome | P | small molecule metabolic process |
| GO:0006668 | IEA:Ensembl | P | sphinganine-1-phosphate metabolic process |
| GO:0030148 | TAS:Reactome | P | sphingolipid biosynthetic process |
| GO:0006665 | TAS:Reactome | P | sphingolipid metabolic process |
| GO:0006670 | IEA:Ensembl | P | sphingosine metabolic process |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| hsa00600 | Sphingolipid metabolism |
BIOCYC Pathway Links
| BIOCYC Pathway ID | Description |
|---|---|
| PWY3DJ-11470 | sphingosine and sphingosine-1-phosphate metabolism |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_115810 | Sphingolipid de novo biosynthesis |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR000326 | Phosphatidic acid phosphatase type 2/haloperoxidase |
UniProt Annotations
Entry Information
Gene Name
sphingosine-1-phosphate phosphatase 1
Protein Entry
SGPP1_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Function | Has enzymatic activity against both sphingosine 1- phosphate (S1P) and dihydro-S1P. Regulates intracellular and extracellular S1P levels. |
| Similarity | Belongs to the type 2 lipid phosphate phosphatase family. |
| Subcellular Location | Endoplasmic reticulum membrane ; Multi-pass membrane protein . |
| Tissue Specificity | Ubiquitous, with the strongest level in placenta and kidney. |
Identical and Related Proteins
Unique RefSeq proteins for LMP006180 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 13540569 | RefSeq | NP_110418 | 441 | sphingosine-1-phosphate phosphatase 1 |
Identical Sequences to LMP006180 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:13540569 | DBBJ | BAG36867.1 | 441 | unnamed protein product [Homo sapiens] |
| GI:13540569 | GenBank | AAH63839.1 | 441 | Sphingosine-1-phosphate phosphatase 1 [Homo sapiens] |
| GI:13540569 | GenBank | AAH70060.1 | 441 | Sphingosine-1-phosphate phosphatase 1 [Homo sapiens] |
| GI:13540569 | GenBank | EAW80834.1 | 441 | sphingosine-1-phosphate phosphatase 1 [Homo sapiens] |
| GI:13540569 | GenBank | ACE36133.1 | 441 | Sequence 2 from patent US 7374889 |
| GI:13540569 | SwissProt | Q9BX95.2 | 441 | RecName: Full=Sphingosine-1-phosphate phosphatase 1; Short=SPPase1; Short=Spp1; Short=hSPP1; Short=hSPPase1; AltName: Full=Sphingosine-1-phosphatase 1 [Homo sapiens] |
Related Sequences to LMP006180 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:13540569 | GenBank | JAA10132.1 | 441 | sphingosine-1-phosphate phosphatase 1 [Pan troglodytes] |
| GI:13540569 | GenBank | JAA14842.1 | 441 | sphingosine-1-phosphate phosphatase 1 [Pan troglodytes] |
| GI:13540569 | GenBank | JAA26035.1 | 441 | sphingosine-1-phosphate phosphatase 1 [Pan troglodytes] |
| GI:13540569 | GenBank | JAA43661.1 | 441 | sphingosine-1-phosphate phosphatase 1 [Pan troglodytes] |
| GI:13540569 | RefSeq | XP_522876.1 | 441 | PREDICTED: sphingosine-1-phosphate phosphatase 1 [Pan troglodytes] |
| GI:13540569 | RefSeq | XP_004055328.1 | 441 | PREDICTED: sphingosine-1-phosphate phosphatase 1 [Gorilla gorilla gorilla] |